8869 results
Cited 18 times since 2018 (2.7 per year)
source: EuropePMC
Molecular therapy. Nucleic acids,
Volume 14, 6 1 2018, Pages 329-338
Posttranscriptional Regulation of 14q32 MicroRNAs by the CIRBP and HADHB during Vascular Regeneration after Ischemia.
Downie Ruiz Velasco A, Welten SMJ, Goossens EAC, Quax PHA, Rappsilber J, Michlewski G, Nossent AY
After induction of ischemia in mice, 14q32 microRNAs are regulated in three distinct temporal patterns. These expression patterns, as well as basal expression levels, are independent of the microRNA genes' order in the 14q32 locus. This implies that posttranscriptional processing is a major determinant of 14q32 microRNA expression. Therefore, we hypothesized that RNA binding proteins (RBPs) regulate posttranscriptional processing of 14q32, and we aimed to identify these RBPs. To identify pr...
Abstract
Cited 5 times since 2018 (0.7 per year)
source: EuropePMC
Injury,
Volume 50, Issue 5, 6 1 2018, Pages 1036-1041
Identification of thoracic injuries by emergency medical services providers among trauma patients.
van Rein EAJ, Lokerman RD, van der Sluijs R, Hjortnaes J, Lichtveld RA, Leenen LPH, van Heijl M
Introduction: Severe thoracic injuries are time sensitive and adequate triage to a facility with a high-level of trauma care is crucial. The emergency medical services (EMS) providers are required to identify patients with a severe thoracic injury to transport the patient to the right hospital. However, identifying these patients on-scene is difficult. The accuracy of prehospital assessment of potential thoracic injury by EMS providers of the ground ambulances is unknown. Therefore, the aim of t...
Abstract
Cited 1 times since 2018 (0.1 per year)
source: EuropePMC
Journal of vascular surgery cases and innovative techniques,
Volume 4, Issue 4, 4 1 2018, Pages 283-286
Minimally invasive treatment of vascular complications after neoaortoiliac system reconstruction using autologous vein grafts.
Brouwers JJWM, Baetens TR, van Schaik J
Treatment of complications after neoaortoiliac system vein reconstruction is a complex clinical problem with poor results. Endovascular treatment might offer an acceptable outcome in selected cases. We report two rare complications after neoaortoiliac system vein reconstruction for an infected aortic graft. These complications were treated with minimally invasive endovascular techniques. A 54-year-old man presented with an arterioureteral fistula located between the right ureter and the right br...
Abstract
Cited 122 times since 2018 (18 per year)
source: EuropePMC
Nature communications,
Volume 9, Issue 1, 3 1 2018, Pages 5141
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.
Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Mela
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Coloc...
Abstract
Cited 64 times since 2018 (9.4 per year)
source: EuropePMC
Frontiers in neuroscience,
Volume 12, 3 1 2018, Pages 891
Large-Scale Neuromorphic Spiking Array Processors: A Quest to Mimic the Brain.
Thakur CS, Molin JL, Cauwenberghs G, Indiveri G, Kumar K, Qiao N, Schemmel J, Wang R, Chicca E, Olson Hasler J, Seo JS, Yu S, Cao Y, van Schaik A, Etienne-Cummings R
Neuromorphic engineering (NE) encompasses a diverse range of approaches to information processing that are inspired by neurobiological systems, and this feature distinguishes neuromorphic systems from conventional computing systems. The brain has evolved over billions of years to solve difficult engineering problems by using efficient, parallel, low-power computation. The goal of NE is to design systems capable of brain-like computation. Numerous large-scale neuromorphic projects have emerged re...
Abstract
Cited 22 times since 2018 (3.2 per year)
source: EuropePMC
Cardiovascular research,
Volume 114, Issue 14, 1 1 2018, Pages 1848-1859
Generation and primary characterization of iAM-1, a versatile new line of conditionally immortalized atrial myocytes with preserved cardiomyogenic differentiation capacity.
Liu J, Volkers L, Jangsangthong W, Bart CI, Engels MC, Zhou G, Schalij MJ, Ypey DL, Pijnappels DA, de Vries AAF
Aims: The generation of homogeneous cardiomyocyte populations from fresh tissue or stem cells is laborious and costly. A potential solution to this problem would be to establish lines of immortalized cardiomyocytes. However, as proliferation and (terminal) differentiation of cardiomyocytes are mutually exclusive processes, their permanent immortalization causes loss of electrical and mechanical functions. We therefore aimed at developing conditionally immortalized atrial myocyte (iAM) lines allo...
Abstract
Cited 22 times since 2018 (3.2 per year)
source: EuropePMC
Nature genetics,
Volume 50, Issue 12, 1 1 2018, Pages 1755
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L, Almgren P, Boutin T, Debette S, Ding J, Giulianini F, Holliday EG, Jackson AU, Li-Gao R, Lin WY, Luan J, Mangino M, Oldmeadow C, Prins BP, Qian Y, Sargurupremraj M, Shah N, Surendran P, Thériault S, Verweij N, Willems SM, Zhao JH, Amouyel P, Connell J, de Mutsert R, Doney ASF, Farrall M, Menni C, Morris AD, Noordam R, Paré G, Poulter NR, Shields DC, Stanton A, Thom S, Abecasis G, Amin N, Arking DE, Ayers KL, Barbieri CM, Batini C, Bis JC, Blake T, Bochud M, Boehnke M, Boerwinkle E, Boomsma DI, Bottinger EP, Braund PS, Brumat M, Campbell A, Campbell H, Chakravarti A, Chambers JC, Chauhan G, Ciullo M, Cocca M, Collins F, Cordell HJ, Davies G, de Borst MH, de Geus EJ, Deary IJ, Deelen J, Del Greco M F, Demirkale CY, Dörr M, Ehret GB, El
In the version of this article originally published, the name of author Martin H. de Borst was coded incorrectly in the XML. The error has now been corrected in the HTML version of the paper.
Abstract
Cited 27 times since 2018 (4 per year)
source: EuropePMC
The Journal of clinical endocrinology and metabolism,
Volume 103, Issue 12, 1 1 2018, Pages 4569-4579
Blood Metabolomic Measures Associate With Present and Future Glycemic Control in Type 2 Diabetes.
't Hart LM, Vogelzangs N, Mook-Kanamori DO, Brahimaj A, Nano J, van der Heijden AAWA, Willems van Dijk K, Slieker RC, Steyerberg EW, Ikram MA, Beekman M, Boomsma DI, van Duijn CM, Slagboom PE, Stehouwer CDA, Schalkwijk CG, Arts ICW, Dekker JM, Dehghan A, Muka T, van der Kallen CJH, Nijpels G, van Greevenbroek MMJ
Objective: We studied whether blood metabolomic measures in people with type 2 diabetes (T2D) are associated with insufficient glycemic control and whether this association is influenced differentially by various diabetes drugs. We then tested whether the same metabolomic profiles were associated with the initiation of insulin therapy. Methods: A total of 162 metabolomic measures were analyzed using a nuclear magnetic resonance-based method in people with T2D from four cohort studies (n = 2641)...
Abstract
Cited 2 times since 2018 (0.3 per year)
source: EuropePMC
Clinical chemistry and laboratory medicine,
Volume 57, Issue 1, 1 1 2018, Pages 78-88
Toward harmonization of clinical molecular diagnostic reports: findings of an international survey.
Payne DA, Baluchova K, Russomando G, Ahmad-Nejad P, Mamotte C, Rousseau F, van Schaik RHN, Marriott K, Maekawa M, Chan KCA, IFCC Committee on Molecular Diagnostics
Background: The International Organization for Standardization (ISO) 15189 standard provides recommendations for the postexamination reporting phase to enhance quality in clinical laboratories. The purpose of this study was to encourage a broad discussion on current reporting practices for molecular diagnostic tests by conducting a global survey of such practices. Methods: The International Federation of Clinical Chemistry and Laboratory Medicine's Committee for Molecular Diagnostics (IFCC...
Abstract
Cited 4 times since 2018 (0.6 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 20, Issue 12, 1 1 2018, Pages 1989-1996
Electrical latency predicts the optimal left ventricular endocardial pacing site: results from a multicentre international registry.
Sieniewicz BJ, Behar JM, Sohal M, Gould J, Claridge S, Porter B, Niederer S, Gamble JHP, Betts TR, Jais P, Derval N, Spragg DD, Steendijk P, van Gelder BM, Bracke FA, Rinaldi CA
Aims: The optimal site for biventricular endocardial (BIVENDO) pacing remains undefined. Acute haemodynamic response (AHR) is reproducible marker of left ventricular (LV) contractility, best expressed as the change in the maximum rate of LV pressure (LV-dp/dtmax), from a baseline state. We examined the relationship between factors known to impact LV contractility, whilst delivering BIVENDO pacing at a variety of LV endocardial (LVENDO) locations. Methods and results: We compiled a registry of ac...
Abstract
Cited 1 times since 2018 (0.1 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 54, Issue 6, 1 1 2018, Pages 1147-1148
Off-pump mitral valve repair: is less really more?
Tomšic A, Klautz RJM, Palmen M
Abstract
Cited 4 times since 2018 (0.6 per year)
source: EuropePMC
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners,
Volume 25, Issue 7, 30 5 2018, Pages 1692-1698
A comparison of response in the presence or absence of a delay in induction therapy with bortezomib, lenalidomide, and dexamethasone.
Schepers AJ, Jones AR, Reeves BN, Tuchman SA, Bates JS
Purpose: Lenalidomide, bortezomib, and dexamethasone (RVd) has emerged as a preferred induction therapy in multiple myeloma (MM) in the United States. Due to lenalidomide's teratogenic risk, patients and prescribers must comply with a risk evaluation and mitigation strategy (REMS) program. The REMS program limits dispensing to certain third-party specialty pharmacies, whose average prescription fill times are longer than in-house specialty pharmacies. In practice, a delay in procurement of...
Abstract
Cited 8 times since 2018 (1.2 per year)
source: Scopus
European journal of preventive cardiology,
Volume 26, Issue 6, 28 4 2018, Pages 606-608
BENEFIT for all: An ecosystem to facilitate sustained healthy living and reduce the burden of cardiovascular disease.
Keesman M, Janssen V, Kemps H, Hollander M, Reimer WSO, Gemert-Pijnen LV, Hoes A, Kraaij W, Chavannes N, Atsma D, Kraaijenhagen R, Evers A, BENEFIT consortium
Abstract
Cited 2 times since 2018 (0.3 per year)
source: EuropePMC
PloS one,
Volume 13, Issue 11, 27 4 2018, Pages e0207943
Qualitative evaluation of coronary atherosclerosis in a large cohort of young and middle-aged Dutch tissue donors implies that coronary thrombo-embolic manifestations are stochastic.
Lindeman JH, Hulsbos L, van den Bogaerdt AJ, Geerts M, van Gool AJ, Hamming JF, van Dijk RA, Schaapherder AF
Background and aims: With the intention to gain support for the hypothesis that incident ischemic complications of atherosclerotic disease involve a stochastic aspect, we performed a histological, qualitative evaluation of the epidemiology of coronary atherosclerotic disease in a cohort of aortic valve donors. Patients and methods: Donors (n = 695, median age 54, range 11-65 years) were dichotomized into a non-cardiovascular (non-CVD) and a cardiovascular disease death (CVD) group. Consecutive 5...
Abstract
Cited 114 times since 2018 (16.7 per year)
source: EuropePMC
Nature microbiology,
Volume 4, Issue 1, 26 4 2018, Pages 112-123
Prediction of the intestinal resistome by a three-dimensional structure-based method.
Ruppé E, Ghozlane A, Tap J, Pons N, Alvarez AS, Maziers N, Cuesta T, Hernando-Amado S, Clares I, Martínez JL, Coque TM, Baquero F, Lanza VF, Máiz L, Goulenok T, de Lastours V, Amor N, Fantin B, Wieder I, Andremont A, van Schaik W, Rogers M, Zhang X, Willems RJL, de Brevern AG, Batto JM, Blottière HM, Léonard P, Léjard V, Letur A, Levenez F, Weiszer K, Haimet F, Doré J, Kennedy SP, Ehrlich SD
The intestinal microbiota is considered to be a major reservoir of antibiotic resistance determinants (ARDs) that could potentially be transferred to bacterial pathogens via mobile genetic elements. Yet, this assumption is poorly supported by empirical evidence due to the distant homologies between known ARDs (mostly from culturable bacteria) and ARDs from the intestinal microbiota. Consequently, an accurate census of intestinal ARDs (that is, the intestinal resistome) has not yet been fully det...
Abstract
International journal of paleopathology,
Volume 24, 23 4 2018, Pages 171-174
Evaluation of lesion burden in a bone-by-bone comparison of osteological and radiological methods of analysis.
van Schaik K, Eisenberg R, Bekvalac J, Glazer A, Rühli F
Objective: To evaluate differences in lesion identification in skeletal remains with respect to bone type and method of analysis. Materials: 212 mostly 19th century adult skeletons from St. Bride's Church in London. Methods: Using a standard protocol, an osteologist evaluated each set of remains for lesions. A radiologist used the same system to examine radiographs of the crania, humeri, pelves, tibiae, and femora. Results: Osteological analysis noted more lesions per bone type. All bone ty...
Abstract
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Volume 145, 22 4 2018, Pages 7-11
Variation of scattering intensity ratios with mean atomic number using a dilution technique in EDXRF.
Akkuş T, Uzunoğlu Z, Yılmaz D
The variation of different intensity ratios with mean atomic number for qualitative analysis was investigated in EDXRF. Ten different samples with a mean atomic number between 4.268 and 5.786 were obtained by mixing zirconyl chloride octahydrate (Cl2OZr·8H2O) and cellulose (C6H10O5) powders. The samples were excited by 59.54 keV gamma rays emitted from a 241Am annular radioactive source with 5 Ci activity. The high purity germanium (HPGe) semiconductor detector with a resolution of 182 eV at 5.9...
Abstract
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 26, Issue 1, 20 3 2018, Pages 76-85
Multimodality imaging: Bird's eye view from The European Society of Cardiology Congress 2018 Munich, August 25-29, 2018.
Delgado V, Bucciarelli-Ducci C, Gaemperli O, Maurovich-Horvat P, Bax JJ
At the European Society of Cardiology (ESC) congress of this year 2018, held in Munich from August 25th to 29th, 4594 abstracts were presented. Of those, 423 (10.8%) belonged to an imaging category. Experts in echocardiography (VD), cardiovascular magnetic resonance (CMR) (CBD), nuclear imaging (OG), and cardiac computed tomography (CT) (PMH) have selected the abstracts in their areas of expertise that were of most interest to them and are summarized in this bird's eye view from this ESC me...
Abstract
Cited 1 times since 2018 (0.1 per year)
source: EuropePMC
PloS one,
Volume 13, Issue 11, 15 3 2018, Pages e0207507
A stochastic simulation model to study respondent-driven recruitment.
Stein ML, Buskens V, van der Heijden PGM, van Steenbergen JE, Wong A, Bootsma MCJ, Kretzschmar MEE
Respondent-driven detection is a chain recruitment method used to sample contact persons of infected persons in order to enhance case finding. It starts with initial individuals, so-called seeds, who are invited for participation. Afterwards, seeds receive a fixed number of coupons to invite individuals with whom they had contact during a specific time period. Recruitees are then asked to do the same, resulting in successive waves of contact persons who are connected in one recruitment tree. How...
Abstract
Cited 16 times since 2018 (2.3 per year)
source: EuropePMC
Genome biology,
Volume 19, Issue 1, 15 3 2018, Pages 193
Genomes reveal marked differences in the adaptive evolution between orangutan species.
Mattle-Greminger MP, Bilgin Sonay T, Nater A, Pybus M, Desai T, de Valles G, Casals F, Scally A, Bertranpetit J, Marques-Bonet T, van Schaik CP, Anisimova M, Krützen M
Background: Integrating demography and adaptive evolution is pivotal to understanding the evolutionary history and conservation of great apes. However, little is known about the adaptive evolution of our closest relatives, in particular if and to what extent adaptions to environmental differences have occurred. Here, we used whole-genome sequencing data from critically endangered orangutans from North Sumatra (Pongo abelii) and Borneo (P. pygmaeus) to investigate adaptive responses of each speci...
Abstract
