Research

Publications

Below you can find a list of our published research.

9523 results

Cited 21 times since 2016 (2.2 per year) source: EuropePMC

Scientific reports, Volume 6, 13 2 2016, Pages 24334 Islands of spatially discordant APD alternans underlie arrhythmogenesis by promoting electrotonic dyssynchrony in models of fibrotic rat ventricular myocardium. Majumder R, Engels MC, de Vries AA, Panfilov AV, Pijnappels DA

Fibrosis and altered gap junctional coupling are key features of ventricular remodelling and are associated with abnormal electrical impulse generation and propagation. Such abnormalities predispose to reentrant electrical activity in the heart. In the absence of tissue heterogeneity, high-frequency impulse generation can also induce dynamic electrical instabilities leading to reentrant arrhythmias. However, because of the complexity and stochastic nature of such arrhythmias, the combined effect... Abstract

Cited 66 times since 2016 (6.9 per year) source: EuropePMC

European journal of heart failure, Volume 18, Issue 5, 12 2 2016, Pages 482-489 Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency. Anker SD, Schroeder S, Atar D, Bax JJ, Ceconi C, Cowie MR, Crisp A, Dominjon F, Ford I, Ghofrani HA, Gropper S, Hindricks G, Hlatky MA, Holcomb R, Honarpour N, Jukema JW, Kim AM, Kunz M, Lefkowitz M, Le Floch C, Landmesser U, McDonagh TA, McMurray JJ, Merkely B, Packer M, Prasad K, Revkin J, Rosano GM, Somaratne R, Stough WG, Voors AA, Ruschitzka F

Composite endpoints are commonly used as the primary measure of efficacy in heart failure clinical trials to assess the overall treatment effect and to increase the efficiency of trials. Clinical trials still must enrol large numbers of patients to accrue a sufficient number of outcome events and have adequate power to draw conclusions about the efficacy and safety of new treatments for heart failure. Additionally, the societal and health system perspectives on heart failure have raised interest... Abstract

Cited 18 times since 2016 (1.9 per year) source: EuropePMC

Pharmacological research, Volume 107, 8 2 2016, Pages 398-406 Pharmacogenetics of CYP2D6 and tamoxifen therapy: Light at the end of the tunnel? Del Re M, Citi V, Crucitta S, Rofi E, Belcari F, van Schaik RH, Danesi R

The clinical usefulness of assessing the enzymatic activity of CYPD6 in patients taking tamoxifen had been longly debated. In favour of preemptive evaluation of phenotypic profile of patients is the strong pharmacologic rationale, being that the formation of endoxifen, the major and clinically most important metabolite of tamoxifen, is largely dependent on the activity of CYP2D6. This enzyme is highly polymorphic for which the activity is largely depending on genetics, but that can also be inhib... Abstract

Cited 4 times since 2016 (0.4 per year) source: EuropePMC

The American journal of emergency medicine, Volume 34, Issue 8, 7 1 2016, Pages 1364-1368 Comparison of near-infrared spectroscopy and head CT interpretations of the ED patients with minor head injury. Akyol PY, Bayram B, Acerer A, Girgin MC, Yılmaz DÇ, Men S, Atilla R

Abstract

Cited 110 times since 2016 (11.5 per year) source: EuropePMC

The Lancet. Neurology, Volume 15, Issue 7, 7 1 2016, Pages 695-707 Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, the Stroke Genetics Network (SiGN), and the International Stroke Genetics Consortium (ISGC)

Background: Genetic determinants of stroke, the leading neurological cause of death and disability, are poorly understood and have seldom been explored in the general population. Our aim was to identify additional loci for stroke by doing a meta-analysis of genome-wide association studies. Methods: For the discovery sample, we did a genome-wide analysis of common genetic variants associated with incident stroke risk in 18 population-based cohorts comprising 84 961 participants, of whom 4348 had... Abstract

Cited 15 times since 2016 (1.6 per year) source: EuropePMC

Scientific reports, Volume 6, 7 1 2016, Pages 24248 Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response. Wezel A, de Vries MR, Maassen JM, Kip P, Peters EA, Karper JC, Kuiper J, Bot I, Quax PHA

Venous grafts are often used to bypass occlusive atherosclerotic lesions; however, poor patency leads to vein graft disease. Deficiency of TLR4, an inflammatory regulator, reduces vein graft disease. Here, we investigate the effects of the accessory molecule and TLR4 analogue RadioProtective 105 (RP105) on vein graft disease. RP105 deficiency resulted in a 90% increase in vein graft lesion area compared to controls. In a hypercholesterolemic setting (LDLr(-/-)/RP105(-/-) versus LDLr(-/-) mice),... Abstract

Cited 92 times since 2016 (9.6 per year) source: EuropePMC

Expert opinion on drug metabolism & toxicology, Volume 12, Issue 5, 7 1 2016, Pages 555-565 Pharmacogenetic aspects of the use of tacrolimus in renal transplantation: recent developments and ethnic considerations. Tang JT, Andrews LM, van Gelder T, Shi YY, van Schaik RH, Wang LL, Hesselink DA

Introduction: Tacrolimus (Tac) is effective in preventing acute rejection but has considerable toxicity and inter-individual variability in pharmacokinetics and pharmacodynamics. Part of this is explained by polymorphisms in genes encoding Tac-metabolizing enzymes and transporters. A better understanding of Tac pharmacokinetics and pharmacodynamics may help to minimize different outcomes amongst transplant recipients by personalizing immunosuppression. Areas covered: The pharmacogenetic contribu... Abstract

Cited 6 times since 2016 (0.6 per year) source: EuropePMC

Applied neuropsychology. Child, Volume 6, Issue 2, 6 1 2016, Pages 145-157 Neuropsychological presentation and adaptive skills in high-functioning adolescents with visual impairment: A preliminary investigation. Greenaway R, Pring L, Schepers A, Isaacs DP, Dale NJ

Studies in infants and young children with congenital visual impairment (VI) have indicated early developmental vulnerabilities, conversely research with older children and adults have highlighted areas of cognitive strength. A minimal amount is known, however, about the possible combination of strengths and weaknesses in adolescence, and this present study therefore aims to explore the neuropsychological presentation and adaptive behavior profile in high-functioning adolescents with congenital... Abstract

Cited 7 times since 2016 (0.7 per year) source: EuropePMC

PloS one, Volume 11, Issue 4, 6 1 2016, Pages e0152938 Discrepant Results of Experimental Human Mesenchymal Stromal Cell Therapy after Myocardial Infarction: Are Animal Models Robust Enough? den Haan MC, van Zuylen VL, Pluijmert NJ, Schutte CI, Fibbe WE, Schalij MJ, Roelofs H, Atsma DE

Background: Human mesenchymal stromal cells (MSCs) have been reported to preserve cardiac function in myocardial infarction (MI) models. Previously, we found a beneficial effect of intramyocardial injection of unstimulated human MSCs (uMSCs) on cardiac function after permanent coronary artery ligation. In the present study we aimed to extend this research by investigating the effect of intramyocardial injection of human MSCs pre-stimulated with the pro-inflammatory cytokine interferon-gamma (iMS... Abstract

Cited 3 times since 2016 (0.3 per year) source: EuropePMC

Renal failure, Volume 38, Issue 5, 6 1 2016, Pages 781-786 Comparison of serum paraoxonase and arylesterase activities between iron deficiency anemia patients and chronic kidney disease patients with anemia. Okuturlar Y, Akalin N, Kaptanogullari OH, Guner NT, Yilmaz D, Gedikbasi A, Soyluk O, Mert M, Serin SO, Kocoglu H, Hursitoglu M, Kumbasar A

Objective: Altered paraoxonase (PON) and arylesterase (ARE) activities have been shown in anemic chronic kidney disease (CKD) patients and in iron deficiency anemia (IDA) patients. Whether accompanying anemia alone is responsible for this diminished PON and ARE activities in CKD patients or an additive factor for this is not well studied. Therefore, we tried to clarify this issue here. Methods: A total of 82 subjects that consisted of 19 patients with IDA (group 1), 23 anemic CKD patients (group... Abstract

Cited 7 times since 2016 (0.7 per year) source: EuropePMC

Neurourology and urodynamics, Volume 36, Issue 3, 6 1 2016, Pages 597-603 Effects of silodosin, a selective alpha-1A adrenoceptor antagonist, on erectile function in a rat model of partial bladder outlet obstruction. Bastaskın T, Kaya E, Ozakca I, Yilmaz D, Bayatlı N, Akdemir AO, Gur S

Aim: We investigated the effects of silodosin (selective α1A -adrenoceptor antagonist) on erectile dysfunction (ED) in a rat model of bladder outlet obstruction. Methods: Adult male Sprague-Dawley rats (n = 32) were divided into four groups: (i) sham-operated control; (ii) silodosin-treated (sham) control (0.1 mg/kg/day); (iii) partial bladder outlet obstruction (PBOO); and (iv) silodosin-treated with PBOO. PBOO was induced by ligation of the urethra for 6 weeks. In vivo, erectile responses were... Abstract

Cited 19 times since 2016 (2 per year) source: EuropePMC

Journal of experimental child psychology, Volume 147, 6 1 2016, Pages 71-81 Little chameleons: The development of social mimicry during early childhood. van Schaik JE, Hunnius S

Adults use behavioral mimicry to blend in with (or stand out from) their social environment. Adopting another's mannerisms and behaviors, or "mimicking", communicates liking and similarity between interaction partners and has been shown to serve as an implicit affiliation mechanism. Given this important social function, it is surprising that so little is known about the development of mimicry. In two studies, we investigated mimicry and its social sensitivity during early childhoo... Abstract

Cited 33 times since 2016 (3.4 per year) source: EuropePMC

PloS one, Volume 11, Issue 4, 6 1 2016, Pages e0151870 Measuring Hair Cortisol Concentrations to Assess the Effect of Anthropogenic Impacts on Wild Chimpanzees (Pan troglodytes). Carlitz EH, Miller R, Kirschbaum C, Gao W, Hänni DC, van Schaik CP

Non-human primates face major environmental changes due to increased human impacts all over the world. Although some species are able to survive in certain landscapes with anthropogenic impact, their long-term viability and fitness may be decreased due to chronic stress. Here we assessed long-term stress levels through cortisol analysis in chimpanzee hair obtained from sleeping nests in northwestern Uganda, in order to estimate welfare in the context of ecotourism, forest fragmentation with huma... Abstract

Cited 21 times since 2016 (2.2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 102, Issue 16, 5 1 2016, Pages 1302-1308 Cardiac adaption during pregnancy in women with congenital heart disease and healthy women. Kampman MA, Valente MA, van Melle JP, Balci A, Roos-Hesselink JW, Mulder BJ, van Dijk AP, Oudijk MA, Jongbloed MR, van Veldhuisen DJ, Pieper PG, ZAHARA II investigators

Objective: Pregnancy in women with congenital heart disease (CHD) is associated with deterioration in cardiac function. However, longitudinal data are scarce. This study describes serial changes in cardiac dimensions and function during pregnancy in women with CHD and compares these with healthy pregnant women (controls). Methods: Eight tertiary centres prospectively enrolled 125 pregnant women with CHD (pregnancy duration 0.1). Left ventricular ejection fraction (LVEF) Abstract

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Volume 62, Issue 11, 5 1 2016, Pages 1470 Reply to Leenders. Hetem DJ, Bootsma MC, Bonten MJ

Abstract

Cited 22 times since 2016 (2.3 per year) source: EuropePMC

The British journal of surgery, Volume 103, Issue 8, 5 1 2016, Pages 995-1002 Quality of life from a randomized trial of open and endovascular repair for abdominal aortic aneurysm. de Bruin JL, Groenwold RH, Baas AF, Brownrigg JR, Prinssen M, Grobbee DE, Blankensteijn JD, DREAM Study Group

Background: Long-term survival is similar after open or endovascular repair of abdominal aortic aneurysm. Few data exist on the effect of either procedure on long-term health-related quality of life (HRQoL) and health status. Methods: Patients enrolled in a multicentre randomized clinical trial (DREAM trial; 2000-2003) in Europe of open repair versus endovascular repair (EVAR) of abdominal aortic aneurysm were asked to complete questionnaires on health status and HRQoL. HRQoL scores were assesse... Abstract

Cited 174 times since 2016 (18.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 67, Issue 19, 2 1 2016, Pages 2263-2288 Natural History, Diagnostic Approaches, and Therapeutic Strategies for Patients With Asymptomatic Severe Aortic Stenosis. Généreux P, Stone GW, O'Gara PT, Marquis-Gravel G, Redfors B, Giustino G, Pibarot P, Bax JJ, Bonow RO, Leon MB

Aortic stenosis (AS) is one of the most common valvular diseases encountered in clinical practice. Current guidelines recommend aortic valve replacement (AVR) when the aortic valve is severely stenotic and the patient is symptomatic; however, a substantial proportion of patients with severe AS are asymptomatic at the time of first diagnosis. Although specific morphological valve features, exercise testing, stress imaging, and biomarkers can help to identify patients with asymptomatic severe AS w... Abstract

Cited 5 times since 2016 (0.5 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 11, Issue 13, 1 1 2016, Pages 1554-1561 Acute effect of MitraClip implantation on mitral valve geometry in patients with functional mitral regurgitation: insights from three-dimensional transoesophageal echocardiography. Al Amri I, Debonnaire P, van der Kley F, Schalij MJ, Bax JJ, Marsan NA, Delgado V

Aims: Our aim was to evaluate the acute effects of transcatheter edge-to-edge mitral valve repair using the MitraClip device on mitral valve geometry in patients with functional mitral regurgitation (FMR). Methods and results: Forty-two patients (age 73 years [IQ range 66.1-78.0], 55% men, 62% ischaemic FMR) with moderate-to-severe and severe FMR treated with the MitraClip were included. Three-dimensional transoesophageal echocardiography was performed prior to and immediately after MitraClip im... Abstract

Cited 9 times since 2016 (0.9 per year) source: EuropePMC

Cited 35 times since 2016 (3.6 per year) source: EuropePMC

Circulation research, Volume 118, Issue 8, 1 1 2016, Pages 1254-1263 Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies: Controversies in Meta-Analyses Results on Cardiac Cell-Based Regenerative Studies. Gyöngyösi M, Wojakowski W, Navarese EP, Moye LÀ, ACCRUE Investigators

In contrast to multiple publication-based meta-analyses involving clinical cardiac regeneration therapy in patients with recent myocardial infarction, a recently published meta-analysis based on individual patient data reported no effect of cell therapy on left ventricular function or clinical outcome. A comprehensive review of the data collection, statistics, and the overall principles of meta-analyses provides further clarification and explanation for this controversy. The advantages and pitfa... Abstract