8684 results
Cited 14 times since 2015 (1.4 per year)
source: EuropePMC
Journal of bacteriology,
Volume 197, Issue 20, 10 2 2015, Pages 3283-3293
Loss of Antibiotic Tolerance in Sod-Deficient Mutants Is Dependent on the Energy Source and Arginine Catabolism in Enterococci.
Ladjouzi R, Bizzini A, van Schaik W, Zhang X, Rincé A, Benachour A, Hartke A
Unlabelled: Enterococci are naturally tolerant to typically bactericidal cell wall-active antibiotics, meaning that their growth is inhibited but they are not killed even when exposed to a high concentration of the drug. The molecular reasons for this extraordinary tolerance are still incompletely understood. Previous work showed that resistance to killing collapsed specifically in mutants affected in superoxide dismutase (Sod) activity, arguing that bactericidal antibiotic treatment led to indu...
Abstract
Cited 5 times since 2015 (0.5 per year)
source: EuropePMC
BMC neurology,
Volume 15, 7 1 2015, Pages 133
Association between changes in brain microstructure and cognition in older subjects at increased risk for vascular disease.
Sala M, de Roos A, Blauw GJ, Middelkoop HA, Jukema JW, Mooijaart SP, van Buchem MA, de Craen AJ, van der Grond J
Background: The purpose of this study is to investigate whether changes in brain microstructure, detected by magnetization transfer imaging, are associated with cognition in older subjects at increased risk for vascular disease. Methods: One hundred ninety three nondemented subjects (105 men, mean age 77 ± 3 years) from the Prospective Study of Pravastatin in the Elderly at Risk were included. To assess cross-sectional associations between magnetization transfer ratio (MTR) peak height and cogni...
Abstract
Cited 7 times since 2015 (0.7 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 48, Issue 4, 6 1 2015, Pages e64-70
Stopping antiplatelet medication before coronary artery bypass graft surgery: is there an optimal timing to minimize bleeding?
Gielen CL, Bruggemans EF, Stijnen T, Eikenboom J, Tavilla G, Brand A, Klautz RJ
Objectives: As the indication for antiplatelet medication expands, patients may be exposed to an increased risk of excessive blood loss when cardiac surgery is required. The optimal timing to stop acetylsalicylic acid (ASA) or ASA combined with clopidogrel (ASA+Clo) before surgery is the subject of controversy. Methods: A total of 1065 patients were selected from a prospective randomized study on the effect of a fibrin sealant application in coronary artery bypass graft surgery [Fibrin sealant I...
Abstract
Cited 19 times since 2015 (1.9 per year)
source: EuropePMC
Neurology,
Volume 85, Issue 9, 5 1 2015, Pages 783-789
Executive function, but not memory, associates with incident coronary heart disease and stroke.
Rostamian S, van Buchem MA, Westendorp RG, Jukema JW, Mooijaart SP, Sabayan B, de Craen AJ
Objective: To evaluate the association of performance in cognitive domains executive function and memory with incident coronary heart disease and stroke in older participants without dementia. Methods: We included 3,926 participants (mean age 75 years, 44% male) at risk for cardiovascular diseases from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) with Mini-Mental State Examination score ≥24 points. Scores on the Stroop Color-Word Test (selective attention) and the Letter...
Abstract
Cited 24 times since 2015 (2.4 per year)
source: EuropePMC
PloS one,
Volume 10, Issue 8, 4 1 2015, Pages e0133888
Optimisations and Challenges Involved in the Creation of Various Bioluminescent and Fluorescent Influenza A Virus Strains for In Vitro and In Vivo Applications.
Spronken MI, Short KR, Herfst S, Bestebroer TM, Vaes VP, van der Hoeven B, Koster AJ, Kremers GJ, Scott DP, Gultyaev AP, Sorell EM, de Graaf M, Bárcena M, Rimmelzwaan GF, Fouchier RA
Bioluminescent and fluorescent influenza A viruses offer new opportunities to study influenza virus replication, tropism and pathogenesis. To date, several influenza A reporter viruses have been described. These strategies typically focused on a single reporter gene (either bioluminescent or fluorescent) in a single virus backbone. However, whilst bioluminescence is suited to in vivo imaging, fluorescent viruses are more appropriate for microscopy. Therefore, the idea l reporter virus varies dep...
Abstract
Cited 24 times since 2015 (2.4 per year)
source: EuropePMC
American heart journal,
Volume 170, Issue 5, 4 1 2015, Pages 981-985.e1
Ticagrelor or prasugrel versus clopidogrel in elderly patients with an acute coronary syndrome: Optimization of antiplatelet treatment in patients 70 years and older--rationale and design of the POPular AGE study.
Qaderdan K, Ishak M, Heestermans AA, de Vrey E, Jukema JW, Voskuil M, de Boer MJ, van't Hof AW, Groenemeijer BE, Vos GJ, Janssen PW, Bergmeijer TO, Kelder JC, Deneer VH, ten Berg JM
Rationale: Dual antiplatelet therapy with acetylsalicylic acid in combination with a more potent P2Y12- inhibitor (ticagrelor or prasugrel) is recommended in patients with acute coronary syndrome without ST-segment elevation (NSTE-ACS) to prevent atherothrombotic complications. The evidence on which this recommendation is based shows that ticagrelor and prasugrel reduce atherothrombotic events at the expense of an increase in bleeding events when compared with clopidogrel. However, it remains un...
Abstract
Cited 5 times since 2015 (0.5 per year)
source: EuropePMC
Intensive care medicine,
Volume 41, Issue 11, 4 1 2015, Pages 2013-2014
Gain-of-function single nucleotide variants of the CYP2C19 gene (CYP2C19*17) can identify subtherapeutic voriconazole concentrations in critically ill patients: a case series.
Weigel JD, Hunfeld NG, Koch BC, Egal M, Bakker J, van Schaik RH, van Gelder T
Abstract
Cited 27 times since 2015 (2.7 per year)
source: EuropePMC
PloS one,
Volume 10, Issue 8, 3 1 2015, Pages e0134245
Serum Cardiac Troponin-I is Superior to Troponin-T as a Marker for Left Ventricular Dysfunction in Clinically Stable Patients with End-Stage Renal Disease.
Buiten MS, de Bie MK, Rotmans JI, Dekker FW, van Buren M, Rabelink TJ, Cobbaert CM, Schalij MJ, van der Laarse A, Jukema JW
Background: Serum troponin assays, widely used to detect acute cardiac ischemia, might be useful biomarkers to detect chronic cardiovascular disease (CVD). Cardiac-specific troponin-I (cTnI) and troponin-T (cTnT) generally detect myocardial necrosis equally well. In dialysis patients however, serum cTnT levels are often elevated, unlike cTnI levels. The present study aims to elucidate the associations of cTnI and cTnT with CVD in clinically stable dialysis patients. Methods: Troponin levels were...
Abstract
Cited 21 times since 2015 (2.1 per year)
source: EuropePMC
Circulation. Cardiovascular interventions,
Volume 8, Issue 8, 1 1 2015, Pages e002740
Repeated Intramyocardial Bone Marrow Cell Injection in Previously Responding Patients With Refractory Angina Again Improves Myocardial Perfusion, Anginal Complaints, and Quality of Life.
Mann I, Rodrigo SF, van Ramshorst J, Beeres SL, Dibbets-Schneider P, de Roos A, Wolterbeek R, Zwaginga JJ, Fibbe WE, Bax JJ, Schalij MJ, Atsma DE
Background: Intramyocardial bone marrow cell injection is associated with improvements in myocardial perfusion and anginal symptoms in patients with refractory angina pectoris. This study evaluates the effect of repeated intramyocardial bone marrow cell injection in patients with residual or recurrent myocardial ischemia. Methods and results: Twenty-three patients (17 men; 69±9 years) who had improved myocardial perfusion after the first injection but had residual or recurrent angina and ischemi...
Abstract
Cited 5 times since 2015 (0.5 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 23, Issue 9, 1 1 2015, Pages 447-449
Heart failure in 2015: let's get organised!
Lucas CM, van Pol PE, Eysink Smeets JB, Niesing M, Verwey HF, Beeres SL
Abstract
Cited 15 times since 2015 (1.5 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 8, Issue 4, 1 1 2015, Pages 951-962
Twelve-lead ECG of ventricular tachycardia in structural heart disease.
de Riva M, Watanabe M, Zeppenfeld K
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 23, Issue 9, 1 1 2015, Pages 453-454
Carotid sinus massage for diagnosis in narrow QRS tachycardia.
Henkens IR, Zeppenfeld K, Hauer AD
Abstract
Cited 10 times since 2015 (1 per year)
source: EuropePMC
Therapeutic drug monitoring,
Volume 37, Issue 4, 1 1 2015, Pages 501-507
The Effect of Tamoxifen Dose Increment in Patients With Impaired CYP2D6 Activity.
Welzen ME, Dezentjé VO, van Schaik RH, Colbers AP, Guchelaar HJ, van Erp NP, den Hartigh J, Burger DM, van Laarhoven HW
Background: The effect of tamoxifen dose elevation on endoxifen serum concentration was investigated in patients with reduced CYP2D6 activity resulting from genetic variation and/or CYP2D6 inhibitor use. Additionally, baseline differences in endoxifen concentrations between the different CYP2D6 phenotypes were studied. Methods: Patients, treated with tamoxifen 20 mg once daily (QD) for at least 4 weeks, were classified as phenotypic extensive (EM), intermediate (IM), or poor (PM) metabolizer bas...
Abstract
Cited 37 times since 2015 (3.8 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 17 Suppl 4, 1 1 2015, Pages iv1-72
Current trends in the use of cardiac implantable electronic devices and interventional electrophysiological procedures in the European Society of Cardiology member countries: 2015 report from the European Heart Rhythm Association.
Raatikainen MJ, Arnar DO, Zeppenfeld K, Merino JL, Kuck KH, Hindricks G
Aims: The aim was to provide comprehensive information on the use of cardiac implantable electronic device (CIED) and catheter ablation therapy in the European Society of Cardiology (ESC) area. Methods and results: The European Heart Rhythm Association (EHRA) has collected data on use of invasive arrhythmia managements since 2008. Fifty-one of the 56 ESC member countries provided data for the EHRA White Book 2015. This analysis is based on the current and previous editions of the EHRA White Book...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 23, Issue 9, 1 1 2015, Pages 450
Carotid sinus massage for diagnosis in narrow QRS tachycardia.
Henkens IR, Zeppenfeld K, Hauer AD
Abstract
Cited 15 times since 2015 (1.5 per year)
source: EuropePMC
Echocardiography (Mount Kisco, N.Y.),
Volume 33, Issue 2, 1 1 2015, Pages 193-206
Reference Values for Echocardiography in Middle-Aged Population: The Cardiovascular Risk in Young Finns Study.
Ruohonen S, Koskenvuo JW, Wendelin-Saarenhovi M, Savontaus M, Kähönen M, Laitinen T, Lehtimäki T, Jokinen E, Viikari J, Juonala M, Taittonen L, Tossavainen P, Kallio M, Bax JJ, Raitakari O
Background: Population and sex-specific reference limits produced with modern ultrasound equipment are needed for accurate clinical echocardiography diagnostics. We report a comprehensive set of reference limits of cardiac function and dimensions in a group of young and middle-aged Finnish men and women produced by the recommendations of European Society of Echocardiography and American Society of Cardiology. Methods and results: Cardiac structure and function was studied in a standardized compr...
Abstract
Cited 8 times since 2015 (0.8 per year)
source: EuropePMC
EBioMedicine,
Volume 2, Issue 9, 31 5 2015, Pages 1217-1223
Continuous Postoperative Pericardial Flushing: A Pilot Study on Safety, Feasibility, and Effect on Blood Loss.
Manshanden JS, Gielen CL, de Borgie CA, Klautz RJ, de Mol BA, Koolbergen DR
Background: Prolonged or excessive blood loss is a common complication after cardiac surgery. Blood remnants and clots, remaining in the pericardial space in spite of chest tube drainage, induce high fibrinolytic activity that may contribute to bleeding complications. Continuous postoperative pericardial flushing (CPPF) with an irrigation solution may reduce blood loss by preventing the accumulation of clots. In this pilot study, the safety and feasibility of CPPF were evaluated and the effect o...
Abstract
Cited 73 times since 2015 (7.4 per year)
source: EuropePMC
Nature protocols,
Volume 10, Issue 9, 30 5 2015, Pages 1285-1296
Population-specific genotype imputations using minimac or IMPUTE2.
van Leeuwen EM, Kanterakis A, Deelen P, Kattenberg MV, Genome of the Netherlands Consortium, Slagboom PE, de Bakker PI, Wijmenga C, Swertz MA, Boomsma DI, van Duijn CM, Karssen LC, Hottenga JJ
In order to meaningfully analyze common and rare genetic variants, results from genome-wide association studies (GWASs) of multiple cohorts need to be combined in a meta-analysis in order to obtain enough power. This requires all cohorts to have the same single-nucleotide polymorphisms (SNPs) in their GWASs. To this end, genotypes that have not been measured in a given cohort can be imputed on the basis of a set of reference haplotypes. This protocol provides guidelines for performing imputation...
Abstract
Cited 33 times since 2015 (3.3 per year)
source: EuropePMC
Physiology & behavior,
Volume 151, 29 5 2015, Pages 246-251
Strongly bonded family members in common marmosets show synchronized fluctuations in oxytocin.
Finkenwirth C, van Schaik C, Ziegler TE, Burkart JM
Oxytocin is a key regulator of social bonding and is positively linked to affiliation and prosocial behavior in several mammal species. In chimpanzees, this link is dyad-specific as affiliative interactions only elicit high oxytocin release if they involve strongly bonded individuals. These studies involved isolated dyads and sampling events. Little is known about the role of oxytocin in affiliation and social bonding, and about potential long-term patterns of bonding-related and dyad-specific o...
Abstract
Cited 68 times since 2015 (6.9 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 100, Issue 3, 28 4 2015, Pages 1126-1131
Reported Outcome After Valve-Sparing Aortic Root Replacement for Aortic Root Aneurysm: A Systematic Review and Meta-Analysis.
Arabkhani B, Mookhoek A, Di Centa I, Lansac E, Bekkers JA, De Lind Van Wijngaarden R, Bogers AJ, Takkenberg JJ
Valve-sparing aortic root techniques have progressively gained ground in the treatment of aortic root aneurysm and aortic insufficiency. By avoiding anticoagulation therapy they offer a good alternative to composite graft replacement. This systematic review describes the reported outcome of valve-sparing aortic root replacement, focusing on the remodeling and reimplantation technique. A systematic literature search on the characteristics of and outcomes after valve-sparing aortic root replacemen...
Abstract
