Research

Publications

Below you can find a list of our published research.

6125 results

Cited 5 times since 2000 (0.2 per year) source: EuropePMC

Thrombosis research, Volume 97, Issue 5, 1 1 2000, Pages 275-280 The -323Ins10 polymorphism for factor VII is not associated with coronary atherosclerosis in symptomatic men. The REGRESS study group. Lievers KJ, Mennen LI, Rattink AP, Zwinderman AH, Jukema JW, Schouten EG, de Maat MP

Elevated factor VII coagulant activity (FVII:C) has been associated with an increased risk of ischaemic heart disease, particularly for fatal events. Results of studies on the association between FVII:C and atherosclerosis are not consistent. FVII:C levels are influenced by several environmental factors and by genetic factors. One of the genetic factors is the -323Ins10 polymorphism in the promoter region of the factor VII gene, which is strongly related to FVII:C, and thus may be associated wit... Abstract

Cited 6 times since 2000 (0.2 per year) source: EuropePMC

International journal of cardiac imaging, Volume 16, Issue 1, 1 1 2000, Pages 35-41 Imaging of an aneurysm of the sinus of Valsalva with transesophageal echocardiography, contrast angiography and MRI. Baur LH, Vliegen HW, van der Wall EE, Hazekamp M, Bootsma M, de Roos A, Bruschke AV

A sinus of Valsalva aneurysm is an uncommon congenital defect, which requires appropriate diagnosis with either echocardiography, magnetic resonance imaging or contrast angiography. Treatment consists of aortic valve repair. We describe a young woman with an aneurysm of the non-coronary sinus of Valsalva, an atrial septal defect and pulmonary insufficiency. The different imaging techniques and possibilities of surgical correction are described. Abstract

Cited 1 times since 2000 (0 per year) source: EuropePMC

Biology of the neonate, Volume 78, Issue 2, 1 1 2000, Pages 98-105 Influence of inhibition of nitric oxide synthesis on cardiac function in the newborn lamb after hypoxic-ischemic injury. Dorrepaal CA, van Bel F, Steendijk P, Shadid M, van de Velde ET, Moison RM, Berger HM, Baan J

The aim of the present study was to investigate the effect of immediate post-hypoxic-ischemic (HI) inhibition of nitric oxide synthesis by N(omega)-nitro-L-arginine (NLA) on cardiac function and reactive oxygen species production. Fifteen newborn lambs were subjected to severe HI. Upon resuscitation 5 received 10 mg NLA/kg, 4 40 mg NLA/kg and 6 a placebo. Left ventricular (LV) contractility, cardiac output (CO), non-protein-bound iron (NPBI), ratio of reduced/oxidized ascorbic acid, alpha-tocoph... Abstract

Cited 24 times since 2000 (1 per year) source: EuropePMC

Clinical & experimental metastasis, Volume 18, Issue 6, 1 1 2000, Pages 445-453 Antibodies to PAI-1 alter the invasive and migratory properties of human tumour cells in vitro. Brooks TD, Slomp J, Quax PH, De Bart AC, Spencer MT, Verheijen JH, Charlton PA

Recent reports suggest that elevated levels of plasminogen activator inhibitor-1 (PAI-1) may contribute to tumour progression. The studies reported here were designed to help elucidate PAI-1's contribution to the invasive and migratory phenotype. Antibodies to PA-1 dose-dependently, and significantly, inhibited the invasive and migratory potential of human HT1080 fibrosarcoma cells, as did an antibody to uPA and the plasmin inhibitor aprotinin. Invasion of the human melanoma cell line, BLM,... Abstract

Cited 49 times since 2000 (1.9 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 278, Issue 1, 1 1 2000, Pages H100-5 Improved contractile performance of right ventricle in response to increased RV afterload in newborn lamb. de Vroomen M, Cardozo RH, Steendijk P, van Bel F, Baan J

Pulmonary hypertension results in an increased afterload for the right ventricle (RV). To determine the effects of this increased afterload on RV contractile performance, we examined RV performance before and during 4 h of partial balloon occlusion of the pulmonary artery and again after releasing the occlusion in nine newborn lambs. RV contractile performance was quantified by indexes derived from systolic RV pressure-volume relations obtained by a combined pressure-conductance catheter during... Abstract

Cited 7 times since 1999 (0.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 82, Issue 6, 1 1 1999, Pages 697-703 Left ventricular function in adults with mild pulmonary insufficiency late after Fallot repair. Niezen RA, Helbing WA, van Der Wall EE, van Der Geest RJ, Vliegen HW, de Roos A

Objective: To assess left ventricular function in adult Fallot patients with residual pulmonary regurgitation. Setting: The radiology department of a tertiary referral centre. Patients: 14 patients with chronic pulmonary regurgitation and right ventricular volume overload after repair of tetralogy of Fallot and 10 healthy subjects were studied using magnetic resonance imaging. Main outcome measures: Biventricular volumes, global biventricular function, and regional left ventricular function were... Abstract

Cited 13 times since 1999 (0.5 per year) source: EuropePMC

Annals of human genetics, Volume 63, Issue Pt 6, 1 1 1999, Pages 499-510 Analysis of lipoprotein lipase haplotypes reveals associations not apparent from analysis of the constituent loci. Hallman DM, Groenemeijer BE, Jukema JW, Boerwinkle E, Kastelein JJ

Simultaneously analysing genotype effects at several closely-linked loci may be preferable to analysing them separately, but can be difficult, due to multiple genotype classes, small class sizes, and non-independence induced by associations among loci. Analysis of haplotype effects offers an alternative approach. We studied effects of haplotypes comprising 3 loci (5' to 3': PvuII, HindIII, and Ser 447 -Stop) in the lipoprotein lipase (LPL) gene on plasma lipid levels and LPL activity,... Abstract

Cited 195 times since 1999 (7.7 per year) source: EuropePMC

The American journal of cardiology, Volume 84, Issue 10, 1 1 1999, Pages 1192-1197 The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER). PROSPER Study Group. PROspective Study of Pravastatin in the Elderly at Risk. Shepherd J, Blauw GJ, Murphy MB, Cobbe SM, Bollen EL, Buckley BM, Ford I, Jukema JW, Hyland M, Gaw A, Lagaay AM, Perry IJ, Macfarlane PW, Meinders AE, Sweeney BJ, Packard CJ, Westendorp RG, Twomey C, Stott DJ

The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) is a randomized, double-blind, placebo-controlled trial designed to test the hypothesis that treatment with pravastatin will diminish risk of subsequent major vascular events in a cohort of men and women (70 to 82 years old) with preexisting vascular disease or significant risk of developing this condition. Five thousand eight hundred four men and women in addition to receiving advice on diet and smoking, have been randomized... Abstract

Cited 13 times since 1999 (0.5 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 6, Issue 6, 1 1 1999, Pages 577-582 Automated ejection fraction determination from gated myocardial FDG-PET data. Willemsen AT, Siebelink HJ, Blanksma PK, Paans AM

Background: The aim of this study was to determine the potential of the automated calculation of the left ventricular ejection fraction from gated myocardial positron emission tomography (PET) scans. Methods: We retrospectively analyzed the data of 20 patients who underwent both gated fluorine 18 deoxyglucose (FDG)-PET and equilibrium radionuclide angiography (ERNA). Gated PET data were analyzed by 2 independent programs (ie, quantitative gated single photon emission computed tomography [QGS]) o... Abstract

Cited 4 times since 1999 (0.2 per year) source: EuropePMC

Seminars in thoracic and cardiovascular surgery, Volume 11, Issue 4 Suppl 1, 1 1 1999, Pages 133-138 Dehiscence of the Freestyle stentless bioprosthesis. Schoof PH, Baur LH, Kappetein AP, Hazekamp MG, van Rijk-Zwikker GL, Huysmans HA

This study aimed to identify and characterize patients who developed prosthetic dehiscence after aortic valve replacement with the Freestyle Stentless bioprosthesis. Review of patients' records and preoperative echocardiogram was performed. Prosthetic dehiscence developed in 10 patients after 2.5 to 49 months (mean 19). Most patients were symptomatic at presentation. Nine patients were reoperated. Dehiscence was typically located at the inflow suture line beneath the noncoronary cusp. Four... Abstract

Cited 75 times since 1999 (3 per year) source: EuropePMC

Cell death and differentiation, Volume 6, Issue 10, 1 1 1999, Pages 976-986 The La (SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis. Rutjes SA, Utz PJ, van der Heijden A, Broekhuis C, van Venrooij WJ, Pruijn GJ

In the past few years, a role for apoptotic processes in the development of autoimmune diseases has been suggested. An increasing number of cellular proteins, which are modified during apoptosis, has been described, and many of these proteins have been identified as autoantigens. We have studied the effects of apoptosis on the La protein in more detail and for the first time demonstrate that this autoantigen is rapidly dephosphorylated after the induction of apoptosis. Dephosphorylation of the L... Abstract

Cited 13 times since 1999 (0.5 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 10, Issue 3, 1 1 1999, Pages 434-441 Evaluation of coronary artery bypass grafts by magnetic resonance imaging. Langerak SE, Kunz P, de Roos A, Vliegen HW, van Der Wall EE

Magnetic resonance (MR) angiography and flow mapping have the potential to become a major noninvasive diagnostic tool for the assessment of coronary artery bypass graft morphology and function. Several MR sequences, such as conventional non-respiratory compensated methods, and phase contrast cine flow sequences have been reported for the evaluation of bypass graft patency. However the visualization of different graft segments and the detection of graft stenosis remains difficult. Recent advances... Abstract

Cited 5 times since 1999 (0.2 per year) source: EuropePMC

Indian journal of pediatrics, Volume 66, Issue 5, 1 1 1999, Pages 651-655 Antioxidant defense systems in newborns undergoing phototherapy. Akisü M, Yilmaz D, Tüzün S, Kültürsay N

This paper was designed to investigate whether phototherapy is an oxidative stress in newborn infants undergoing phototherapy. A day-light continuous phototherapy was given to jaundiced 20 term and 16 preterm newborns for 72 hours. We measured serum vitamin E and the activities of red blood cell anti-oxidation enzymes (superoxide dismutase, catalase and glutathione peroxidase) before and after 72 h of phototherapy. Serum vitamin E levels were not different before and after 72 h of phototherapy i... Abstract

Cited 6 times since 1999 (0.2 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 12, Issue 9, 1 1 1999, Pages 729-735 Echocardiographic parameters of the freestyle stentless bioprosthesis in aortic position: the European experience. Baur LH, Jin XY, Houdas Y, Peels CH, Braun J, Kappetein AP, Prat A, Hazekamp MG, Van Straten BH, Ploeg A, Sieders A, Voogd PJ, Bruschke AV, van der Wall EE, Westaby S, Huysmans HA

The objective of this study was to determine normal Doppler and 2-dimensional characteristics of the Freestyle stentless aortic bioprosthesis. The Freestyle aortic bioprosthesis is a new type of aortic xenograft, and experience is limited. We therefore determined the normal range of echocardiographic and Doppler examinations of this valve. Three hundred thirty-nine consecutive patients with a Freestyle aortic bioprosthesis underwent an echocardiographic and Doppler examination according to a com... Abstract

Cited 4 times since 1999 (0.2 per year) source: EuropePMC

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 48, Issue 1, 1 1 1999, Pages 105-112 Stenting of long coronary artery lesions: initial angiographic results and 6-month clinical outcome of the micro stent II-XL. Schalij MJ, Udayachalerm W, Oemrawsingh P, Jukema JW, Reiber JH, Bruschke AV

To evaluate the results of long Micro Stent II (MS-XL) implantations, 119 MS-XLs were implanted in 102 patients (age, 62.83 years). Nineteen stents (16%) were implanted in saphenous vein grafts; 100 stents (84%) were implanted in native coronary arteries. Twenty-five patients (25%) were treated because of acute myocardial infarction (AMI); 30 patients (29%) because of unstable angina or angina class IV, and 47 patients (46%) because of stable angina. Eighty-six de novo lesions (84%) and 16 reste... Abstract

Cited 35 times since 1999 (1.4 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 118, Issue 2, 1 1 1999, Pages 252-258 Brom's three-patch technique for repair of supravalvular aortic stenosis. Hazekamp MG, Kappetein AP, Schoof PH, Ottenkamp J, Witsenburg M, Huysmans HA, Bogers AJ

Objective: Case histories of all patients (n = 29) operated on for supravalvular aortic stenosis from 1962 to the present were reviewed to study different techniques and outcomes. The technique of symmetric aortoplasty with 3 patches (1 in each sinus) is described and compared with other methods. Methods: Case reports were reviewed and follow-up was completed by contacting the patient's (pediatric) cardiologist. We aimed for a last follow-up visit, including Doppler echocardiographic studie... Abstract

Cited 4 times since 1999 (0.2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 82, Issue 2, 1 1 1999, Pages 126-127 Matching treatment to the genetic basis of (lipid) disorder in patients with coronary artery disease. Jukema JW

Abstract

Cited 118 times since 1999 (4.6 per year) source: EuropePMC

Journal of virology, Volume 73, Issue 8, 1 1 1999, Pages 6335-6345 Identification of a novel structural protein of arteriviruses. Snijder EJ, van Tol H, Pedersen KW, Raamsman MJ, de Vries AA

Arteriviruses are positive-stranded RNA viruses with an efficiently organized, polycistronic genome. A short region between the replicase gene and open reading frame (ORF) 2 of the equine arteritis virus (EAV) genome was previously assumed to be untranslated. However, here we report that this segment of the EAV genome contains the 5' part of a novel gene (ORF 2a) which is conserved in all arteriviruses. The 3' part of EAV ORF 2a overlaps with the 5' part of the former ORF 2 (now r... Abstract

Cited 5 times since 1999 (0.2 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 18, Issue 2, 1 1 1999, Pages 174-175 Spontaneous perforation of an aortic endoprosthesis. Breek JC, Hamming JF, Lohle PN, Lampmann LE, van Berge Henegouwen DP

Abstract

Cited 62 times since 1999 (2.4 per year) source: EuropePMC

The Journal of biological chemistry, Volume 274, Issue 35, 1 1 1999, Pages 24799-24807 Rapid nucleolytic degradation of the small cytoplasmic Y RNAs during apoptosis. Rutjes SA, van der Heijden A, Utz PJ, van Venrooij WJ, Pruijn GJ

We have investigated the fate of the RNA components of small ribonucleoprotein particles in apoptotic cells. We show that the cytoplasmic Ro ribonucleoprotein-associated Y RNAs are specifically and rapidly degraded during apoptosis via a caspase-dependent mechanism. This is the first study describing the selective degradation of a specific class of small structural RNA molecules in apoptotic cells. Cleavage and subsequent truncation of Y RNAs was observed upon exposure of cells to a variety of a... Abstract