7401 results
Clinical and translational science,
Volume 18, Issue 8, 1 1 2025, Pages e70303
Recommendations for (Pharmaco)Genetic Sampling in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation.
Bokma A, Matic M, Ralf A, van den Bosch BJC, Kayser M, van Schaik RHN, Lafeber M, Coenen MJH, Atrafi F
In patients receiving allogenic hematopoietic stem cell transplantation (aHSCT) complete chimerism is desired. However, this brings a challenge when non-invasive assessment of recipient germline DNA is required for genetic testing. Here, we aim to create awareness for (pharmaco)genetic sampling in patients following aHSCT based on a case report of a patient following aHSCT in which pharmacogenetic analysis was performed. Six pharmacogenetic genes were analyzed in DNA extracted from peripheral bl...
Abstract
Journal of experimental botany,
Volume 76, Issue 12, 1 1 2025, Pages 3560-3576
Gpa2 detects the potato cyst nematode effector GpRBP-1 in the cytoplasm but requires a balanced nucleocytoplasmic distribution to trigger cell death.
Zheng Q, Putker V, Slootweg EJ, Overmars H, van Leeuwen F, van Schaik CC, Sterken MG, Sukarta OCA, Smant G, Goverse A
The potato immune receptor Gpa2 confers host-specific resistance to the cyst nematode Globodera pallida. When transiently expressed in Nicotiana benthamiana it triggers cell death upon recognition of the matching effector GpRBP-1. Effector-triggered immunity by Gpa2 depends on the host factor RanGAP2, which is known to regulate the nucleocytoplasmic distribution and functioning of the highly homologous potato immune receptor Rx1. However, the subcellular localisation of Gpa2 and the role of RanG...
Abstract
The journal of vascular access,
1 1 2025, Pages 11297298251350745
Cephalic vein dilatation at the elbow by preoperative supervised forearm exercise depends on adherence to therapy: Results from the randomized controlled single-blind PINCH trial.
Wilschut ED, de Winter EP, Bos EJ, de Vries MR, Putter H, van der Steenhoven TJ, Eefting D, Hamming JF, Rotmans JI, van der Bogt KEA
Background: Maturation failure may be as high as 30%-60% of arteriovenous fistulas (AVF). Forearm exercise postoperatively has shown potential in increasing blood vessel size in patients with end-stage renal disease and may promote maturation of AVFs. Little evidence exists on the impact of pre-operative forearm exercises on the increase of vascular diameters. Aim of this study was to evaluate the effect of supervised forearm exercises on vascular diameters and AVF maturation. Methods: The PINCH...
Abstract
European heart journal,
1 1 2025, Pages ehaf480
Heart failure with reduced ejection fraction and ventricular secondary mitral regurgitation: a holistic approach.
Adamo M, Pagnesi M, Ajmone Marsan N, Bauersachs J, Hausleiter J, Zieroth S, Metra M
Optimal management of patients with heart failure with reduced ejection fraction (HFrEF) and secondary mitral regurgitation (SMR) requires the integration of multiple competencies with the interplay of guideline-directed medical therapy (GDMT) for HFrEF, devices, namely cardiac resynchronization therapy (CRT), when indicated, and mitral transcatheter edge-to-edge repair (M-TEER). Both GDMT and CRT can reduce SMR severity. However, GDMT may not be tolerated in patients with HFrEF who develop hypo...
Abstract
Cited 2 times since 2025 (14.1 per year)
source: EuropePMC
European heart journal. Quality of care & clinical outcomes,
Volume 11, Issue 5, 1 1 2025, Pages 691-697
Key priorities for the implementation of the 2023 ESC Guidelines for the management of endocarditis in low-resource settings.
Borger MA, de Waha S, Marsan NA, Zühlke L, Mestres CA, Fosbol E, Bonaros N, Pizzi MN, Brida M, Sionis A, Delgado V, Members of the Task Force for the 2023 ESC Guidelines for the management of endocarditis
European Society of Cardiology (ESC) Guidelines provide best practice, evidence-based recommendations for diagnosing and treating patients with cardiovascular diseases. It is not always possible for best practices to be followed, however, particularly in low-resource settings. To address this issue, a set of guideline-related documents were created to identify key priorities for users in these settings. The documents highlight the related recommendations and describe key strategies for clinician...
Abstract
The Journal of asthma : official journal of the Association for the Care of Asthma,
31 5 2025, Pages 1-7
Inhaled muscarinic antagonists during pregnancy in women with asthma: case series from a Dutch prospective observational cohort study.
Kathiravetpillai N, van Buul AR, Ezinga M, Koehorst-Ter Huurne K, Van Nederveen-Bendien SA
Introduction: A large proportion of women with asthma experience worsening of asthma during pregnancy. Well-controlled asthma during pregnancy decreases the risk of maternal and fetal complications. Long-acting muscarinic antagonists (LAMAs) are part of treatment guidelines for poorly controlled asthma. There are no clinical safety data available on LAMA and short-acting muscarinic antagonists (SAMAs) use in pregnancy.Objective: The aim was to evaluate asthma control and pregnancy outcomes in pr...
Abstract
Cited 1 times since 2025 (6.9 per year)
source: EuropePMC
Alimentary pharmacology & therapeutics,
Volume 62, Issue 5, 31 5 2025, Pages 553-554
Letter: Efficacy Versus Effectiveness-An Important Nuance Among Real-World Studies.
Naber MR, Ubbink D, van Schaik FDM, Löwenberg M
Abstract
The Journal of dermatological treatment,
Volume 36, Issue 1, 30 5 2025, Pages 2539282
Upadacitinib in daily practice for refractory atopic dermatitis in adolescents: a case series of the BioDay registry.
Vroman F, van der Rijst LP, Bacoş-Cosma OI, Zuithoff NPA, Kamsteeg M, van Lumig PPM, Loman L, Schuttelaar MLA, de Bruin-Weller MS, de Graaf M
Purpose: Upadacitinib is approved for treating moderate-to-severe atopic dermatitis (AD) aged ≥12 years. We evaluated upadacitinib's effectiveness and safety in AD adolescents in daily practice. Materials and methods: Fifteen adolescent AD patients from the BioDay registry, treated with upadacitinib 15 mg once daily were evaluated at baseline and after 4, 8, 16, and 28 weeks. Effectiveness was assessed using Eczema Area and Severity Index (EASI) score and Investigator Global Assessment (IGA...
Abstract
Immuno-oncology technology,
Volume 27, 29 5 2025, Pages 101065
Comprehensive analysis of the systemic immune landscape across breast cancer subtypes and disease stages.
Bakker NAM, Garner H, Geurts VCM, Champanhet E, Klaver C, Duijst M, Nederlof I, Gielen RCAM, de Graaf M, Voorthuis R, Liefaard MC, Lips EH, Oosterkamp HM, Kok M, de Visser KE
Background: Breast cancer is a systemic disease, yet the impact of tumor molecular subtype and disease stage on the systemic immune landscape remains poorly understood. In this study, we comprehensively analyzed the systemic immune landscape in a large cohort of breast cancer patients, encompassing all molecular subtypes and disease stages, alongside a control group of healthy donors. Materials and methods: Using multi-parameter flow cytometry, we assessed the abundance, phenotype, and activatio...
Abstract
Journal of orthopaedics,
Volume 68, 29 5 2025, Pages 283-286
Indomethacin versus Ketorolac for the prevention of heterotopic ossification in hip arthroscopy patients.
Frey CS, Spears TM, Puczko D, Hymel AM, Mathews CG, Luchini PM, Van Schaik KD, Leschied JR, Sullivan J
Background: Nonsteroidal anti-inflammatory drugs are commonly utilized to reduce the risk of developing heterotopic ossification (HO) after hip arthroscopy. However, it is not known which regimen is optimal. Purpose: The purpose of this study is to determine the rate of HO formation after hip arthroscopy in response to different NSAID protocols. Methods: Consecutive cases of a single fellowship-trained surgeon at a tertiary referral center were retrospectively reviewed. Patients received a regim...
Abstract
JACC. Basic to translational science,
Volume 10, Issue 8, 29 5 2025, Pages 101323
CD137 Signaling Modulates Vein Graft Atherosclerosis by Driving T-Cell Activation and Regulating Intraplaque Angiogenesis.
de Jong A, Sluiter TJ, Peters HAB, Lamens A, Jukema JW, Arens R, Quax PHA, de Vries MR
Atherosclerotic vein graft failure still presents a major problem. T-cells have been identified as one of the most abundant immune cell subset in atherosclerotic plaques. Their role, however, remains only partly understood. Using a murine vein graft model for advanced, unstable atherosclerotic lesions, we find that T-cells accumulate over time in atherosclerotic vein grafts, and appear to be activated rapidly after engraftment, demonstrated by increased expression of CD137 on plaque T-cells. Tar...
Abstract
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association,
28 4 2025, Pages S1542-3565(25)00636-6
Preoperative Body Composition Parameters Are Associated With Postoperative Outcomes in Patients With Crohn's Disease.
Bak MTJ, Demers K, van Ruler O, Pierik MJ, van Dijk DPJ, van der Bilt JDW, Romberg-Camps M, Dijkstra G, Duijvestein M, van der Marel S, Maljaars PWJ, Buskens CJ, Bakers FCH, Brecheisen R, Bongers BC, de Witte D, Jansen SV, Jharap B, Horjus CS, van Schaik FDM, West RL, de Boer NKH, Hansen BE, van der Woude CJ, van Rossum EFC, Stassen LPS, de Vries AC, RAP-CD study group, Dutch Initiative on Crohn and Colitis (ICC) and Dutch Initiative on Crohn and Colitis – Surgery (ICC-S)
Background & aims: Preoperative body composition is a potential modifiable risk factor for poor postoperative outcomes in Crohn's disease (CD). This study aimed to investigate the association of preoperative body composition parameters with postoperative complications and endoscopic postoperative recurrence (ePOR) in patients with CD following ileocolic (re-)resection (ICR). Methods: Patients with CD (≥16 years) scheduled for ICR with preoperative abdominal imaging (
Abstract
European heart journal,
25 4 2025, Pages ehaf456
Arrhythmia ablation in patients with congenital heart disease: challenges and opportunities in using complex spectrum data to guide individual care.
Kimura Y, Zeppenfeld K
Abstract
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
25 4 2025, Pages S0894-7317(25)00396-7
Left Atrial Strain Index in Patients With Heart Failure With Preserved Ejection Fraction.
Chua APA, Weerts J, Achten A, Nabeta T, Sarrazyn C, Lopez-Santi P, Mourmans SGJ, Su JL, Bax JJ, Knackstedt C, van Empel VPM, Ajmone-Marsan N
Abstract
Circulation. Arrhythmia and electrophysiology,
Volume 18, Issue 8, 25 4 2025, Pages e013150
Regional Cardiac Denervation Predicts Sustained Ventricular Arrhythmias in Nonischemic Cardiomyopathy Patients Without LGE on CMR Imaging.
Jungen C, Chen HS, Wijnmaalen AP, Dibbets-Schneider P, Meretta A, Piers SR, Kimura Y, Androulakis AFA, van der Geest RJ, de Geus-Oei LF, Mertens BJA, Scholte AJHA, Lamb HJ, Jongbloed MRM, Zeppenfeld K
Background: In patients with nonischemic cardiomyopathy and no late gadolinium enhancement (LGE) on cardiac magnetic resonance, risk prediction for the occurrence of sustained ventricular arrhythmias (VA) is challenging. Global and regional sympathetic denervation has been associated with VA in patients with ischemic cardiomyopathy. Its prognostic relevance in nonischemic cardiomyopathy is unknown. Methods: Consecutive patients from the Leiden Nonischemic Cardiomyopathy Study who underwent progr...
Abstract
Veterinary microbiology,
Volume 309, 24 4 2025, Pages 110652
Evaluating the effect of vaccination on the impact of BTV-3 in Dutch sheep flocks in 2024.
Dijkstra E, Santman-Berends IMGA, Stegeman A, van den Brink KMJA, van Schaik G, van den Brom R
Bluetongue virus serotype 3 (BTV-3) emerged in the Netherlands in 2023 and re-emerged in 2024, causing a substantial impact on the sheep population. In 2024, inactivated BTV-3 vaccines became available, yet clinical cases and excess mortality were still reported, including among vaccinated flocks. This study aimed to quantify the effect of BTV-3 vaccination on excess mortality in sheep and lambs during the 2024 epidemic, using data from twenty veterinary practises, and to evaluate whether a prot...
Abstract
Frontiers in cardiovascular medicine,
Volume 12, 24 4 2025, Pages 1649558
Editorial: New trends in vascular biology 2024.
Chelvanambi S, Chen H, De Vries MR, Fang Y, Fredman G, Gomez D, Iwata H, Uchida S, Yanagisawa H, Aikawa M
Abstract
Biological reviews of the Cambridge Philosophical Society,
23 4 2025
Assessing flexibility in meaning and context in non-human communication.
Fröhlich M, Aychet J, Clark PR, Crockford C, Dezecache G, Rebout N, van Schaik CP, Graham KE
The concept of flexibility in communication is central to reconstructing the evolutionary history of language, and grappling with "contextual flexibility" in particular is pivotal to address implications for pragmatics-first accounts of language evolution. Despite significant advances in the field, research is hindered by definitional inconsistencies and methodological gaps across modalities. We build on recent frameworks to propose further, detailed methods for studying contextual and...
Abstract
Frontiers in medicine,
Volume 12, 23 4 2025, Pages 1587912
Immersion to impact: does one or three years of rural immersion influence graduate clinical practice intentions and locations?
Harvey W, Ali Z, Van Schaik L, Develyn T, Wright J
Background: Addressing rural healthcare workforce shortages requires evidence-based strategies in medical education. Extended rural immersion programs offer a potential solution, but the optimal duration for fostering long-term regional and rural practice remains unclear. Methods: This retrospective study evaluates the impact of one-year versus three-year rural immersion experiences at the University of Melbourne's Rural Clinical School (RCS) on graduate clinical practice locations of the 2...
Abstract
British journal of anaesthesia,
22 4 2025, Pages S0007-0912(25)00404-0
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period: withdraw or continue? A multicentre randomised controlled trial.
Miggelbrink LA, van Klei WA, Verhaar MC, Asselbergs FW, Spiering W, Buhre WFFA, Hollmann MW, van Lier F, van Dongen EHPA, Schober P, Rettig TCD, Reitsma HJB, van Schaik EPC, Vernooij LM, van Waes JAR
Abstract
