Research

Publications

Below you can find a list of our published research.

7365 results

NeuroImage. Clinical, Volume 48, 19 3 2025, Pages 103881 Brain age gap reduction following exercise mirrors clinical improvements in schizophrenia spectrum disorders. Yilmaz D, Papiol S, Keeser D, Cole JH, Malchow B, Walter H, Meyer-Lindenberg A, Hirjak D, Schmitt A, Falkai P, Maurus I, Roell L

Schizophrenia spectrum disorders (SSD) are associated with accelerated brain aging, reflected in an increased brain age gap. This gap serves as a biomarker, indicating poorer brain health, cognitive deficits, and greater severity in specific symptom domains. Exercise holds promise as an adjunct therapy to mitigate these deficits by potentially promoting brain recovery. However, the extent of overall improvements in brain health following exercise, along with their predictors and relationships to... Abstract

Applied and environmental microbiology, Volume 91, Issue 10, 19 3 2025, Pages e0082225 Evidence of ESBL plasmid transfer and selective persistence of multiple host-associated Escherichia coli isolates in a chicken cecal fermentation model. Leng J, Ferrandis-Vila M, Oldenkamp R, Mehat JW, Fivian-Hughes AS, Kumar Tiwari S, Van der Putten B, Trung Nguyen V, Bethe A, Clark J, Singh P, Semmler T, Schwarz S, Alvarez J, Hoa NT, Bootsma M, Menge C, Berens C, Schultsz C, Ritchie JM, La Ragione RM

The guts of animals and humans harbor diverse microbial communities that are regularly exposed to bacteria originating from food, water, and their surroundings. Species such as Escherichia coli are adept at colonizing multiple hosts, along with surviving in the environment. By encoding pathogenic traits and transmissible forms of antimicrobial resistance (AMR), E. coli can also pose a zoonotic risk. Our understanding of the factors that govern host residency is limited. Here, we used a chicken c... Abstract

American journal of clinical dermatology, Volume 26, Issue 6, 19 3 2025, Pages 1031-1043 Systemic Treatments in Moderate-to-Severe Atopic Dermatitis in Pediatric Patients up to 12 Years of Age: Real-World Treatment Outcomes from the PEDISTAD Registry. Paller AS, Marcoux D, Ramien M, Baselga E, Carvalho VO, Ardusso LRF, de Graaf M, Pasmans S, Toledo-Bahena M, Rubin C, Joyce JC, Lee LW, Gupta R, Adams B, Ardeleanu M, Zhang A

Background: Atopic dermatitis (AD), a chronic systemic disease, can cause intense skin itching and negatively impact sleep, mood, and quality of life (QoL) for patients and families. Methods: PEDISTAD is an ongoing, 10-year, observational registry describing disease characteristics, atopic comorbidities, and treatment patterns in pediatric patients (aged Abstract

The Journal of cardiovascular surgery, 19 3 2025 Contemporary randomized controlled trials in uncomplicated type B aortic dissection: a comparative methodological analysis. Rahman T, Bicknell CD, Mussa FF, Björkman P, SUNDAY Investigators, EARNEST Investigators

The management of uncomplicated type B aortic dissection (uTBAD) remains a subject of ongoing debate. While best medical therapy (BMT) has been the conventional approach, thoracic endovascular aortic repair (TEVAR) has been proposed as an alternative due to its potential to promote aortic remodeling and reduce long-term complications. However, conflicting evidence regarding its survival benefits, procedural risks, and long-term durability has limited its widespread adoption. Three contemporary r... Abstract

Epidemiology and infection, Volume 153, 19 3 2025, Pages e115 Phylodynamic inference suggests introductions as main driver of Mpox Clade II outbreak in 2022 in Slovenia. Van der Roest B, Fischer EAJ, Klinkenberg D, Bootsma MCJ, Maticic M, Resman-Rus K, Korva M, Avsic-Zupanc T, Kretzschmar M

In 2022, an Mpox clade II outbreak affected many countries. To optimize control, knowledge on the number of new introductions (human cases infected from outside the study population) versus local transmission is important. We extracted sequences of all 48 Mpox cases in Slovenia in 2022 from the NCBI database, of which 42 passed quality control. We estimated the number of introductions using the phylodynamic model phybreak by integrating genomic and epidemiological data and inferred transmission... Abstract

Journal of neurological surgery. Part A, Central European neurosurgery, 19 3 2025 Duraplasty with Autologous Blood: A Cost-Effective and Efficient Alternative to Medical Products. Haciyakupoglu E, Yüvrük E, Yilmaz DM, Polat S, Haciyakupoglu S

Objective The aim of this experimental study was to investigate the effects of autologous plasma used as an alternative to duraplasty Materials and Methods We operated 21 patients and 8 New Zealand Rabbits and performed duraplasty with autologous blood. First heparin was added to autologous blood withdrawn from the patient/ rabbit, The sample was then centrifuged to obtain plasma. protamine sulfate was added to the plasma This mixture was then applied to the dural space and tumor cavity, resulti... Abstract

Microbiology spectrum, Volume 13, Issue 10, 18 3 2025, Pages e0176225 Activity of HOCl-generating e-bandage with clinically available hydrogels against Staphylococcus aureus and Acinetobacter baumannii biofilms. Dagsuyu E, Kies P, Karau MJ, Patel R, Beyenal H

Biofilms hinder wound infection healing, making wound infections a healthcare challenge for which innovative treatments are needed. A 1.77 cm2 electrochemical bandage (e-bandage), which generates the biocide hypochlorous acid (HOCl), has shown promising anti-biofilm activity in vitro, ex vivo, and in vivo. The e-bandage is a three-electrode system operationalized by a hydrogel. In addition to providing a conductive electrolyte for the electrodes, the hydrogel provides a protective barrier for th... Abstract

Signal transduction and targeted therapy, Volume 10, Issue 1, 18 3 2025, Pages 311 Reversion of aortic valve cells calcification by activation of Notch signalling via histone acetylation induction. Garoffolo G, Ferrari S, De Martino S, Pizzo E, Candino V, Curini L, Macrì F, Kruithof BPT, Mongelli A, Grillo M, Fanotti N, Fejzaj P, Casaburo M, Alanazi A, Marsan NA, Khaliel F, Alsulbud A, Agrifoglio M, Colombo GI, Chiesa M, Farsetti A, Gaetano C, Raucci A, Pesce M

Calcification of the aortic valve is a prevalent cardiovascular pathology in the aging population. Traditionally linked to inflammation, lipid accumulation, and risk conditions, this disease remains poorly understood, and effective treatments to halt its progression are not yet available. We hypothesized that calcification of the human valve interstitial cells (VICs) is associated with cellular senescence and alterations in the epigenetic setup, like in arteries. To verify this hypothesis, we ex... Abstract

Annals of vascular surgery, Volume 122, 17 3 2025, Pages 774-779 Diagnostic Accuracy of Elastic Deformation for Detecting High Aneurysm Sac Pressure After Endovascular Aneurysm Repair. van Rijn K, van Genderen OS, Putter H, Eiberg JP, van Wissen RC, Hamming JF, van Schaik J, van der Vorst JR

Objectives: Elastic deformation (ED) is a novel noninvasive follow-up modality after endovascular aortic repair (EVAR). ED is defined as the percentage of diameter change of the aneurysm sac after application of a controlled ultrasound transducer pressure. It is hypothesized that low aneurysm sac deformation indicates high sac pressure. The current study aims to determine the ideal cutoff value of ED and analyze the corresponding diagnostic accuracy. Methods: A prospective cohort study was perfo... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 33, Issue 11, 17 3 2025, Pages 335-342 Radiofrequency ablation of supraventricular tachyarrhythmias in newborns and infants: why, when, and how? Palma A, Bertels RA, de Riva M, Zeppenfeld K, Blom NA

Supraventricular tachyarrhythmias (SVTs) in newborns and infants ( Abstract

Transfusion, 17 3 2025 Storage duration of platelet concentrates and clinical outcomes in cardiac surgery patients. van Hout FMA, Caram-Deelder C, Pors A, Middelburg RA, Klautz RJM, Rosseel PMJ, Helmerhorst HJF, van de Watering LMG, Kerkhoffs JL, Palmen M, van der Bom JG

Background: The changes in platelet structure and function arising from its collection and storage are collectively called "platelet storage lesion." In patients this might potentially be associated with impaired hemostasis and adverse events. We performed a hypothesis-generating retrospective study in cardiac surgery patients transfused with platelets in two hospitals between 2005 and 2017. Study design and methods: We explored whether longer storage duration of platelets is associate... Abstract

Innovations (Philadelphia, Pa.), 16 3 2025, Pages 15569845251367418 Application of Augmented Reality in Robot-Assisted Mitral Valve Repair Surgery: A Feasibility Study. Peek JJ, Hildebrandt K, Zhang X, Kharbanda RK, Oudeman MAP, Klautz RJM, Palmen M, Mahtab EAF

Objective: In mitral valve surgery, it is important to be aware of adjacent intraoperatively invisible anatomy, to avoid complications and enhance safety. In this feasibility study, we aimed to develop semi-automated intraoperative 3-dimensional (3D) augmented reality (3D-AR) overlays for robotic mitral valve repair. Methods: In 5 patients undergoing robot-assisted mitral valve repair, a 3D point cloud was generated, using intraoperatively recorded images from both eyes of the stereoscopic da Vi... Abstract

Frontiers in sports and active living, Volume 7, 15 3 2025, Pages 1642180 Platform power, athlete branding, generative AI, and the future of sport governance-a systematic review. Westerbeek H, van Schaik T

This systematic review examines how elite athletes are leveraging digital platforms, generative artificial intelligence (AI), and blockchain to build autonomous brands, bypass traditional sport gatekeepers, and develop athlete-owned business models. Drawing on 47 peer-reviewed studies (2016-2025), we synthesise evidence across five domains: athlete branding and self-production, disintermediation, platform-enabled empowerment, AI-driven content innovation, and emerging commercial structures. The... Abstract

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 21, Issue 18, 15 3 2025, Pages e1081-e1089 VARC-HBR criteria validation in TAVI patients on oral anticoagulation. Overduin DC, van Ginkel DJ, Bor WL, Kobari Y, Aarts HM, Dubois C, De Backer O, Rooijakkers MJP, Rosseel L, Veenstra L, van der Kley F, van Bergeijk KH, van Mieghem NM, Agostoni P, Voskuil M, Schotborgh CE, Ijsselmuiden AJJ, Van Heyden JAS, Hermanides RS, Barbato E, Mylotte D, Fabris E, Frambach P, Dujardin K, Ferdinande B, Peper J, Rensing BJWM, Timmers L, Swaans MJ, Brouwer J, Nijenhuis VJ, Adriaenssens T, Vriesendorp PA, Montero-Cabezas JM, Jattari HE, Halim J, Van den Branden BJL, Leonora R, Vanderheyden M, Lauterbach M, Wykrzykowska JJ, van 't Hof AWJ, van Royen N, Tijssen JGP, Delewi R, Ten Berg JM

Background: Bleeding remains a frequent complication after transcatheter aortic valve implantation (TAVI). Recently, the Valve Academic Research Consortium High Bleeding Risk (VARC-HBR) criteria were introduced to identify patients at (very) high risk of bleeding. Aims: This study aimed to evaluate the validity of the VARC-HBR criteria for predicting bleeding risk in TAVI patients and to compare its performance with other existing criteria. Methods: Data were obtained from the POPular PAUSE TAVI... Abstract

Journal of oral & facial pain and headache, Volume 39, Issue 3, 12 2 2025, Pages 172-182 Exploring the relationship between clinical symptoms and MRI findings in temporomandibular joint disorders: a preliminary study. Sancar E, Yılmaz D, Parlak S, Bulut EG, Ozer G, Hersek NE

Background: This study aimed to evaluate the relationships between magnetic resonance imaging (MRI) findings (such as condylar degeneration, disc displacement, joint effusion and disc deformity) and clinical symptoms in patients with temporomandibular joint disorders (TMDs). Methods: A total of 54 patients (108 temporomandibular joints (TMJs)) were included. Clinical evaluations assessed joint pain, joint sounds, mouth opening limitations, deviation/deflection and locking. MRI scans were analyze... Abstract

BMJ open, Volume 15, Issue 9, 11 2 2025, Pages e093639 Two years and counting: a prospective cohort study on the scope and severity of post-COVID symptoms across diverse patient groups in the Netherlands-insights from the CORFU study. Klein DO, Waardenburg SF, Janssen EBNJ, Wintjens MSJN, Imkamp M, Heemskerk SCM, Birnie E, Bonsel GJ, Warlé MC, Jacobs LMC, Hemmen B, Verbunt J, van Bussel BCT, van Santen S, Kietelaer BLJH, Jansen G, Klok FA, de Kruif MD, Vernooy K, Haagsma JA, Asselbergs FW, Linschoten M, Cals JWL, Ten Cate H, van der Horst ICC, Wilmes N, CAPACITY-COVID Collaborative Consortium, Ghossein-Doha C, van Kuijk SMJ

Importance: Little research has been done on post-COVID symptoms at 24 months postinfection and on the association these may have on health-related quality of life (HRQOL). Objective: We assessed the prevalence and severity of post-COVID symptoms and quantified EuroQol 5 Dimension 5 Level (EQ-5D-5L), self-perceived health question (EuroQol Visual Analogue Scale (EQ-VAS)) and health utility scores (HUS) up to 24 months follow-up. Design: The longitudinal multiple cohort CORona Follow-Up (CORFU) s... Abstract

Frontiers in digital health, Volume 7, 10 2 2025, Pages 1603389 Stress management interventions for university students in low-and middle-income countries: a systematic review and meta-analysis. Juniar D, van Ballegooijen W, Kleygrewe G, van Schaik A, Passchier J, Riper H

Background: Stress is one of major issues among university students which can lead to negative academic performance and poor quality of life. Stress-management interventions (SMIs) have been proved as being effective in helping university students cope with stress. However, most of prior studies focused on high income countries while there is still scarce evidence for low-and-middle-income countries (LMICs). The objective of the present study was to examine the effectiveness of SMIs in reducing... Abstract

Interventional cardiology (London, England), Volume 20, 9 2 2025, Pages e23 Introduction to Pulmonary Embolism Treatment: An Evolving Paradigm. Montero-Cabezas JM

Abstract

JACC. Cardiovascular imaging, 8 2 2025, Pages S1936-878X(25)00483-8 Clinical Integration of AI-Enabled Plaque Quantification to Improve Cardiovascular Risk Stratification. Shaw LJ, Blankstein R, Leipsic JA, Sengupta PP, Nieman K, Bax JJ, Zoghbi WA, Chandrashekhar Y

Abstract

Neurology, Volume 105, Issue 7, 5 1 2025, Pages e214071 Sensitivity of Different Clinical Outcome Measures in Assessing Adults With Becker Muscular Dystrophy: A 3-Year Natural History Study. Schrama EJ, Koeks Z, Van De Velde NM, Alleman I, van Benthem JJ, van Weperen PW, Hooijmans MT, Kan HE, Spitali P, Ajmone Marsan N, Atsma DE, van Duyvenvoorde HA, Verschuuren JJGM, Niks EH

Background and objectives: Slow and highly variable disease progression in Becker muscular dystrophy (BMD) stresses the need to develop sensitive outcome measures for clinical trials. We evaluated responsiveness of different outcome measures in adult patients with BMD over 3 years and explored if the sensitivity of outcome measures can be increased by selecting on phenotype or genotype. Methods: Genetically confirmed patients with BMD were recruited via the Dutch Dystrophinopathy Database. Funct... Abstract