Research

Publications

Below you can find a list of our published research.

6173 results

Annals of medicine and surgery (2012), Volume 87, Issue 4, 19 3 2025, Pages 1995-1999 Fostering an open surgical culture: strategies to eliminate inappropriate behavior in surgical practice. Blok JJ, Snijders HS, Huizing F, Schmitz RF, Kerstjens LJ, Sier VQ, Blok CC, Lijkwan MA, Schepers A

Surgery is a demanding and stressful profession. Unfortunately, inappropriate behavior is still not banished from the daily surgical practice and we are dealing with the negative consequences (e.g. negative working environments or burn-out). To adequately treat this type of behavior we first have to acknowledge its existence and create a proper path to discuss it inside our own ranks. The only manner to achieve this, is through an open culture. An 'open surgical culture' is the key, as... Abstract

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 18 3 2025 Dupilumab-Associated Ocular Surface Disease in Paediatric Atopic Dermatitis Patients: Results From the BioDay Registry. van der Rijst LP, van Luijk CM, van der Kamp S, Zuithoff NPA, de Boer JH, de Bruin-Weller MS, de Graaf M

Background: Dupilumab-associated ocular surface disease (DAOSD) is a common side effect in paediatric atopic dermatitis (AD) patients treated with dupilumab. However, long-term real-world safety data is limited. Therefore, this study investigates the incidence of DAOSD in paediatric AD patients treated with dupilumab and identifies associated risk factors. Methods: This prospective study included paediatric AD patients (aged 3-17 years) treated with dupilumab. Ocular symptoms were assessed every... Abstract

International journal of cardiology. Heart & vasculature, Volume 58, 17 3 2025, Pages 101654 Association of indexed aortic dimensions with the presence and extent of coronary artery ectasia in patients with acute coronary syndrome. van Oort MJH, Oliveri F, de Lange FWJ, Regeer MV, Bingen BO, Jukema JW, van der Kley F, Al Amri I, Montero-Cabezas JM

Background: Conflicting findings have been reported on the potential association between CAE and aortic dilatation. This study aimed to investigate the relationship between CAE extent and aortic dimensions in patients with acute coronary syndrome (ACS). Methods: This retrospective cohort study included 448 adult patients who underwent coronary angiography for ACS between 2004 and 2015. The cohort was divided into 224 patients with CAE and 224 control patients without CAE, matched for age, sex, a... Abstract

Pediatric cardiology, 13 2 2025 Fontan-Associated Liver Disease (FALD) in the EUROFontan Experience. An Insight into European Awareness. Gozzi A, Vedovelli L, Bergonzoni E, Cao I, Angeli E, Zanoni R, Biffanti R, Butera G, Dimopoulos K, Rocafort AG, Hazekamp MG, Kansky A, Lenoir M, Martens T, Meliota G, Meyns B, Nosal M, Napoleone CP, Rijnberg FM, Dolzer ES, Scrascia G, Vairo U, Van Puyvelde J, Di Salvo G, Montanaro C, Padalino MA

Fontan-Associated Liver Disease (FALD) is a dramatically emerging problem even if not precisely defined in term of debated diagnosis and surveillance protocols. We analyze FALD prevalence, clinical impact and implications in a European cohort of patients. It's a retrospective observational multicenter study including Fontan patients operated between 1990 and 2022. Anatomical, clinical, surgical and liver-related data were collected, defining FALD as a spectrum of time-related structural-fun... Abstract

Arteriosclerosis, thrombosis, and vascular biology, 13 2 2025 Role of Perivascular Adipose Tissue in Vein Remodeling. Kruit N, Sluiter TJ, de Vries MR

Perivascular adipose tissue (PVAT) plays a crucial, yet underexplored, role in vein remodeling, which occurs after bypass surgery using a venous graft or creation of arteriovenous fistulae for hemodialysis access. PVAT exhibits significant heterogeneity in phenotype and tissue composition depending on the vascular bed, as well as its anatomic location within the vasculature. Through the excretion of adipokines, cytokines, and chemokines, PVAT can shape the vascular response to local and systemic... Abstract

Journal of lipid research, Volume 66, Issue 4, 13 2 2025, Pages 100778 Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease. Ao L, van Heemst D, Jukema JW, Rensen PCN, Willems van Dijk K, Noordam R

Plasma 1H-NMR metabolomic measures have yielded significant insight into the pathophysiology of cardiometabolic disease, but their inter-related nature complicates causal inference and clinical interpretation. This study aimed to investigate the associations of unrelated 1H-NMR metabolomic profiles with coronary artery disease (CAD) and ischemic stroke (IS). Principal component (PC) analysis was performed on 168 1H-NMR metabolomic measures in 56,712 unrelated European participants from UK Bioban... Abstract

The Pediatric infectious disease journal, Volume 44, Issue 4, 10 2 2025, Pages 281-286 The Prevalence, Serogroup Distribution and Risk Factors of Meningococcal Carriage in Children, Adolescents and Young Adults in Turkey Meningo-Carr-TR Study PART 3: COVID-19 Pandemic Situation. Kizil MC, Kara Y, Karbuz A, Oz FN, Ciftci E, Kurugol Z, Iseri Nepesov M, Celebi S, Cetin BS, Yilmaz D, Dinleyici M, Kizmaz Isancli D, Kilicaslan O, Ozdemir H, Inceli BH, Penezoglu DN, Dortkardesler B, Sezer Yamanel RG, Aksoy FD, Tekin Can S, Agrali Eröz N, Kaya M, Kilic O, Dinleyici EC

Background: The prevalence of meningococcal carriage and serogroup distribution is crucial for assessing the epidemiology of invasive meningococcal disease, forecasting outbreaks and formulating potential immunization strategies. Following the meningococcal carriage studies conducted in Turkey in 2016 and 2018, we planned to re-evaluate meningococcal carriage in children, adolescents and young adults during the COVID-19 pandemic period. Methods: In the MENINGO-CARR-3 study, we collected nasophar... Abstract

Cited 2 times since 2025 (16.3 per year) source: EuropePMC

Nature genetics, Volume 57, Issue 3, 6 1 2025, Pages 539-547 Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases. Roselli C, Surakka I, Olesen MS, Sveinbjornsson G, Marston NA, Choi SH, Holm H, Chaffin M, Gudbjartsson D, Hill MC, Aegisdottir H, Albert CM, Alonso A, Anderson CD, Arking DE, Arnar DO, Barnard J, Benjamin EJ, Braunwald E, Brumpton B, Campbell A, Chami N, Chasman DI, Cho K, Choi EK, Christophersen IE, Chung MK, Conen D, Crijns HJ, Cutler MJ, Czuba T, Damrauer SM, Dichgans M, Dörr M, Dudink E, Duong T, Erikstrup C, Esko T, Fatkin D, Faul JD, Ferreira M, Freitag DF, Ganesh SK, Gaziano JM, Geelhoed B, Ghouse J, Gieger C, Giulianini F, Graham SE, Gudnason V, Guo X, Haggerty C, Hayward C, Heckbert SR, Hveem K, Ito K, Johnson R, Jukema JW, Jurgens SJ, Kääb S, Kane JP, Kany S, Kardia SLR, Kavousi M, Khurshid S, Kamanu FK, Kirchhof P, Kleber ME, Knight S, Komuro I, Krieger JE, Launer LJ, Li D, Lin H, Lin HJ, Loos RJF, Lotta L, Lubitz SA, Lunetta KL, Macfarlane PW, Magnusson PKE, Malik R, Mantineo H, Marcus GM, März W, McManus DD, Melander O, Melloni GEM, Meyre PB, Miyazawa K, Mohanty S, Monfort LM, Müller-Nurasyid M,

Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause of heart failure and stroke. This large-scale meta-analysis of genome-wide association studies increased the power to detect single-nucleotide variant associations and found more than 350 AF-associated genetic loci. We identified candidate genes related to muscle contractility, cardiac muscle development and cell-cell communication at 139 loci. Furthermore, we assayed chromatin accessibility using assay f... Abstract

JACC. Clinical electrophysiology, 5 1 2025, Pages S2405-500X(25)00086-6 Impact of Anterior Right Ventricular Outflow Tract Conduction Block on QRS Morphology in Repaired Tetralogy of Fallot. Moore JP, Zeppenfeld K

Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 4 1 2025 Clinical and Technical Predictors of Treatment Success After Coronary Intravascular Lithotripsy in Calcific Coronary Lesions. van Oort MJH, Bingen BO, Oliveri F, Al Amri I, Phagu AAS, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Girgis H, van der Kley F, Jukema JW, Montero-Cabezas JM

Background: Intravascular lithotripsy (IVL) is increasingly used to treat coronary artery calcification (CAC). This study aimed to identify clinical and procedural factors associated with IVL treatment success. Methods: This retrospective analysis included 454 patients (73 ± 9 years, 75% male) treated with IVL from the multicenter BENELUX-IVL registry (May 2019 to February 2024). Treatment success was defined as achieving residual coronary diameter stenosis Abstract

Radiation and environmental biophysics, 4 1 2025 Commissioning and performance assessment of diodes and MOSFETs in in-vivo dosimetry for external beam radiation therapy. Al Kharusi O, Al Mamari R, Al Hosni B, Al Amri I, Al Fishawy M, Boulassel MR, Bouchareb Y

The precision of radiation therapy treatment depends on several calibration and quality assurance processes. In-vivo dosimetry (IVD) is used in external beam radiotherapy to evaluate the delivered versus planned dose as a patient-specific quality assurance verification procedure. This study aimed at assessing the performance of diodes (EDP-103G and EDP-203G) and metal oxide semiconductor field-effect transistors (MOSFETs) and corresponding correction factors followed by IVD evaluation in differe... Abstract

Nature genetics, Volume 57, Issue 4, 4 1 2025, Pages 815-828 Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes. Henry A, Mo X, Finan C, Chaffin MD, Speed D, Issa H, Denaxas S, Ware JS, Zheng SL, Malarstig A, Gratton J, Bond I, Roselli C, Miller D, Chopade S, Schmidt AF, Abner E, Adams L, Andersson C, Aragam KG, Ärnlöv J, Asselin G, Raja AA, Backman JD, Bartz TM, Biddinger KJ, Biggs ML, Bloom HL, Boersma E, Brandimarto J, Brown MR, Brunak S, Bruun MT, Buckbinder L, Bundgaard H, Carey DJ, Chasman DI, Chen X, Cook JP, Czuba T, de Denus S, Dehghan A, Delgado GE, Doney AS, Dörr M, Dowsett J, Dudley SC, Engström G, Erikstrup C, Esko T, Farber-Eger EH, Felix SB, Finer S, Ford I, Ghanbari M, Ghasemi S, Ghouse J, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gui H, Gutmann R, Hägg S, Haggerty CM, Hedman ÅK, Helgadottir A, Hemingway H, Hillege H, Hyde CL, Aagaard Jensen B, Jukema JW, Kardys I, Karra R, Kavousi M, Kizer JR, Kleber ME, Køber L, Koekemoer A, Kuchenbaecker K, Lai YP, Lanfear D, Langenberg C, Lin H, Lind L, Lindgren CM, Liu PP, London B, Lowery BD, Luan J, Lubitz SA, Magnusson P, Margulies KB,

Heart failure (HF) is a major contributor to global morbidity and mortality. While distinct clinical subtypes, defined by etiology and left ventricular ejection fraction, are well recognized, their genetic determinants remain inadequately understood. In this study, we report a genome-wide association study of HF and its subtypes in a sample of 1.9 million individuals. A total of 153,174 individuals had HF, of whom 44,012 had a nonischemic etiology (ni-HF). A subset of patients with ni-HF were st... Abstract

ERJ open research, Volume 11, Issue 2, 3 1 2025, Pages 619-2024 Enzymatic therapy <i>versus</i> video-assisted thoracoscopic surgery for pleural infections: a systematic review and meta-analysis. de Jonge WR, Smits B, Ket JCF, Altenburg J, Annema J, Daniels JMA, Dickhoff C, van Dorp M, Braun J, Korevaar DA, Heineman DJ

Aims: Parapneumonic pleural infections are frequently encountered, but the optimal treatment regimen remains controversial. The aim of this systematic review was to investigate whether immediate video-assisted thoracoscopic surgery (VATS) has advantages over intrapleural enzymatic therapy (IET). Methods: We searched MEDLINE, Embase and Web of Science Core Collection till November 2023 and included studies comparing IET and VATS in adult patients with parapneumonic pleural infections. Primary out... Abstract

Frontiers in medicine, Volume 12, 3 1 2025, Pages 1492596 Quality assessment of a training program for undergraduate sonography peer tutors: paving the future way for peer-assisted learning in medical ultrasound education. Weimer J, Yilmaz D, Ille C, Weinmann-Menke J, Müller L, Büchner H, Buggenhagen H, Stäuber M, Neubauer R, Winter L, Weimer A, Dirks K, Künzel J, Rink M, Dionysopoulou A, Lorenz L, Kloeckner R, Recker F, Schiestl L

Introduction: Peer tutoring has been increasingly used to support university sonography teaching, necessitating well-qualified tutors. This study aims to evaluate the quality of a training program for sonography peer tutors developed and implemented at a university hospital. Materials and methods: A training program consisting of 11 modules was developed and subsequently evaluated for success with two subjective and two objective assessments of peer-tutoring quality. The two subjective assessmen... Abstract

Interdisciplinary cardiovascular and thoracic surgery, Volume 40, Issue 3, 1 1 2025, Pages ivaf071 The arterial switch operation for transposition of the great arteries with left ventricular outflow tract obstruction and ventricular septal defect: clinical outcomes and specimen study. van der Palen RLF, den Ouden A, Knobbe I, Bouma BJ, Koolbergen DR, Jongbloed MRM, Hazekamp MG

Objectives: In selected patients with transposition of the great arteries (TGA), ventricular septal defect (VSD) and left ventricular outflow tract obstruction (LVOTO), the arterial switch operation (ASO) may be the procedure of choice. This study reviews the clinical outcomes of TGA-VSD-LVOTO patients after ASO and compares mechanisms of LVOTO in this patient group to a historical series of cardiac specimens. Methods: This retrospective analysis included all cases with TGA-VSD-LVOTO who underwe... Abstract

European heart journal. Cardiovascular Imaging, Volume 26, Issue 3, 1 1 2025, Pages 385-413 The role of multi-modality imaging for the assessment of left atrium and left atrial appendage: a clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC). Sade LE, Faletra FF, Pontone G, Gerber BLM, Muraru D, Edvardsen T, Cosyns B, Popescu BA, Klein A, Marwick TH, Cameli M, Saric M, Thomas L, Ajmone Marsan N, Fontes-Carvalho R, Podlesnikar T, Fontana M, La Gerche A, Petersen SE, Moharem-Elgamal S, Bittencourt MS, Vannan MA, Glikson M, Peichl P, Cochet H, Stankovic I, Donal E, Thomas D, Marta RS

Structural, architectural, contractile, or electrophysiological alterations may occur in the left atrium (LA). The concept of LA cardiopathy is supported by accumulating scientific evidence demonstrating that LA remodelling has become a cornerstone diagnostic and prognostic marker. The structure and the function of the LA and left atrial appendage (LAA), which is an integral part of the LA, are key elements for a better understanding of multiple clinical conditions, most notably atrial fibrillat... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 27, Issue 4, 1 1 2025, Pages euaf055 Epicardial ventricular arrhythmia ablation: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology and the Heart Rhythm Society, the Asian Pacific Heart Rhythm Society, the Latin American Heart Rhythm Society, and the Canadian Heart Rhythm Society. Arya A, Di Biase L, Bazán V, Berruezo A, d'Avila A, Della Bella P, Enriquez A, Hocini M, Kautzner J, Pak HN, Stevenson WG, Zeppenfeld K, Sepehri Shamloo A, Meyer C, de Chillou C, Deneke T, de Riva M, Porta-Sanchez A, Sapp J, Schmidt B, Shivkumar K, Sommer P, Soejima K, Supple GE, Wilde A, Zucchelli G

Epicardial access during electrophysiology procedures offers valuable insights and therapeutic options for managing ventricular arrhythmias (VAs). The current clinical consensus statement on epicardial VA ablation aims to provide clinicians with a comprehensive understanding of this complex clinical scenario. It offers structured advice and a systematic approach to patient management. Specific sections are devoted to anatomical considerations, criteria for epicardial access and mapping evaluatio... Abstract

Journal of the American College of Cardiology, Volume 85, Issue 10, 1 1 2025, Pages 1042-1055 Best Practices for Imaging of Transcatheter Valve Failure: An Update From the Heart Valve Collaboratory. Khalique OK, Zaid S, Tang GHL, Abdel-Wahab M, Akodad M, Bapat VN, Bax JJ, Blackman DJ, Blanke P, Bleiziffer S, Capodanno D, Cavalcante JL, Dasi LP, De Backer O, De Beuel M, Duncan A, Dweck MR, Fukui M, Gupta A, Hayashida K, Herrmann HC, Kaneko T, Karam N, Khan JM, Kovac J, Landes U, Leipsic JA, Leon MB, Mack MJ, Madhavan MV, Makar MM, Makkar RR, Al Mallah M, Meier D, Modine T, Okada A, Parikh RK, Parma R, Patel D, Pibarot P, Prendergast B, Quader N, Reardon MJ, Rogers T, Safi LM, Sellers SL, Skaf S, Tarantini G, Tchetche D, van Mieghem N, Wang DD, Webb JG, Windecker S, Yakubov SJ, Delgado V, Hahn RT, Jilaihawi H

This updated Heart Valve Collaboratory framework addresses the growing concern for transcatheter valve failure (TVF) following transcatheter aortic valve replacement (TAVR). With the increasing volume of redo-TAV and surgical TAV explantation, there is a critical need for standardized pathways and protocols for evaluating TVF using echocardiography and cardiac computed tomography (CT) angiography. This document clarifies prior definitions of bioprosthetic valve deterioration and bioprosthetic va... Abstract

Cited 1 times since 2025 (7.3 per year) source: EuropePMC

Interdisciplinary cardiovascular and thoracic surgery, Volume 40, Issue 3, 1 1 2025, Pages ivaf009 Survival outcomes after surgery for type A aortic dissection: a contemporary Dutch nationwide registry study. Timmermans PT, Velders BJJ, Groenwold RHH, Vos RJ, Roefs MM, Braun J, Klautz RJM, Mecozzi G, Hjortnaes J, Cardiothoracic Surgery Registration Committee and the Aortic Surgery Work Group of the Netherlands Heart Registration

Objectives: To describe the nationwide survival outcomes after surgery for type A aortic dissection. Methods: All patients who underwent surgery for type A aortic dissection in the Netherlands between 2018 and 2021 were identified in the Netherlands Heart Registration (NHR) database. The NHR data were linked to lifelong survival data from Statistics Netherlands (98% match). Time trends for in-hospital and mid-term mortality were described, and age- and sex-adjusted regression analysis was perfor... Abstract

British journal of anaesthesia, Volume 134, Issue 4, 28 4 2025, Pages 1009-1017 Regulation of cerebrovascular resistance below the lower limit of cerebral autoregulation during induced hypotension: an observational study. Kho E, van den Dool REC, Mahes SS, Corsmit OT, Vlaar APJ, Koolbergen DR, Veelo DP, Sperna Weiland NH, Immink RV

Background: To maintain adequate perfusion, cerebral blood flow (CBF) is preserved by changes in cerebrovascular resistance (CVR) inversely related to fluctuations in mean arterial blood pressure (MAP). It has been hypothesised that during progressive hypotension, a lower limit of cerebral autoregulation (LLCA) is reached beyond which cerebrovascular dilation becomes exhausted and CBF starts to decrease together with BP. We tested this hypothesis by assessing CVR above and below the LLCA. Method... Abstract