Research

Publications

Below you can find a list of our published research.

6131 results

Cited 11 times since 2018 (1.7 per year) source: EuropePMC

BMJ quality & safety, Volume 28, Issue 3, 21 3 2018, Pages 180-189 Connecting perspectives on quality and safety: patient-level linkage of incident, adverse event and complaint data. de Vos MS, Hamming JF, Chua-Hendriks JJC, Marang-van de Mheen PJ

Background and objective: Incident, adverse event (AE) and complaint data are typically used separately, but may be related at the patient level with one event triggering a cascade of events, ultimately resulting in a complaint. This study examined relations between incidents, AEs and complaints that co-occurred in admissions. Methods: Independently and routinely collected incident, AE and complaint data were retrospectively linked for surgical admissions in an academic centre (2008-2014). Two i... Abstract

Cited 8 times since 2018 (1.2 per year) source: EuropePMC

Clinical and experimental rheumatology, Volume 36 Suppl 113, Issue 4, 18 3 2018, Pages 109-117 To what extent do autoantibodies help to identify high-risk patients in systemic sclerosis? Boonstra M, Mertens BJA, Bakker JA, Ninaber MK, Ajmone Marsan N, van der Helm-van Mil AHM, Scherer HU, Huizinga TWJ, de Vries-Bouwstra JK

Objectives: To evaluate the additive value of autoantibodies in identifying systemic sclerosis (SSc) patients with high complication risk. Methods: Patients entering the Combined Care In SSc cohort, Leiden University Medical Centre between April 2009 and May 2016 were included. Subgroups of patients were determined using hierarchical clustering, performed on Principal Component Analysis scores, 1) using baseline data of demographic and clinical variables only and 2) with additional use of antibo... Abstract

Cited 30 times since 2018 (4.5 per year) source: EuropePMC

Genome biology, Volume 19, Issue 1, 17 3 2018, Pages 87 Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, Klena NT, Gabriel GC, Liu X, Gulec C, Grarup N, Haessler J, Hall LM, Iorio A, Isaacs A, Li-Gao R, Lin H, Liu CT, Lyytikäinen LP, Marten J, Mei H, Müller-Nurasyid M, Orini M, Padmanabhan S, Radmanesh F, Ramirez J, Robino A, Schwartz M, van Setten J, Smith AV, Verweij N, Warren HR, Weiss S, Alonso A, Arnar DO, Bots ML, de Boer RA, Dominiczak AF, Eijgelsheim M, Ellinor PT, Guo X, Felix SB, Harris TB, Hayward C, Heckbert SR, Huang PL, Jukema JW, Kähönen M, Kors JA, Lambiase PD, Launer LJ, Li M, Linneberg A, Nelson CP, Pedersen O, Perez M, Peters A, Polasek O, Psaty BM, Raitakari OT, Rice KM, Rotter JI, Sinner MF, Soliman EZ, Spector TD, Strauch K, Thorsteinsdottir U, Tinker A, Trompet S, Uitterlinden A, Vaartjes I, van der Meer P, Völker U, Völzke H, Waldenberger M, Wilson JG, Xie Z, Asselbergs FW, Dörr M, van Duijn CM, Gasparini P, Gudbjartsson DF, Gudnason V, Hansen T, Kääb S,

Background: Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants identified fall predominantly in non-coding regions and their underlying mechanisms remain unclear. Results: Here, we identify putative functional coding variation associated with changes in the QRS interval duration by combining Illumina HumanExome Bead... Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

Heart rhythm, Volume 15, Issue 12, 12 2 2018, Pages 1816-1822 Impact of atrial fibrillation on improvement of functional mitral regurgitation in cardiac resynchronization therapy. van der Bijl P, Vo NM, Leung M, Ajmone Marsan N, Delgado V, Stone GW, Bax JJ

Background: Functional mitral regurgitation (FMR) and atrial fibrillation (AF) are frequent heart failure (HF) complications. Cardiac resynchronization therapy (CRT) can improve FMR; however, little is known about the influence of AF on FMR improvement. Objective: The purpose of this study was to investigate the mechanisms and impact of baseline AF on FMR improvement after CRT. Methods: CRT recipients with HF, AF, or sinus rhythm (SR) at baseline with moderate or severe FMR, were included from a... Abstract

Cited 6 times since 2018 (0.9 per year) source: EuropePMC

Journal of periodontal research, Volume 53, Issue 5, 4 1 2018, Pages 916-923 Matrix metalloproteinase-7 in periodontitis with type 2 diabetes mellitus. Zeidán-Chuliá F, Yilmaz D, Häkkinen L, Könönen E, Neves de Oliveira BH, Güncü G, Uitto VJ, Caglayan F, Gürsoy UK

Background and objective: Elevated levels of matrix metalloproteinase-7 (MMP7) have been observed in serum samples of subjects with type 2 diabetes mellitus (T2DM) and in gingival tissues of subjects with periodontitis. The aim of the present study was to collect in vivo and in silico evidence on the role of MMP7 in the interplay between T2DM and generalized periodontitis (GP). Material and methods: The extent of MMP7 expression and localization were immunohistochemically analyzed in gingival ti... Abstract

Cited 33 times since 2018 (4.9 per year) source: EuropePMC

Applied and environmental microbiology, Volume 84, Issue 14, 2 1 2018, Pages e00309-18 Human-Associated Lachnospiraceae Genetic Markers Improve Detection of Fecal Pollution Sources in Urban Waters. Feng S, Bootsma M, McLellan SL

The human microbiome contains many organisms that could potentially be used as indicators of human fecal pollution. Here we report the development of two novel human-associated genetic marker assays that target organisms within the family Lachnospiraceae Next-generation sequencing of the V6 region of the 16S rRNA gene from sewage and animal stool samples identified 40 human-associated marker candidates with a robust signal in sewage and low or no occurrence in samples from nonhuman hosts. Two we... Abstract

Cited 221 times since 2018 (33.1 per year) source: EuropePMC

JAMA cardiology, Volume 3, Issue 7, 1 1 2018, Pages 619-627 Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis. Burgess S, Ference BA, Staley JR, Freitag DF, Mason AM, Nielsen SF, Willeit P, Young R, Surendran P, Karthikeyan S, Bolton TR, Peters JE, Kamstrup PR, Tybjærg-Hansen A, Benn M, Langsted A, Schnohr P, Vedel-Krogh S, Kobylecki CJ, Ford I, Packard C, Trompet S, Jukema JW, Sattar N, Di Angelantonio E, Saleheen D, Howson JMM, Nordestgaard BG, Butterworth AS, Danesh J, European Prospective Investigation Into Cancer and Nutrition–Cardiovascular Disease (EPIC-CVD) Consortium

Importance: Human genetic studies have indicated that plasma lipoprotein(a) (Lp[a]) is causally associated with the risk of coronary heart disease (CHD), but randomized trials of several therapies that reduce Lp(a) levels by 25% to 35% have not provided any evidence that lowering Lp(a) level reduces CHD risk. Objective: To estimate the magnitude of the change in plasma Lp(a) levels needed to have the same evidence of an association with CHD risk as a 38.67-mg/dL (ie, 1-mmol/L) change in low-dens... Abstract

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 54, Issue 1, 1 1 2018, Pages 199 Mitral valve infective endocarditis: putting the puzzle pieces together. Tomšic A, Klautz RJM, Palmen M

Abstract

Heart, lung & circulation, Volume 27, Issue 7, 1 1 2018, Pages 782-784 Lessons from an International Bicuspid Aortic Valve Disease Registry: the Raphe and Beyond. Ng ACT, Delgado V, Kong WKF, Bax JJ

Abstract

Cited 43 times since 2018 (6.4 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 11, Issue 7, 1 1 2018, Pages e007562 Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease. Lee SE, Sung JM, Rizvi A, Lin FY, Kumar A, Hadamitzky M, Kim YJ, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, Leipsic JA, Shin S, Hyun Choi J, Chinnaiyan K, Raff G, Virmani R, Samady H, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Min JK, Chang HJ

Background: Diagnosis of coronary artery disease and management strategies have relied solely on the presence of diameter stenosis ≥50%. We assessed whether direct quantification of plaque burden (PB) and plaque characteristics assessed by coronary computed tomography angiography could provide additional value in terms of predicting rapid plaque progression. Methods and results: From a 13-center, 7-country prospective observational registry, 1345 patients (60.4±9.4 years old; 57.1% male) who und... Abstract

JACC. Cardiovascular imaging, Volume 11, Issue 7, 1 1 2018, Pages 984-986 Will Cardiac Magnetic Resonance Change the Management of Severe Aortic Stenosis Patients? Delgado V, Bax JJ

Abstract

Cited 5 times since 2018 (0.7 per year) source: EuropePMC

European heart journal, Volume 39, Issue 27, 1 1 2018, Pages 2600-2601 New prospects for PCSK9 inhibition? Landmesser U, Chapman MJ, Stock JK, Amarenco P, Belch JJF, Borén J, Farnier M, Ference BA, Gielen S, Graham I, Grobbee DE, Hovingh GK, Lüscher TF, Piepoli MF, Ray KK, Ray KK, Stroes ES, Wiklund O, Windecker S, Zamorano JL, Pinto F, Tokgözoglu L, Bax JJ, Catapano AL, European Society of Cardiology/European Atherosclerosis Society Task Force

Abstract

Interactive cardiovascular and thoracic surgery, Volume 27, Issue 1, 1 1 2018, Pages 124-130 Papillary muscle head repositioning for commissural prolapse in degenerative mitral valve disease. Tomšic A, Klautz RJM, van Brakel TJ, Ajmone Marsan N, Versteegh MIM, Palmen M

Objectives: Surgical correction of commissural mitral valve prolapse can be challenging. Several surgical techniques, including commissural closure, leaflet resection with sliding plasty and chordal replacement, remain commonly in use. Conversely, papillary muscle head repositioning remains uncommonly utilized for the treatment of commissural prolapse. Methods: Between January 2003 and December 2015, 518 patients underwent primary mitral valve repair for severe degenerative mitral valve regurgit... Abstract

Cited 1 times since 2018 (0.1 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 54, Issue 1, 1 1 2018, Pages 98-105 Programmed electrical stimulation-guided encircling cryoablation concomitant to surgical ventricular reconstruction for primary prevention of ventricular arrhythmias. van Huls van Taxis CF, Wijnmaalen AP, Klein P, Dekkers OM, Braun J, Verwey HF, Schalij MJ, Klautz RJ, Zeppenfeld K

Objectives: Surgical ventricular reconstruction (SVR) is an effective treatment to improve left ventricular (LV) function in patients with ischaemic heart failure and an LV anterior-apical aneurysm. Ventricular arrhythmia (VA) is an important cause for morbidity and mortality in these patients. Therefore, encircling cryoablation targeting the VA substrate may be required. Programmed electrical stimulation (PES) can identify patients at risk for VA. The objective of this study was to evaluate the... Abstract

Cited 9 times since 2018 (1.3 per year) source: EuropePMC

Revista espanola de cardiologia (English ed.), Volume 71, Issue 11, 30 5 2018, Pages 961-970 Sudden Cardiac Death Risk Prediction: The Role of Cardiac Magnetic Resonance Imaging. van der Bijl P, Podlesnikar T, Bax JJ, Delgado V

Sudden cardiac death (SCD) accounts for more than 4 million global deaths per year. While it is most commonly caused by coronary artery disease, a final common pathway of ventricular arrhythmias is shared by different etiologies. The most effective primary and secondary prevention strategy is an implantable cardioverter-defibrillator (ICD). The decision to implant an ICD for primary prevention is largely based on a left ventricular ejection fraction ≤ 35%, but this criterion in isolation is neit... Abstract

Cited 29 times since 2018 (4.3 per year) source: EuropePMC

Journal of the American Heart Association, Volume 7, Issue 13, 22 4 2018, Pages e008163 Infective Endocarditis After Melody Valve Implantation in the Pulmonary Position: A Systematic Review. Abdelghani M, Nassif M, Blom NA, Van Mourik MS, Straver B, Koolbergen DR, Kluin J, Tijssen JG, Mulder BJM, Bouma BJ, de Winter RJ

Background: Infective endocarditis (IE) after transcatheter pulmonary valve implantation (TPVI) in dysfunctioning right ventricular outflow tract conduits has evoked growing concerns. We aimed to investigate the incidence and the natural history of IE after TPVI with the Melody valve through a systematic review of published data. Methods and results: PubMed, EMBASE, and Web of Science databases were systematically searched for articles published until March 2017, reporting on IE after TPVI with... Abstract

Cited 14 times since 2018 (2.1 per year) source: EuropePMC

Current cardiology reports, Volume 20, Issue 8, 21 3 2018, Pages 66 HDL Mimetics Infusion and Regression of Atherosclerosis: Is It Still Considered a Valid Therapeutic Option? Karalis I, Jukema JW

Purpose of review: This review aims to summarize and discuss the recent findings in the field of using HDL mimetics for the treatment of patients with coronary artery disease. Recent findings: Following the largely disappointing results with the cholesteryl ester transfer protein inhibitors, focus moved to HDL functionality rather than absolute HDL cholesterol values. A number of HDL/apoA-I mimicking molecules were developed, aiming to enhance reverse cholesterol transport that has been associat... Abstract

Cited 9 times since 2018 (1.3 per year) source: EuropePMC

The American journal of cardiology, Volume 122, Issue 4, 20 3 2018, Pages 656-662 Development of and Progression of Overt Heart Failure in Nonobstructive Hypertrophic Cardiomyopathy. Hiemstra YL, Debonnaire P, van Zwet EW, Bootsma M, Schalij MJ, Bax JJ, Delgado V, Marsan NA

Only few studies aimed at identifying predictors of heart failure (HF) in hypertrophic cardiomyopathy (HC) patients. Furthermore, serial echocardiographic analyses are lacking in these patients and little is known about the natural progression of left ventricular (LV) abnormalities and their association with HF development. Aim of this study was to assess the prognostic value of LV global longitudinal strain (GLS) and other clinical and echocardiographic characteristics for the development of HF... Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

Acta obstetricia et gynecologica Scandinavica, Volume 97, Issue 10, 17 3 2018, Pages 1192-1199 Increased cardiovascular disease risk in women with a history of recurrent miscarriage. Wagner MM, Beshay MM, Rooijakkers S, Hermes W, Jukema JW, Le Cessie S, De Groot CJM, Ballieux BEPB, Van Lith JMM, Bloemenkamp KWM

Introduction: Cardiovascular disease is the leading cause of death in women. Observational studies suggest that women with a history of recurrent miscarriage have an increased risk of cardiovascular disease. Material and methods: Women who visited the recurrent miscarriage clinic at Leiden University Medical Center between 2000 and 2010 and who had their third consecutive miscarriage before the age of 31 years, were invited to participate in this follow-up study (between 2012 and 2014). The refe... Abstract

Cited 162 times since 2018 (24.1 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 11, Issue 10, 13 2 2018, Pages 1475-1484 Effects of Statins on Coronary Atherosclerotic Plaques: The PARADIGM Study. Lee SE, Chang HJ, Sung JM, Park HB, Heo R, Rizvi A, Lin FY, Kumar A, Hadamitzky M, Kim YJ, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, Leipsic JA, Shin S, Choi JH, Chinnaiyan K, Raff G, Virmani R, Samady H, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Min JK

Objectives: This study sought to describe the impact of statins on individual coronary atherosclerotic plaques. Background: Although statins reduce the risk of major adverse cardiovascular events, their long-term effects on coronary atherosclerosis remain unclear. Methods: We performed a prospective, multinational study consisting of a registry of consecutive patients without history of coronary artery disease who underwent serial coronary computed tomography angiography at an interscan interval... Abstract