7890 results
Cited 27 times since 2021 (6 per year)
source: EuropePMC
eLife,
Volume 10, 8 2 2021, Pages e62161
Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones.
Kirstein N, Buschle A, Wu X, Krebs S, Blum H, Kremmer E, Vorberg IM, Hammerschmidt W, Lacroix L, Hyrien O, Audit B, Schepers A
Eukaryotic DNA replication initiates during S phase from origins that have been licensed in the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, Mcm3, and Mcm7 with gene expression, replication timing, and fork directionality profiles obtained by RNA-seq, Repli-seq, and OK-seq. Both, the origin recognition complex (ORC) and the minichromosome maintenance complex (MCM) are significantly and homogeneously depleted from transcribed genes, enriched at gene...
Abstract
Journal of neurological surgery. Part B, Skull base,
Volume 83, Issue Suppl 2, 8 2 2021, Pages e191-e200
Vision Deterioration and Hydrocephalus: Rare Presentations of Vestibular Schwannoma and Evolution of Management.
Keulen MV, Pace J, Burant CJ, Penn DL, Wilson B, Ronald A, Mowry SE, Megerian CA, Bambakidis NC
Introduction The incidence of vestibular schwannoma is reported as 12 to 54 new cases per million per year, increasing over time. These patients usually present with unilateral sensorineural hearing loss, tinnitus, or vertigo. Rarely, these patients present with symptoms of hydrocephalus or vision changes. Objective The study aimed to evaluate the surgical management of vestibular schwannoma at a single institution and to identify factors that may contribute to hydrocephalus, papilledema, and...
Abstract
Cited 74 times since 2021 (16.3 per year)
source: EuropePMC
The American journal of cardiology,
Volume 148, 3 1 2021, Pages 138-145
Right Ventricular-Pulmonary Arterial Coupling in Secondary Tricuspid Regurgitation.
Fortuni F, Butcher SC, Dietz MF, van der Bijl P, Prihadi EA, De Ferrari GM, Ajmone Marsan N, Bax JJ, Delgado V
Chronic pressure-overload induces right ventricular (RV) adaptation to maintain RV-pulmonary arterial (PA) coupling. RV remodeling is frequently associated with secondary tricuspid regurgitation (TR) which may accelerate uncoupling. Our aim is to determine whether the non-invasive analysis of RV-PA coupling could improve risk stratification in patients with secondary TR. A total of 1,149 patients (median age 72[IQR, 63 to 79] years, 51% men) with moderate or severe secondary TR were included. RV...
Abstract
Cited 10 times since 2021 (2.2 per year)
source: EuropePMC
ESC heart failure,
Volume 8, Issue 3, 2 1 2021, Pages 2306-2309
Reparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies.
Povsic TJ, Sanz-Ruiz R, Climent AM, Bolli R, Taylor DA, Gersh BJ, Menasché P, Perin EC, Pompilio G, Atsma DE, Badimon L, DeMaria AN, Hare JM, Henry TD, Janssens S, Kastrup J, Torella D, Traverse JH, Willerson JT, Fernández-Avilés F
The concept that cell-based repair of myocardial injury might be possible was introduced almost two decades ago; however, the field of cardiovascular reparative medicine has been criticized as translation to clinically effective approaches has been slow. The recent retraction of a series of papers has further impacted perception of this area of research. As researchers, clinicians, and teachers in this field, we felt it incumbent to critically appraise the current state of cardiac cell repair, d...
Abstract
Cited 34 times since 2021 (7.5 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 14, Issue 3, 2 1 2021, Pages e012072
Global Left Ventricular Myocardial Work Efficiency and Long-Term Prognosis in Patients After ST-Segment-Elevation Myocardial Infarction.
Lustosa RP, Butcher SC, van der Bijl P, El Mahdiui M, Montero-Cabezas JM, Kostyukevich MV, Rocha De Lorenzo A, Knuuti J, Ajmone Marsan N, Bax JJ, Delgado V
Background: Left ventricular (LV) global longitudinal strain has demonstrated incremental prognostic value over LV ejection fraction in patients with ST-segment-elevation myocardial infarction. However, LV global longitudinal strain does not take into consideration the effect of afterload. Novel speckle-tracking echocardiographic indices of myocardial work integrate blood pressure measurements (afterload) with LV global longitudinal strain. The present study aimed to investigate the prognostic v...
Abstract
Cited 2 times since 2021 (0.4 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 10, Issue 5, 1 1 2021, Pages 932
Common Genetic Variation in MC4R Does Not Affect Atherosclerotic Plaque Phenotypes and Cardiovascular Disease Outcomes.
Blauw LL, Noordam R, van der Laan SW, Trompet S, Kooijman S, van Heemst D, Jukema JW, van Setten J, de Borst GJ, Tybjærg-Hansen A, Pasterkamp G, Berbée JFP, Rensen PCN
We analyzed the effects of the common BMI-increasing melanocortin 4 receptor (MC4R) rs17782313-C allele with a minor allele frequency of 0.22-0.25 on (1) cardiovascular disease outcomes in two large population-based cohorts (Copenhagen City Heart Study and Copenhagen General Population Study, n = 106,018; and UK Biobank, n = 357,426) and additionally in an elderly population at risk for cardiovascular disease (n = 5241), and on (2) atherosclerotic plaque phenotypes in samples of patients who und...
Abstract
Cited 9 times since 2021 (2 per year)
source: EuropePMC
European heart journal. Cardiovascular pharmacotherapy,
Volume 7, Issue 2, 1 1 2021, Pages 94-103
Comparison of P2Y12 receptor inhibitors in patients with ST-elevation myocardial infarction in clinical practice: a propensity score analysis of five contemporary European registries.
De Luca L, Zeymer U, Claeys MJ, Dörler J, Erne P, Matter CM, Radovanovic D, Weidinger F, Lüscher TF, Jukema JW, PIRAEUS group
Aims: Among acute coronary syndromes (ACS), ST-segment elevation myocardial infarction (STEMI) has the most severe early clinical course. Recent randomized clinical trials have demonstrated that novel antithrombotic therapies improve in-hospital outcomes in STEMI patients. We aimed to describe the effectiveness and safety of P2Y12 receptor inhibitors in clinical practice in patients with STEMI based on data from contemporary European ACS registries. Methods and results: Five registries from the...
Abstract
Open heart,
Volume 8, Issue 1, 1 1 2021, Pages e001252
Patient information portal for congenital aortic and pulmonary valve disease: a stepped-wedge cluster randomised trial.
Etnel JRG, Bons LR, De Heer F, Robbers-Visser D, Van Beynum IM, Straver B, Jongbloed MR, Kiès P, Slieker MG, Van Dijk APJ, Kluin J, Bertels RA, Utens EMWJ, The R, Van Galen E, Mulder BJM, Blom NA, Hazekamp MG, Roos-Hesselink JW, Helbing WA, Bogers AJJC, Takkenberg JJM
Background: In response to an increased need for patient information in congenital heart disease, we previously developed an online, evidence-based information portal for patients with congenital aortic and pulmonary valve disease. To assess its effectiveness, a stepped-wedge cluster randomised trial was conducted. Methods: Adult patients and caregivers of paediatric patients with congenital aortic and/or pulmonary valve disease and/or tetralogy of Fallot who visited the outpatient clinic at any...
Abstract
Cited 72 times since 2021 (15.8 per year)
source: EuropePMC
European heart journal,
Volume 42, Issue 13, 1 1 2021, Pages 1254-1269
The management of secondary mitral regurgitation in patients with heart failure: a joint position statement from the Heart Failure Association (HFA), European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA), and European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC.
Coats AJS, Anker SD, Baumbach A, Alfieri O, von Bardeleben RS, Bauersachs J, Bax JJ, Boveda S, Čelutkienė J, Cleland JG, Dagres N, Deneke T, Farmakis D, Filippatos G, Hausleiter J, Hindricks G, Jankowska EA, Lainscak M, Leclercq C, Lund LH, McDonagh T, Mehra MR, Metra M, Mewton N, Mueller C, Mullens W, Muneretto C, Obadia JF, Ponikowski P, Praz F, Rudolph V, Ruschitzka F, Vahanian A, Windecker S, Zamorano JL, Edvardsen T, Heidbuchel H, Seferovic PM, Prendergast B
Secondary (or functional) mitral regurgitation (SMR) occurs frequently in chronic heart failure (HF) with reduced left ventricular (LV) ejection fraction, resulting from LV remodelling that prevents coaptation of the valve leaflets. Secondary mitral regurgitation contributes to progression of the symptoms and signs of HF and confers worse prognosis. The management of HF patients with SMR is complex and requires timely referral to a multidisciplinary Heart Team. Optimization of pharmacological an...
Abstract
Cited 1 times since 2021 (0.2 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 23, Issue 3, 1 1 2021, Pages 379
An accessory pathway with automaticity and bidirectional conductive capacity.
Bruyndonckx L, de Riva Silva M, Blom NA, Bertels RA
Abstract
Cited 6 times since 2021 (1.3 per year)
source: EuropePMC
Nature genetics,
Volume 53, Issue 3, 1 1 2021, Pages 413
Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.
Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA, Benlloch S, Dadaev T, Brook MN, Sahimi A, Hoffmann TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Muir K, Lophatananon A, Wan P, Le Marchand L, Wilkens LR, Stevens VL, Gapstur SM, Carter BD, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Giles GG, Southey MC, MacInnis RJ, Cybulski C, Wokołorczyk D, Lubiński J, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nordestgaard BG, Nielsen SF, Weischer M, Bojesen SE, Røder MA, Iversen P, Batra J, Chambers S, Moya L, Horvath L, Clements JA, Tilley W, Risbridger GP, Gronberg H, Aly M, Szulkin R, Eklund M, Nordström T, Pashayan N, Dunning AM, Ghoussaini M, Travis RC, Key TJ, Riboli E, Park JY, Sellers TA, Lin HY, Albanes D, Weinstein SJ, Mucci LA, Giovannucci E, Lindstrom S, Kraft P, Hunter DJ, Penney KL, Turman C, Tangen CM, Goodman PJ, Thompson IM, Hamilton RJ, Fleshner NE, Finelli A, Parent MÉ, Stanford JL, Ostrander EA, Geybels MS, Koutros S, Freeman LEB, Stampfer M, Wolk A, Håkansson
Abstract
Cited 1 times since 2021 (0.2 per year)
source: EuropePMC
Anesthesia and analgesia,
Volume 132, Issue 3, 1 1 2021, Pages 726-734
Predicting Unacceptable Pain in Cardiac Surgery Patients Receiving Morphine Maintenance and Rescue Doses: A Model-Based Pharmacokinetic-Pharmacodynamic Analysis.
Goulooze SC, Krekels EH, Saleh MA, Ahlers SJ, Välitalo PA, van Dongen EP, van Schaik RH, Hankemeier T, Tibboel D, Knibbe CAJ
Background: Optimal analgesic treatment following cardiac surgery is crucial for both patient comfort and successful postoperative recovery. While knowledge of both the pharmacokinetics and pharmacodynamics of analgesics is required to predict optimal drug dosing, models quantifying the pharmacodynamics are scarce. Here, we quantify the pharmacodynamics of morphine by modeling the need for rescue morphine to treat unacceptable pain in 118 patients after cardiac surgery. Methods: The rescue morph...
Abstract
Cited 9 times since 2021 (2 per year)
source: EuropePMC
Rheumatology (Oxford, England),
Volume 60, Issue 3, 1 1 2021, Pages 1565-1567
Disease progression in systemic sclerosis.
van Leeuwen NM, Liem SIE, Maurits MP, Ninaber M, Marsan NA, Allaart CF, Huizinga TWJ, Knevel R, de Vries-Bouwstra JK
Abstract
Cited 7 times since 2021 (1.5 per year)
source: EuropePMC
Journal of patient safety,
Volume 17, Issue 2, 1 1 2021, Pages e91-e97
The Association Between Complications, Incidents, and Patient Experience: Retrospective Linkage of Routine Patient Experience Surveys and Safety Data.
de Vos MS, Hamming JF, Boosman H, Marang-van de Mheen PJ
Objectives: Linkage of safety data to patient experience data may provide information to improve surgical care. This retrospective observational study aimed to assess associations between complications, incidents, patient-reported problems, and overall patient experience. Methods: Routinely collected data from safety reporting on complications and incidents, as well as patient-reported problems and experience on the Picker Patient Experience Questionnaire 15, covering seven experience dimensions...
Abstract
Cited 7 times since 2021 (1.5 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 22, Issue 4, 1 1 2021, Pages 367-371
The EACVI survey on cardiac imaging in cardio-oncology.
Stankovic I, Dweck MR, Marsan NA, Bergler-Klein J, Holte E, Manka R, Schulz-Menger J, Sitges M, Haugaa KH
Early and late cardiovascular (CV) toxicities related to many cancer treatments may complicate the clinical course of patients, offsetting therapeutic benefits, and altering prognosis. The early detection, monitoring, and treatment of cardiotoxicity have therefore become essential parts of cancer patient care. CV imaging is a cornerstone of every cardio-oncology unit, but its use may vary across Europe because of the non-uniform availability of advanced imaging techniques and differences in the...
Abstract
Cited 4 times since 2021 (0.9 per year)
source: EuropePMC
Infection prevention in practice,
Volume 3, Issue 2, 28 4 2021, Pages 100129
Association of environmental surface contamination with hand hygiene and infections in nursing homes: a prospective cohort study.
Teesing GR, de Graaf M, Petrignani M, Erasmus V, Klaassen CHW, Schapendonk CME, Verduijn-Leenman A, Schols JMGA, Vos MC, Koopmans MPG, Richardus JH, Voeten H
Background: Little is known about the presence of infections in nursing home residents, the causative micro-organisms, how hand hygiene (HH) influences the presence of infections in residents, and the extent to which environmental contamination is associated with the incidence of infection among residents. Aims: To establish if environmental contamination can be used as an indicator for HH compliance, and if environmental contamination is associated with the incidence of infection. Methods: Envi...
Abstract
Cited 4 times since 2021 (0.9 per year)
source: EuropePMC
Prenatal diagnosis,
Volume 41, Issue 6, 26 4 2021, Pages 754-765
The prognosis of common arterial trunk from a fetal perspective: A prenatal cohort study and systematic literature review.
van Nisselrooij AEL, Herling L, Clur SA, Linskens IH, Pajkrt E, Rammeloo LA, Ten Harkel ADJ, Hazekamp MG, Blom NA, Haak MC
Objective: The limited number of large fetal cohort studies on common arterial trunk (CAT) impedes prenatal counseling at midgestation. This study evaluates the prognosis of CAT from a fetal perspective. Method: Fetuses with a prenatally diagnosed CAT were extracted from the PRECOR registry (2002-2016). We evaluated fetal and postnatal survival and the presence of additional morbidity at last follow-up. Literature databases were searches systematically for additional cases. Results: Thirty-eight...
Abstract
Cited 12 times since 2021 (2.6 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 8, Issue 3, 26 4 2021, Pages 25
The Clinical Spectrum of Kommerell's Diverticulum in Adults with a Right-Sided Aortic Arch: A Case Series and Literature Overview.
van Rosendael PJ, Stöger JL, Kiès P, Vliegen HW, Hazekamp MG, Koolbergen DR, Lamb HJ, Jongbloed MRM, Egorova AD
Background: Kommerell's diverticulum is a rare vascular anomaly characterized as an outpouch at the onset of an aberrant subclavian artery. In the variant of a right-sided aortic arch, the trachea and esophagus are enclosed dorsally by the arch. In the configuration of an aberrant left subclavian artery, a Kommerell's diverticulum and persisting ductus arteriosus or ductal ligament enclose the lateral side, forming a vascular ring which may result in (symptomatic) esophageal or trachea...
Abstract
Cited 31 times since 2021 (6.8 per year)
source: EuropePMC
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
Volume 46, Issue 7, 26 4 2021, Pages 1307-1314
The clinical effectiveness of using a predictive algorithm to guide antidepressant treatment in primary care (PReDicT): an open-label, randomised controlled trial.
Browning M, Bilderbeck AC, Dias R, Dourish CT, Kingslake J, Deckert J, Goodwin GM, Gorwood P, Guo B, Harmer CJ, Morriss R, Reif A, Ruhe HG, van Schaik A, Simon J, Sola VP, Veltman DJ, Elices M, Lever AG, Menke A, Scanferla E, Stäblein M, Dawson GR
Depressed patients often do not respond to the first antidepressant prescribed, resulting in sequential trials of different medications. Personalised medicine offers a means of reducing this delay; however, the clinical effectiveness of personalised approaches to antidepressant treatment has not previously been tested. We assessed the clinical effectiveness of using a predictive algorithm, based on behavioural tests of affective cognition and subjective symptoms, to guide antidepressant treatmen...
Abstract
Cited 16 times since 2021 (3.5 per year)
source: EuropePMC
The American journal of cardiology,
Volume 147, 25 4 2021, Pages 109-115
Sex-Specific Differences in Etiology and Prognosis in Patients With Significant Tricuspid Regurgitation.
Dietz MF, Prihadi EA, van der Bijl P, Fortuni F, Marques AI, Ajmone Marsan N, Bax JJ, Delgado V
The aim of this study was to assess differences in etiology, comorbidities, echocardiographic parameters, and prognosis between men and women with significant tricuspid regurgitation (TR). Clinical and echocardiographic characteristics of 1569 patients (age 71 [62 to 78] years) at first diagnosis of significant TR were compared between men and women. Patients with congenital heart disease or previous tricuspid valve surgery were excluded. TR etiologies were defined as primary, left valvular dise...
Abstract
