Research

Publications

Below you can find a list of our published research.

6555 results

Cited 10 times since 2011 (0.8 per year) source: EuropePMC

Journal of electrocardiology, Volume 45, Issue 2, 9 2 2011, Pages 154-160 Role of the vectorcardiogram-derived spatial QRS-T angle in diagnosing left ventricular hypertrophy. Man S, Rahmattulla C, Maan AC, Holman E, Bax JJ, van der Wall EE, Schalij MJ, Swenne CA

Introduction: Current criteria for electrocardiographic (ECG) diagnosis of left ventricular hypertrophy (LVH) have a low diagnostic accuracy. Addition of demographic, anthropomorphic, and additional ECG variables may improve accuracy. As hypertrophy affects action potential morphology and intraventricular conduction, QRS prolongation and T-wave morphology may occur and become manifest in the vectorcardiographic variables spatial QRS-T angle (SA) and spatial ventricular gradient. In this study, w... Abstract

Cited 4 times since 2011 (0.3 per year) source: EuropePMC

Journal of interventional cardiology, Volume 25, Issue 1, 8 2 2011, Pages 1-9 Aspiration thrombectomy during primary percutaneous coronary intervention as adjunctive therapy to early (in-ambulance) abciximab administration in patients with acute ST elevation myocardial infarction: an analysis from Leiden MISSION! acute myocardial infarction treatment optimization program. Ahmed TA, Atary JZ, Wolterbeek R, Hasan-Ali H, Abdel-Kader SS, Schalij MJ, Jukema JW

Background: The benefits of early abciximab administration and thrombus aspiration in ST elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI) have previously been elaborated. However, whether there is an adjunctive effect of thrombus aspiration among STEMI patients, with angiographic evidence of thrombus, receiving early prehospital abciximab remains unclear. Methods: In the context of a fixed protocol for PPCI, 158 consecutive patients w... Abstract

Cited 40 times since 2011 (3 per year) source: EuropePMC

Heart rhythm, Volume 9, Issue 4, 3 1 2011, Pages 494-498 Cardiac device infections are associated with a significant mortality risk. de Bie MK, van Rees JB, Thijssen J, Borleffs CJ, Trines SA, Cannegieter SC, Schalij MJ, van Erven L

Background: Cardiac device infections (CDIs) are a serious complication associated with the implantation of cardiac rhythm devices. However, the effect of CDI on the subsequent risk of mortality is unknown. Objective: To assess the prognostic importance of CDI in recipients of implantable cardioverter-defibrillator and cardiac resynchronization therapy - defibrillator. Methods: All patients who received their initial implantable cardioverter-defibrillator/cardiac resynchronization therapy - defi... Abstract

Cited 49 times since 2011 (3.7 per year) source: EuropePMC

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Volume 21, Issue 8, 1 1 2011, Pages 1472-1478 Optimization of near-infrared fluorescent sentinel lymph node mapping in cervical cancer patients. van der Vorst JR, Hutteman M, Gaarenstroom KN, Peters AA, Mieog JS, Schaafsma BE, Kuppen PJ, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Objective: In early cervical cancer, a total pelvic lymphadenectomy is the standard of care, even though most patients have negative nodes and thus undergo lymphadenectomy unnecessarily. Although the value of sentinel lymph node (SLN) mapping in early-stage cervical cancer has not yet been established, near-infrared (NIR) fluorescence imaging is a promising technique to perform this procedure. Near-infrared fluorescence imaging is based on invisible NIR light and can provide high sensitivity, hi... Abstract

Cited 3 times since 2011 (0.2 per year) source: EuropePMC

Journal of nephrology, Volume 24, Issue 6, 1 1 2011, Pages 764-770 Preoperative left ventricular dysfunction predisposes to postoperative acute kidney injury and long-term mortality. van Kuijk JP, Flu WJ, Valentijn TM, Chonchol M, Voûte MT, Kuiper RJ, Verhagen HJ, Bax JJ, Poldermans D

Background: Both preoperative left ventricular dysfunction (LVD) and acute kidney injury (AKI) in the postoperative period are independently associated with mortality. We evaluated the prevalence and prognostic implications of AKI in a cohort of vascular surgery patients. Methods: Before vascular surgery, 1,158 patients were screened for LVD. Development of AKI, defined by RIFLE classification, was detected by serial serum creatinine measurements at days 1 to 3 after surgery. Primary end point w... Abstract

Cited 32 times since 2011 (2.4 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 58, Issue 22, 1 1 2011, Pages 2282-2289 Implantable cardioverter-defibrillator patients who are upgraded and respond to cardiac resynchronization therapy have less ventricular arrhythmias compared with nonresponders. Thijssen J, Borleffs CJ, Delgado V, van Rees JB, Mooyaart EA, van Bommel RJ, van Erven L, Boersma E, Bax JJ, Schalij MJ

Objectives: The purpose of this study was to evaluate the impact of upgrading implantable cardioverter-defibrillator (ICD) therapy to cardiac resynchronization therapy (CRT) combined with defibrillator (CRT-D) on the occurrence of ventricular arrhythmia (VA) and appropriate ICD therapies. Background: CRT has been shown to improve left ventricular (LV) systolic function and induce reverse LV remodeling. In addition, it has been hypothesized that CRT may reduce the incidence of VA. Methods: Heart... Abstract

Cited 13 times since 2011 (1 per year) source: EuropePMC

Developmental dynamics : an official publication of the American Association of Anatomists, Volume 240, Issue 11, 1 1 2011, Pages 2561-2577 Expression of Id2 in the second heart field and cardiac defects in Id2 knock-out mice. Jongbloed MR, Vicente-Steijn R, Douglas YL, Wisse LJ, Mori K, Yokota Y, Bartelings MM, Schalij MJ, Mahtab EA, Poelmann RE, Gittenberger-De Groot AC

The inhibitor of differentiation Id2 is expressed in mesoderm of the second heart field, which contributes myocardial and mesenchymal cells to the primary heart tube. The role of Id2 in cardiac development is insufficiently known. Heart development was studied in sequential developmental stages in Id2 wildtype and knockout mouse embryos. Expression patterns of Id2, MLC-2a, Nkx2.5, HCN4, and WT-1 were analyzed. Id2 is expressed in myocardial progenitor cells at the inflow and outflow tract, in th... Abstract

Cited 65 times since 2011 (4.9 per year) source: EuropePMC

Foot & ankle international, Volume 32, Issue 11, 1 1 2011, Pages 1040-1044 Complications of syndesmotic screw removal. Schepers T, Van Lieshout EM, de Vries MR, Van der Elst M

Background: Currently, the metallic syndesmotic screw is the gold standard in the treatment of syndesmotic disruption. Whether or not this screw needs to be removed remains debatable. The aim of the current study was to determine the complications which occur following routine removal of the syndesmotic screw following operative treatment of unstable ankle fractures. Methods: This was a retrospective study with consecutive cases in a Level-2 Trauma center. All patients with routine removal of a... Abstract

Cited 180 times since 2011 (13.5 per year) source: EuropePMC

Science (New York, N.Y.), Volume 334, Issue 6056, 1 1 2011, Pages 686-690 Drosophila CENH3 is sufficient for centromere formation. Mendiburo MJ, Padeken J, Fülöp S, Schepers A, Heun P

CENH3 is a centromere-specific histone H3 variant essential for kinetochore assembly. Despite its central role in centromere function, there has been no conclusive evidence supporting CENH3 as sufficient to determine centromere identity. To address this question, we artificially targeted Drosophila CENH3 (CENP-A/CID) as a CID-GFP-LacI fusion protein to stably integrated lac operator (lacO) arrays. This ectopic CID focus assembles a functional kinetochore and directs incorporation of CID molecule... Abstract

Cited 8 times since 2011 (0.6 per year) source: EuropePMC

Journal of affective disorders, Volume 136, Issue 3, 26 4 2011, Pages 751-757 Beta blocker therapy is associated with reduced depressive symptoms 12 months post percutaneous coronary intervention. Battes LC, Pedersen SS, Oemrawsingh RM, van Geuns RJ, Al Amri I, Regar E, de Jaegere PP, Serruys P, van Domburg RT

Background: Beta blocker therapy may induce depressive symptoms, although current evidence is conflicting. We examined the association between beta blocker therapy and depressive symptoms in percutaneous coronary intervention (PCI) patients and the extent to which there is a dose-response relationship between beta blocker dose and depressive symptoms. Methods: Patients treated with PCI (N=685) completed the depression scale of the Hospital Anxiety and Depression Scale 1 and 12 months post PCI. I... Abstract

Cited 10 times since 2011 (0.7 per year) source: EuropePMC

Atherosclerosis, Volume 220, Issue 1, 25 4 2011, Pages 86-92 C1-esterase inhibitor protects against early vein graft remodeling under arterial blood pressure. Krijnen PA, Kupreishvili K, de Vries MR, Schepers A, Stooker W, Vonk AB, Eijsman L, Van Hinsbergh VW, Zeerleder S, Wouters D, van Ham M, Quax PH, Niessen HW

Objectives: Arterial pressure induced vein graft injury can result in endothelial loss, accelerated atherosclerosis and vein graft failure. Inflammation, including complement activation, is assumed to play a pivotal role herein. Here, we analyzed the effects of C1-esterase inhibitor (C1inh) on early vein graft remodeling. Methods: Human saphenous vein graft segments (n=8) were perfused in vitro with autologous blood either supplemented or not with purified human C1inh at arterial pressure for 6h... Abstract

Cited 3 times since 2011 (0.2 per year) source: EuropePMC

European journal of preventive cardiology, Volume 19, Issue 6, 19 3 2011, Pages 1316-1323 Three life years gained after reperfusion therapy in acute myocardial infarction: 25-30 years after a randomized controlled trial. Domburg RT, Hendriks JM, Kamp O, Smits P, Melle Mv, Schenkeveld L, Bax JJ, Simoons ML

Aim: Reperfusion therapy in acute myocardial infarction reduces infarct size and increases hospital survival. We investigated whether the benefit of reperfusion therapy for myocardial infarction was sustained long-term and assessed the gain in life expectancy by reperfusion therapy. Methods and results: We analysed the outcome of 533 patients (mean age 56 years, 82% men), who were randomized to either reperfusion therapy or conventional therapy during 1980-1985. Median follow up was 27 years (25... Abstract

Cited 43 times since 2011 (3.2 per year) source: EuropePMC

European journal of endocrinology, Volume 166, Issue 1, 17 3 2011, Pages 27-34 Increased myocardial fibrosis and left ventricular dysfunction in Cushing's syndrome. Yiu KH, Marsan NA, Delgado V, Biermasz NR, Holman ER, Smit JW, Feelders RA, Bax JJ, Pereira AM

Objective: Active Cushing's syndrome (CS) is associated with cardiomyopathy, characterized by myocardial structural, and ultrastructural abnormalities. The extent of myocardial fibrosis in patients with CS has not been previously evaluated. Therefore, the objective of this study was to assess myocardial fibrosis in CS patients, its relationship with left ventricular (LV) hypertrophy and function, and its reversibility after surgical treatment. Design and methods: Fifteen consecutive CS pati... Abstract

Cited 10 times since 2011 (0.7 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 24, Issue 12, 14 2 2011, Pages 1392-1399.e1 Biventricular performance in patients with marfan syndrome without significant valvular disease: comparison to normal subjects and longitudinal follow-up. Scherptong RW, Vliegen HW, van der Wall EE, Hilhorst-Hofstee Y, Bax JJ, Scholte AJ, Delgado V

Background: The presence and progressive nature of primary myocardial involvement in Marfan syndrome are debated. The aim of this study was to evaluate the clinical relevance of left ventricular (LV) and right ventricular (RV) strain in adult patients with Marfan syndrome without significant valvular disease. Methods: Adult patients with Marfan syndrome (n = 50; mean age, 35.2 ± 12.9 years) were followed prospectively. Echocardiography was performed annually and consisted of comprehensive assess... Abstract

Cited 41 times since 2011 (3.1 per year) source: EuropePMC

Nature reviews. Cardiology, Volume 9, Issue 2, 11 2 2011, Pages 79-90 Restenosis after PCI. Part 2: prevention and therapy. Jukema JW, Ahmed TA, Verschuren JJ, Quax PH

The techniques and materials used during percutaneous coronary intervention have advanced considerably over the past 3 decades, yet restenosis remains one of the major drawbacks of this procedure. Many innovative technologies, including drug-eluting stents, with or without specific polymers, and fully biodegradable stents have been and continue to be developed in the search for a safe and effective antirestenosis therapy. Remarkable advances in stent design and nanoparticle delivery systems (�... Abstract

Cited 27 times since 2011 (2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 97, Issue 24, 11 2 2011, Pages 2063-2068 Intrinsic biventricular dysfunction in Marfan syndrome. de Witte P, Aalberts JJ, Radonic T, Timmermans J, Scholte AJ, Zwinderman AH, Mulder BJ, Groenink M, van den Berg MP

Background: Marfan syndrome (MFS) is an autosomal, dominantly inherited, connective tissue disorder usually caused by a mutation in the fibrillin-1 gene (FBN1). As fibrillin-1 is a component of the extracellular matrix of the myocardium, mutations in FBN1 may cause impairment of ventricular function. Furthermore, aortic elasticity is decreased in patients with MFS, which might also impair ventricular function. We assessed biventricular function and the influence of aortic elasticity in patients... Abstract

Cited 17 times since 2011 (1.3 per year) source: EuropePMC

European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, Volume 12, Issue 12, 10 2 2011, Pages 953-960 Tissue Doppler imaging in the left ventricle and right ventricle in healthy children: normal age-related peak systolic velocities, timings, and time differences. van der Hulst AE, Delgado V, Ten Harkel AD, Klitsie LM, Filippini LH, Bax JJ, Blom NA, Roest AA

Aims: Tissue Doppler imaging (TDI) enables assessment of velocities and timings within the left (LV) and the right (RV) ventricle with high temporal resolution. Knowledge on normal age-related values of peak systolic velocities and timings in healthy children may optimize the benefit of device-based therapies in paediatric patients with heart failure. Methods and results: A total of 123 healthy children (from 1 month to 18 years old) underwent TDI evaluation of the RV and LV. Peak systolic veloc... Abstract

Cited 51 times since 2011 (3.8 per year) source: EuropePMC

Circulation, Volume 124, Issue 20, 10 2 2011, Pages 2195-2201 Surgery in adults with congenital heart disease. Zomer AC, Verheugt CL, Vaartjes I, Uiterwaal CS, Langemeijer MM, Koolbergen DR, Hazekamp MG, van Melle JP, Konings TC, Bellersen L, Grobbee DE, Mulder BJ

Background: A significant proportion of patients with congenital heart disease require surgery in adulthood. We aimed to give an overview of the prevalence, distribution, and outcome of cardiovascular surgery for congenital heart disease. We specifically questioned whether the effects of surgical treatment on subsequent long-term survival depend on sex. Methods and results: From the Dutch Congenital Corvitia (CONCOR) registry for adults with congenital heart disease, we identified 10 300 patient... Abstract

Cited 2 times since 2011 (0.1 per year) source: EuropePMC

Expert opinion on investigational drugs, Volume 20, Issue 11, 7 1 2011, Pages 1517-1522 Low molecular weight heparins in the treatment of lung cancer. Mellema WW, Smit EF, Dingemans AM

Introduction: Lung cancer is the major cause of cancer-related death. Venous thromboembolic events (VTEs) occur frequently in lung cancer and are a poor prognostic marker. For prevention and treatment of VTE, low molecular weight heparins (LMWH) are superior to vitamin K antagonists. There is some evidence that LMWH may improve survival in cancer patients. Areas covered: The areas covered in this review are: lung cancer and VTEs; role of LMWH in treatment of VTEs; anticancer mechanism of heparin... Abstract

Cited 53 times since 2011 (3.9 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 58, Issue 18, 6 1 2011, Pages 1910-1918 Hemodynamic and clinical impact of prosthesis-patient mismatch after transcatheter aortic valve implantation. Ewe SH, Muratori M, Delgado V, Pepi M, Tamborini G, Fusini L, Klautz RJ, Gripari P, Bax JJ, Fusari M, Schalij MJ, Marsan NA

Objectives: This study examined the mid-term hemodynamic and clinical impact of prosthesis-patient mismatch (PPM) in patients undergoing transcatheter aortic valve implantation (TAVI) with balloon-expandable valves. Background: PPM can be observed after aortic valve surgery. However, little is known about the incidence of PPM in patients undergoing TAVI. Methods: Echocardiography and clinical assessment were performed in 165 patients at baseline, before hospital discharge, and at 6 months after... Abstract