Research

Publications

Below you can find a list of our published research.

6128 results

Cited 303 times since 2007 (17.2 per year) source: EuropePMC

Circulation, Volume 116, Issue 5, 9 2 2007, Pages 545-551 Preoperative thresholds for pulmonary valve replacement in patients with corrected tetralogy of Fallot using cardiovascular magnetic resonance. Oosterhof T, van Straten A, Vliegen HW, Meijboom FJ, van Dijk AP, Spijkerboer AM, Bouma BJ, Zwinderman AH, Hazekamp MG, de Roos A, Mulder BJ

Background: To facilitate the optimal timing of pulmonary valve replacement, we analyzed preoperative thresholds of right ventricular (RV) volumes above which no decrease or normalization of RV size takes place after surgery. Methods and results: Between 1993 and 2006, 71 adult patients with corrected tetralogy of Fallot underwent pulmonary valve replacement in a nationwide, prospective follow-up study. Patients were evaluated with cardiovascular magnetic resonance both preoperatively and postop... Abstract

Cited 114 times since 2007 (6.5 per year) source: EuropePMC

The American journal of cardiology, Volume 100, Issue 6, 5 1 2007, Pages 930-936 Comparison of myocardial infarct size assessed with contrast-enhanced magnetic resonance imaging and left ventricular function and volumes to predict mortality in patients with healed myocardial infarction. Roes SD, Kelle S, Kaandorp TA, Kokocinski T, Poldermans D, Lamb HJ, Boersma E, van der Wall EE, Fleck E, de Roos A, Nagel E, Bax JJ

Currently, left ventricular (LV) ejection fraction (EF) and/or LV volumes are the established predictors of mortality in patients with coronary artery disease (CAD) and severe LV dysfunction. With contrast-enhanced magnetic resonance imaging (MRI), precise delineation of infarct size is now possible. The relative merits of LVEF/LV volumes and infarct size to predict long-term outcome are unknown. The purpose of this study was to determine the predictive value of infarct size assessed with contra... Abstract

Cited 20 times since 2007 (1.1 per year) source: EuropePMC

Archives of surgery (Chicago, Ill. : 1960), Volume 142, Issue 7, 1 1 2007, Pages 662-667 Type-D personality and ankle brachial index as predictors of impaired quality of life and depressive symptoms in peripheral arterial disease. Aquarius AE, Denollet J, Hamming JF, Van Berge Henegouwen DP, De Vries J

Background: Patient-based outcomes, such as impaired quality of life (QOL) and depression, may adversely affect the clinical course of patients with peripheral arterial disease (PAD). Disease severity indices, including the ankle brachial index, are only partially associated with these outcomes. Objective: To examine whether individual differences in personality would predict impaired QOL and depression above and beyond PAD severity. Design: A prospective follow-up study. Setting: Vascular outpa... Abstract

Cited 15 times since 2007 (0.8 per year) source: EuropePMC

The Journal of heart valve disease, Volume 16, Issue 4, 1 1 2007, Pages 398-403 Outcome of pregnancy in women after pulmonary autograft valve replacement for congenital aortic valve disease. Yap SC, Drenthen W, Pieper PG, Moons P, Mulder BJ, Klieverik LM, Vliegen HW, van Dijk AP, Meijboom FJ, Roos-Hesselink JW, ZAHARA investigators

Background and aim of the study: The pulmonary autograft has been recommended as the valve of choice for aortic valve replacement (AVR) in young women contemplating pregnancy. However, current information on maternal and perinatal outcome of pregnancy in women with pulmonary autograft valve replacement is limited. Methods: Using a nationwide Dutch registry (CONCOR) and a local Belgian tertiary care center database, 17 women (age range: 18 to 45 years) with pulmonary autograft valve replacement w... Abstract

Cited 7 times since 2007 (0.4 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 14, Issue 4, 1 1 2007, Pages 604-612 The current status of multislice computed tomography in the diagnosis and prognosis of coronary artery disease. Schuijf JD, Jukema JW, van der Wall EE, Bax JJ

Abstract

Cited 3 times since 2007 (0.2 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 14, Issue 4, 1 1 2007, Pages 550-554 Prognostic implications of stress Tc-99m tetrofosmin myocardial perfusion imaging in patients with left ventricular hypertrophy. Elhendy A, Schinkel AF, van Domburg RT, Bax JJ, Feringa HH, Noordzij PG, Schouten O, Poldermans D

Background: Left ventricular hypertrophy (LVH) is associated with an increased risk of cardiac death. Data on the prognostic value of myocardial perfusion imaging (MPI) in patients with LVH are limited. The aim of this study is to assess the independent value of stress technetium 99m tetrofosmin MPI in predicting the long-term mortality rate in patients with LVH. Methods and results: We studied 177 patients (mean age, 59 +/- 12 years; 134 men) with LVH by electrocardiographic criteria who underw... Abstract

Cited 8 times since 2007 (0.5 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 26, Issue 1, 1 1 2007, Pages 14-22 Applications of multislice computed tomography in coronary artery disease. de Roos A, Kroft LJ, Bax JJ, Geleijns J

Multislice computed tomography (MSCT) provides high accuracy for noninvasive assessment of coronary artery disease (CAD). The introduction of the latest computed tomography (CT) technology allows comprehensive evaluation of various aspects of CAD, including the coronary calcium score, coronary artery stenoses, bypass patency, and myocardial function. Other applications, such as plaque characterization, first-pass perfusion imaging, and viability imaging using delayed contrast enhancement, are st... Abstract

Cited 178 times since 2007 (10.1 per year) source: EuropePMC

Current problems in cardiology, Volume 32, Issue 7, 1 1 2007, Pages 375-410 Hibernating myocardium: diagnosis and patient outcomes. Schinkel AF, Bax JJ, Poldermans D, Elhendy A, Ferrari R, Rahimtoola SH

Approximately 50% of the patients with chronic obstructive coronary artery disease resulting in chronic contractile dysfunction have hibernating myocardium and may benefit from revascularization. This pooled analysis describes the relative merits of dobutamine echocardiography, thallium-201 and technetium-99m scintigraphy, positron emission tomography, and magnetic resonance imaging, for the diagnosis of hibernating myocardium and prediction of patient outcomes. Abstract

Cited 59 times since 2007 (3.3 per year) source: EuropePMC

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, Volume 9, Issue 4, 1 1 2007, Pages 645-651 Magnetic resonance assessment of aortic pulse wave velocity, aortic distensibility, and cardiac function in uncomplicated type 2 diabetes mellitus. van der Meer RW, Diamant M, Westenberg JJ, Doornbos J, Bax JJ, de Roos A, Lamb HJ

Background: Type 2 diabetes mellitus (DM2) may augment arterial stiffening and thereby modulates left ventricular (LV) function. Cardiovascular magnetic resonance (CMR) is well suited to assess aortic pulse wave velocity (PWV) and aortic distensibility, both markers of arterial stiffness, without the use of geometric assumptions. Furthermore, CMR is a reliable method for assessing left ventricular (LV) function. The purpose of this study was to assess LV function, PWV, and aortic distensibility... Abstract

Cited 71 times since 2007 (4 per year) source: EuropePMC

European heart journal, Volume 28, Issue 18, 29 5 2007, Pages 2223-2230 Impaired myocardial perfusion and perfusion reserve associated with increased coronary resistance in persistent idiopathic atrial fibrillation. Range FT, Schäfers M, Acil T, Schäfers KP, Kies P, Paul M, Hermann S, Brisse B, Breithardt G, Schober O, Wichter T

Aims: Patients with atrial fibrillation (AF) present with symptoms of myocardial ischaemia despite exclusion of coronary artery disease. A small vessel disease has been suggested. We quantified myocardial perfusion, perfusion reserve, and coronary vascular resistance (CVR) in AF patients using positron emission tomography (PET). Methods and results: Twenty-five male patients (age: 58 +/- 13 years) with persistent idiopathic AF were compared with 13 age- and risk-matched male controls (age: 56 +/... Abstract

Cited 49 times since 2007 (2.8 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 27, Issue 9, 28 4 2007, Pages 2050-2057 Vaccination against VEGFR2 attenuates initiation and progression of atherosclerosis. Hauer AD, van Puijvelde GH, Peterse N, de Vos P, van Weel V, van Wanrooij EJ, Biessen EA, Quax PH, Niethammer AG, Reisfeld RA, van Berkel TJ, Kuiper J

Objective: Vascular endothelial growth factor receptor 2 (VEGFR2)-overexpressing cells may form an interesting target for the treatment of atherosclerosis because of their involvement in processes that contribute to this disease, such as angiogenesis. Methods and results: We vaccinated mice against VEGFR2 by an orally administered DNA vaccine, comprising a plasmid, encoding murine VEGFR2, carried by live attenuated Salmonella typhimurium. This vaccine induces cellular immunity against cells that... Abstract

Cited 40 times since 2007 (2.3 per year) source: EuropePMC

European journal of heart failure, Volume 9, Issue 8, 22 4 2007, Pages 808-813 Importance of the echocardiographic evaluation of right ventricular function in patients with AL amyloidosis. Ghio S, Perlini S, Palladini G, Marsan NA, Faggiano G, Vezzoli M, Klersy C, Campana C, Merlini G, Tavazzi L

Background: Patients with AL amyloidosis often present with signs of congestive heart failure. Aim: This study was prospectively designed to assess the significance of RV dysfunction in AL amyloidosis. Methods and results: Seventy-four patients with biopsy proven AL amyloidosis underwent a thorough echocardiographic evaluation. A tricuspid annular plane systolic excursion (TAPSE) Abstract

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 34, Issue 3, 19 3 2007, Pages 378 The Oslo Balloon Angioplasty versus Conservative Treatment Study (OBACT) - The 2-years results of a single centre, prospective, randomised study in patients with intermittent claudication. Breek JC, De Vries J, Hamming JF

Abstract

Cited 28 times since 2007 (1.6 per year) source: EuropePMC

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Volume 21, Issue 12, 19 3 2007, Pages 3369-3379 Fibroblasts from human postmyocardial infarction scars acquire properties of cardiomyocytes after transduction with a recombinant myocardin gene. van Tuyn J, Pijnappels DA, de Vries AA, de Vries I, van der Velde-van Dijke I, Knaän-Shanzer S, van der Laarse A, Schalij MJ, Atsma DE

Myocardial scar formation impairs heart function by inducing cardiac remodeling, decreasing myocardial compliance, and compromising normal electrical conduction. Conversion of myocardial scar fibroblasts (MSFs) into (functional) cardiomyocytes may be an effective alternative treatment to limit loss of cardiac performance after myocardial injury. In this study, we investigated whether the phenotype of MSFs can be modified by gene transfer into cells with properties of cardiomyocytes. To this end,... Abstract

Cited 182 times since 2007 (10.3 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 48, Issue 7, 15 3 2007, Pages 1104-1111 Can LV dyssynchrony as assessed with phase analysis on gated myocardial perfusion SPECT predict response to CRT? Henneman MM, Chen J, Dibbets-Schneider P, Stokkel MP, Bleeker GB, Ypenburg C, van der Wall EE, Schalij MJ, Garcia EV, Bax JJ

Unlabelled: Cardiac resynchronization therapy (CRT) is now a well-recognized therapeutic option for patients with end-stage heart failure. However, not all patients respond to CRT, and, therefore, preimplantation identification of responders is desirable. The aim of the present study was to investigate whether the degree of left ventricular (LV) dyssynchrony, as assessed with phase analysis from gated myocardial perfusion SPECT (GMPS), can predict which patients will respond to CRT. Methods: For... Abstract

Cited 64 times since 2007 (3.6 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 48, Issue 7, 15 3 2007, Pages 1135-1146 Assessment of myocardial viability in patients with heart failure. Schinkel AF, Poldermans D, Elhendy A, Bax JJ

The prognosis for patients with chronic ischemic left ventricular dysfunction is poor, despite advances in different therapies. Noninvasive assessment of myocardial viability may guide patient management. Multiple imaging techniques have been developed to assess viable and nonviable myocardium by evaluating perfusion, cell membrane integrity, mitochondria, glucose metabolism, scar tissue, and contractile reserve. PET, (201)Tl and (99m)Tc scintigraphy, and dobutamine stress echocardiography have... Abstract

Cited 17 times since 2007 (1 per year) source: EuropePMC

The American journal of cardiology, Volume 100, Issue 3, 14 2 2007, Pages 476-482 Usefulness of triplane tissue Doppler imaging to predict acute response to cardiac resynchronization therapy. Van de Veire NR, Bleeker GB, Ypenburg C, De Sutter J, Ajmone Marsan N, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

This study evaluated the value of triplane tissue Doppler imaging (TDI) to predict acute response after cardiac resynchronization therapy (CRT). Forty-nine patients scheduled for CRT underwent triplane echocardiography with simultaneous TDI acquisition before and 48 hours after implantation. A 3-dimensional left ventricular (LV) volume was generated and LV volumes and ejection fraction were calculated. A parametric imaging technique, tissue synchronization imaging, was applied to portray the are... Abstract

Cited 250 times since 2007 (14.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 49, Issue 24, 4 1 2007, Pages 2303-2311 Outcome of pregnancy in women with congenital heart disease: a literature review. Drenthen W, Pieper PG, Roos-Hesselink JW, van Lottum WA, Voors AA, Mulder BJ, van Dijk AP, Vliegen HW, Yap SC, Moons P, Ebels T, van Veldhuisen DJ, ZAHARA Investigators

A search of peer-reviewed literature was conducted to identify reports that provide data on complications associated with pregnancy in women with structural congenital heart disease (CHD). This review describes the outcome of 2,491 pregnancies, including 377 miscarriages (15%) and 114 elective abortions (5%). Important cardiac complications were seen in 11% of the pregnancies. Obstetric complications do not appear to be more prevalent. In complex CHD, premature delivery rates are high, and more... Abstract

Cited 19 times since 2007 (1.1 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 104, Issue 24, 4 1 2007, Pages 10000-10005 Global distribution of negative cofactor 2 subunit-alpha on human promoters. Albert TK, Grote K, Boeing S, Stelzer G, Schepers A, Meisterernst M

Negative cofactor 2 (NC2) forms a stable complex with TATA-binding protein (TBP) on promoters in vitro. Its association with TBP prevents the binding of TFIIB and leads to inhibition of preinitiation complex formation. Here, we investigate the association of NC2 subunit-alpha with human RNA polymerase II promoter regions by using gene-specific ChIP and genome-wide promoter ChIPchip analyses. We find NC2alpha associated with a large number of human promoters, where it peaks close to the core regi... Abstract

Cited 17 times since 2007 (1 per year) source: EuropePMC

Journal of the American Geriatrics Society, Volume 55, Issue 6, 1 1 2007, Pages 872-877 The routine electrocardiogram for cardiovascular risk stratification in old age: the Leiden 85-plus study. de Ruijter W, Westendorp RG, Macfarlane PW, Jukema JW, Assendelft WJ, Gussekloo J

Objectives: To explore the prognostic value of signs of prior myocardial infarction (MI) and atrial fibrillation (AF) on routine electrocardiograms (ECGs) at the age of 85 with respect to mortality and changes in functional status. Design: Observational, prospective cohort study with complete 6-year follow-up. Setting: General population. Participants: A population-based sample of 566 85-year-old participants (377 women, 189 men), without exclusion criteria. Measurements: Annual ECG recording an... Abstract