8892 results
European heart journal,
30 5 2025, Pages ehaf660
AAV9-mediated KCNH2 suppression-replacement gene therapy in a transgenic rabbit model of type 1 short QT syndrome.
Nimani S, Bains S, Alerni N, Ördög B, Horváth A, Matas L, Louradour J, Giammarino L, Tester DJ, Beslac O, Lopez R, Meier S, Egle M, Christoforou N, Barbieri M, Vashanthakumar V, Perez-Feliz S, Parodi C, Garcia Casalta LG, Kim CSJ, Zhou W, Ye D, Jurgensen J, Barry MA, Bego M, Keyes L, Owens J, Pinkstaff J, Christoph J, Zehender M, Brunner M, Heijman J, Casoni D, Praz F, Haeberlin A, Brooks G, Ackerman MJ, Odening KE
Background and aims: Type 1 short QT syndrome (SQT1) is a genetic channelopathy caused by gain-of-function variants in KCNH2. This shortens cardiac repolarization and QT intervals, predisposing patients to ventricular arrhythmias and sudden cardiac death. This study aimed to investigate the therapeutic efficacy of KCNH2-specific suppression-and-replacement (KCNH2-SupRep) gene therapy in a transgenic rabbit model of SQT1. Methods: KCNH2-SupRep was developed by combining a KCNH2-shRNA with its cor...
Abstract
European heart journal,
29 5 2025, Pages ehaf194
2025 ESC/EACTS Guidelines for the management of valvular heart disease.
Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Ajmone Marsan N, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W, ESC/EACTS Scientific Document Group
Abstract
European heart journal,
29 5 2025, Pages ehaf193
2025 ESC Guidelines for the management of cardiovascular disease and pregnancy.
De Backer J, Haugaa KH, Hasselberg NE, de Hosson M, Brida M, Castelletti S, Cauldwell M, Cerbai E, Crotti L, de Groot NMS, Estensen ME, Goossens ES, Haring B, Kurpas D, McEniery CM, Peters SAE, Rakisheva A, Sambola A, Schlager O, Schoenhoff FS, Simoncini T, Steinbach F, Sudano I, Swan L, Valente AM, ESC Scientific Document Group
Abstract
The Annals of thoracic surgery,
29 5 2025, Pages S0003-4975(25)00805-7
Mitral Valve Repair in Infective Endocarditis: A Patient-Tailored Approach.
Tomšič A, Palmen M
Abstract
European heart journal,
29 5 2025, Pages ehaf192
2025 ESC Guidelines for the management of myocarditis and pericarditis.
Schulz-Menger J, Collini V, Gröschel J, Adler Y, Brucato A, Christian V, Ferreira VM, Gandjbakhch E, Heidecker B, Kerneis M, Klein AL, Klingel K, Lazaros G, Lorusso R, Nesukay EG, Rahimi K, Ristić AD, Rucinski M, Sade LE, Schaubroeck H, Semb AG, Sinagra G, Thune JJ, Imazio M, ESC Scientific Document Group
Abstract
Cited 3 times since 2025 (22.4 per year)
source: EuropePMC
European heart journal,
29 5 2025, Pages ehaf190
2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias.
Mach F, Koskinas KC, Roeters van Lennep JE, Tokgözoğlu L, Badimon L, Baigent C, Benn M, Binder CJ, Catapano AL, De Backer GG, Delgado V, Fabin N, Ference BA, Graham IM, Landmesser U, Laufs U, Mihaylova B, Nordestgaard BG, Richter DJ, Sabatine MS, ESC/EAS Scientific Document Group
Abstract
Cited 2 times since 2025 (14.9 per year)
source: EuropePMC
European heart journal,
29 5 2025, Pages ehaf191
2025 ESC Clinical Consensus Statement on mental health and cardiovascular disease: developed under the auspices of the ESC Clinical Practice Guidelines Committee.
Bueno H, Deaton C, Farrero M, Forsyth F, Braunschweig F, Buccheri S, Dragan S, Gevaert S, Held C, Kurpas D, Ladwig KH, Lionis CD, Maas AHEM, Merșa CO, Mindham R, Pedersen SS, Rojnic Kuzman M, Szmit S, Taylor RS, Uchmanowicz I, Vilchinsky N, ESC Scientific Document Group
Abstract
Clinical genitourinary cancer,
28 4 2025, Pages 102423
Addressing Uneven Treatment Discontinuation Rate in the Chemotherapy Arm of the EV-302 Phase 3 Randomized Clinical Trial: Implications for Outcome Interpretation.
Robesti D, Micheli F, Rai SN, Fallara G, Gallina A, Montorsi F, Briganti A, Fossati N, Grivas P, van der Heijden AG, Ploussard G, Malavaud B, Martini A
Introduction: The EV-302 trial demonstrated a very significant overall survival (OS) benefit for Enfortumab Vedotin plus Pembrolizumab (EVP) relative to standard chemotherapy (CHT) for patients with metastatic urothelial carcinoma. However, questions have been raised regarding the high rate of treatment discontinuation in the CHT arm for reasons unrelated to adverse events or progression (33% vs. 10% with EVP, P < .01), potentially resulting in loss of unaccounted information, or informative...
Abstract
Communications biology,
Volume 8, Issue 1, 28 4 2025, Pages 1293
Publisher Correction: Observational social learning of "know-how" and "know-what" in wild orangutans: evidence from nest-building skill acquisition.
Permana AL, Permana JJ, Nellissen L, Prayogi ES, Prasetyo D, Wich SA, van Schaik CP, Schuppli C
Abstract
Open heart,
Volume 12, Issue 2, 27 4 2025, Pages e003534
Long-term clinical outcomes in adult congenital aortic stenosis: results from a national study.
Keuning ZA, Meccanici F, Schreurs BA, Veen K, Bouma BJ, Voskuil M, Jongbloed MRM, van Melle JP, van Kimmenade RRJ, Kapoor R, Bozkurt I, Hirsch A, Roos-Hesselink JW, van den Bosch AE
Background: Previous research on congenital aortic stenosis (AS) mainly focused on children, while data on long-term outcomes in adults is scarce. Therefore, this study aims to evaluate outcomes in adult patients with congenital AS and identify prognostic markers for aortic valve replacement (AVR). Methods: In this multicentre study, patients aged 18-55 years with congenital AS (peak velocity ≥2.5 m/s) registered in the Dutch CONCOR (Congential Cor Vitia) registry from expert centres for congeni...
Abstract
Journal of the American College of Cardiology,
27 4 2025, Pages S0735-1097(25)07551-5
Lipoprotein(a) Levels and Time to Cardiovascular Benefit With Alirocumab in Patients With Recent Acute Coronary Syndrome.
Ray KK, Szarek M, Bhatt DL, Bittner VA, Fazio S, Goodman SG, Harrington RA, Jukema JW, White HD, Steg PG, Schwartz GG
Abstract
Scientific reports,
Volume 15, Issue 1, 27 4 2025, Pages 31537
Perspectives of adults aged 55+ on plant-based diets rich in protein.
van Oppenraaij SL, Putker M, van Schaik A, Weijs PJM, Verlaan S
An increased protein intake is required during aging to preserve muscle mass. A predominantly plant-based diet is beneficial for the climate and may lower the risk of certain non-communicable diseases, but could also lead to protein below recommendations. This study seeks to elucidate facilitators and barriers in adults aged 55+ adopting a diet that is both predominantly plant-based and provides sufficient protein to preserve muscle mass. Three focus groups were conducted with 30 Dutch adults, a...
Abstract
PharmacoEconomics,
23 4 2025
Cost-Utility Analysis of Treatment Sequences for Moderate-to-Severe Crohn's Disease.
Versteegh MM, Huygens SA, Bermejo I, Grimm S, Pierik M, Römkens T, van Schaik F, Wahab P
Objectives: The clinical pathway for patients with moderate-to-severe Crohn's disease (CD) typically includes sequential pharmacologic treatment as well as surgery, but positioning of different therapies within these sequences remains challenging. Cost-utility analysis rarely captures these sequences and does not incorporate registry data on long-term effectiveness. In this study, we aim to overcome these limitations. Methods: We developed an individual state transition model with four heal...
Abstract
International journal of stroke : official journal of the International Stroke Society,
22 4 2025, Pages 17474930251372371
Interaction of CYP2C19 with the effect of clopidogrel in secondary prevention of major ischemic events: Systematic review and meta-analysis.
Kremers FC, van den Biggelaar J, Lingsma HF, van Schaik RH, Roozenbeek B, Dippel DW
Background and aims: Clopidogrel may be a less effective antiplatelet agent for secondary prevention after cardiovascular events in carriers of the CYP2C19 Loss of Function (LoF) allele. Randomized controlled trials (RCTs) of clopidogrel in patients with known CYP2C19 carrier status have provided inconsistent results. This meta-analysis aims to pool evidence on the effect of different antiplatelet strategies on outcomes according to CYP2C19 LoF status. Methods: We conducted a systematic review a...
Abstract
Scientific reports,
Volume 15, Issue 1, 21 3 2025, Pages 30672
Metagenomic analysis and genomic characterization of enterovirus A76 and Norovirus GI.6[P11] co-infection in a patient with acute gastroenteritis in Thailand.
Chuchaona W, Izquierdo-Lara RW, Schapendonk CME, Khongwichit S, Koopmans MPG, de Graaf M, Poovorawan Y
Acute gastroenteritis (AGE) remains a significant global health concern, with noroviruses among the most prevalent viral pathogens. However, other enteric viruses also contribute substantially to the public health burden. This study provides the first molecular characterization of a co-infection involving a rarely reported enterovirus A76 (EV-A76) and a norovirus GI.6[P11] in a patient from Thailand. Metagenomic sequencing successfully identified complete viral genomes, revealing unique genetic...
Abstract
European journal of cancer (Oxford, England : 1990),
Volume 229, 21 3 2025, Pages 115731
Final clinical analysis of pre-operative ipilimumab and nivolumab in locally advanced urothelial cancer and exploration of tumor-draining lymph node composition: The NABUCCO trial.
Stockem CF, van Dorp J, van Dijk N, Vis DJ, Harkes R, van den Broek B, Alkemade M, Broeks A, Hendricksen K, Boellaard TN, de Feijter JM, van Montfoort ML, Daletzakis A, van der Heijden AG, Meijer RP, Mehra N, Wessels LFA, van Rhijn BWG, Suelmann BBM, van der Heijden MS
Background: Pre-operative immune checkpoint blockade (ICB) with ipilimumab and nivolumab has shown encouraging pathological complete response (pCR) rates in stage III urothelial cancer (UC). A previous analysis of NABUCCO suggested that ipilimumab 3 mg/kg is more effective than ipilimumab 1 mg/kg. However, long-term progression-free and overall survival (PFS, OS) following pre-operative combination ICB are unknown. Methods: In NABUCCO, 54 patients received pre-operative ipilimumab plus nivolumab...
Abstract
Pediatric allergy, immunology, and pulmonology,
Volume 38, Issue 3, 21 3 2025, Pages 108-111
A Rare Clinical Course in Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome: Lung Involvement.
Yılmaz D, Emeksiz ZŞ, İclal G, Bilgiç I, Mısırlıoğlu ED
Background: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare, potentially life-threatening hypersensitivity reaction characterized by skin rash, fever, eosinophilia, and multi-organ involvement. Although pulmonary complications are uncommon, they can significantly impact prognosis. Case Presentation: Here, we present a 6-year-old male with antibiotic-induced DRESS syndrome complicated by pleural effusion and pneumonitis. The patient was treated successfully with s...
Abstract
JACC. Basic to translational science,
Volume 10, Issue 9, 21 3 2025, Pages 101359
Triglycerides and T Cells in Cardiovascular Risk: Inflammatory Transcriptomic Profile in Hypertriglyceridemia Patients' T Cells.
Reilly NA, Mulder JWCM, Dekkers KF, Kuipers TB, van Vark-van der Zee LC, Mulder MT, Roeters van Lennep JE, Jukema JW, Heijmans BT
Triglycerides and T cells play a key role in atherosclerosis, the leading cause of cardiovascular disease (CVD). Moderately elevated triglycerides have emerged as a causal risk factor, and T cells are a prominent component of atherosclerotic plaques. This cross-sectional study examined transcriptomic differences in T cells among patients with varying triglyceride levels via RNA sequencing. We analyzed CD4+ and CD8+ T cells from 49 participants, including those with primary (genetic) and secondar...
Abstract
Scientifica,
Volume 2025, 20 3 2025, Pages 4314722
The Effect of Nano-Fertilization With NPK and Spraying With Potassium Silicate on Improving the Physical Characteristics of Date Palm (<i>Phoenix dactylifera</i>) Fruits of Khastawi and Khadhrawi Cultivars.
Al-Khafaji ZAH, Al-Amri IAU
This study was conducted during the 2024 growing season at the Palm Research Station in Al-Zafaraniya, Baghdad, Iraq. A total of 54 uniform date palm trees (Khastawi and Khadhrawi cultivars), approximately 15 years old and planted at 10-m spacing, were selected for experimental treatments. The objective was to evaluate the effects of three concentrations of nano NPK fertilizer (0, 2, and 4 g·L-1), applied in six foliar doses, and three concentrations of potassium silicate (0, 2, and 4 mL·L-1), a...
Abstract
Molecular therapy : the journal of the American Society of Gene Therapy,
20 3 2025, Pages S1525-0016(25)00656-2
In vivo base editing reduces liver cysts in autosomal dominant polycystic kidney disease.
Ibel A, Bhardwaj R, Yilmaz DE, Kong S, Wendlinger S, Cordero C, Papaioannou D, Papazian M, Schönauer R, Meng Q, Eckardt KU, Hassan F, Volpe I, Klämbt V, Halbritter J, Fedeles S, Krappitz M, Kaminski MM
Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent genetic kidney disorder, affecting over 10 million individuals worldwide. Cystic expansion typically progresses to kidney failure and also involves the liver with limited treatment options. Pathogenic variants in PKD1 or PKD2 account for 85%-90% of cases. Genetic re-expression of Pkd1 or Pkd2 has been shown to partially reverse key characteristics of the disease phenotype in mice. Despite advancements in understanding the...
Abstract
