8800 results
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
Epilepsy & behavior : E&B,
Volume 126, 2 1 2021, Pages 108456
Infantile spasms: Knowledge, attitude, and practice of pediatricians in Turkey.
Yılmaz D, Yayıcı Köken Ö, Gürkaş E, Ceylan N, Çıtak Kurt AN
Background: Infantile Spasms Syndrome (ISS) encompasses both West syndrome (WS), comprising epileptic spasms, psychomotor stagnation or regression and hypsarrhythmia, and also infants presenting with epileptic spasms who do not fulfill the triad of WS. Objective: To investigate the knowledge, attitude, and practice regarding ISS among Turkish pediatricians and pediatric residents. Methods: A cross-sectional study was conducted among pediatricians and pediatric residents from all regions of Turke...
Abstract
Cited 2 times since 2021 (0.6 per year)
source: EuropePMC
Indian heart journal,
Volume 74, Issue 1, 2 1 2021, Pages 76-78
Acute aortic syndromes in India: The need for a nationwide program to increase awareness.
Shetty V, Shetty D, Grewal N
Acute aortic dissection is a rare, but potentially life-threatening and time-critical condition that is frequently misdiagnosed. Therefore, its prompt and proper diagnosis is vital to increase a patient's chance of survival and to prevent grievous complications. Raising awareness and educating the general population and healthcare professionals about an aortic dissection is mandatory, for early diagnosis and improving the chances of survival.
Abstract
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 1, 1 1 2021, Pages 113-114
Atrial positron emission tomography in atrial fibrillation: predicting radiofrequency catheter ablation success.
van der Bijl P, van Rosendael A, Bax JJ
Abstract
The Journal of invasive cardiology,
Volume 33, Issue 12, 1 1 2021, Pages E1004
Delayed Iatrogenic Left Ventricular Apex Perforation Sealed With an Amplatzer Septal Occluder Device Under Transthoracic Echocardiography Guidance.
Montero-Cabezas JM, Delgado V, van der Kley F
High rates of spontaneous rupture and death have been described when the pseudoaneurysm is left untreated. Percutaneous closure has emerged as an alternative to surgery in patients with unacceptable surgical risk. In this case, transthoracic echocardiography allowed optimal characterization of the defect and successful procedure guidance, avoiding risks derived from more invasive intraprocedural imaging techniques.
Abstract
Annals of surgery,
Volume 274, Issue 6, 1 1 2021, Pages e858
Response to the Comment on "Long-term Prognosis After Elective Abdominal Aortic Aneurysm Repair is Poor in Women and Men".
Bulder RMA, Talvitie M, Bastiaannet E, Hamming JF, Hultgren R, Lindeman JHN
Abstract
Cited 18 times since 2021 (5.1 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 23, Issue 12, 1 1 2021, Pages 1989-1997
Accuracy of electroanatomical mapping-guided cardiac radiotherapy for ventricular tachycardia: pitfalls and solutions.
Abdel-Kafi S, Sramko M, Omara S, de Riva M, Cvek J, Peichl P, Kautzner J, Zeppenfeld K, Zeppenfeld K
Aims: To analyse and optimize the interobserver agreement for gross target volume (GTV) delineation on cardiac computed tomography (CCT) based on electroanatomical mapping (EAM) data acquired to guide radiotherapy for ventricular tachycardia (VT). Methods and results: Electroanatomical mapping data were exported and merged with the segmented CCT using manual registration by two observers. A GTV was created by both observers for predefined left ventricular (LV) areas based on preselected endocard...
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
Medical mycology,
Volume 60, Issue 1, 1 1 2021, Pages myab060
Implementation of a clinical decision rule for selecting empiric treatment for invasive aspergillosis in a setting with high triazole resistance.
van de Peppel RJ, van Grootveld R, Hendriks BJC, van Paassen J, Bernards S, Jolink H, Koopmans JG, von dem Borne PA, van der Beek MT, de Boer MGJ
World-wide, emerging triazole resistance increasingly complicates treatment of invasive aspergillosis (IA). In settings with substantial (>10%) prevalence of triazole resistance, empiric combination therapy with both a triazole and liposomal amphotericin B (LAmB) can be considered because of the low yields of susceptibility testing. To avoid toxicity while optimizing outcome, a strategy with monotherapy would be preferable. A newly designed treatment algorithm based on literature and expert c...
Abstract
Cited 5 times since 2021 (1.4 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 1, 1 1 2021, Pages 95-101
Comparison of left atrial strain measured by feature tracking computed tomography and speckle tracking echocardiography in patients with aortic stenosis.
Hirasawa K, Kuneman JH, Singh GK, Gegenava T, Hautemann D, Reiber JHC, Ajmone Marsan N, Bax JJ, Delgado V
Aims: Peak left atrial longitudinal strain (PALS) is a marker of the left atrial (LA) reservoir function. Novel feature tracking (FT) software allows assessment of LA strain from multidetector computed tomography (MDCT) data. This study aimed at evaluating the agreement between speckle tracking echocardiography (STE) and FT MDCT for the measurement of PALS in patients with sinus rhythm (SR) and with atrial fibrillation (AF). Methods and results: The current study included 318 patients (80 ± 7 ye...
Abstract
Cited 66 times since 2021 (18.5 per year)
source: EuropePMC
Nature,
Volume 600, Issue 7890, 1 1 2021, Pages 748-753
Activation of homologous recombination in G1 preserves centromeric integrity.
Yilmaz D, Furst A, Meaburn K, Lezaja A, Wen Y, Altmeyer M, Reina-San-Martin B, Soutoglou E
Centromeric integrity is key for proper chromosome segregation during cell division1. Centromeres have unique chromatin features that are essential for centromere maintenance2. Although they are intrinsically fragile and represent hotspots for chromosomal rearrangements3, little is known about how centromere integrity in response to DNA damage is preserved. DNA repair by homologous recombination requires the presence of the sister chromatid and is suppressed in the G1 phase of the cell cycle4. H...
Abstract
Cited 8 times since 2021 (2.2 per year)
source: EuropePMC
Pediatric emergency care,
Volume 37, Issue 12, 1 1 2021, Pages e1075-e1081
Integration of Physical Examination, Old and New Biomarkers, and Ultrasonography by Using Neural Networks for Pediatric Appendicitis.
Akgül F, Er A, Ulusoy E, Çağlar A, Çitlenbik H, Keskinoğlu P, Şişman AR, Karakuş OZ, Özer E, Duman M, Yılmaz D
Objective: The objective of this study was to evaluate physical examinations, imaging, and laboratory analyses individually and combined using innovative statistical analysis methods for the accurate diagnosis of pediatric appendicitis. Methods: Patients admitted to hospital with symptoms of abdominal pain whose pediatric appendicitis scores greater than 3 were included in the study. Clinical, radiologic, and laboratory findings and as a new biomarker calprotectin (CPT) concentrations were evalu...
Abstract
Cited 7 times since 2021 (2 per year)
source: EuropePMC
International journal of molecular sciences,
Volume 22, Issue 23, 24 4 2021, Pages 12678
Cold-Inducible RNA-Binding Protein but Not Its Antisense lncRNA Is a Direct Negative Regulator of Angiogenesis In Vitro and In Vivo via Regulation of the 14q32 angiomiRs-microRNA-329-3p and microRNA-495-3p.
Goossens EAC, Zhang L, de Vries MR, Jukema JW, Quax PHA, Nossent AY
Inhibition of the 14q32 microRNAs, miR-329-3p and miR-495-3p, improves post-ischemic neovascularization. Cold-inducible RNA-binding protein (CIRBP) facilitates maturation of these microRNAs. We hypothesized that CIRBP deficiency improves post-ischemic angiogenesis via downregulation of 14q32 microRNA expression. We investigated these regulatory mechanisms both in vitro and in vivo. We induced hindlimb ischemia in Cirp-/- and C57Bl/6-J mice, monitored blood flow recovery with laser Doppler perfus...
Abstract
Cited 24 times since 2021 (6.7 per year)
source: EuropePMC
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
Volume 28, Issue 6, 24 4 2021, Pages 880.e1-880.e8
Alcaligenes faecalis metallo-β-lactamase in extensively drug-resistant Pseudomonas aeruginosa isolates.
Li Y, Zhu Y, Zhou W, Chen Z, Moran RA, Ke H, Feng Y, van Schaik W, Shen H, Ji J, Ruan Z, Hua X, Yu Y
Objectives: To characterize Alcaligenes faecalis metallo-β-lactamase (MBL) AFM-2 and AFM-3 from clinical Pseudomonas aeruginosa isolates NDTH10366, NDTH9845 and WTJH17. Methods: Clinical isolates were whole-genome sequenced using the Illumina and Oxford Nanopore platforms. MICs of clinical isolates and transformants containing MBL genes were determined using broth microdilution methods. Kinetic parameters of purified AFM and NDM-1 were measured using a spectrophotometer. The AFM structure was mo...
Abstract
Cited 4 times since 2021 (1.1 per year)
source: EuropePMC
Biomicrofluidics,
Volume 15, Issue 6, 22 4 2021, Pages 064103
Nucleation kinetics of calcium oxalate monohydrate as a function of pH, magnesium, and osteopontin concentration quantified with droplet microfluidics.
Ibis F, Yu TW, Penha FM, Ganguly D, Nuhu MA, van der Heijden AEDM, Kramer HJM, Eral HB
A droplet-based microfluidic platform is presented to study the nucleation kinetics of calcium oxalate monohydrate (COM), the most common constituent of kidney stones, while carefully monitoring the pseudo-polymorphic transitions. The precipitation kinetics of COM is studied as a function of supersaturation and pH as well as in the presence of inhibitors of stone formation, magnesium ions (Mg2+), and osteopontin (OPN). We rationalize the trends observed in the measured nucleation rates leveragin...
Abstract
Cited 12 times since 2021 (3.3 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 10, Issue 22, 20 3 2021, Pages 5426
Inaccurate Risk Assessment by the ACS NSQIP Risk Calculator in Aortic Surgery.
Hers TM, Van Schaik J, Keekstra N, Putter H, Hamming JF, Van Der Vorst JR
Objectives: The aim of this retrospective study was to assess the predictive performance of the American College of Surgeons (ACS) risk calculator for aortic aneurysm repair for the patient population of a Dutch tertiary referral hospital. Methods: This retrospective study included all patients who underwent elective endovascular or open aortic aneurysm repair at our institution between the years 2013 and 2019. Preoperative patient demographics and postoperative complication data were collected,...
Abstract
Cited 13 times since 2021 (3.6 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 10, Issue 23, 19 3 2021, Pages e022567
Diet-Derived Antioxidants Do Not Decrease Risk of Ischemic Stroke: A Mendelian Randomization Study in 1 Million People.
Martens LG, Luo J, Willems van Dijk K, Jukema JW, Noordam R, van Heemst D
Background Dietary intake and blood concentrations of vitamins E and C, lycopene, and carotenoids have been associated with a lower risk of incident (ischemic) stroke. However, causality cannot be inferred from these associations. Here, we investigated causality by analyzing the associations between genetically influenced antioxidant levels in blood and ischemic stroke using Mendelian randomization. Methods and Results For each circulating antioxidant (vitamins E and C, lycopene, β-carotene, and...
Abstract
Cited 20 times since 2021 (5.6 per year)
source: EuropePMC
Clinical cardiology,
Volume 45, Issue 3, 19 3 2021, Pages 273-281
Left atrial appendage size is a marker of atrial fibrillation recurrence after radiofrequency catheter ablation in patients with persistent atrial fibrillation.
Simon J, El Mahdiui M, Smit JM, Száraz L, van Rosendael AR, Herczeg S, Zsarnóczay E, Nagy AI, Kolossváry M, Szilveszter B, Szegedi N, Nagy KV, Tahin T, Gellér L, van der Geest RJ, Bax JJ, Maurovich-Horvat P, Merkely B
Introduction: There are no consistently confirmed predictors of atrial fibrillation (AF) recurrence after catheter ablation. Therefore, we aimed to study whether left atrial appendage volume (LAAV) and function influence the long-term recurrence of AF after catheter ablation, depending on AF type. Methods: AF patients who underwent point-by-point radiofrequency catheter ablation after cardiac computed tomography (CT) were included in this analysis. LAAV and LAA orifice area were measured by CT....
Abstract
Cited 58 times since 2021 (16.1 per year)
source: EuropePMC
European journal of human genetics : EJHG,
Volume 30, Issue 10, 16 3 2021, Pages 1114-1120
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2C19 and CYP2D6 and SSRIs.
Brouwer JMJL, Nijenhuis M, Soree B, Guchelaar HJ, Swen JJ, van Schaik RHN, Weide JV, Rongen GAPJM, Buunk AM, de Boer-Veger NJ, Houwink EJF, van Westrhenen R, Wilffert B, Deneer VHM, Mulder H
The Dutch Pharmacogenetics Working Group (DPWG) guideline presented here, presents the gene-drug interaction between the genes CYP2C19 and CYP2D6 and antidepressants of the selective serotonin reuptake inhibitor type (SSRIs). Both genes' genotypes are translated into predicted normal metabolizer (NM), intermediate metabolizer (IM), poor metabolizer (PM), or ultra-rapid metabolizer (UM). Evidence-based dose recommendations were obtained, based on a structured analysis of published literature...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
Annals of the New York Academy of Sciences,
Volume 1506, Issue 1, 16 3 2021, Pages 98-117
Synthetic biology: at the crossroads of genetic engineering and human therapeutics-a Keystone Symposia report.
Cable J, Leonard JN, Lu TK, Xie Z, Chang MW, Fernández LÁ, Lora JM, Kaufman HL, Quintana FJ, Geiger R, F Lesser C, Lynch JP, Hava DL, Cornish VW, Lee GK, DiAndreth B, Fero M, Srivastava R, De Coster T, Roybal KT, Rackham OJL, Kiani S, Zhu I, Hernandez-Lopez RA, Guo T, Chen WCW
Synthetic biology has the potential to transform cell- and gene-based therapies for a variety of diseases. Sophisticated tools are now available for both eukaryotic and prokaryotic cells to engineer cells to selectively achieve therapeutic effects in response to one or more disease-related signals, thus sparing healthy tissue from potentially cytotoxic effects. This report summarizes the Keystone eSymposium "Synthetic Biology: At the Crossroads of Genetic Engineering and Human Therapeutics,...
Abstract
Cited 4 times since 2021 (1.1 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 16, Issue 4, 14 2 2021, Pages 294-302
Plaque progression: Where, why, and how fast? A review of what we have learned from the analysis of patient data from the PARADIGM registry.
Indraratna P, Khasanova E, Gulsin GS, Tzimas G, Takagi H, Park KH, Lin FY, Shaw LJ, Lee SE, Narula J, Bax JJ, Chang HJ, Leipsic J, PARADIGM investigators
Ischemic heart disease is the most common cause of mortality worldwide. The pathophysiology of myocardial infarction relates to temporal changes of atherosclerotic plaque culminating in plaque rupture, erosion or hemorrhage and the subsequent thrombotic response. Coronary computed tomographic angiography (CCTA) provides the ability to visualize and quantify plaque, and plaque progression can be measured on a per-patient basis by comparing findings of serial CCTA. The Progression of AtheRosclerot...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
Annals of vascular surgery,
Volume 81, 12 2 2021, Pages 202-210
A New Doppler-Derived Parameter to Quantify Internal Carotid Artery Stenosis: Maximal Systolic Acceleration.
Brouwers JJWM, Jiang JFY, Feld RT, van Doorn LP, van Wissen RC, van Walderveen MAA, Hamming JF, Schepers A
Objective: Doppler ultrasonography (DUS) is used as initial measurement to diagnose and classify carotid artery stenosis. Local distorting factors such as vascular calcification can influence the ability to obtain DUS measurements. The DUS derived maximal systolic acceleration (ACCmax) provides a different way to determine the degree of stenosis. While conventional DUS parameters are measured at the stenosis itself, ACCmax is measured distal to the internal carotid artery (ICA) stenosis. The val...
Abstract
