6196 results
Cited 4 times since 2018 (0.6 per year)
source: EuropePMC
Nature genetics,
Volume 50, Issue 5, 1 1 2018, Pages 766-767
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF, Masca NGD, Manning AK, Medina-Gomez C, Mudgal P, Ng MCY, Reiner AP, Vedantam S, Willems SM, Winkler TW, Abecasis G, Aben KK, Alam DS, Alharthi SE, Allison M, Amouyel P, Asselbergs FW, Auer PL, Balkau B, Bang LE, Barroso I, Bastarache L, Benn M, Bergmann S, Bielak LF, Blüher M, Boehnke M, Boeing H, Boerwinkle E, Böger CA, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Brumat M, Burt AA, Butterworth AS, Campbell PT, Cappellani S, Carey DJ, Catamo E, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Corominas Galbany J, Cox AJ, Crosslin DS, Cuellar-Partida G, D'Eustacchio A, Danesh J, Davies G, Bakker PIW, Groot MCH, Mutsert R, Deary IJ, Dedoussis G, Demerath EW, Heij
In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in the author list. In addition, the ORCID for Wei Zhao (Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA) was incorrectly assigned to author Wei Zhou. The errors have been corrected in the HTML and PDF versions of th...
Abstract
Cited 51 times since 2018 (7.3 per year)
source: EuropePMC
Circulation,
Volume 137, Issue 22, 1 1 2018, Pages 2393-2407
Energetics of Blood Flow in Cardiovascular Disease: Concept and Clinical Implications of Adverse Energetics in Patients With a Fontan Circulation.
Rijnberg FM, Hazekamp MG, Wentzel JJ, de Koning PJH, Westenberg JJM, Jongbloed MRM, Blom NA, Roest AAW
Visualization and quantification of the adverse effects of distorted blood flow are important emerging fields in cardiology. Abnormal blood flow patterns can be seen in various cardiovascular diseases and are associated with increased energy loss. These adverse energetics can be measured and quantified using 3-dimensional blood flow data, derived from computational fluid dynamics and 4-dimensional flow magnetic resonance imaging, and provide new, promising hemodynamic markers. In patients with p...
Abstract
Cited 31 times since 2018 (4.4 per year)
source: EuropePMC
Circulation. Genomic and precision medicine,
Volume 11, Issue 5, 1 1 2018, Pages e002034
CETP (Cholesteryl Ester Transfer Protein) Concentration: A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease.
Blauw LL, Li-Gao R, Noordam R, de Mutsert R, Trompet S, Berbée JFP, Wang Y, van Klinken JB, Christen T, van Heemst D, Mook-Kanamori DO, Rosendaal FR, Jukema JW, Rensen PCN, Willems van Dijk K
Background: We aimed to identify independent genetic determinants of circulating CETP (cholesteryl ester transfer protein) to assess causal effects of variation in CETP concentration on circulating lipid concentrations and cardiovascular disease risk. Methods: A genome-wide association discovery and replication study on serum CETP concentration were embedded in the NEO study (Netherlands Epidemiology of Obesity). Based on the independent identified variants, Mendelian randomization was conducted...
Abstract
Cited 4 times since 2018 (0.6 per year)
source: EuropePMC
Journal of pediatric orthopedics,
Volume 38, Issue 5, 1 1 2018, Pages 260-265
Prognostication in Developmental Dysplasia of the Hip Using the Ossific Nucleus Center Edge Angle.
Firth GB, Robertson AJF, Ramguthy Y, Ramachandran M, Schepers A
Background: The aim of this paper was to determine the prognostic potential of the ossific nucleus center edge angle (ONCEA) in patients below 5 years of age treated for developmental dysplasia of the hip (DDH) to predict final outcome and the need for a secondary procedure. Methods: The interobserver and intraobserver reliability was calculated using the intraclass correlation coefficient for measurement of the ONCEA. The ONCEA was divided a priori into 3 groups: group A≥10 degrees, group B -9...
Abstract
Cited 7 times since 2018 (1 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 26, Issue 5, 1 1 2018, Pages 783-789
Early and long-term outcomes of mitral valve repair for Barlow's disease: a single-centre 16-year experience.
Tomšic A, Hiemstra YL, van der Pas SL, Putter H, Versteegh MIM, van Brakel TJ, Ajmone Marsan N, Klautz RJM, Palmen M
Objectives: Following mitral valve repair for Barlow's disease, recurrent mitral regurgitation (MR) is believed to occur frequently and is mainly attributed to disease progression. Methods: Between January 2000 and December 2015, 180 patients (40% women, mean age 58.7 ± 13.5 years) with Barlow's disease underwent mitral valve repair. To provide a longitudinal assessment of mitral valve repair durability, a multistate model for interval-censored observations (4 states: 1, Grade 0/1+ MR;...
Abstract
Nature genetics,
Volume 50, Issue 5, 1 1 2018, Pages 765-766
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF, Masca NGD, Manning AK, Medina-Gomez C, Mudgal P, Ng MCY, Reiner AP, Vedantam S, Willems SM, Winkler TW, Abecasis G, Aben KK, Alam DS, Alharthi SE, Allison M, Amouyel P, Asselbergs FW, Auer PL, Balkau B, Bang LE, Barroso I, Bastarache L, Benn M, Bergmann S, Bielak LF, Blüher M, Boehnke M, Boeing H, Boerwinkle E, Böger CA, Bork-Jensen J, Bots ML, Bottinger EP, Bowden DW, Brandslund I, Breen G, Brilliant MH, Broer L, Brumat M, Burt AA, Butterworth AS, Campbell PT, Cappellani S, Carey DJ, Catamo E, Caulfield MJ, Chambers JC, Chasman DI, Chen YI, Chowdhury R, Christensen C, Chu AY, Cocca M, Collins FS, Cook JP, Corley J, Corominas Galbany J, Cox AJ, Crosslin DS, Cuellar-Partida G, D'Eustacchio A, Danesh J, Davies G, Bakker PIW, Groot MCH, Mutsert R, Deary IJ, Dedoussis G, Demerath EW, Heij
In the published version of this paper, the name of author Emanuele Di Angelantonio was misspelled. This error has now been corrected in the HTML and PDF versions of the article.
Abstract
Cited 24 times since 2018 (3.4 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 11, Issue 5, 1 1 2018, Pages 736-754
Imaging Needs in Novel Transcatheter Tricuspid Valve Interventions.
Prihadi EA, Delgado V, Hahn RT, Leipsic J, Min JK, Bax JJ
The advent of novel transcatheter therapies for severe tricuspid regurgitation (TR) has attracted much attention. Novel 3-dimensional imaging techniques have permitted analysis of the tricuspid valve (TV) anatomy from unparalleled views and better understanding of the underlying pathophysiology of TR. Grading TR and assessment of right ventricular function remain challenging, and although 2-dimensional echocardiography is the mainstay imaging technique to evaluate patients with severe TR the use...
Abstract
Cited 8 times since 2018 (1.1 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 19, Issue 5, 1 1 2018, Pages 516-523
Right ventricular outflow tract dimensions in arrhythmogenic right ventricular cardiomyopathy/dysplasia-a multicentre study comparing echocardiography and cardiovascular magnetic resonance.
Gotschy A, Saguner AM, Niemann M, Hamada S, Akdis D, Yoon JN, Parmon EV, Delgado V, Bax JJ, Kozerke S, Brunckhorst C, Duru F, Tanner FC, Manka R
Aims: Right ventricular outflow tract (RVOT) dilation is one of the echocardiographic criteria in the 2010 revised Task Force Criteria (TFC) of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). However, studies comparing cardiac magnetic resonance (CMR) and transthoracic echocardiography (TTE) suggest a lower diagnostic accuracy of TTE due to its operator dependence and limited reproducibility. The goal of this study was to compare the 2010 TFC measures of RVOT dilation with th...
Abstract
Cited 35 times since 2018 (5 per year)
source: EuropePMC
Scientific reports,
Volume 8, Issue 1, 30 5 2018, Pages 6753
Annexin A5 reduces infarct size and improves cardiac function after myocardial ischemia-reperfusion injury by suppression of the cardiac inflammatory response.
de Jong RCM, Pluijmert NJ, de Vries MR, Pettersson K, Atsma DE, Jukema JW, Quax PHA
Annexin A5 (AnxA5) is known to have anti-inflammatory and anti-apoptotic properties. Inflammation and apoptosis are key processes in post-ischemic cardiac remodeling. In this study, we investigated the effect of AnxA5 on left ventricular (LV) function and remodeling three weeks after myocardial ischemia-reperfusion (MI-R) injury in hypercholesterolemic ApoE*3-Leiden mice. Using a mouse model for MI-R injury, we demonstrate AnxA5 treatment resulted in a 27% reduction of contrast-enhanced MRI asse...
Abstract
Cited 71 times since 2018 (10.1 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 12, Issue 3, 30 5 2018, Pages 204-209
Maximization of the usage of coronary CTA derived plaque information using a machine learning based algorithm to improve risk stratification; insights from the CONFIRM registry.
van Rosendael AR, Maliakal G, Kolli KK, Beecy A, Al'Aref SJ, Dwivedi A, Singh G, Panday M, Kumar A, Ma X, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, Pontone G, Raff GL, Rubinshtein R, Shaw LJ, Villines TC, Gransar H, Lu Y, Jones EC, Peña JM, Lin FY, Min JK
Introduction: Machine learning (ML) is a field in computer science that demonstrated to effectively integrate clinical and imaging data for the creation of prognostic scores. The current study investigated whether a ML score, incorporating only the 16 segment coronary tree information derived from coronary computed tomography angiography (CCTA), provides enhanced risk stratification compared with current CCTA based risk scores. Methods: From the multi-center CONFIRM registry, patients were inclu...
Abstract
Cited 9 times since 2018 (1.3 per year)
source: EuropePMC
Clinical oral investigations,
Volume 22, Issue 5, 30 5 2018, Pages 2135-2140
Gingival crevicular fluid levels of human beta-defensin-1 in type 2 diabetes mellitus and periodontitis.
Yilmaz D, Caglayan F, Buber E, Könönen E, Aksoy Y, Gursoy UK, Guncu GN
Objectives: Human β-defensin (hBD)-1 is an important gatekeeper of the gingiva against constant bacterial challenge, and glucose levels are involved in its optimal expression. The aims of the study were to investigate hBD-1 levels in gingival crevicular fluid (GCF) and to compare these levels between type 2 diabetics with or without periodontitis and healthy individuals. Materials and methods: Altogether, 81 subjects were included in the study: 21 subjects with type 2 diabetes mellitus (T2DM) su...
Abstract
Cited 33 times since 2018 (4.7 per year)
source: EuropePMC
The Canadian journal of cardiology,
Volume 34, Issue 8, 25 4 2018, Pages 1069-1078
Prognostic Value of Right Ventricular Strain Using Speckle-Tracking Echocardiography in Pulmonary Hypertension: A Systematic Review and Meta-analysis.
Shukla M, Park JH, Thomas JD, Delgado V, Bax JJ, Kane GC, Howlett JG, White JA, Fine NM
Background: Right ventricular (RV) strain imaging using speckle-tracking echocardiography (STE) is a quantitative method of assessing RV systolic function that has shown prognostic utility in patients with pulmonary hypertension (PH). However, its prognostic value for a large and mixed PH population remains poorly defined. Methods: A systematic review and meta-analysis was performed using the MedLine, Embase, and Cochrane Library databases for publications reporting the prognostic value of RV st...
Abstract
Cited 5 times since 2018 (0.7 per year)
source: EuropePMC
The American journal of pathology,
Volume 188, Issue 7, 22 4 2018, Pages 1524-1529
Leukocyte Dynamics during the Evolution of Human Coronary Atherosclerosis: Conclusions from a Sevenfold, Chromogen-Based, Immunohistochemical Evaluation.
Zuiderwijk M, Geerts M, van Rhijn CJ, van den Bogaerdt A, Hamming JF, van Dijk RA, Lindeman JH
Atherosclerosis is a complex process with strong inflammatory component. We developed a straightforward sevenfold staining protocol for simultaneous assessment of dominant leukocyte classes, vascularization, and expression of the putative foam cell maker CD36. The method was applied on human coronaries covering the full spectrum of atherosclerotic disease. Results confirm the progressive association of macrophages and T cells with the process and a global presence of mast cells. B cells are excl...
Abstract
Cited 3 times since 2018 (0.4 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 26, Issue 5, 12 2 2018, Pages 1731-1733
Chronic total occlusion without collateral blood flow does not exclude myocardial viability and subsequent recovery after revascularization.
Bax JJ, Delgado V
Abstract
Cited 11 times since 2018 (1.6 per year)
source: EuropePMC
Journal of cellular biochemistry,
Volume 119, Issue 7, 10 2 2018, Pages 6146-6153
Cardiomyogenic differentiation of human adipose-derived mesenchymal stem cells transduced with Tbx20-encoding lentiviral vectors.
Neshati V, Mollazadeh S, Fazly Bazzaz BS, de Vries AA, Mojarrad M, Naderi-Meshkin H, Neshati Z, Kerachian MA
Ischemic heart disease often results in myocardial infarction and is the leading cause of mortality and morbidity worldwide. Improvement in the function of infarcted myocardium is a main purpose of cardiac regenerative medicine. One possible way to reach this goal is via stem cell therapy. Mesenchymal stem cells (MSCs) are multipotent stromal cells that can differentiate into a variety of cell types but display limited cardiomyogenic differentiation potential. Members of the T-box family of tran...
Abstract
Cited 14 times since 2018 (2 per year)
source: EuropePMC
European radiology,
Volume 28, Issue 9, 6 1 2018, Pages 4027-4035
High spatial resolution free-breathing 3D late gadolinium enhancement cardiac magnetic resonance imaging in ischaemic and non-ischaemic cardiomyopathy: quantitative assessment of scar mass and image quality.
Bizino MB, Tao Q, Amersfoort J, Siebelink HJ, van den Bogaard PJ, van der Geest RJ, Lamb HJ
Purpose: To compare breath-hold (BH) with navigated free-breathing (FB) 3D late gadolinium enhancement cardiac MRI (LGE-CMR) MATERIALS AND METHODS: Fifty-one patients were retrospectively included (34 ischaemic cardiomyopathy, 14 non-ischaemic cardiomyopathy, three discarded). BH and FB 3D phase sensitive inversion recovery sequences were performed at 3T. FB datasets were reformatted into normal resolution (FB-NR, 1.46x1.46x10mm) and high resolution (FB-HR, isotropic 0.91-mm voxels). Scar mass,...
Abstract
Cited 103 times since 2018 (14.5 per year)
source: EuropePMC
The Journal of clinical investigation,
Volume 128, Issue 5, 3 1 2018, Pages 1837-1851
Mycobacterial growth inhibition is associated with trained innate immunity.
Joosten SA, van Meijgaarden KE, Arend SM, Prins C, Oftung F, Korsvold GE, Kik SV, Arts RJ, van Crevel R, Netea MG, Ottenhoff TH
The lack of defined correlates of protection hampers development of vaccines against tuberculosis (TB). In vitro mycobacterial outgrowth assays are thought to better capture the complexity of the human host/Mycobacterium tuberculosis (Mtb) interaction. Here, we used a mycobacterial growth inhibition assay (MGIA) based on peripheral blood mononuclear cells to investigate the capacity to control outgrowth of bacille Calmette-Guérin (BCG). Interestingly, strong control of BCG outgrowth was observed...
Abstract
Cited 5 times since 2018 (0.7 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 12, Issue 3, 3 1 2018, Pages 212-219
Diagnostic accuracy of semi-automatic quantitative metrics as an alternative to expert reading of CT myocardial perfusion in the CORE320 study.
Ostovaneh MR, Vavere AL, Mehra VC, Kofoed KF, Matheson MB, Arbab-Zadeh A, Fujisawa Y, Schuijf JD, Rochitte CE, Scholte AJ, Kitagawa K, Dewey M, Cox C, DiCarli MF, George RT, Lima JAC
Aims: To determine the diagnostic accuracy of semi-automatic quantitative metrics compared to expert reading for interpretation of computed tomography perfusion (CTP) imaging. Methods: The CORE320 multicenter diagnostic accuracy clinical study enrolled patients between 45 and 85 years of age who were clinically referred for invasive coronary angiography (ICA). Computed tomography angiography (CTA), CTP, single photon emission computed tomography (SPECT), and ICA images were interpreted manually...
Abstract
Cited 15 times since 2018 (2.1 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 106, Issue 2, 3 1 2018, Pages 412-420
National Comparison of Hospital Performances in Lung Cancer Surgery: The Role of Case Mix Adjustment.
Beck N, Hoeijmakers F, van der Willik EM, Heineman DJ, Braun J, Tollenaar RAEM, Schreurs WH, Wouters MWJM
Background: When comparing hospitals on outcome indicators, proper adjustment for case mix (a combination of patient and disease characteristics) is indispensable. This study examines the need for case mix adjustment in evaluating hospital outcomes for non-small cell lung cancer surgery. Methods: Data from the Dutch Lung Cancer Audit for Surgery were used to validate factors associated with postoperative 30-day mortality and complicated course with multivariable logistic regression models. Betwe...
Abstract
Cited 4 times since 2018 (0.6 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 71, Issue 15, 1 1 2018, Pages 1661-1662
Machine Learning for Electrocardiographic Diagnosis of Left Ventricular Early Diastolic Dysfunction.
Bax JJ, van der Bijl P, Delgado V
Abstract
