8684 results
Cited 2 times since 2022 (0.8 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 31, Issue 5, 28 4 2022, Pages 177-180
Career perspectives for young cardiologists in the Netherlands: a steady increase in temporary positions.
Vorselaars VMM, Minneboo M, Meijers WC, van der Heijden AC, Haroun D, Baggen VJM, Berger WR, van Hout GPJ
In the Netherlands, concerns have been raised regarding the high unemployment rates and the lack of permanent positions for young medical specialists. In the current study, we present data on contemporary early career perspectives in the field of cardiology. We conducted a survey among 304 young cardiologists who completed their training between 2015 and 2020; the response rate was 91%. Our analysis revealed a low unemployment rate (0.3%). One, 3 and 5 years after registration, 81%, 41% and 18%...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
28 4 2022, Pages 1-4
Career perspectives for young cardiologists in the Netherlands: a steady increase in temporary positions.
Vorselaars VMM, Minneboo M, Meijers WC, van der Heijden AC, Haroun D, Baggen VJM, Berger WR, van Hout GPJ
In the Netherlands, concerns have been raised regarding the high unemployment rates and the lack of permanent positions for young medical specialists. In the current study, we present data on contemporary early career perspectives in the field of cardiology. We conducted a survey among 304 young cardiologists who completed their training between 2015 and 2020; the response rate was 91%. Our analysis revealed a low unemployment rate (0.3%). One, 3 and 5 years after registration, 81%, 41% and 18%...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Herz,
Volume 48, Issue 1, 28 4 2022, Pages 3-14
[The new ESC guidelines on the management of ventricular tachyarrhythmias : Implications for daily practice].
Könemann H, Frommeyer G, Zeppenfeld K, Eckardt L
The recently published guidelines of the European Society of Cardiology (ESC) on the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death is an update of the 2015 guideline. For the first time a new section is dedicated to public basic life support. In the acute treatment of ventricular arrhythmias electrical cardioversion is upgraded, and there is a new focus on the management of electrical storm. Recommendations for the comprehensive diagnostic evaluat...
Abstract
Cited 4 times since 2022 (1.6 per year)
source: EuropePMC
Biomedicines,
Volume 10, Issue 12, 28 4 2022, Pages 3056
NLRP3-Inflammasome Inhibition with IZD334 Does Not Reduce Cardiac Damage in a Pig Model of Myocardial Infarction.
Silvis MJM, Demkes EJ, Timmers L, Arslan F, de Jager SCA, Sluijter JPG, Mosterd A, de Kleijn DPV, Bosch L, van Hout GPJ
NLRP3-inflammasome-mediated signaling is thought to significantly contribute to the extent of myocardial damage after myocardial infarction (MI). The purpose of this study was to investigate the effects of the NLRP3-inflammasome inhibitor IZD334 on cardiac damage in a pig model of myocardial infarction. Prior to in vivo testing, in vitro, porcine peripheral blood mononuclear cells and whole blood were treated with increasing dosages of IZD334, a novel NLRP3-inflammasome inhibitor, and were stimu...
Abstract
Cited 10 times since 2022 (4 per year)
source: EuropePMC
Acta dermato-venereologica,
Volume 102, 24 4 2022, Pages adv00820
Daily Practice Experience of Baricitinib Treatment for Patients with Difficult-to-Treat Atopic Dermatitis: Results from the BioDay Registry.
Boesjes CM, Kamphuis E, Zuithoff NPA, Bakker DS, Loman L, Spekhorst LS, Haeck I, Kamsteeg M, Van Lynden-van Nes AMT, Garritsen FM, Politiek K, Oldhoff M, De Graaf M, Schuttelaar MLA, De Bruin-Weller MS
Clinical trials have shown that baricitinib, an oral selective Janus kinase 1/2 inhibitor, is effective for the treatment of moderate-to-severe atopic dermatitis. However, daily practice data are limited. Therefore, this multicentre prospective study evaluated the effectiveness and safety of 16-weeks' treatment with baricitinib in adult patients with moderate-to-severe atopic dermatitis in daily practice. A total of 51 patients from the BioDay registry treated with baricitinib were included...
Abstract
Cited 3 times since 2022 (1.2 per year)
source: EuropePMC
International journal of cardiology,
Volume 373, 23 4 2022, Pages 101-106
Incremental value of left ventricular global longitudinal strain in moderate aortic stenosis and reduced left ventricular ejection fraction.
Stassen J, Singh GK, Pio SM, Chimed S, Butcher SC, Hirasawa K, Marsan NA, Bax JJ
Background: Moderate aortic stenosis (AS) often coexists with left ventricular (LV) systolic dysfunction and may affect survival through afterload mismatch. Because outcomes are ultimately driven by the condition of the LV, accurate assessment of LV performance is crucial to improve risk stratification. This study investigated the prognostic value of LV global longitudinal strain (GLS) in patients with moderate AS and reduced LV systolic dysfunction. Methods: Patients with moderate AS (aortic va...
Abstract
Cited 10 times since 2022 (4 per year)
source: EuropePMC
European journal of heart failure,
Volume 25, Issue 2, 23 4 2022, Pages 213-222
Sequencing and titrating approach of therapy in heart failure with reduced ejection fraction following the 2021 European Society of Cardiology guidelines: an international cardiology survey.
Fauvel C, Bonnet G, Mullens W, Giraldo CIS, Mežnar AZ, Barasa A, Tokmakova M, Shchendrygina A, Costa FM, Mapelli M, Zemrak F, Tops LF, Jakus N, Sultan A, Bahouth F, Hadjseyd CE, Salvat M, Anselmino M, Messroghli D, Weberndörfer V, Giverts I, Bochaton T, Courand PY, Berthelot E, Legallois D, Beauvais F, Bauer F, Lamblin N, Damy T, Girerd N, Sebbag L, Pezel T, Cohen-Solal A, Rosano G, Roubille F, Mewton N
Aims: In symptomatic patients with heart failure and reduced ejection fraction (HFrEF), recent international guidelines recommend initiating four major therapeutic classes rather than sequential initiation. It remains unclear how this change in guidelines is perceived by practicing cardiologists versus heart failure (HF) specialists. Methods and results: An independent academic web-based survey was designed by a group of HF specialists and posted by email and through various social networks to a...
Abstract
Cited 31 times since 2022 (12.2 per year)
source: EuropePMC
Nature cancer,
Volume 3, Issue 11, 22 4 2022, Pages 1284-1299
cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis.
Wang L, Jin H, Jochems F, Wang S, Lieftink C, Martinez IM, De Conti G, Edwards F, de Oliveira RL, Schepers A, Zhou Y, Zheng J, Wu W, Zheng X, Yuan S, Ling J, Jastrzebski K, Santos Dias MD, Song JY, Celie PNH, Yagita H, Yao M, Zhou W, Beijersbergen RL, Qin W, Bernards R
Senolytics, drugs that kill senescent cells, have been proposed to improve the response to pro-senescence cancer therapies; however, this remains challenging due to a lack of broadly acting senolytic drugs. Using CRISPR/Cas9-based genetic screens in different senescent cancer cell models, we identify loss of the death receptor inhibitor cFLIP as a common vulnerability of senescent cancer cells. Senescent cells are primed for apoptotic death by NF-κB-mediated upregulation of death receptor 5 (DR5...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
European journal of trauma and emergency surgery : official publication of the European Trauma Society,
Volume 49, Issue 2, 22 4 2022, Pages 825-835
The effect of age on resilience of health-related quality of life among polytrauma patients: a cross-sectional multicenter study.
de Vries R, Reininga I, de Graaf M, Banierink H, Bosma E, Munzebrock A, Heineman E, Moumni ME, Wendt K
Purpose: The aim of this study was to determine the impact of age on patient-reported health-related quality of life (HRQoL) and the capacity to show resilience-i.e., the ability to adapt to stressful adverse events-after sustaining a polytrauma. Methods: A cross-sectional multicenter cohort was conducted between 2013 and 2016 that included surviving polytrauma patients (ISS ≥ 16). HRQoL was obtained by the Short Musculoskeletal Function assessment and EuroQol (SMFA and EQ-5D-5L). The effect of...
Abstract
Cited 9 times since 2022 (3.5 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 11, Issue 22, 19 3 2022, Pages 6843
Anemia and Iron Deficiency in Outpatients with Inflammatory Bowel Disease: Ubiquitous Yet Suboptimally Managed.
Loveikyte R, Boer M, van der Meulen CN, Ter Steege RWF, Tack G, Kuyvenhoven J, Jharap B, Vu MK, Vogelaar L, West RL, van der Marel S, Römkens TEH, Mujagic Z, Hoentjen F, van Bodegraven AA, van Schaik FDM, de Vries AC, Dijkstra G, van der Meulen-de Jong AE, Dutch Initiative on Crohn and Colitis (ICC)
Background: Iron deficiency (ID) and anemia in patients with Inflammatory Bowel Disease (IBD) are associated with a reduced quality of life. We assessed the prevalence of ID and anemia in Dutch outpatients with IBD and compared routine ID(A) management among medical professionals to the European Crohn’s and Colitis Organisation (ECCO) treatment guidelines. Methods: Between January and November 2021, consecutive adult outpatients with IBD were included in this study across 16 Dutch hospitals. Cli...
Abstract
Cited 7 times since 2022 (2.8 per year)
source: EuropePMC
Communications medicine,
Volume 2, Issue 1, 19 3 2022, Pages 146
The importance of sustained compliance with physical distancing during COVID-19 vaccination rollout.
Teslya A, Rozhnova G, Pham TM, van Wees DA, Nunner H, Godijk NG, Bootsma M, Kretzschmar ME
Background: Increasing vaccination coverage against SARS-CoV-2 enabled relaxation of lockdowns in many countries in Europe. As the vaccination rollouts progressed, the public health authorities were seeking recommendations on the continuation of physical distancing measures during ongoing vaccination rollouts. Compliance with these measures was declining while more transmissible virus variants have emerged. Methods: We used a SARS-CoV-2 transmission model to investigate the feedback between comp...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology,
Volume 63, 18 3 2022, Pages 107498
Can transforming growth factor beta and downstream signalers distinguish bicuspid aortic valve patients susceptible for future aortic complications?
Grewal N, Klautz R, Poelmann RE
Patients with a bicuspid aortic valve have an extreme high risk to develop a thoracic aortic aneurysm and dissection (TAAD). TAADs form a leading cause of death worldwide, with the majority of deaths being preventable if individuals at risk are identified and properly managed. Risk stratification for TAADs in bicuspidy is so far solely based on the aortic diameter. Exclusive use of aortic wall dimension, as in the current guidelines, is however not sufficient in selecting patients vulnerable for...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Clinical nutrition (Edinburgh, Scotland),
Volume 42, Issue 1, 17 3 2022, Pages 18-21
An omission in guidelines. Cardiovascular disease prevention should also focus on dietary policies for healthcare facilities.
de Frel DL, Assendelft WJJ, Hondmann S, Janssen VR, Molema JJW, Trines SA, de Vries IAC, Schalij MJ, Atsma DE
Suboptimal diet is a major modifiable risk factor in cardiovascular disease. Governments, individuals, educational institutes, healthcare facilities and the industry all share the responsibility to improve dietary habits. Healthcare facilities in particular present a unique opportunity to convey the importance of healthy nutrition to patients, visitors and staff. Guidelines on cardiovascular disease do include policy suggestions for population-based approaches to diet in a broad list of settings...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 101, Issue 1, 16 3 2022, Pages 97-101
Bail out lithotripsy to treat delayed valve-in-valve TAVR-related coronary obstruction.
Bingen BO, Al Amri I, Montero-Cabezas JM, van der Kley F
Coronary access difficulty and stent compression by the juxtaposed aortic valve leaflet hamper percutaneous management of delayed coronary artery obstruction (CAO) after valve-in-valve (Edwards Sapien 3 in St. Jude Trifecta) transcatheter aortic valve replacement (TAVR). Here, we present a case of delayed post-TAVR CAO treated with intravascular lithotripsy and multistenting to overcome stent compression by the adjacent calcified leaflet.
Abstract
Cited 3 times since 2022 (1.2 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 30, Issue 1, 15 3 2022, Pages 178-188
Incorporating coronary artery calcium scoring in the prediction of obstructive coronary artery disease with myocardial ischemia: a study with sequential use of coronary computed tomography angiography and positron emission tomography imaging.
van den Hoogen IJ, Wang X, Butcher SC, Maaniitty T, Schultz J, van Rosendael AR, Saraste A, Knuuti J, Bax JJ
Background: Additional strategies are needed to refine the referral for diagnostic testing of symptomatic patients with suspected coronary artery disease (CAD). We aimed to compare various models to predict hemodynamically obstructive CAD. Methods and results: Symptomatic patients with suspected CAD who underwent coronary artery calcium scoring (CACS) and sequential coronary computed tomography angiography (CCTA) and [15O]H2O positron emission tomography (PET) myocardial perfusion imaging were a...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
Cardio-oncology (London, England),
Volume 8, Issue 1, 15 3 2022, Pages 18
Case report: challenges in monitoring and treatment of anthracycline induced cardiotoxicity in young adults with osteosarcoma.
Heemelaar JC, Janson J, Braun J, Speetjens FM, van de Sande MAJ, Hugo JDV, Barge-Schaapveld DQCM, Beeres SLMA, Tops LF, Gelderblom H, Antoni ML
Neo(adjuvant) systemic treatment regimens containing anthracyclines such as doxorubicin cause a significant risk of heart failure. These regimens are one of the corner stones of osteosarcoma treatment, and therefore several guidelines are in place to steer cardiotoxicity monitoring through baseline risk stratification and cardiac surveillance during and after completion of cancer therapy.Importantly, baseline risk stratification modules are dependent on age, prior cardiovascular disease and card...
Abstract
Cited 4 times since 2022 (1.6 per year)
source: EuropePMC
International journal of cardiology,
Volume 370, 14 2 2022, Pages 442-444
Introduction to hemodynamic forces by echocardiography.
Laenens D, van der Bijl P, Stassen J, Rossi AC, Pedrizzetti G, Reiber JHC, Marsan NA, Bax JJ
Hemodynamic force (HDF) analysis represents a novel approach to quantify intraventricular pressure gradients, responsible for blood flow. A new mathematical model allows the derivation of HDF parameters from routine transthoracic echocardiography, making this tool more accessible for clinical use. HDF analysis is considered the fluid dynamics correlate of deformation imaging and may be even more sensitive to detect mechanical abnormalities. This has the potential to add incremental clinical valu...
Abstract
Cited 7 times since 2022 (2.7 per year)
source: EuropePMC
Cardiovascular diabetology,
Volume 21, Issue 1, 12 2 2022, Pages 239
Glycemic control is independently associated with rapid progression of coronary atherosclerosis in the absence of a baseline coronary plaque burden: a retrospective case-control study from the PARADIGM registry.
Won KB, Lee BK, Lin FY, Hadamitzky M, Kim YJ, Sung JM, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Chun EJ, Cademartiri F, Maffei E, Marques H, de Araújo Gonçalves P, Leipsic JA, Lee SE, Shin S, Choi JH, Virmani R, Samady H, Chinnaiyan K, Berman DS, Narula J, Shaw LJ, Bax JJ, Min JK, Chang HJ
Background: The baseline coronary plaque burden is the most important factor for rapid plaque progression (RPP) in the coronary artery. However, data on the independent predictors of RPP in the absence of a baseline coronary plaque burden are limited. Thus, this study aimed to investigate the predictors for RPP in patients without coronary plaques on baseline coronary computed tomography angiography (CCTA) images. Methods: A total of 402 patients (mean age: 57.6 ± 10.0 years, 49.3% men) without...
Abstract
Cited 13 times since 2022 (5.1 per year)
source: EuropePMC
Trials,
Volume 23, Issue 1, 12 2 2022, Pages 939
Efficacy of belimumab combined with rituximab in severe systemic lupus erythematosus: study protocol for the phase 3, multicenter, randomized, open-label Synbiose 2 trial.
van Schaik M, Arends EJ, Soonawala D, van Ommen E, de Leeuw K, Limper M, van Paassen P, Huizinga TWJ, Toes REM, van Kooten C, Rotmans JI, Rabelink TJ, Teng YKO
Background: Belimumab, an anti-B-cell activating factor antibody, is approved for the treatment of auto-antibody positive systemic lupus erythematosus with a high degree of disease activity. Anti-CD20 B cell depletion with rituximab is used in refractory SLE as well, although with variable responses. We hypothesized that incomplete B cell depletion, related to a surge in BAFF levels following rituximab treatment, can cause ongoing disease activity and flares. The Synbiose 1 study primarily focus...
Abstract
Cited 3 times since 2022 (1.2 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 210, 11 2 2022, Pages 105797
Longevity and the association with cattle health in Dutch dairy farms.
Bisschop PIH, Santman-Berends IMGA, Nijhoving GH, Muskens J, van Schaik G
Longevity of a herd is defined as the average age of all cattle over two years old at the moment of death (either natural, by euthanasia or by slaughter), and is increasing since 2018. The aim of this study was to evaluate the association between longevity and cattle health indicators in Dutch dairy herds. Anonymized census data were available for 16,200 Dutch dairy herds (∼98 % of the dairy herds) between 2016 and 2020. All herds were categorized into one of six longevity groups: herds with a h...
Abstract
