Publications
Below you can find a list of our published research.
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Below you can find a list of our published research.
7971 results
Cited 3 times since 2022 (0.9 per year) source: EuropePMC
Archives of physical medicine and rehabilitation, Volume 103, Issue 8, 6 1 2022, Pages 1582-1591 Reducing the Number of Test Items of the Action Research Arm Test Poststroke: A Decision Tree Analysis<sup>✰</sup>. Zonjee VJ, Selles RW, Roorda LD, Nijland RH, van der Oest MJW, Bosomworth HJ, van Wijck F, Meskers CGM, van Schaik SM, Van den Berg-Vos RM, Kwakkel G
Objective: The present study aimed to create a shorter version of the Action Research Arm Test (ARAT) without compromising its measurement properties. Design: Secondary analysis of stroke recovery cohorts that used the ARAT to measure upper limb impairment. Setting: Rehabilitation centers. Participants: Patients with stroke from 5 different stroke recovery cohorts (N=1425). Interventions: Not applicable. Main outcome measures: A decision tree version of the ARAT (ARAT-DT) was developed using chi... Abstract
Cited 11 times since 2022 (3.2 per year) source: EuropePMC
Frontiers in microbiology, Volume 12, 6 1 2022, Pages 765492 Temperature-Regulated IncX3 Plasmid Characteristics and the Role of Plasmid-Encoded H-NS in Thermoregulation. Baomo L, Lili S, Moran RA, van Schaik W, Chao Z
Carbapenem-resistant Enterobacteriaceae (CRE) are a critical public health problem worldwide. Globally, IncX3-type plasmids have emerged as the predominant vehicles carrying the metallo-β-lactamase gene bla NDM. Although bla NDM-bearing IncX3 plasmids have been found in various hosts from diverse environments, whether their transfer and persistence properties vary under different conditions and what factors influence any variation is unknown. By observing the effects of different temperatures on... Abstract
Cited 20 times since 2022 (5.9 per year) source: EuropePMC
Nature biomedical engineering, Volume 6, Issue 4, 6 1 2022, Pages 389-402 Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation. Harlaar N, Dekker SO, Zhang J, Snabel RR, Veldkamp MW, Verkerk AO, Fabres CC, Schwach V, Lerink LJS, Rivaud MR, Mulder AA, Corver WE, Goumans MJTH, Dobrev D, Klautz RJM, Schalij MJ, Veenstra GJC, Passier R, van Brakel TJ, Pijnappels DA, de Vries AAF
The lack of a scalable and robust source of well-differentiated human atrial myocytes constrains the development of in vitro models of atrial fibrillation (AF). Here we show that fully functional atrial myocytes can be generated and expanded one-quadrillion-fold via a conditional cell-immortalization method relying on lentiviral vectors and the doxycycline-controlled expression of a recombinant viral oncogene in human foetal atrial myocytes, and that the immortalized cells can be used to generat... Abstract
Cited 3 times since 2022 (0.9 per year) source: EuropePMC
Surgical endoscopy, Volume 36, Issue 8, 6 1 2022, Pages 6214-6222 Does livestreaming surgical education have the future? Development and participant evaluation of a national COVID-19 livestreaming initiative. Feenstra TM, van Felius LP, Vriens MR, Stassen LPS, van Acker GJD, van Dijkum EJMN, Schijven MP, Bonjer HJ, NVvH Livestream Collaborative Group
Backgrounds: COVID-19 related reduction of surgical procedures jeopardizes learning on the job of surgical residents. Many educators resorted to digital resources in the search for alternatives. However, these resources are often limited to the extent they offer resident-surgeon interaction like a joint surgical performance does. Here we present a roadmap of livestreaming surgical procedures, and evaluate how surgical livestreams on human cadavers address the unmet educational needs of surgical... Abstract
Cited 26 times since 2022 (7.7 per year) source: EuropePMC
European journal of cancer (Oxford, England : 1990), Volume 162, 5 1 2022, Pages 148-157 UGT1A1 genotype-guided dosing of irinotecan: A prospective safety and cost analysis in poor metaboliser patients. Hulshof EC, de With M, de Man FM, Creemers GJ, Deiman BALM, Swen JJ, Houterman S, Koolen SLW, Bins S, Thijs AMJ, Laven MMJ, Hövels AM, Luelmo SAC, Houtsma D, Shulman K, McLeod HL, van Schaik RHN, Guchelaar HJ, Mathijssen RHJ, Gelderblom H, Deenen MJ
Aim: To determine the safety, feasibility, pharmacokinetics, and cost of UGT1A1 genotype-guided dosing of irinotecan. Patients and methods: In this prospective, multicentre, non-randomised study, patients intended for treatment with irinotecan were pre-therapeutically genotyped for UGT1A1∗28 and UGT1A1∗93. Homozygous variant carriers (UGT1A1 poor metabolisers; PMs) received an initial 30% dose reduction. The primary endpoint was incidence of febrile neutropenia in the first two cycles of treatme... Abstract
Cited 8 times since 2022 (2.4 per year) source: EuropePMC
Frontiers in immunology, Volume 12, 3 1 2022, Pages 802877 Spatial and Temporal Heterogeneity of Tumor-Infiltrating Lymphocytes in Advanced Urothelial Cancer. van Wilpe S, Gorris MAJ, van der Woude LL, Sultan S, Koornstra RHT, van der Heijden AG, Gerritsen WR, Simons M, de Vries IJM, Mehra N
Checkpoint inhibitors targeting PD-(L)1 induce objective responses in 20% of patients with metastatic urothelial cancer (UC). CD8+ T cell infiltration has been proposed as a putative biomarker for response to checkpoint inhibitors. Nevertheless, data on spatial and temporal heterogeneity of tumor-infiltrating lymphocytes in advanced UC are lacking. The major aims of this study were to explore spatial heterogeneity for lymphocyte infiltration and to investigate how the immune landscape changes du... Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 30, Issue 2, 3 1 2022, Pages 76-83 No substantial excess all-cause mortality among cardiac implantable electronic device patients during the first COVID‑19 lockdown in the Leiden area. Feijen M, Egorova AD, van der Velde ET, Schalij MJ, Beeres SLMA
In the Netherlands, the coronavirus disease 2019 (COVID‑19) pandemic has resulted in excess mortality nationwide. Chronic heart disease patients are at risk for a complicated COVID‑19 course. The current study investigates all-cause mortality among cardiac implantable electronic device (CIED) patients during the first peak of the pandemic and compares the data to the statistics for the corresponding period in the two previous years. Data of adult CIED patients undergoing follow-up at the Leiden... Abstract
Cited 12 times since 2022 (3.5 per year) source: EuropePMC
The Journal of clinical endocrinology and metabolism, Volume 107, Issue 2, 1 1 2022, Pages 512-524 The Cortisol Response of Male and Female Choroidal Endothelial Cells: Implications for Central Serous Chorioretinopathy. Brinks J, van Dijk EHC, Kiełbasa SM, Mei H, van der Veen I, Peters HAB, Sips HCM, Notenboom RGE, Quax PHA, Boon CJF, Meijer OC
Context: Central serous chorioretinopathy (CSC) is a severe ocular disease characterized by fluid accumulation under the retina and abnormalities in the underlying vascular layer, the choroid. CSC has a striking prevalence in males of 80% to 90% of total patients. Corticosteroids are the most pronounced extrinsic risk factor for CSC. Choroidal endothelial cells (CECs) are important for the vascular integrity of the choroid, but the effects of corticosteroid effects in these cells are unknown. Ob... Abstract
Cited 16 times since 2022 (4.7 per year) source: EuropePMC
European heart journal. Cardiovascular Imaging, Volume 23, Issue 2, 1 1 2022, Pages e62-e84 Multimodality imaging approach to left ventricular dysfunction in diabetes: an expert consensus document from the European Association of Cardiovascular Imaging. Marwick TH, Gimelli A, Plein S, Bax JJ, Charron P, Delgado V, Donal E, Lancellotti P, Levelt E, Maurovich-Horvat P, Neubauer S, Pontone G, Saraste A, Cosyns B, Edvardsen T, Popescu BA, Galderisi M, Derumeaux G, Reviewers: This document was reviewed by members of the 2020–2022 EACVI Scientific Documents Committee, Bäck M, Bertrand PB, Dweck M, Keenan N, Magne J, Neglia D, Stankovic I
Heart failure (HF) is among the most important and frequent complications of diabetes mellitus (DM). The detection of subclinical dysfunction is a marker of HF risk and presents a potential target for reducing incident HF in DM. Left ventricular (LV) dysfunction secondary to DM is heterogeneous, with phenotypes including predominantly systolic, predominantly diastolic, and mixed dysfunction. Indeed, the pathogenesis of HF in this setting is heterogeneous. Effective management of this problem wil... Abstract
Tijdschrift voor psychiatrie, Volume 64, Issue 9, 1 1 2022, Pages 574-579 [Guided discontinuation of antidepressants: approach and first results of a Dutch multidisciplinary outpatient clinic]. Dozeman E, van der Lande HJ, Bet PM, Fransen K, Jager I, Jonker J, Philippo E, Reisman-Dolman J, van Schaik DJF, Scholten W, van de Velde I, Verheijen V, van der Wart M, van Zon M, Batelaan N, Vinkers CH
Background: Discontinuation of antidepressant medication can be difficult due to withdrawal symptoms and relapse risk. Scientific evidence on the questions of who, when, and how to stop antidepressants is limited. In Amsterdam a multidisciplinary outpatient clinic was started to provide advice and guidance. Aim: To substantiate the design of the clinic. Central questions relate to knowing which patients are referred, the background of their request, and their experiences with the outpatient clin... Abstract
Cited 2 times since 2022 (0.6 per year) source: EuropePMC
Methods in molecular biology (Clifton, N.J.), Volume 2478, 1 1 2022, Pages 701-723 Quantifying the Interaction Strength Between Biopolymers. Lorenz C, Schepers AV, Köster S
The cytoskeleton consists of three types of biopolymers-actin filaments, microtubules, and intermediate filaments-and the interplay between these components is essential for many cellular functions such as cell migration, mitosis, and the mechanical response to external cues. In the cell, the interactions between the filaments are mediated by a myriad of cross-linkers and motor proteins; however, direct forces, mediated by electrostatics or hydrophobicity, may also play an important role. Here,... Abstract
Cited 84 times since 2022 (24.6 per year) source: EuropePMC
Proceedings of the National Academy of Sciences of the United States of America, Volume 119, Issue 1, 1 1 2022, Pages e2110877119 <i>Coxiella burnetii</i> inhibits host immunity by a protein phosphatase adapted from glycolysis. Zhang Y, Fu J, Liu S, Wang L, Qiu J, van Schaik EJ, Samuel JE, Song L, Luo ZQ
Coxiella burnetii is a bacterial pathogen that replicates within host cells by establishing a membrane-bound niche called the Coxiella-containing vacuole. Biogenesis of this compartment requires effectors of its Dot/Icm type IV secretion system. A large cohort of such effectors has been identified, but the function of most of them remain elusive. Here, by a cell-based functional screening, we identified the effector Cbu0513 (designated as CinF) as an inhibitor of NF-κB signaling. CinF is highly... Abstract
Tijdschrift voor psychiatrie, Volume 64, Issue 2, 1 1 2022, Pages 108-111 [Plea for a work policy aiming autonomy and recovery in child and adolescent psychiatry]. van Schaik HJ, Pelzer ACM
When a child or adolescent is admitted to a High & Intensive Care (HIC) unit for adolescents, this implies that they find themselves in a severe psychiatric crisis. The work policy aiming autonomy and recovery is a vision that has been implemented in the treatment method at the HIC unit for adolescents. This policy focuses on the recovery of young people, in which learning to understand their own story and learning taking responsibility, are essential components. Sharing these experience... Abstract
Cited 11 times since 2022 (3.2 per year) source: EuropePMC
Gut microbes, Volume 14, Issue 1, 1 1 2022, Pages 2060676 <i>Enterobacteriaceae</i> and <i>Bacteroidaceae</i> provide resistance to travel-associated intestinal colonization by multi-drug resistant <i>Escherichia coli</i>. Davies M, Galazzo G, van Hattem JM, Arcilla MS, Melles DC, de Jong MD, Schultsz C, Wolffs P, McNally A, Schaik WV, Penders J
Previous studies have shown high acquisition risks of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) among international travelers visiting antimicrobial resistance (AMR) hotspots. Although antibiotic use and travelers' diarrhea have shown to influence the ESBL-E acquisition risk, it remains largely unknown whether successful colonization of ESBL-E during travel is associated with the composition, functional capacity and resilience of the traveler's microbiome.... Abstract
Cited 12 times since 2022 (3.5 per year) source: EuropePMC
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, Volume 23, Issue 1, 1 1 2022, Pages 54-59 Establishing Entrustable Professional Activities in Pediatric Cardiac Critical Care. Werho DK, DeWitt AG, Owens ST, McBride ME, van Schaik S, Roth SJ
Objectives: Define a set of entrustable professional activities for pediatric cardiac critical care that are recognized as the core activities of the subspecialty by a diverse group of pediatric cardiac critical care physicians and that can be broadly and consistently applied irrespective of training pathway. Design: Mixed methods study with sequential integration of qualitative and quantitative data. Setting: Structured telephone interviews of pediatric cardiac critical care medical directors a... Abstract
Cited 2 times since 2022 (0.6 per year) source: EuropePMC
Methods in molecular biology (Clifton, N.J.), Volume 2458, 1 1 2022, Pages 215-229 Genome-Wide Mapping and Microscopy Visualization of Protein-DNA Interactions by pA-DamID. van Schaik T, Manzo SG, van Steensel B
Several methods have been developed to map protein-DNA interactions genome-wide in the last decades. Protein A-DamID (pA-DamID) is a recent addition to this list with distinct advantages. pA-DamID relies on antibody-based targeting of the bacterial Dam enzyme, resulting in adenine methylation of DNA in contact with the protein of interest. This m6A can then be visualized by microscopy, or mapped genome-wide. The main advantages of pA-DamID are an easy and direct visualization of DNA that is in c... Abstract
Cited 1 times since 2022 (0.3 per year) source: EuropePMC
The Journal of the Acoustical Society of America, Volume 151, Issue 1, 1 1 2022, Pages 500 Noise-robust text-dependent speaker identification using cochlear models. Islam MA, Xu Y, Monk T, Afshar S, van Schaik A
One challenging issue in speaker identification (SID) is to achieve noise-robust performance. Humans can accurately identify speakers, even in noisy environments. We can leverage our knowledge of the function and anatomy of the human auditory pathway to design SID systems that achieve better noise-robust performance than conventional approaches. We propose a text-dependent SID system based on a real-time cochlear model called cascade of asymmetric resonators with fast-acting compression (CARFAC)... Abstract
Cited 2 times since 2022 (0.6 per year) source: EuropePMC
BJS open, Volume 6, Issue 1, 1 1 2022, Pages zrab150 Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery. STARSurg Collaborative and EuroSurg Collaborative
Background: Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods: The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 day... Abstract
Cited 6 times since 2022 (1.8 per year) source: EuropePMC
European heart journal. Cardiovascular pharmacotherapy, Volume 8, Issue 1, 1 1 2022, Pages 77-84 Medication in adults after atrial switch for transposition of the great arteries: clinical practice and recommendations. Woudstra OI, Kuijpers JM, Jongbloed MRM, van Dijk APJ, Sieswerda GT, Vliegen HW, Egorova AD, Kiès P, Duijnhouwer AL, Robbers-Visser D, Konings TC, Zwinderman AH, Meijboom FJ, Mulder BJM, Bouma BJ
Aims: Heart failure is the main threat to long-term health in adults with transposition of the great arteries (TGA) corrected by an atrial switch operation (AtrSO). Current guidelines refrain from recommending heart failure medication in TGA-AtrSO, as there is insufficient data to support the hypothesis that it is beneficial. Medication is therefore prescribed based on personal judgements. We aimed to evaluate medication use in TGA-AtrSO patients and examine the association of use of renin-angio... Abstract
Cited 2 times since 2022 (0.6 per year) source: EuropePMC
Pediatrics international : official journal of the Japan Pediatric Society, Volume 64, Issue 1, 1 1 2022, Pages e14858 Early application of non-invasive ventilation for children with pulmonary edema after drowning. Şık N, Şenol HB, Çağlar A, Yılmaz D, Duman M
Background: The present study aimed to assess the efficacy of non-invasive ventilation (NIV) on the clinical course, oxygenation, need for invasive mechanical ventilation (IMV), and outcomes for children with pulmonary edema after drowning. Methods: We conducted a retrospective chart review. Children who were referred to the pediatric emergency department due to drowning-related pulmonary edema and underwent NIV between May 2014 and October 2020 were included. Demographics, vital signs, clinical... Abstract