Publications
Below you can find a list of our published research.
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Below you can find a list of our published research.
7976 results
Cited 1 times since 2021 (0.2 per year) source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 29, Issue 4, 20 3 2021, Pages 1534-1536 Diastolic dyssynchrony by SPECT: A novel parameter to predict post-infarct adverse remodeling. van der Bijl P, Delgado V, Bax JJ
Cited 11 times since 2021 (2.5 per year) source: EuropePMC
Cancers, Volume 13, Issue 3, 20 3 2021, Pages 377 Long-Term Experience with Radiofrequency-Induced Hyperthermia Combined with Intravesical Chemotherapy for Non-Muscle Invasive Bladder Cancer. Brummelhuis ISG, Wimper Y, Witjes-van Os HGJM, Arends TJH, van der Heijden AG, Witjes JA
Background: The recurrence rate of non-muscle invasive bladder cancer (NMIBC) is high, despite intravesical treatments. Importantly, patients are frequently unfit or unwilling to undergo a recommended radical cystectomy when standard intravesical treatments fail, due to the substantial risk of morbidity and mortality. For these patients, radiofrequency-induced hyperthermia combined with intravesical chemotherapy (RF-CHT) has shown promising results. We aim to determine treatment outcomes and ass... Abstract
Cited 27 times since 2021 (6.2 per year) source: EuropePMC
Gastroenterology, Volume 160, Issue 6, 19 3 2021, Pages 1970-1985 Healthy Cotwins Share Gut Microbiome Signatures With Their Inflammatory Bowel Disease Twins and Unrelated Patients. Brand EC, Klaassen MAY, Gacesa R, Vich Vila A, Ghosh H, de Zoete MR, Boomsma DI, Hoentjen F, Horjus Talabur Horje CS, van de Meeberg PC, Willemsen G, Fu J, Wijmenga C, van Wijk F, Zhernakova A, Oldenburg B, Weersma RK, Dutch TWIN-IBD consortium and the Dutch Initiative on Crohn and Colitis
Background & aims: It is currently unclear whether reported changes in the gut microbiome are cause or consequence of inflammatory bowel disease (IBD). Therefore, we studied the gut microbiome of IBD-discordant and -concordant twin pairs, which offers the unique opportunity to assess individuals at increased risk of developing IBD, namely healthy cotwins from IBD-discordant twin pairs. Methods: Fecal samples were obtained from 99 twins (belonging to 51 twin pairs), 495 healthy age-, sex-, an... Abstract
Cited 20 times since 2021 (4.6 per year) source: EuropePMC
Circulation, Volume 143, Issue 3, 19 3 2021, Pages 209-211 Changing the Paradigm in the Management of Valvular Heart Disease: In Addition to Left Ventricular Ejection Fraction, Focus on the Myocardium. Fortuni F, Bax JJ, Delgado V
Cited 16 times since 2021 (3.7 per year) source: EuropePMC
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, Volume 32, Issue 4, 18 3 2021, Pages 720-726 Safety and effectiveness of omalizumab for the treatment of chronic urticaria in pediatric patients. Dekkers C, Alizadeh Aghdam M, de Graaf M, Knulst AC, Meijer Y, van den Reek JMPA, Stadermann MB, Röckmann H
Background: Evidence on safety and effectiveness of omalizumab for treatment of chronic urticaria in pediatric patients is scarce and limited to case reports. In particular, drug survival of omalizumab has not yet been investigated, which is a key element in the evaluation of its clinical performance. The aim of this study was to investigate safety, effectiveness, and drug survival rates of omalizumab in a daily practice cohort of pediatric patients with chronic urticaria (CU). Methods: This is... Abstract
Cited 41 times since 2021 (9.4 per year) source: EuropePMC
Atherosclerosis, Volume 319, 18 3 2021, Pages 51-61 New cardiovascular prevention guidelines: How to optimally manage dyslipidaemia and cardiovascular risk in 2021 in patients needing secondary prevention? Atar D, Jukema JW, Molemans B, Taub PR, Goto S, Mach F, CerezoOlmos C, Underberg J, Keech A, Tokgözoğlu L, Bonaca MP
Elevated low-density lipoprotein cholesterol (LDL-C) is a principally modifiable cause of atherosclerotic cardiovascular disease; accordingly, recent European and US multisociety dyslipidaemia guidelines emphasise the importance of lowering LDL-C to reduce cardiovascular risk. This review provides perspectives on established and emerging agents that reduce LDL-C to help providers synthesize the abundance of new evidence related to prevention of cardiovascular disease. We provide hypothetical cas... Abstract
Cited 9 times since 2021 (2.1 per year) source: EuropePMC
Zoonoses and public health, Volume 68, Issue 3, 17 3 2021, Pages 194-202 Antimicrobial resistance clusters in commensal Escherichia coli from livestock. Hesp A, Ter Braak C, van der Goot J, Veldman K, van Schaik G, Mevius D
To combat antimicrobial resistance (AMR), policymakers need an overview of evolution and trends of AMR in relevant animal reservoirs, and livestock is monitored by susceptibility testing of sentinel organisms such as commensal E. coli. Such monitoring data are often vast and complex and generates a need for outcome indicators that summarize AMR for multiple antimicrobial classes. Model-based clustering is a data-driven approach that can help to objectively summarize AMR in animal reservoirs. In... Abstract
Cited 2 times since 2021 (0.5 per year) source: EuropePMC
Journal of environmental management, Volume 282, 16 3 2021, Pages 111916 Mathematically formulated key performance indicators for design and evaluation of treatment trains for resource recovery from urban wastewater. van Schaik MO, Sucu S, Cappon HJ, Chen WS, Martinson DB, Ouelhadj D, Rijnaarts HHM
While urban wastewater infrastructure is aging and no longer adequate, climate change and sustainability are urging the transition from pollution management to resource recovery. Lacking evidence-based quantitative evaluation of the potential benefits and consequences of resource recovery from wastewater hinders the negotiation amongst stakeholders and slows down the transition. This study proposes mathematical formulations for technical, environmental, economic, and social key performance indic... Abstract
Cited 7 times since 2021 (1.6 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 7, 15 3 2021, Pages 604821 P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3<sup>*</sup>Leiden Mice via Systemic Inhibition of Regulatory T Cells. de Jong A, de Jong RCM, Peters EA, Arens R, Jukema JW, de Vries MR, Quax PHA
Background: Inflammatory stimuli induced by NF-kB drive atherosclerotic lesion formation. The epigenetic P300/CBP associated factor (PCAF) post-transcriptionally acetylates FoxP3, which is required for regulatory T-cell (Treg) differentiation and immune modulation. We hypothesize that PCAF deficiency affects atherosclerosis via regulation of regulatory Tregs. Method: ApoE3*Leiden (n = 13) and ApoE3*LeidenxPCAF-/- (n = 13) were fed a high-fat diet (HFD) containing 1.25% cholesterol. Systemic FoxP... Abstract
Cited 33 times since 2021 (7.5 per year) source: EuropePMC
Heart (British Cardiac Society), Volume 107, Issue 21, 15 3 2021, Pages 1725-1730 Sacubitril/valsartan in the treatment of systemic right ventricular failure. Zandstra TE, Nederend M, Jongbloed MRM, Kiès P, Vliegen HW, Bouma BJ, Tops LF, Schalij MJ, Egorova AD
Objective: Pharmacological options for patients with a failing systemic right ventricle (RV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are not well defined. This study aims to investigate the feasibility and effects of sacubitril/valsartan treatment in a single-centre cohort of patients. Methods: Data on all consecutive adult patients (n=20, mean age 46 years, 50% women) with a failing systemic RV in a biventricular circ... Abstract
Cited 78 times since 2021 (17.8 per year) source: EuropePMC
Genome biology, Volume 22, Issue 1, 14 2 2021, Pages 36 SPIN reveals genome-wide landscape of nuclear compartmentalization. Wang Y, Zhang Y, Zhang R, van Schaik T, Zhang L, Sasaki T, Peric-Hupkes D, Chen Y, Gilbert DM, van Steensel B, Belmont AS, Ma J
We report SPIN, an integrative computational method to reveal genome-wide intranuclear chromosome positioning and nuclear compartmentalization relative to multiple nuclear structures, which are pivotal for modulating genome function. As a proof-of-principle, we use SPIN to integrate nuclear compartment mapping (TSA-seq and DamID) and chromatin interaction data (Hi-C) from K562 cells to identify 10 spatial compartmentalization states genome-wide relative to nuclear speckles, lamina, and putative... Abstract
Cited 16 times since 2021 (3.6 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 14, Issue 7, 13 2 2021, Pages 1410-1421 Topological Data Analysis of Coronary Plaques Demonstrates the Natural History of Coronary Atherosclerosis. Hwang D, Kim HJ, Lee SP, Lim S, Koo BK, Kim YJ, Kook W, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Conte E, Marques H, de Araújo Gonçalves P, Gottlieb I, Hadamitzky M, Leipsic JA, Maffei E, Pontone G, Raff GL, Shin S, Lee BK, Chun EJ, Sung JM, Lee SE, Berman DS, Lin FY, Virmani R, Samady H, Stone PH, Narula J, Bax JJ, Shaw LJ, Min JK, Chang HJ
Objectives: This study sought to identify distinct patient groups and their association with outcome based on the patient similarity network using quantitative coronary plaque characteristics from coronary computed tomography angiography (CTA). Background: Coronary CTA can noninvasively assess coronary plaques quantitatively. Methods: Patients who underwent 2 coronary CTAs at a minimum of 24 months' interval were analyzed (n = 1,264). A similarity Mapper network of patients was built by top... Abstract
Cited 4 times since 2021 (0.9 per year) source: EuropePMC
International journal of molecular sciences, Volume 22, Issue 2, 13 2 2021, Pages E755 Cell-Based Tracers as Trojan Horses for Image-Guided Surgery. Sier VQ, de Vries MR, van der Vorst JR, Vahrmeijer AL, van Kooten C, Cruz LJ, de Geus-Oei LF, Ferreira V, Sier CFM, Alves F, Muthana M
Surgeons rely almost completely on their own vision and palpation to recognize affected tissues during surgery. Consequently, they are often unable to distinguish between different cells and tissue types. This makes accurate and complete resection cumbersome. Targeted image-guided surgery (IGS) provides a solution by enabling real-time tissue recognition. Most current targeting agents (tracers) consist of antibodies or peptides equipped with a radiolabel for Positron Emission Tomography (PET) an... Abstract
Cited 4 times since 2021 (0.9 per year) source: EuropePMC
Journal of virology, Volume 95, Issue 3, 13 2 2021, Pages e01492-20 Human Noroviruses Attach to Intestinal Tissues of a Broad Range of Animal Species. Villabruna N, Schapendonk CME, Aron GI, Koopmans MPG, de Graaf M
Human noroviruses are the most common nonbacterial cause of gastroenteritis outbreaks, with new variants and genotypes frequently emerging. The origin of these new viruses is unknown; however, animals have been proposed as a potential source, as human noroviruses have been detected in animal species. Here, we investigated the potential of animals to serve as a reservoir of human noroviruses by testing norovirus attachment to formalin-fixed intestinal tissues of a range of potential reservoir ani... Abstract
Cited 43 times since 2021 (9.8 per year) source: EuropePMC
Circulation, Volume 143, Issue 11, 13 2 2021, Pages 1109-1122 Clinical Efficacy and Safety of Alirocumab After Acute Coronary Syndrome According to Achieved Level of Low-Density Lipoprotein Cholesterol: A Propensity Score-Matched Analysis of the ODYSSEY OUTCOMES Trial. Schwartz GG, Gabriel Steg P, Bhatt DL, Bittner VA, Diaz R, Goodman SG, Jukema JW, Kim YU, Li QH, Manvelian G, Pordy R, Sourdille T, White HD, Szarek M, ODYSSEY OUTCOMES Committees and Investigators
Background: Recent international guidelines have lowered recommended target levels of low-density lipoprotein cholesterol (LDL-C) for patients at very high risk for major adverse cardiovascular events (MACE). However, uncertainty persists whether additional benefit results from achieved LDL-C levels below the conventional targets. Inferences from previous analyses are limited because patients who achieve lower versus higher LDL-C on lipid-lowering therapy differ in other characteristics prognost... Abstract
Cited 12 times since 2021 (2.7 per year) source: EuropePMC
Scientific reports, Volume 11, Issue 1, 12 2 2021, Pages 825 Higher social tolerance in wild versus captive common marmosets: the role of interdependence. de Oliveira Terceiro FE, Arruda MF, van Schaik CP, Araújo A, Burkart JM
Social tolerance in a group reflects the balance between within-group competition and interdependence: whereas increased competition leads to a reduction in social tolerance, increased interdependence increases it. Captivity reduces both feeding competition and interdependence and can therefore affect social tolerance. In independently breeding primates, social tolerance has been shown to be higher in captivity, indicating a strong effect of food abundance. It is not known, however, how social t... Abstract
Cited 2 times since 2021 (0.5 per year) source: EuropePMC
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, Volume 27, Issue 4, 12 2 2021, Pages 939-953 Clinical controversies in the treatment of cancer-associated venous thromboembolism. Nachar VR, Schepers AJ
Cancer-associated venous thromboembolism (VTE) is a common complication of malignancy. Patients with cancer exhibit risk factors for both recurrent VTE and major or minor bleeding. Direct oral anticoagulants (DOACs) are an attractive treatment option; however, there is a lack of consensus among national guidelines for choice between DOACs and LMWH, agent selection, dosing strategy, and duration of anticoagulation. Characteristics of the thrombotic event, the malignancy, the patient, and the anti... Abstract
The Journal of thoracic and cardiovascular surgery, Volume 161, Issue 5, 12 2 2021, Pages e371-e372 A bigger picture for valve charts. Vriesendorp MD, de Lind van Wijngaarden RAF, Klautz RJM
Cited 77 times since 2021 (17.5 per year) source: EuropePMC
Biomedicines, Volume 9, Issue 1, 9 2 2021, Pages 57 Endothelial Dysfunction in Pulmonary Hypertension: Cause or Consequence? Kurakula K, Smolders VFED, Tura-Ceide O, Jukema JW, Quax PHA, Goumans MJ
Pulmonary arterial hypertension (PAH) is a rare, complex, and progressive disease that is characterized by the abnormal remodeling of the pulmonary arteries that leads to right ventricular failure and death. Although our understanding of the causes for abnormal vascular remodeling in PAH is limited, accumulating evidence indicates that endothelial cell (EC) dysfunction is one of the first triggers initiating this process. EC dysfunction leads to the activation of several cellular signalling path... Abstract
Cited 6 times since 2021 (1.4 per year) source: EuropePMC
Scientific reports, Volume 11, Issue 1, 8 2 2021, Pages 113 Stimulatory, but not anxiogenic, doses of caffeine act centrally to activate interscapular brown adipose tissue thermogenesis in anesthetized male rats. Van Schaik L, Kettle C, Green R, Sievers W, Hale MW, Irving HR, Whelan DR, Rathner JA
The role of central orexin in the sympathetic control of interscapular brown adipose tissue (iBAT) thermogenesis has been established in rodents. Stimulatory doses of caffeine activate orexin positive neurons in the lateral hypothalamus, a region of the brain implicated in stimulating BAT thermogenesis. This study tests the hypothesis that central administration of caffeine is sufficient to activate BAT. Low doses of caffeine administered either systemically (intravenous [IV]; 10 mg/kg) and cent... Abstract