7971 results
Drug metabolism and personalized therapy,
13 2 2020
The need of the clinical implementation of pharmacogenetics in European health services for routine drug prescription. What's next? An urgent clinical unmet need for patients.
Taron M, Llerena A, Manolopoulos VG, Rodriguez-Antona C, Stankovic S, van Schaik RHN
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
Drug metabolism and personalized therapy,
Volume 35, Issue 4, 13 2 2020
The need of the clinical implementation of pharmacogenetics in European health services for routine drug prescription. What's next? An urgent clinical unmet need for patients.
Taron M, Llerena A, Manolopoulos VG, Rodriguez-Antona C, Stankovic S, van Schaik RHN
Abstract
Cited 157 times since 2020 (34.5 per year)
source: EuropePMC
Nature reviews. Cardiology,
Volume 18, Issue 4, 13 2 2020, Pages 291-304
Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging.
Ng ACT, Delgado V, Borlaug BA, Bax JJ
Diabesity is a term used to describe the combined adverse health effects of obesity and diabetes mellitus. The worldwide dual epidemic of obesity and type 2 diabetes is an important public health issue. Projections estimate a sixfold increase in the number of adults with obesity in 40 years and an increase in the number of individuals with diabetes to 642 million by 2040. Increased adiposity is the strongest risk factor for developing diabetes. Early detection of the effects of diabesity on the...
Abstract
Cited 3 times since 2020 (0.7 per year)
source: EuropePMC
Pacing and clinical electrophysiology : PACE,
Volume 44, Issue 1, 12 2 2020, Pages 120-128
Mechanical extraction of cardiac implantable electronic devices leads with long dwell time: Efficacy and safety of the step up approach.
Lensvelt LMH, Egorova AD, Schalij MJ, Yilmaz D, Kennergren C, Bootsma M, van Erven L
The aim of this study was to evaluate the efficacy and safety of the stepwise mechanical transvenous lead extraction approach in a patient population with chronically implanted transvenous leads with a long dwell time. From January 2014 till December 2018, all lead extractions with lead dwell time ≥5 years performed at our tertiary centre were retrospectively analysed. A total of 173 leads, from 78 patients (median age 68 years; 81% male) with a median dwell time of 9 years (interquartile range...
Abstract
Cited 10 times since 2020 (2.2 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 164, Issue 3, 12 2 2020, Pages 822-829.e6
Why the categorization of indexed effective orifice area is not justified for the classification of prosthesis-patient mismatch.
Vriesendorp MD, Deeb GM, Reardon MJ, Kiaii B, Bapat V, Labrousse L, Rao V, Sabik JF, Gearhart E, Klautz RJM
Objectives: Although the impact of prosthesis-patient mismatch (PPM) on survival has been widely studied, there has been little debate about whether the current definition of PPM truly reflects hemodynamic obstruction. This study aimed to validate the categorization of indexed effective orifice area (EOAi) for the classification of PPM. Methods: In total, 2171 patients who underwent aortic valve replacement with a surgical stented bioprosthesis in 5 trials (CoreValve US High-Risk, SURTAVI [Surgi...
Abstract
Cited 9 times since 2020 (2 per year)
source: EuropePMC
Scientific reports,
Volume 10, Issue 1, 11 2 2020, Pages 19596
Increased Ca<sup>2+</sup> content of the sarcoplasmic reticulum provides arrhythmogenic trigger source in swimming-induced rat athlete's heart model.
Gazdag P, Oravecz K, Acsai K, Demeter-Haludka V, Ördög B, Szlovák J, Kohajda Z, Polyák A, Barta BA, Oláh A, Radovits T, Merkely B, Papp JG, Baczkó I, Varró A, Nagy N, Prorok J
Sudden cardiac death among top athletes is very rare, however, it is 2-4 times more frequent than in the age-matched control population. In the present study, the electrophysiological consequences of long-term exercise training were investigated on Ca2+ homeostasis and ventricular repolarization, together with the underlying alterations of ion channel expression, in a rat athlete's heart model. 12-week swimming exercise-trained and control Wistar rats were used. Electrophysiological data we...
Abstract
Trends in cardiovascular medicine,
Volume 31, Issue 8, 11 2 2020, Pages 495-496
Editorial commentary: Future of transcatheter mitral valve interventions for secondary mitral regurgitation.
Vo NM, Bax JJ, Delgado V
Abstract
Cited 8 times since 2020 (1.8 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 48, Issue 5, 11 2 2020, Pages 1434-1444
Global and segmental absolute stress myocardial blood flow in prediction of cardiac events: [<sup>15</sup>O] water positron emission tomography study.
Harjulahti E, Maaniitty T, Nammas W, Stenström I, Biancari F, Bax JJ, Knuuti J, Saraste A
Purpose: We evaluated the value of reduced global and segmental absolute stress myocardial blood flow (sMBF) quantified by [15O] water positron emission tomography (PET) for predicting cardiac events in patients with suspected obstructive coronary artery disease (CAD). Methods: Global and segmental sMBF during adenosine stress were retrospectively quantified in 530 symptomatic patients who underwent [15O] water PET for evaluation of coronary stenosis detected by coronary computed tomography angi...
Abstract
Cited 27 times since 2020 (5.9 per year)
source: EuropePMC
Cell reports. Medicine,
Volume 1, Issue 9, 10 2 2020, Pages 100146
Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons.
Rother N, Yanginlar C, Lindeboom RGH, Bekkering S, van Leent MMT, Buijsers B, Jonkman I, de Graaf M, Baltissen M, Lamers LA, Riksen NP, Fayad ZA, Mulder WJM, Hilbrands LB, Joosten LAB, Netea MG, Vermeulen M, van der Vlag J, Duivenvoorden R
Hydroxychloroquine is being investigated for a potential prophylactic effect in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but its mechanism of action is poorly understood. Circulating leukocytes from the blood of coronavirus disease 2019 (COVID-19) patients show increased responses to Toll-like receptor ligands, suggestive of trained immunity. By analyzing interferon responses of peripheral blood mononuclear cells from healthy donors conditioned with heat-killed Can...
Abstract
Cited 5 times since 2020 (1.1 per year)
source: EuropePMC
Scientific reports,
Volume 10, Issue 1, 9 2 2020, Pages 19312
From remote sensing and machine learning to the history of the Silk Road: large scale material identification on wall paintings.
Kogou S, Shahtahmassebi G, Lucian A, Liang H, Shui B, Zhang W, Su B, van Schaik S
Automatic remote reflectance spectral imaging of large painted areas in high resolution, from distances of tens of meters, has made the imaging of entire architectural interior feasible. However, it has significantly increased the volume of data. Here we present a machine learning based method to automatically detect 'hidden' writings and map material variations. Clustering of reflectance spectra allowed materials at inaccessible heights to be properly identified by performing non-inva...
Abstract
Cited 20 times since 2020 (4.4 per year)
source: Scopus
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 34, Issue 3, 9 2 2020, Pages 257-266
Left Ventricular Myocardial Work in Patients with Severe Aortic Stenosis.
Fortuni F, Butcher SC, van der Kley F, Lustosa RP, Karalis I, de Weger A, Priori SG, van der Bijl P, Bax JJ, Delgado V, Ajmone Marsan N
Background: Left ventricular myocardial work (LVMW) is a novel method to assess left ventricular (LV) function using pressure-strain loops that takes into consideration LV afterload. The estimation of LV afterload in patients with severe aortic stenosis (AS) may be challenging, and no study so far has investigated LVMW in this setting. The aim of this study was to develop a method to calculate LVMW in patients with severe AS and to analyze its relationship with heart failure symptoms. Methods: I...
Abstract
Cited 105 times since 2020 (23.1 per year)
source: EuropePMC
Journal of cardiovascular computed tomography,
Volume 15, Issue 2, 9 2 2020, Pages 93-109
Society of Cardiovascular Computed Tomography / North American Society of Cardiovascular Imaging - Expert Consensus Document on Coronary CT Imaging of Atherosclerotic Plaque.
Shaw LJ, Blankstein R, Bax JJ, Ferencik M, Bittencourt MS, Min JK, Berman DS, Leipsic J, Villines TC, Dey D, Al'Aref S, Williams MC, Lin F, Baskaran L, Litt H, Litmanovich D, Cury R, Gianni U, van den Hoogen I, R van Rosendael A, Budoff M, Chang HJ, E Hecht H, Feuchtner G, Ahmadi A, Ghoshajra BB, Newby D, Chandrashekhar YS, Narula J
Coronary computed tomographic angiography (CCTA) provides a wealth of clinically meaningful information beyond anatomic stenosis alone, including the presence or absence of nonobstructive atherosclerosis and high-risk plaque features as precursors for incident coronary events. There is, however, no uniform agreement on how to identify and quantify these features or their use in evidence-based clinical decision-making. This statement from the Society of Cardiovascular Computed Tomography and Nort...
Abstract
Cited 14 times since 2020 (3.1 per year)
source: EuropePMC
Scientific reports,
Volume 10, Issue 1, 5 1 2020, Pages 19111
An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms.
Wildisen L, Del Giovane C, Moutzouri E, Beglinger S, Syrogiannouli L, Collet TH, Cappola AR, Åsvold BO, Bakker SJL, Yeap BB, Almeida OP, Ceresini G, Dullaart RPF, Ferrucci L, Grabe H, Jukema JW, Nauck M, Trompet S, Völzke H, Westendorp R, Gussekloo J, Klöppel S, Aujesky D, Bauer D, Peeters R, Feller M, Rodondi N
In subclinical hypothyroidism, the presence of depressive symptoms is often a reason for starting levothyroxine treatment. However, data are conflicting on the association between subclinical thyroid dysfunction and depressive symptoms. We aimed to examine the association between subclinical thyroid dysfunction and depressive symptoms in all prospective cohorts with relevant data available. We performed a systematic review of the literature from Medline, Embase, Cumulative Index to Nursing and A...
Abstract
Cited 6 times since 2020 (1.3 per year)
source: EuropePMC
Cells,
Volume 9, Issue 11, 4 1 2020, Pages E2412
Cardiac and Vascular α<sub>1</sub>-Adrenoceptors in Congestive Heart Failure: A Systematic Review.
Kaykı-Mutlu G, Papazisi O, Palmen M, Danser AHJ, Michel MC, Arioglu-Inan E
As heart failure (HF) is a devastating health problem worldwide, a better understanding and the development of more effective therapeutic approaches are required. HF is characterized by sympathetic system activation which stimulates α- and β-adrenoceptors (ARs). The exposure of the cardiovascular system to the increased locally released and circulating levels of catecholamines leads to a well-described downregulation and desensitization of β-ARs. However, information on the role of α-AR is limit...
Abstract
Journal of critical care,
Volume 63, 4 1 2020, Pages 282
Corrigendum to Pharmacogenomic response of low dose haloperidol in critically ill adults with delirium journal of critical care 57 (2020) 203-207.
Zoran Trogrlić, van der Jagt M, Osse RJ, Devlin JW, Nieboer D, Koch BCP, van Schaik RHN, Hunfeld NGM
Abstract
Cited 11 times since 2020 (2.4 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 9, Issue 22, 4 1 2020, Pages e016391
Periprocedural Hydrogen Sulfide Therapy Improves Vascular Remodeling and Attenuates Vein Graft Disease.
Kip P, Tao M, Trocha KM, MacArthur MR, Peters HAB, Mitchell SJ, Mann CG, Sluiter TJ, Jung J, Patterson S, Quax PHA, de Vries MR, Mitchell JR, Keith Ozaki C
Background Failure rates after revascularization surgery remain high, both in vein grafts (VG) and arterial interventions. One promising approach to improve outcomes is endogenous upregulation of the gaseous transmitter-molecule hydrogen sulfide, via short-term dietary restriction. However, strict patient compliance stands as a potential translational barrier in the vascular surgery patient population. Here we present a new therapeutic approach, via a locally applicable gel containing the hydrog...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 28, Issue 12, 3 1 2020, Pages 625-627
Dutch cardiology residents and the COVID-19 pandemic: Every little thing counts in a crisis.
Berger WR, Baggen V, Vorselaars VMM, van der Heijden AC, van Hout GPJ, Kapel GFL, Woudstra P, Junior Board (Juniorkamer) of the Netherlands Society of Cardiology (NVVC)
The COVID-19 pandemic has overwhelmed healthcare systems worldwide, and a large part of regular cardiology care came to a quick halt. A Dutch nationwide survey showed that 41% of cardiology residents suspended their training and worked at COVID-19 cohort units for up to 3 months. With tremendous flexibility, on-call schedules were altered and additional training was provided in order for residents to be directly available where needed most. These unprecedented times have taught them important le...
Abstract
Cited 12 times since 2020 (2.6 per year)
source: EuropePMC
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Volume 71, Issue 8, 1 1 2020, Pages 1847-1855
Dynamics of Intestinal Carriage of Extended-Spectrum Beta-lactamase-Producing Enterobacteriaceae in the Dutch General Population, 2014-2016.
van den Bunt G, Fluit AC, Bootsma MCJ, van Duijkeren E, Scharringa J, van Pelt W, Bonten MJM
Background: In the Netherlands, the prevalence of intestinal extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) carriage in community-dwelling subjects is ~5%. Little is known about the dynamics of ESBL-E carriage. Methods: In a nationwide, population-based study (2014-2016) with 4177 community-dwelling subjects, fecal samples from 656 subjects were collected after 1 (time point [T] = 1) and 6 (T = 2) months. The growth of ESBL-E was quantified and a whole-genome sequence ana...
Abstract
Cited 7 times since 2020 (1.5 per year)
source: EuropePMC
American journal of respiratory cell and molecular biology,
Volume 63, Issue 5, 1 1 2020, Pages 710-713
Decreased Glycolysis as Metabolic Fingerprint of Endothelial Cells in Chronic Thromboembolic Pulmonary Hypertension.
Smolders VFED, Rodríguez C, Morén C, Blanco I, Osorio J, Piccari L, Bonjoch C, Quax PHA, Peinado VI, Castellà M, Barberà JA, Cascante M, Tura-Ceide O
Abstract
Cited 14 times since 2020 (3.1 per year)
source: EuropePMC
Journal of orthopaedic trauma,
Volume 34 Suppl 3, 1 1 2020, Pages S15-S21
Factors Associated With Mortality After Surgical Management of Femoral Neck Fractures.
Bzovsky S, Comeau-Gauthier M, Schemitsch EH, Swiontkowski M, Heels-Ansdell D, Frihagen F, Bhandari M, Sprague S, FAITH Investigators, HEALTH Investigators
Background: Hip fractures are recognized as one of the most devastating injuries impacting older adults because of the complications that follow. Mortality rates postsurgery can range from 14% to 58% within one year of fracture. We aimed to identify factors associated with increased risk of mortality within 24 months of a femoral neck fracture in patients aged ≥50 years enrolled in the FAITH and HEALTH trials. Methods: Two multivariable Cox proportional hazards regressions were used to investiga...
Abstract
