8759 results
Rheumatology advances in practice,
Volume 9, Issue 1, 20 3 2025, Pages rkaf010
Anti-citrullinated protein antibody detection by hemagglutination.
Kruis I, Kumari J, van der Heijden A, Weijn A, Vree Egberts W, Peeters IR, van Herwaarden N, Salden M, Pruijn GJM
Objectives: ACPAs play an important role in the classification of RA and can be detected by serological tests. Several ACPA detection assays are available for clinical use, which are all based on ELISA(-like) tests with citrullinated peptides (CCP2) or alternative citrullinated proteins/peptides. We aimed to facilitate ACPA detection in low-volume laboratories and resource-poor environments by developing a rapid and easy-to-perform test. Methods: We designed and generated an agglutination mediat...
Abstract
Respiratory research,
Volume 26, Issue 1, 18 3 2025, Pages 20
Radiation decreases bronchial epithelial progenitor function as assessed by organoid formation.
Kuipers ME, Ninaber DK, van Doorn-Wink KCJ, Slats AM, Hiemstra PS
Objective: Radiation-induced lung injury (RILI) is a serious side-effect of radiotherapy for lung cancer, in which effects on the normal lung epithelium may play a key role. Since these effects are incompletely understood, the aim of the present study was to evaluate the effect of ionizing radiation (IR) on cultured well-differentiated primary bronchial epithelial cells (PBEC) with a focus on cytotoxicity, barrier formation, inflammation and epithelial progenitor function. Materials and methods:...
Abstract
Cited 2 times since 2025 (3.3 per year)
source: EuropePMC
Scientific reports,
Volume 15, Issue 1, 16 3 2025, Pages 2180
Iron metabolism in a mouse model of hepatocellular carcinoma.
Yilmaz D, Tharehalli U, Paganoni R, Knoop P, Gruber A, Chen Y, Dong R, Leithäuser F, Seufferlein T, Leopold K, Lechel A, Vujić Spasić M
Hepatocellular carcinoma (HCC) remains the most prevalent type of primary liver cancer worldwide. p53 is one of the most frequently mutated tumor-suppressor genes in HCC and its deficiency in hepatocytes triggers tumor formation in mice. To investigate iron metabolism during liver carcinogenesis, we employed a model of chronic carbon tetrachloride injections in liver-specific p53-deficient mice to induce liver fibrosis, cirrhosis and subsequent carcinogenesis. A transcriptome analysis of liver c...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
Journal of translational medicine,
Volume 23, Issue 1, 15 3 2025, Pages 73
Development of autonomic innervation at the venous pole of the heart: bridging the gap from mice to human.
Zwanenburg F, Bos TA, Ten Harkel ADJ, Haak MC, Hahurij ND, Poelmann RE, van Munsteren CJ, Wisse LJ, Blom NA, DeRuiter MC, Jongbloed MRM
Background: Prenatal development of autonomic innervation of sinus venosus-related structures might be related to atrial arrhythmias later in life. Most of the pioneering studies providing embryological background are conducted in animal models. To date, a detailed comparison with the human cardiac autonomic nervous system (cANS) is lacking. The aim of this study was to compare the morphological and functional development of the cANS between mouse and human, specifically aimed at the venous pole...
Abstract
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 105, Issue 4, 13 2 2025, Pages 951-958
Angiographic Characterization and Sex-Related Anatomical Differences of Atrial Coronary Arteries Anatomy-A Proposal of Systematic Classification.
Marques-Antunes M, van Oort MJH, Oliveri F, Al Amri I, Bingen BO, Cruz-Ferreira R, Wouter Jukema J, Montero-Cabezas JM
Background: The coronary atrial circulation is the network of vessels that supply blood to the atria, originating from the left circumflex and right coronary arteries. Current descriptions of this arterial system are based on anatomical studies with a limited number of patients, predominantly male. In addition, there is a lack of consensus its angiographic nomenclature. Aims: This study aimed to evaluate the anatomical variations of coronary atrial branches (CAB) and investigate sex-related diff...
Abstract
Heart rhythm,
13 2 2025, Pages S1547-5271(25)00022-0
Application of artificial intelligence to analyze data from randomized controlled trials: An example from DECAAF II.
Mekhael M, Feng H, Akoum N, Sohns C, Sommer P, Mahnkopf C, Kholmovski E, Bax JJ, Sanders P, McGann C, Marchlinski F, Mansour M, Hindricks G, Wilber D, Calkins H, Jais P, Younes H, Assaf A, Noujaim C, Lim C, Huang C, Pandey A, Wazni O, Marrouche N
Background: Causal machine learning (ML) provides an efficient way of identifying heterogeneous treatment effect groups from hundreds of possible combinations, especially for randomized trial data. Objective: The aim of this paper is to illustrate the potential of applying causal ML on the DECAAF II trial data. We proposed a causal ML model to predict the treatment response heterogeneity. Methods: We applied causal tree learning to the DECAAF II trial data as an example of real applications, ide...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
Cellular and molecular biology (Noisy-le-Grand, France),
Volume 70, Issue 12, 12 2 2025, Pages 52-58
Inhibition of RIPK1-driven necroptosis ameliorates inflammatory hyperalgesia caused by lipopolysaccharide: involvement of TLR-, NLRP3-, and caspase-11-mediated signaling pathways.
Kurt S, Senol SP, Yilmaz DE, Bahceli O, Ozgen B, Sabrie Z, Ahmed-Reda Elosman M, Tunctan B
Increasing evidence suggests that inhibition of receptor-interacting serine/threonine-protein kinase (RIPK) 1/RIPK3/mixed lineage kinase domain-like pseudokinase (MLKL) necrosome has protective effects in vivo models of painful conditions seen in humans associated with inflammation and demyelination in the central nervous system. However, the contribution of RIPK1-driven necroptosis to inflammatory pain remains unknown. Therefore, this study aims to determine the effect of necrostatin (Nec) -1s,...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
The American journal of cardiology,
Volume 241, 11 2 2025, Pages 61-68
Arrhythmogenic Right Ventricular Cardiomyopathy: The Importance of Biventricular Strain in Risk-Stratification.
Chua AP, Laenens D, Sarrazyn C, Lopez-Santi MP, Nabeta T, Myagmardorj R, Bootsma M, Barge-Schaapveld DQCM, Bax JJ, Marsan NA
Despite arrhythmogenic right ventricular cardiomyopathy (ARVC) being predominantly a right ventricular (RV) disease, concomitant left ventricular (LV) involvement has been recognized. ARVC is diagnosed by the RV-centric 2010 Task Force Criteria(TFC) using routine echocardiography, but previous studies have suggested that strain imaging may be more sensitive to detect RV and LV dysfunction. No data however are available regarding the additional value of combining biventricular strain for risk str...
Abstract
Cited 3 times since 2025 (4.8 per year)
source: EuropePMC
Nature communications,
Volume 16, Issue 1, 10 2 2025, Pages 576
Small-molecule-induced ERBB4 activation to treat heart failure.
Cools JMT, Goovaerts BK, Feyen E, Van den Bogaert S, Fu Y, Civati C, Van Fraeyenhove J, Tubeeckx MRL, Ott J, Nguyen L, Wülfers EM, Van Berlo B, De Vries AAF, Vandersickel N, Pijnappels DA, Audenaert D, Roderick HL, De Winter H, De Keulenaer GW, Segers VFM
Heart failure is a common and deadly disease requiring new treatments. The neuregulin-1/ERBB4 pathway offers cardioprotective benefits, but using recombinant neuregulin-1 as therapy has limitations due to the need for intravenous delivery and lack of receptor specificity. We hypothesize that small-molecule activation of ERBB4 could protect against heart damage and fibrosis. To test this, we conduct a screening of 10,240 compounds and identify eight structurally similar ones (EF-1 to EF-8) that i...
Abstract
Cited 2 times since 2025 (3.2 per year)
source: EuropePMC
Breast (Edinburgh, Scotland),
Volume 79, 9 2 2025, Pages 103880
Implementation of model-informed precision dosing for tamoxifen therapy in patients with breast cancer: A prospective intervention study.
van Nijnatten RYM, Buijs SM, Agema BC, Fischer RMJ, Moghaddam-Helmantel IG, Contant CME, de Jongh FE, Huijben AMT, Kop M, van der Padt-Pruijsten A, Zuetenhorst HJM, van Schaik RHN, Koch BCP, Jager A, Koolen SLW, Mathijssen RHJ
Tamoxifen is an estrogen-receptor (ER) antagonist, used as adjuvant treatment of ER-positive breast cancer. It is converted by CYP2D6 into endoxifen, its most active metabolite. Patients with endoxifen plasma concentrations
Abstract
American heart journal,
Volume 282, 9 2 2025, Pages 134-145
Increased prevalence of coronary atherosclerosis in cancer survivors: A retrospective matched cross-sectional study with coronary CT angiography.
Polomski EAS, Heemelaar JC, de Ronde MES, Al Jaff AAM, Mertens BJA, van Dijkman PRM, Jukema JW, Antoni ML
Background: Cancer and cancer treatment may accelerate the development of cardiovascular disease. With the improved prognosis of cancer survivors, cardiovascular events are increasing in this patient group. However, it is unknown whether the prevalence of coronary atherosclerosis is increased in patients with a history of cancer. This study aims to evaluate the prevalence and severity of coronary atherosclerosis in different age groups of cancer survivors compared to matched controls. Methods: C...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
BMC medical education,
Volume 25, Issue 1, 9 2 2025, Pages 40
Applying principles of adult learning to rural health electives in a medical school curriculum.
Van Schaik L, Develyn T, Kelly K, Yazdabadi A, Scarff C, Harvey W, Wright J
The health disparities between rural and urban populations in Australia, driven by socioeconomic, environmental, and healthcare access factors, highlight the urgent need for rural-focused medical education. The Melbourne Medical School's Rural Health Discovery program addresses this need by integrating adult learning principles within a redesigned curriculum that includes the Rural Health Foundations and Integrating Rural Health topics. These Discovery topics engage medical students from di...
Abstract
Pharmacological research,
Volume 212, 9 2 2025, Pages 107575
GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study.
Magavern EF, Deshmukh H, Asselin G, Theusch E, Trompet S, Li X, Noordam R, Chen YI, Seeman TE, Taylor KD, Post WS, Tardif JC, Paul DS, Benjamin EJ, Heard-Costa NL, Vasan RS, Rotter JI, Krauss RM, Jukema JW, Ridker PM, Munroe PB, Caulfield MJ, Chasman DI, Dubé MP, Hitman GA, Warren HR, Genomic Investigation of Statin Therapy Consortium (GIST)
Statins are first-line treatments in the primary and secondary prevention of cardiovascular disease. Clinical studies show statins act independently of lipid-lowering mechanisms to decrease C-reactive protein (CRP), an inflammation marker. We aim to elucidate genetic loci associated with CRP statin response. CRP statin response is the change in log-CRP between off-treatment and on-treatment measurements. Cohort-level Genome-Wide Association Studies (GWAS) of CRP response were performed using 100...
Abstract
JACC. Advances,
Volume 4, Issue 2, 8 2 2025, Pages 101535
Genetic Predisposition to Coronary Artery Disease: Evaluating Statin Therapy in Elder Populations From PROSPER.
Choi SH, Young R, Koyama S, Jukema JW, Trompet S, Ford I, Natarajan P, Peloso GM
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
Langenbeck's archives of surgery,
Volume 410, Issue 1, 8 2 2025, Pages 28
Establishing reference curves for vital tissue perfusion using quantitative near-infrared fluorescence imaging with indocyanine green.
Tange FP, Peul RC, van den Hoven P, Koning S, Kruiswijk MW, Faber RA, Verduijn PS, van Rijswijk CSP, Galema HA, Hilling DE, van Dijk SPJ, van Ginhoven TM, Keereweer S, Mureau MAM, Feitsma EA, Noltes ME, Kruijff S, Driessen C, Achiam MP, Schepers A, van Schaik J, Mieog JSD, Vahrmeijer AL, Hamming JF, van der Vorst JR
Purpose: Assessment of tissue perfusion using near-infrared fluorescence (NIR) with indocyanine green (ICG) is gaining popularity, however reliable and objective interpretation remains a challenge. Therefore, this study aimed to establish reference curves for vital tissue perfusion across target tissues using this imaging modality. Methods: Data from five prospective study cohorts conducted in three Dutch academic medical centres between December 2018 and June 2023 was included. Quantitative ana...
Abstract
PloS one,
Volume 20, Issue 1, 8 2 2025, Pages e0313916
Decreased risk-proneness with increasing age in equally raised and kept wolves and dogs.
Jean-Joseph H, Kortekaas K, Range F, Kotrschal K
A basic mechanism of domestication is the selection for fearlessness and acceptance of humans as social partners, which may affect risk-taking behavior and the ability to use humans as social support, both at the behavioural and physiological levels. We combined behavioural observations with heart rate parameters (i.e., HR and heart rate variability, HRV) in equally raised and housed wolves and dogs to assess the responses to food offered in the vicinity of a potential stressor (an unknown spinn...
Abstract
Cited 2 times since 2025 (3.1 per year)
source: EuropePMC
BMJ open,
Volume 15, Issue 1, 6 1 2025, Pages e095392
FAecal micRobiota transplantation in primary sclerosinG chOlangitis (FARGO): study protocol for a randomised, multicentre, phase IIa, placebo-controlled trial.
Al-Shakhshir S, Quraishi MN, Mullish B, Patel A, Vince A, Rowe A, Homer V, Jackson N, Gyimah D, Shabir S, Manzoor S, Cooney R, Alrubaiy L, Quince C, van Schaik W, Hares M, Beggs AD, Efstathiou E, Rimmer P, Weston C, Iqbal T, Trivedi PJ
Introduction: Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD). The strong association between gut and liver inflammation has driven several pathogenic hypotheses to which the intestinal microbiome is proposed to contribute. Pilot studies of faecal microbiota transplantation (FMT) in PSC and IBD are demonstrated to be safe and associated with increased gut bacterial diversity. However, the longevity of such changes and the impa...
Abstract
Pediatric cardiology,
6 1 2025
Printed Models for Better Prediction of Surgery in Patients with Double Outlet Right Ventricle.
Hoogerbeets SF, Roest AAW, Valverde I, Gomez-Ciriza G, Kroft L, Hazekamp MG
The complex and variable anatomy of complex double outlet right ventricle makes it imperative to understand the spatial anatomic structures to determine whether it is feasible to repair the anomaly in a biventricular or univentricular fashion. Biventricular repair should be aimed for but is not always feasible. Choosing the correct surgical technique is of great importance in surgical planning of biventricular repair. Conventional imaging is typically insufficient to predict feasibility and tech...
Abstract
Cited 1 times since 2025 (1.6 per year)
source: EuropePMC
International journal of cardiology. Heart & vasculature,
Volume 56, 3 1 2025, Pages 101595
Epicardial fat tissue, a hidden enemy against the early recovery of left ventricular systolic function after transcatheter aortic valve implantation.
Anwar HS, Lopez Santi P, Algowhary M, Abdelmegid MAF, Helmy HA, Jukema JW, Ajmone Marsan N, Van Der Kley F
Background: Epicardial fat tissue (EFT) is an active organ that can affect cardiac function and structure through endocrine, paracrine, and proinflammatory mechanisms. We hypothesized that greater thickness of EFT may harm the recovery of left ventricular (LV) systolic function in patients with severe aortic stenosis (AS) and reduced LV ejection fraction (EF ≤ 50 %) undergoing transcatheter aortic valve implantation (TAVI). Methods: A sixty six patients with severe AS and 20 % ≥ LVEF ≤ 50 % who...
Abstract
The Lancet regional health. Europe,
Volume 50, 3 1 2025, Pages 101197
Dynamic association of antimicrobial resistance in urinary isolates of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> between primary care and hospital settings in the Netherlands (2008-2020): a population-based study.
Martínez EP, Verbon A, Schoffelen AF, Altorf-van der Kuil W, van Rosmalen J, ISIS-AR study group
Background: It is unclear whether changes in antimicrobial resistance (AMR) in primary care influence AMR in hospital settings. Therefore, we investigated the dynamic association of AMR between primary care and hospitals. Methods: We studied resistance percentages of Escherichia coli and Klebsiella pneumoniae isolates to co-amoxiclav, ciprofloxacin, fosfomycin, nitrofurantoin and trimethoprim submitted by primary care, hospital outpatient and hospital inpatient settings to the Dutch National AMR...
Abstract
