6128 results
Cited 125 times since 2010 (8.2 per year)
source: EuropePMC
European heart journal,
Volume 31, Issue 15, 4 1 2010, Pages 1908-1915
Diagnostic accuracy of 320-row multidetector computed tomography coronary angiography in the non-invasive evaluation of significant coronary artery disease.
de Graaf FR, Schuijf JD, van Velzen JE, Kroft LJ, de Roos A, Reiber JH, Boersma E, Schalij MJ, Spanó F, Jukema JW, van der Wall EE, Bax JJ
Aims: Multidetector computed tomography coronary angiography (CTA) has emerged as a feasible imaging modality for non-invasive assessment of coronary artery disease (CAD). Recently, 320-row CTA systems were introduced, with 16 cm anatomical coverage, allowing image acquisition of the entire heart within a single heart beat. The aim of the present study was to assess the diagnostic accuracy of 320-row CTA in patients with known or suspected CAD. Methods and results: A total of 64 patients (34 mal...
Abstract
Cited 1274 times since 2010 (84 per year)
source: EuropePMC
Stem cell research,
Volume 4, Issue 3, 4 1 2010, Pages 214-222
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.
Lai RC, Arslan F, Lee MM, Sze NS, Choo A, Chen TS, Salto-Tellez M, Timmers L, Lee CN, El Oakley RM, Pasterkamp G, de Kleijn DP, Lim SK
Human ESC-derived mesenchymal stem cell (MSC)-conditioned medium (CM) was previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury through large complexes of 50-100 nm. Here we show that these MSCs secreted 50- to 100-nm particles. These particles could be visualized by electron microscopy and were shown to be phospholipid vesicles consisting of cholesterol, sphingomyelin, and phosphatidylcholine. They contained coimmunoprecipitating exosome-associated proteins,...
Abstract
Cited 28 times since 2010 (1.8 per year)
source: EuropePMC
Journal of lipid research,
Volume 51, Issue 1, 1 1 2010, Pages 202-209
Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial.
Matthan NR, Resteghini N, Robertson M, Ford I, Shepherd J, Packard C, Buckley BM, Jukema JW, Lichtenstein AH, Schaefer EJ, PROSPER Group
Cholesterol homeostasis, defined as the balance between absorption and synthesis, influences circulating cholesterol concentrations and subsequent coronary heart disease (CHD) risk. Statin therapy targets the rate-limiting enzyme in cholesterol biosynthesis and is efficacious in lowering CHD events and mortality. Nonetheless, CHD events still occur in some treated patients. To address differences in outcome during pravastatin therapy (40 mg/day), plasma markers of cholesterol synthesis (desmoste...
Abstract
Cited 19 times since 2010 (1.3 per year)
source: EuropePMC
Disability and rehabilitation,
Volume 32, Issue 2, 1 1 2010, Pages 142-147
Psychological intervention targets for people with visual impairments: the importance of cognitive coping and goal adjustment.
Garnefski N, Kraaij V, De Graaf M, Karels L
Purpose: This study represents, to our knowledge, the first examination of the joint influence of cognitive coping strategies and goal-related coping on depressive symptoms in people with severe visual impairments with the aim of finding targets for intervention. Method: In total, data of 67 individuals with visual impairments were assembled by telephone interviews. Depressive symptomatology, cognitive coping strategies, and goal-related coping processes were measured. Relationships between thes...
Abstract
The American journal of the medical sciences,
Volume 339, Issue 1, 1 1 2010, Pages 89-91
Do not put money where your mouth is!
de Groot NM, Scholte AJ, Jongbloed MR, Schuijf JD, DeRuiter MC, Bax JJ, Schalij MJ
A 60-year-old woman presented with repolarization disorders on the electrocardiogram after a generalized seizure, which immediately disappeared after vomiting up a 20-eurocent coin. We did not find any evidence of coronary artery disease. Multislice computed tomography demonstrated no coronary atherosclerotic stenosis but a close relationship of the esophagus with the coronary arteries. This relation was further studied in detail in a human cadaver. From our findings, it is most likely that the...
Abstract
Cited 2 times since 2010 (0.1 per year)
source: EuropePMC
Disease markers,
Volume 29, Issue 5, 1 1 2010, Pages 265-273
Matrix metalloproteinases 2 and 3 gene polymorphisms and the risk of target vessel revascularization after percutaneous coronary intervention: Is there still room for determining genetic variation of MMPs for assessment of an increased risk of restenosis?
Verschuren JJ, Sampietro ML, Pons D, Trompet S, Ewing MM, Quax PH, de Knijff P, Zwinderman AH, de Winter RJ, Tio RA, de Maat MP, Doevendans PA, Jukema JW
Objective: Mixed results have been reported of matrix metalloproteinases (MMP) and their association with restenosis after percutaneous coronary intervention (PCI). The current study examines whether multiple single nucleotide polymorphisms (SNPs), covering the full genomic region of MMP2 and MMP3, were associated with restenosis in the GENDER study population. Methods and results: The GENetic DEterminants of Restenosis (GENDER) study enrolled 3104 consecutive patients after successful PCI. The...
Abstract
Cited 25 times since 2010 (1.6 per year)
source: EuropePMC
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology,
Volume 18, Issue 1, 1 1 2010, Pages 63-77
Why are we where we are? Understanding replication origins and initiation sites in eukaryotes using ChIP-approaches.
Schepers A, Papior P
DNA replication initiates from origins of replication following a strict sequential activation programme and a conserved temporal order of activation. The number of replication initiation sites varies between species, according to the complexity of the genomes, with an average spacing of 100,000 bp. In contrast to yeast genomes, the location and definition of origins in mammalian genomes has been elusive. Historically, mammalian replication initiation sites have been mapped in situ by systematic...
Abstract
Cited 48 times since 2010 (3.2 per year)
source: EuropePMC
American heart journal,
Volume 159, Issue 1, 1 1 2010, Pages 148-157
Incremental value of subclinical left ventricular systolic dysfunction for the identification of patients with obstructive coronary artery disease.
Nucifora G, Schuijf JD, Delgado V, Bertini M, Scholte AJ, Ng AC, van Werkhoven JM, Jukema JW, Holman ER, van der Wall EE, Bax JJ
Background: Left ventricular (LV) diastolic dysfunction and subclinical systolic dysfunction may be markers of coronary artery disease (CAD). However, whether these markers are useful for prediction of obstructive CAD is unknown. Methods: A total of 182 consecutive outpatients (54 +/- 10 years, 59% males) without known CAD and overt LV systolic dysfunction underwent 64-slice multislice computed tomography (MSCT) coronary angiography and echocardiography. The MSCT angiograms showing atheroscleros...
Abstract
Cited 9 times since 2010 (0.6 per year)
source: EuropePMC
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,
Volume 26, Issue 6, 1 1 2010, Pages 999-1010
Integrin stimulation favors uptake of macromolecules by cardiomyocytes in vitro.
Swildens J, de Vries AA, Li Z, Umar S, Atsma DE, Schalij MJ, van der Laarse A
Previously, our research group showed that integrin stimulation induces release of cardiac troponin I from viable neonatal rat ventricular cardiomyocytes (NRCMs), but would it also stimulate uptake of exogenous macromolecules? For this purpose, beating NRCMs were incubated without or with an RGD motif-containing peptide (GRGDS) to stimulate integrins in the presence of Texas Red-conjugated ovalbumin (OTR; 45 kDa) or dextran (DTR; 70 kDa). After incubation periods of 8, 16 and 24 hours endocytosi...
Abstract
Journal of the American College of Cardiology,
Volume 55, Issue 4, 1 1 2010, Pages 380-407
Highlights of the Year in JACC 2009.
DeMaria AN, Bax JJ, Ben-Yehuda O, Feld GK, Greenberg BH, Hall J, Hlatky M, Lew WY, Lima JA, Maisel AS, Narayan SM, Nissen S, Sahn DJ, Tsimikas S
Abstract
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 17, Issue 1, 1 1 2010, Pages 97-105
Highlights of the 2009 Scientific Session of the American Society of Nuclear Cardiology: Minneapolis, Minnesota, October 1-4, 2009.
Russell RR, Abbott BG, Arrighi JA, Blankstein R, Cohen MC, Faber TL, Mieres JH, Miller TD, Tilkemeier PL, Travin MI, Bax JJ
Abstract
Cited 3 times since 2010 (0.2 per year)
source: EuropePMC
Asian Pacific journal of cancer prevention : APJCP,
Volume 11, Issue 1, 1 1 2010, Pages 53-56
Relations between breast and cervical cancer prevention behaviour of female students at a school of health and their healthy life style.
Malak AT, Yilmaz D, Tuna A, Gümüs AB, Turgay AS
Regular breast self-examination (BSE) and pap-smear tests are the two of the positive heath behaviors for improving, promoting and protecting the health of adolescent girls. The present quasi-experimental research was carried out with the purpose of analyzing the relations between breast and cervical cancer prevention behavior of female students at a School of Health and their health lifestyle. The research was conducted at Canakkale Onsekiz Mart University School of Health between November 2008...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 154, 1 1 2010, Pages A1578
[Trainee feedback: trainer assessment].
Hamming JF, de Leede BJ
The quality of medical specialty education depends highly on the trainers, i.e. the specialists. Trainees are very important in the assessment of their trainers because they continuously undergo all the important aspects of the training. Currently, periodical announced visits take place, creating a formal atmosphere. A regular, semi-structured questionnaire for the trainees would be a better way of evaluating the program. Additionally there should be a thorough follow-up leading to a system with...
Abstract
Cited 1 times since 2010 (0.1 per year)
source: EuropePMC
Innovations (Philadelphia, Pa.),
Volume 5, Issue 1, 1 1 2010, Pages 16-21
Resizable ventricular patch plasty in the porcine left ventricle: a pilot study.
Huijgen WH, Gründeman PF, van der Spoel T, Cramer MJ, Steendijk P, Klautz RJ, van Herwerden LA
Objective: : Endoventricular circular patch plasty is a method used to reconstruct the ventricular cavity in patients with (post) ischemic left ventricular aneurysm or global dilatation. However, late redilatation with mitral regurgitation has been reported, in which postoperative apex shape seems to play an important role. We studied the feasibility of ventricular volume downsizing with a variably shaped patch in porcine hearts. Methods: : In five in vitro and two acute animal experiments, a dy...
Abstract
Cited 24 times since 2010 (1.6 per year)
source: EuropePMC
Expert review of cardiovascular therapy,
Volume 8, Issue 1, 1 1 2010, Pages 113-123
Transcatheter aortic valve implantation: role of multimodality cardiac imaging.
Delgado V, Ng AC, Shanks M, van der Kley F, Schuijf JD, van de Veire NR, Kroft L, de Roos A, Schalij MJ, Bax JJ
Current evidence based on more than 8000 high-risk patients with severe aortic stenosis has demonstrated that transcatheter aortic valve implantation (TAVI) is a feasible alternative to surgical aortic valve replacement in selected patients. Despite current promising results on hemodynamic and clinical improvements, there are several unresolved safety issues, such as the frequency of vascular complications, postprocedural paravalvular leak, atrioventricular heart block and stroke. Multimodality...
Abstract
Cited 1 times since 2009 (0.1 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 26, Issue 2, 29 5 2010, Pages 199-202
Cardiac resynchronization therapy; evaluation by advanced imaging techniques.
van der Wall EE, Schalij MJ, Bax JJ
Abstract
Cited 42 times since 2009 (2.8 per year)
source: EuropePMC
European heart journal,
Volume 31, Issue 8, 27 4 2010, Pages 992-999
Long-term prognosis of patients with peripheral arterial disease with or without polyvascular atherosclerotic disease.
van Kuijk JP, Flu WJ, Welten GM, Hoeks SE, Chonchol M, Vidakovic R, Verhagen HJ, Bax JJ, Poldermans D
Aims: Patients with peripheral atherosclerotic disease often have multiple affected vascular beds (AVB), however, data on long-term follow-up and medical therapy are scarce. We assessed the prevalence and prognostic implications of polyvascular disease on long-term outcome in symptomatic peripheral arterial disease (PAD) patients. Methods and results: Two thousand nine hundred and thirty-three consecutive patients were screened prior to surgery for concomitant documented cerebrovascular disease...
Abstract
Cited 1 times since 2009 (0.1 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 26, Issue 3, 24 4 2009, Pages 355-358
CT perfusion angiography; beware of artifacts!
van der Wall EE, Schuijf JD, Bax JJ, Jukema JW, Schalij MJ
Abstract
Cited 12 times since 2009 (0.8 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 51, Issue 2, 24 4 2009, Pages 429-437
In vivo suppression of vein graft disease by nonviral, electroporation-mediated, gene transfer of tissue inhibitor of metalloproteinase-1 linked to the amino terminal fragment of urokinase (TIMP-1.ATF), a cell-surface directed matrix metalloproteinase inhibitor.
Eefting D, de Vries MR, Grimbergen JM, Karper JC, van Bockel JH, Quax PH
Background: Smooth muscle cell (SMC) migration and proliferation are important in the development of intimal hyperplasia, the major cause of vein graft failure. Proteases of the plasminogen activator (PA) system and of the matrix metalloproteinase (MMP) system are pivotal in extracellular matrix degradation and, by that, SMC migration. Previously, we demonstrated that inhibition of both protease systems simultaneously with viral gene delivery of the hybrid protein TIMP-1.ATF, consisting of the t...
Abstract
Cited 21 times since 2009 (1.4 per year)
source: EuropePMC
Journal of virology,
Volume 84, Issue 5, 23 4 2009, Pages 2533-2546
The latent origin of replication of Epstein-Barr virus directs viral genomes to active regions of the nucleus.
Deutsch MJ, Ott E, Papior P, Schepers A
The Epstein-Barr virus efficiently infects human B cells. The EBV genome is maintained extrachromosomally and replicates synchronously with the host's chromosomes. The latent origin of replication (oriP) guarantees plasmid stability by mediating two basic functions: replication and segregation of the viral genome. While the segregation process of EBV genomes is well understood, little is known about its chromatin association and nuclear distribution during interphase. Here, we analyzed the...
Abstract
