Research

Publications

Below you can find a list of our published research.

9562 results

Journal of cardiovascular computed tomography, 8 2 2025, Pages S1934-5925(25)00442-3 Incremental value of a CCTA-derived AI-based ischemia algorithm over standard CCTA interpretation of predicting myocardial ischemia in patients with suspected coronary artery disease. Nabeta T, Bär S, Maaniitty T, Kärpijoki H, Bax JJ, Saraste A, Knuuti J

Background: A novel artificial intelligence-guided quantitative computed tomography ischemia algorithm (AI-QCTischemia) comprises a machine-learned method using atherosclerosis and vascular morphology features from coronary computed tomography angiography (CCTA) images to predict myocardial ischemia. This study evaluates the diagnostic performance of AI-QCTischemia compared to standard CCTA interpretation in detecting myocardial ischemia. Methods and results: Patients with suspected coronary art... Abstract

Biological research for nursing, 8 2 2025, Pages 10998004251385121 Effect of Infant Massage in Neonates With Hyperbilirubinemia Receiving Phototherapy: A Systematic Review and Meta-Analysis. Erçelik ZE, Yilmaz DA

Most infants are diagnosed with hyperbilirubinemia in the first day of life. Although phototherapy is the most common treatment used in hyperbilirubinemia, different alternative therapies such as massage are also used. This systematic review and meta-analysis was designed to evaluate the effect of massage on serum bilirubin levels, defecation frequency, and length of hospital stay in neonates with hyperbilirubinemia receiving phototherapy. A review of randomized controlled trials published in En... Abstract

Annals of vascular surgery, Volume 123, 7 1 2025, Pages 94-103 Prediction of Wound Healing Following Amputation Surgery Based on Near-Infrared Fluorescence with Indocyanine Green. Kruiswijk MW, Peul RC, Tange FP, Koning S, van der Aa LE, Eefting D, van der Bogt KEA, van den Hoven P, van der Vorst JR, Vascular Fluorescence group

Background: The objective of this study was to evaluate the predictive value of near-infrared (NIR) fluorescence imaging with indocyanine on wound healing complications within 6 weeks after lower extremity amputation. Methods: In this dual-center cohort study, patients undergoing minor (below ankle) or major (above ankle) amputations due to peripheral arterial disease (PAD) or diabetes mellitus, with perfusion assessment performed using indocyanine green (ICG) NIR fluorescence imaging, were incl... Abstract

Endocrine connections, Volume 14, Issue 10, 6 1 2025, Pages e250400 Validation and implementation of the Dutch PHPQoL for primary hyperparathyroidism. Zhang JLH, Schepers A, Hamming JF, Osman L, Webb SM, Welling L, Winter EM, Snel M, Appelman-Dijkstra NM

Background: Patients with primary hyperparathyroidism (PHPT) often present with nonspecific neuropsychological symptoms, which remain challenging to quantify. While parathyroidectomy (PTx) recently has been recommended for asymptomatic patients, its benefit remains unclear as existing evidence relies on generic health-related quality of life (HRQoL) tools. In contrast, the disease-specific PHPQoL questionnaire offers more sensitive and clinically relevant symptom assessment. This study aims to t... Abstract

Molecular syndromology, 4 1 2025 Personalized Treatment in Rare Genetic Syndromes: A Case-Report in Witteveen-Kolk Syndrome (SIN3A). Janssen V, van Dongen LCM, Custers MCC, Willemsen MH, Kleefstra T, Egger JIM

Introduction: Neurodevelopmental disorders (NDDs) include a broad spectrum of disorders. NDDs caused by rare gene mutations are referred to as Rare Genetic Neurodevelopmental Syndromes (RGNS). Witteveen-Kolk syndrome (WITKOS) is such a RGNS, caused by heterozygous mutations in SIN3A and characterized by developmental problems, facial dysmorphisms, short stature, brain abnormalities, intellectual disability, and behavioral problems. Care for individuals with WITKOS mainly focuses on somatic chara... Abstract

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 2 1 2025 Development and Validation of a Prognostic Model for Persistent Hypoparathyroidism After Total or Completion Thyroidectomy. van Dijk SPJ, Maas CCHM, Alshangi A, van Driel MHE, Feitsma EA, van Kinschot CMJ, Lončar I, van Noord C, Koppert LB, Kruijff S, van Klaveren D, Verhoef C, Peeters RP, van Ginhoven TM, Hypoparathyroidism Study Group of the Thyroid Network

Background: The aim of this study was to develop and validate a clinical prediction model to predict the occurrence of persistent hypoparathyroidism after total or completion thyroidectomy. Methods: This multicentre retrospective cohort study included patients who underwent total or completion thyroidectomy between January 2010 and June 2021 in 12 Dutch hospitals. Results: Of the 366 patients included, 44 (12.0%) patients developed persistent hypoparathyroidism in the first year follow-up after... Abstract

Microbial genomics, Volume 11, Issue 10, 1 1 2025 The Kocurious case of Noodlococcus: genomic insights into Kocuria rhizophila from characterisation of a laboratory contaminant. McCallum GE, Ho SFS, Cummins EA, Wildsmith AJ, McInnes RS, Weigel C, Tong LYS, Quick J, van Schaik W, Moran RA

The laboratory contaminant strain Noodlococcus was named for its coccoid cells and unusual colony morphology, which resembled a pile of noodles. Along with laboratory characterisation and electron microscopy, we generated a complete Noodlococcus genome sequence using Illumina and Oxford Nanopore data. The genome consisted of a single, circular, 2,732,108 bp chromosome that shared 97.5% average nucleotide identity (ANI) with the Kocuria rhizophila type strain TA68. We identified genomic features... Abstract

The New England journal of medicine, Volume 393, Issue 17, 1 1 2025, Pages 1669-1680 European Study of Prostate Cancer Screening - 23-Year Follow-up. Roobol MJ, de Vos II, Månsson M, Godtman RA, Talala KM, den Hond E, Nelen V, Villers A, Poinas G, Kwiatkowski M, Wyler S, Recker F, Puliti D, Gorini G, Zappa M, Paez A, Lujan M, Bangma CH, Tammela T, Schröder FH, Remmers S, Hugosson J, Auvinen A, ERSPC Investigators

Background: The European Randomized Study of Screening for Prostate Cancer (ERSPC) was initiated in 1993 to assess the effect of prostate-specific antigen (PSA) testing on prostate cancer mortality. Because deaths from prostate cancer are expected to rise worldwide owing to increased life expectancy and population growth, a final analysis of the long-term outcomes of prostate cancer screening is essential to understanding the benefits and harms of PSA testing. Methods: We updated the findings fr... Abstract

Global change biology, Volume 31, Issue 10, 1 1 2025, Pages e70531 One Species Hibernates Shorter, the Other Longer: Rapid but Opposing Responses to Warming Climate in Two Sympatric Bat Species. Krivek G, Meier F, Grosche L, Kerth G, van Schaik J

The timing of hibernation represents a key seasonal transition in the annual cycle of hibernators, directly impacting their survival and reproductive success. Ongoing climate change affects many of the factors that influence hibernation phenology, such as weather patterns, food availability and the timing of mating and reproduction. The extent to which individuals should adjust their hibernation phenology in response is likely to vary between species, sexes and age classes. Consequently, long-te... Abstract

Frontiers in digital health, Volume 7, 1 1 2025, Pages 1528860 Content evaluation of the inclusive eHealth guide: how to develop interventions for people with a lower socioeconomic position? Al-Dhahir I, Breeman LD, Faber JS, Wentzel J, van den Berg-Emons RJG, Kraal JJ, Janssen VR, Kraaijenhagen RA, Visch VT, Chavannes NH, Evers AWM

Objectives: eHealth interventions favor those with higher socio-economic positions (SEPs). This can widen disparities, as people with lower SEPs may lack resources and face digital or financial barriers, making tailored solutions necessary. This study evaluates professionals' perceptions of the Inclusive eHealth Guide (IeG) regarding its content. The aim was to ensure it meets the needs of professionals and the targeted lower SEP demographic, thereby enhancing the effectiveness of eHealth i... Abstract

Therapeutic advances in medical oncology, Volume 17, 1 1 2025, Pages 17588359251379665 Predicting response and survival to first-line treatment with baseline [18F]FDG-PET-CT in patients with small-cell lung cancer: an integrated diagnostic approach. Ventura D, Schindler P, Kies P, Bleckmann A, Mohr M, Lenz G, Schäfers M, Roll W, Evers G

Background: Small-cell lung cancer (SCLC) is a highly malignant disease with a propensity for early progression and high mortality. The prognostic value of treatment response and survival has been verified for solely established imaging, clinical, and biochemical markers. There is a lack of evidence for the combination of those parameters with machine learning and integrated models, particularly in the context of molecular imaging. Objectives: The aim of this study was to predict early disease p... Abstract

JB & JS open access, Volume 10, Issue 4, 1 1 2025, Pages e25.00230 Revisiting the FAITH Trial: A Secondary Analysis Yielding Novel Insights with the Win Ratio. Bzovsky S, O'Hara NN, Slobogean GP, Sprague S, Axelrod DE, Hoit G, Pannozzo K, Bhandari M, Swiontkowski M, Schemitsch E, Poolman RW, FAITH Investigators

Background: Many orthopaedic trials use any unplanned reoperation as the primary outcome, but this overlooks how patients experience those outcomes. Using a high-quality hip fracture trial, we demonstrate how the relative importance of multiple patient-important outcomes can be effectively incorporated into data analysis, providing a more comprehensive understanding of treatment impact. Methods: This secondary analysis of the Fixation using Alternative Implants for the Treatment of Hip Fracture... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 27, Issue 11, 1 1 2025, Pages euaf276 The SIDECAR 2.0 (S-ICD registry in European paediatric and young adult patients with congenital heart defects 2.0): an analysis of European S-ICD clinical practice and its evolution in paediatric patients. Silvetti MS, Bruyndonckx L, Waldmann V, Gebauer R, Környei L, Ksiazczyk T, Illikova V, Tavacova T, Roses-Noguer F, Kwiatkowska J, Pazzano V, Wilkin M, Paech C, Fésüs G, Egorova AD, Wieniawski P, Rivas-Gandara N, Kempa M, Battipaglia I, Klehs S, Chalupka M, Maltret A, Knops RE, Janousek J, Blom NA, Lovecchio M, Valsecchi S, Drago F

Aims: Subcutaneous implantable cardioverter-defibrillators (S-ICDs) are effective in patients who require protection from sudden cardiac death while avoiding the long-term risks associated with transvenous leads. However, data on their real-world performance in paediatric and young patients remain limited. This study aims to evaluate the safety and efficacy of S-ICDs in a large, multicentre cohort of paediatric and young patients across Europe, with a focus on contemporary implantation practices... Abstract

Family practice, Volume 42, Issue 6, 1 1 2025, Pages cmaf081 Cost-effectiveness of a corticosteroid injection versus exercise therapy for shoulder pain in general practice (SIX-Shoulder Study): a randomized controlled trial. Versloot AHC, Toy M, Schiphof D, Bindels P, Ottenheijm RPG, de Graaf M, van der Windt DA, van Ochten JM, Koes BW, Runhaar J

Background: Shoulder pain often results in functional limitations leading to substantial societal and healthcare costs. Guidelines recommend a corticosteroid injection or exercise therapy, but long-term comparative cost-effectiveness remains unclear. This study examined the cost-effectiveness of these two treatments over 12 months in patients with shoulder pain presenting in Dutch primary care. Methods: A randomized controlled trial was conducted with patients consulting for a new episode of sho... Abstract

Cited 12 times since 2025 (74.1 per year) source: EuropePMC

European heart journal, Volume 46, Issue 40, 1 1 2025, Pages 3952-4041 2025 ESC Guidelines for the management of myocarditis and pericarditis. Schulz-Menger J, Collini V, Gröschel J, Adler Y, Brucato A, Christian V, Ferreira VM, Gandjbakhch E, Heidecker B, Kerneis M, Klein AL, Klingel K, Lazaros G, Lorusso R, Nesukay EG, Rahimi K, Ristić AD, Rucinski M, Sade LE, Schaubroeck H, Semb AG, Sinagra G, Thune JJ, Imazio M, ESC Scientific Document Group

Abstract

Aims: In non-ischaemic cardiomyopathy (NICM), late gadolinium enhancement (LGE) detected by cardiovascular magnetic resonance is related to ventricular arrhythmia (VA) and sudden cardiac death (SCD) risk. The incremental prognostic value of quantifying LGE volume or mass beyond its mere presence, however, remains unresolved. The aim was to evaluate whether LGE quantification improves the prediction of SCD. Methods and results: PubMed, Embase, and Web of Science were searched on 20 November 2024... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 27, Issue 10, 1 1 2025, Pages euaf240 Evolution of implantable cardioverter-defibrillator shock therapy in children in the era of optimized ICD programming and remote monitoring. Bertels RA, Boersma E, Zeggelaar MD, van Dongen SAF, Ten Harkel ADJ, van Erven L, Smeding C, Bartelds B, van den Berg G, Boesaard EP, Bhagwandien RE, Yap SC, Knops RE, Blom NA, Kammeraad JAE

Aims: Implantable cardioverter defibrillator (ICD) therapy is effective in preventing sudden cardiac death in children. Unnecessary shocks should be avoided. ICD programming strategies and remote monitoring have been proven to be effective in preventing ICD shock therapy in adults; the present study evaluates the effectiveness in children. Methods and results: Retrospective multi-centre study, including children with transvenous or epicardial ICD implantation. During follow-up data on ICD shocks... Abstract

Interdisciplinary cardiovascular and thoracic surgery, 30 5 2025, Pages ivaf231 A European survey on non-technical skills in robotic thoracic surgery for lung resections. Shahin GMM, Verhagen MJ, Hutteman M, Wink J, Stamenkovic SA, Durand M, Baste JM, Melfi F, Braun J

Objectives: In robotic surgery, interaction between team-members differs from that in open surgery, which impacts the team-members' tasks and responsibilities. Training for robot-assisted thoracic surgery (RATS) is primarily focused on technical skills. However, non-technical skills (NOTECHS) are equally important for safe and high-quality surgery. There is debate whether NOTECHS require adjustments to meet specific needs of RATS. The aim of this study is to evaluate how NOTECHS-domains are... Abstract

BJA open, Volume 16, 29 5 2025, Pages 100485 The association between postoperative myocardial injury of unexplained aetiology after noncardiac surgery and sex and cancer on 1-yr survival: a retrospective, single-centre, observational cohort study. van Schaik EPC, Vernooij LM, Haddou Y, Grobben RB, van Klei WA, van Waes JAR

Background: The aetiology of postoperative myocardial injury (PMI) is often unexplained, and the effect of sex and cancer surgery on prognosis in patients with PMI is unknown. We aimed to estimate the proportion of patients developing PMI of unknown aetiology and compare their prognosis with those with explained PMI, and to investigate the interaction with sex and cancer surgery. Methods: This retrospective, single-centre, observational cohort study included patients aged ≥60 yr undergoing nonca... Abstract

Scientific reports, Volume 15, Issue 1, 26 4 2025, Pages 33000 Green synthesis of antimicrobial alginate/hydroxyethyl cellulose hydrogels crosslinked by Ca2+ and dual Ca2+/Mg2. Jahir Hussain FS, Ghosh S, Al Saadi HSO, Al-Sibani M, Al Amri IS, Al Harrasi A, Al Abri AM, Al-Hinai A, Al-Housni SK, Al-Hatmi AMS

Eco-friendly antimicrobial hydrogels derived from carbohydrate polymers are receiving significant attention for their sustainable and cost-effective properties. This study focuses on developing antimicrobial hydrogels based on alginate and hydroxyethyl cellulose (SA/HEC) using a green chemistry approach. The impact of bivalent metal ions on cross-linking efficiency and the hydrogels' physicochemical properties were analyzed, with hydrogels produced in various forms, such as beads, sponges,... Abstract