7695 results
Cited 3 times since 2023 (1.6 per year)
source: EuropePMC
Journal of the mechanical behavior of biomedical materials,
Volume 144, 28 4 2023, Pages 105980
Cyclic strain has antifibrotic effects on the human cardiac fibroblast transcriptome in a human cardiac fibrosis-on-a-chip platform.
Bracco Gartner TCL, Wang Y, Leiteris L, van Adrichem I, Marsman J, Goumans MJ, Bouten CVC, Sluijter JPG, den Toonder JMJ, Suyker WJL, Hjortnaes J
In cardiac fibrosis, in response to stress or injury, cardiac fibroblasts deposit excessive amounts of collagens which contribute to the development of heart failure. The biochemical stimuli in this process have been extensively studied, but the influence of cyclic deformation on the fibrogenic behavior of cardiac fibroblasts in the ever-beating heart is not fully understood. In fact, most investigated mechanotransduction pathways in cardiac fibroblasts seem to ultimately have profibrotic effect...
Abstract
Cited 8 times since 2023 (4.3 per year)
source: EuropePMC
International journal of molecular sciences,
Volume 24, Issue 13, 28 4 2023, Pages 10825
Building a Scaffold for Arteriovenous Fistula Maturation: Unravelling the Role of the Extracellular Matrix.
Laboyrie SL, de Vries MR, Bijkerk R, Rotmans JI
Vascular access is the lifeline for patients receiving haemodialysis as kidney replacement therapy. As a surgically created arteriovenous fistula (AVF) provides a high-flow conduit suitable for cannulation, it remains the vascular access of choice. In order to use an AVF successfully, the luminal diameter and the vessel wall of the venous outflow tract have to increase. This process is referred to as AVF maturation. AVF non-maturation is an important limitation of AVFs that contributes to their...
Abstract
Cited 3 times since 2023 (1.6 per year)
source: EuropePMC
Pathology, research and practice,
Volume 248, 28 4 2023, Pages 154620
Intrinsic histological and morphological abnormalities of the pediatric thoracic aorta in bicuspid aortic valve patients are predictive for future aortopathy.
Grewal N, Klautz RJM, Poelmann RE
Background: Patients with a bicuspid aortic valve (BAV) have an increased risk to develop aortic complications. Many studies are pointing towards a possible embryonic explanation for the development of both a bicuspid aortic valve as well as a defective ascending aortic wall in these patients. The fetal and newborn ascending aortic wall has however scarcely been studied in bicuspid aortic valve patients. We hypothesize that early histopathological defects might already be visible in the fetal an...
Abstract
Annals of vascular surgery,
Volume 98, 28 4 2023, Pages 388-397
Pilot Study on Feasibility and Outcome of a Nerve-Preserving Aortoiliac Exposure Technique.
van Schaik J, Witt D, Albers L, Wever J, Elzevier H, Hamming J
Background: Dysfunctional ejaculation is a common complication following open aortoiliac aneurysm surgery. It may occur in 49-63% of patients and is caused by iatrogenic damage to the sympathetic lumbar splanchnic nerves and superior hypogastric plexus. A nerve-preserving operative technique based on a unilateral right-sided approach to the abdominal aorta, was implemented in clinical practice. The aim of this pilot study was to establish the safety and feasibility of the technique, and whether...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 109, Issue 14, 26 4 2023, Pages 1106-1112
Perioperative care differences of surgical aortic valve replacement between North America and Europe.
Velders BJJ, Vriesendorp MD, De Lind Van Wijngaarden RAF, Rao V, Reardon MJ, Shrestha M, Chu MWA, Sabik JF, Liu F, Klautz RJM
Objective: To describe differences between North America and Europe in the perioperative management of patients undergoing surgical aortic valve replacement (SAVR). Methods: Patients with moderate or greater aortic stenosis or regurgitation requiring SAVR were enrolled in a prospective observational cohort evaluating the safety and efficacy of a new stented bioprosthesis at 25 centres in North America (Canada and the USA) and 13 centres in Europe (Germany, the Netherlands, France, the UK, Switze...
Abstract
Cited 4 times since 2023 (2.1 per year)
source: EuropePMC
Angiology,
Volume 75, Issue 9, 26 4 2023, Pages 884-892
Near-Infrared Fluorescence Imaging With Indocyanine Green to Predict Clinical Outcome After Revascularization in Lower Extremity Arterial Disease.
Tange FP, van den Hoven P, van Schaik J, Schepers A, van der Bogt KEA, van Rijswijk CSP, Putter H, Vahrmeijer AL, Hamming JF, van der Vorst JR
Contemporary quality control methods are often insufficient in predicting clinical outcomes after revascularization in lower extremity arterial disease (LEAD) patients. This study evaluates the potential of near-infrared fluorescence imaging with indocyanine green to predict the clinical outcome following revascularization. Near-infrared fluorescence imaging was performed before and within 5 days following the revascularization procedure. Clinical improvement was defined as substantial improveme...
Abstract
Cited 8 times since 2023 (4.3 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 10, 26 4 2023, Pages 1093201
The potential of sodium-glucose cotransporter 2 inhibitors for the treatment of systemic right ventricular failure in adults with congenital heart disease.
Neijenhuis RML, Nederend M, Jongbloed MRM, Kiès P, Rotmans JI, Vliegen HW, Jukema JW, Egorova AD
Aims: Given the compelling evidence on the effectiveness of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in the conventional heart failure population, SGLT2i deserve exploration in systemic right ventricular (sRV) failure. The initial experience with dapagliflozin in sRV failure patients is described, with a focus on tolerability and short-term effects on clinical outcomes. Methods and results: Ten patients (70% female, median age 50 years [46.5-52]) with symptomatic sRV failure who receiv...
Abstract
Annals of vascular surgery,
Volume 98, 23 4 2023, Pages 87-101
Perspectives of Patients and Professionals on Patient Education in Complex Endovascular Aortic Repair.
Warmerdam B, Oomen F, Hilt A, Melles M, Eefting D, Hamming J, van der Vorst J, van Schaik J
Background: Misinterpretation of patient preferences in perioperative education can lead to an undesired treatment decision. This explorative interview study presents differences in perspectives of patients and professionals on patient education in complex endovascular aortic aneurysm management. Methods: Using convenience sampling, a cross-sectional interview study was performed among patients who were in various stages of the decision-making process for complex endovascular aortic repair. Five...
Abstract
Cited 8 times since 2023 (4.3 per year)
source: EuropePMC
The Journal of molecular diagnostics : JMD,
Volume 25, Issue 9, 23 4 2023, Pages 655-664
Characterization of Reference Materials for CYP3A4 and CYP3A5: A (GeT-RM) Collaborative Project.
Gaedigk A, Boone EC, Turner AJ, van Schaik RHN, Chernova D, Wang WY, Broeckel U, Granfield CA, Hodge JC, Ly RC, Lynnes TC, Mitchell MW, Moyer AM, Oliva J, Kalman LV
Pharmacogenetic testing for CYP3A4 is increasingly provided by clinical and research laboratories; however, only a limited number of quality control and reference materials are currently available for many of the CYP3A4 variants included in clinical tests. To address this need, the Division of Laboratory Systems, CDC-based Genetic Testing Reference Material Coordination Program (GeT-RM), in collaboration with members of the pharmacogenetic testing and research communities and the Coriell Institu...
Abstract
Cited 4 times since 2023 (2.1 per year)
source: EuropePMC
Frontiers in neuroscience,
Volume 17, 23 4 2023, Pages 1187252
SENECA: building a fully digital neuromorphic processor, design trade-offs and challenges.
Tang G, Vadivel K, Xu Y, Bilgic R, Shidqi K, Detterer P, Traferro S, Konijnenburg M, Sifalakis M, van Schaik GJ, Yousefzadeh A
Neuromorphic processors aim to emulate the biological principles of the brain to achieve high efficiency with low power consumption. However, the lack of flexibility in most neuromorphic architecture designs results in significant performance loss and inefficient memory usage when mapping various neural network algorithms. This paper proposes SENECA, a digital neuromorphic architecture that balances the trade-offs between flexibility and efficiency using a hierarchical-controlling system. A SENE...
Abstract
JACC. Cardiovascular interventions,
Volume 16, Issue 14, 21 3 2023, Pages 1813-1815
Retrograde Use of Intravascular Lithotripsy in Anterograde Uncrossable In-Stent Chronic Occlusion: "Retrotripsy Technique".
Montero-Cabezas JM, Al Amri I, van Oort MJH, Bingen BO, Scherptong RWC, van der Kley F
Abstract
Multiple sclerosis and related disorders,
Volume 77, 21 3 2023, Pages 104847
Role of serostatus in pediatric neuromyelitis optica spectrum disorders: A nationwide multicentric study.
Solmaz I, Öncel IH, Konuşkan B, Erol I, Orgun LT, Yılmaz Ü, Ünalp A, Atasoy E, Aksoy E, Yılmaz D, Öztürk M, Karaca NB, Yılmaz S, Yiş U, Dündar NO, Parlak Ş, Vural A, Günbey C, Anlar B
Background: Neuromyelitis optica spectrum disorders (NMOSD) are immune-mediated inflammatory disorders of the central nervous system (CNS) mostly presenting as optic neuritis and acute myelitis. NMOSD can be associated with seropositivity for aquaporin 4 antibody (AQP4 IgG), myelin oligodendrocyte glycoprotein antibody (MOG IgG), or can be seronegative for both. In this study, we retrospectively examined our seropositive and seronegative pediatric NMOSD patients. Method: Data were collected from...
Abstract
Cited 5 times since 2023 (2.7 per year)
source: EuropePMC
Journal of internal medicine,
Volume 294, Issue 3, 21 3 2023, Pages 347-357
Light transmittance in human atrial tissue and transthoracic illumination in rats support translatability of optogenetic cardioversion of atrial fibrillation.
Nyns ECA, Portero V, Deng S, Jin T, Harlaar N, Bart CI, van Brakel TJ, Palmen M, Hjortnaes J, Ramkisoensing AA, Zhang GQ, Poelma RH, Ördög B, de Vries AAF, Pijnappels DA
Background: Optogenetics could offer a solution to the current lack of an ambulatory method for the rapid automated cardioversion of atrial fibrillation (AF), but key translational aspects remain to be studied. Objective: To investigate whether optogenetic cardioversion of AF is effective in the aged heart and whether sufficient light penetrates the human atrial wall. Methods: Atria of adult and aged rats were optogenetically modified to express light-gated ion channels (i.e., red-activatable ch...
Abstract
Microbiology resource announcements,
Volume 12, Issue 7, 20 3 2023, Pages e0130422
Metagenomic Sequencing of Two Cultures Grown on Chemically Deconstructed Plastic Products.
Putman LI, Schaerer LG, Wu R, Kulas DG, Zolghadr A, Ong RG, Shonnard DR, Techtmann SM, Arbanas LG, Bannerman GG, Cart B, Cureton A, Doerr BP, Jovicevic Z, Langosch M, MacLeod AB, McCloskey C, McNally AM, Monkevich MK, Noecker A, Norris D, Pellizzon VG, Strom KB, Taylor EE
We report the metagenome sequences of two microbial cultures that were grown with chemically deconstructed plastic products as their sole carbon source. These metagenomes will provide insights into the metabolic capabilities of cultures grown on deconstructed plastics and can serve as a starting point for the identification of novel plastic degradation mechanisms.
Abstract
Cited 4 times since 2023 (2.1 per year)
source: EuropePMC
Global change biology,
Volume 29, Issue 17, 20 3 2023, Pages 4939-4948
Heat over heritability: Increasing body size in response to global warming is not stabilized by genetic effects in Bechstein's bats.
Mundinger C, van Schaik J, Scheuerlein A, Kerth G
How well populations can cope with global warming will often depend on the evolutionary potential and plasticity of their temperature-sensitive, fitness-relevant traits. In Bechstein's bats (Myotis bechsteinii), body size has increased over the last decades in response to warmer summers. If this trend continues it may threaten populations as larger females exhibit higher mortality. To assess the evolutionary potential of body size, we applied a Bayesian 'animal model' to estimate...
Abstract
Cited 4 times since 2023 (2.1 per year)
source: EuropePMC
BMC ophthalmology,
Volume 23, Issue 1, 16 3 2023, Pages 279
Effect of alirocumab on cataracts in patients with acute coronary syndromes.
Suc G, Schwartz GG, Goodman SG, Jukema JW, Manvelian G, Poulouin Y, Pordy R, Scemama M, Szarek M, Steg PG, ODYSSEY OUTCOMES Investigators
Background: Some data suggest that low levels of low-density lipoprotein cholesterol (LDL-C) are associated with risk of cataracts. Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors reduce LDL-C below levels achieved with statins alone. We determined whether the incidence of cataracts was influenced by treatment with the PCSK9 inhibitor alirocumab versus placebo, and whether that incidence was affected by achieved LDL-C levels. Methods: The ODYSSEY OUTCOMES trial (NCT01663402) com...
Abstract
Cited 23 times since 2023 (12.1 per year)
source: EuropePMC
Annals of oncology : official journal of the European Society for Medical Oncology,
Volume 34, Issue 9, 16 3 2023, Pages 813-825
Fragmentomic analysis of circulating tumor DNA-targeted cancer panels.
Helzer KT, Sharifi MN, Sperger JM, Shi Y, Annala M, Bootsma ML, Reese SR, Taylor A, Kaufmann KR, Krause HK, Schehr JL, Sethakorn N, Kosoff D, Kyriakopoulos C, Burkard ME, Rydzewski NR, Yu M, Harari PM, Bassetti M, Blitzer G, Floberg J, Sjöström M, Quigley DA, Dehm SM, Armstrong AJ, Beltran H, McKay RR, Feng FY, O'Regan R, Wisinski KB, Emamekhoo H, Wyatt AW, Lang JM, Zhao SG
Background: The isolation of cell-free DNA (cfDNA) from the bloodstream can be used to detect and analyze somatic alterations in circulating tumor DNA (ctDNA), and multiple cfDNA-targeted sequencing panels are now commercially available for Food and Drug Administration (FDA)-approved biomarker indications to guide treatment. More recently, cfDNA fragmentation patterns have emerged as a tool to infer epigenomic and transcriptomic information. However, most of these analyses used whole-genome sequ...
Abstract
Cited 3 times since 2023 (1.6 per year)
source: EuropePMC
Frontiers in medicine,
Volume 10, 16 3 2023, Pages 1112573
Endoglin and squamous cell carcinomas.
Hakuno SK, Janson SGT, Trietsch MD, de Graaf M, de Jonge-Muller E, Crobach S, Harryvan TJ, Boonstra JJ, Dinjens WNM, Slingerland M, Hawinkels LJAC
Despite the fact that the role of endoglin on endothelial cells has been extensively described, its expression and biological role on (epithelial) cancer cells is still debatable. Especially its function on squamous cell carcinoma (SCC) cells is largely unknown. Therefore, we investigated SCC endoglin expression and function in three types of SCCs; head and neck (HNSCC), esophageal (ESCC) and vulvar (VSCC) cancers. Endoglin expression was evaluated in tumor specimens and 14 patient-derived cell...
Abstract
Cited 15 times since 2023 (7.9 per year)
source: EuropePMC
Science (New York, N.Y.),
Volume 380, Issue 6650, 15 3 2023, Pages 1155-1160
Widespread diversity deficits of coral reef sharks and rays.
Simpfendorfer CA, Heithaus MR, Heupel MR, MacNeil MA, Meekan M, Harvey E, Sherman CS, Currey-Randall LM, Goetze JS, Kiszka JJ, Rees MJ, Speed CW, Udyawer V, Bond ME, Flowers KI, Clementi GM, Valentin-Albanese J, Adam MS, Ali K, Asher J, Aylagas E, Beaufort O, Benjamin C, Bernard ATF, Berumen ML, Bierwagen S, Birrell C, Bonnema E, Bown RMK, Brooks EJ, Brown JJ, Buddo D, Burke PJ, Cáceres C, Cambra M, Cardeñosa D, Carrier JC, Casareto S, Caselle JE, Charloo V, Cinner JE, Claverie T, Clua EEG, Cochran JEM, Cook N, Cramp JE, D'Alberto BM, de Graaf M, Dornhege MC, Espinoza M, Estep A, Fanovich L, Farabaugh NF, Fernando D, Ferreira CEL, Fields CYA, Flam AL, Floros C, Fourqurean V, Gajdzik L, Barcia LG, Garla R, Gastrich K, George L, Giarrizzo T, Graham R, Guttridge TL, Hagan V, Hardenstine RS, Heck SM, Henderson AC, Heithaus P, Hertler H, Padilla MH, Hueter RE, Jabado RW, Joyeux JC, Jaiteh V, Johnson M, Jupiter SD, Kaimuddin M, Kasana D, Kelley M, Kessel ST, Kiilu B, Kirata T, Kuguru B, Kyne F, Langlois T, Lara F,
A global survey of coral reefs reveals that overfishing is driving resident shark species toward extinction, causing diversity deficits in reef elasmobranch (shark and ray) assemblages. Our species-level analysis revealed global declines of 60 to 73% for five common resident reef shark species and that individual shark species were not detected at 34 to 47% of surveyed reefs. As reefs become more shark-depleted, rays begin to dominate assemblages. Shark-dominated assemblages persist in wealthy n...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 80, 13 2 2023, Pages 133-138
Prolongation of the QTc interval is associated with an increased risk of cardiovascular diseases: The Hoorn study.
Welten SJGC, van der Heijden AA, Remmelzwaal S, Blom MT, Nijpels G, Rutters F, Beulens JWJ, Elders PJM, ESCAPE-NET investigators
Background/objective: Prolonged heart rate-corrected QT interval (QTc) on the electrocardiogram (ECG) is maybe associated with the occurrence of cardiovascular diseases (CVD), but the evidence is inconsistent. Therefore, we investigated whether baseline prolongation of the QTc interval is associated with CVD morbidity and mortality and its subtypes and whether glucose tolerance modifies this association in a population-based cohort study with a mean follow-up of 10.8 years. Methods: We analyzed...
Abstract
