6125 results
Clinical and translational radiation oncology,
Volume 52, 29 5 2025, Pages 100927
Effect of FLASH proton therapy on primary bronchial epithelial cell organoids.
Kuipers ME, van Liefferinge F, van der Wal E, Rovituso M, Slats AM, Hiemstra PS, Van Doorn-Wink KCJ
Purpose: The effects of conventional (CONV) and FLASH proton therapy on primary bronchial epithelial cell (PBEC) organoids from individuals with chronic obstructive pulmonary disease (COPD) were investigated. The primary objective was to compare the effect of FLASH and CONV on COPD PBEC organoids with a focus on DNA damage, organoid formation, and gene expression. Methods: PBECs were obtained from six COPD donors, cultured as three-dimensional (3D) organoids and exposed to 2 and 8 Gy CONV and FL...
Abstract
Journal of clinical medicine,
Volume 14, Issue 3, 28 4 2025, Pages 859
From Survival to Recovery: Understanding the Life Impact of an Acute Aortic Dissection Through Activity, Sleep, and Quality of Life.
Bacour N, Grewal S, Theijsse RT, Klautz RJM, Grewal N
Background/Objectives: An acute aortic dissection (AAD) is a cardiovascular emergency with high mortality rates if left untreated. Survival has increased due to improvements in diagnosis and therapy. However, during their recovery, survivors frequently encounter major social, psychological, and physical challenges. This study aimed to evaluate the recovery experience of AAD survivors in The Netherlands. Insights on sleep quality, physical activity, and quality of life were collected from a uniqu...
Abstract
Journal of the European Academy of Dermatology and Venereology : JEADV,
22 4 2025
Increasing dosing intervals for biologics in atopic dermatitis-why, who, when and how?
Jacobson ME, Boesjes CM, de Bruin-Weller MS, de Graaf M, Morimoto RY, Simpson EL
Biologics approved and in development for atopic dermatitis offer life-changing clinical efficacy with a relatively banal long-term safety profile requiring no laboratory monitoring. Biologic therapies also have their drawbacks, including high payor cost and the need to be administered as every other week subcutaneous injections. Addressing these concerns, studies of longer dosing intervals have been performed in the formal clinical trial setting and during real-world clinical care. Here, we rev...
Abstract
Vascular medicine (London, England),
21 3 2025, Pages 1358863X241309326
Prognostic performance of bedside tests for predicting ulcer healing and wound healing after minor amputation in patients prone to medial arterial calcification: A systematic review.
Willems SA, Nieuwstraten JA, Schepers A, van Schaik J, van den Hoven P, van der Vorst JR, Hamming JF, Brouwers JJ
Foot ulceration is a significant and growing health problem worldwide, particularly due to rises in diabetes mellitus (DM) and peripheral artery disease. The prediction of ulcer healing remains a major challenge. In patients with foot ulcers, medial arterial calcification (MAC) can be present as a result of concomitant DM or chronic kidney disease and is a prognostic factor for unfavorable outcome. This systematic review aimed to evaluate the prognostic reliability of bedside tests to predict ul...
Abstract
Open heart,
Volume 12, Issue 1, 21 3 2025, Pages e003055
Prognostic role of con-/discordant coronary flow reserve and microvascular resistance in coronary microvascular disease: a systematic review and network meta-analysis.
Al-Gully J, Oliveri F, Forouzanfar JP, Montero-Cabezas JM, Jukema JW, den Haan MC, Al Amri I, Bingen BO
Background: Coronary microvascular disease (CMD) is defined as impaired coronary flow reserve (CFR) and/or increased microvascular resistance (MR) without significant epicardial coronary stenosis. This definition allows for discordant CFR and MR values within patients with CMD. The aim of this meta-analysis is to characterise the prognostic value and pathophysiological backgrounds of CFR and MR con-/discordance. Methods: A systematic search (PROSPERO CRD42024573004) identified studies determinin...
Abstract
International journal of cardiology,
Volume 423, 21 3 2025, Pages 132996
Intravascular lithotripsy in calcified left main coronary artery: Procedural success and 1-year clinical outcomes.
Oliveri F, van Oort MJH, Phagu AAS, Al Amri I, Bingen BO, Claessen BEPM, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Intravascular lithotripsy (IVL) has an excellent efficacy and safety profile in the treatment of calcified coronary lesions during percutaneous coronary intervention (PCI). However, data regarding its use on left main (LM) lesions are still limited. Objective: We aimed to analyze the technical success and 1-year clinical outcomes in calcified LM lesions treated with IVL. Methods: Patients who underwent IVL from the ongoing prospective BENELUX registry were eligible for inclusion. Pat...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
20 3 2025
Symptomatic early coronary graft failure in bypass surgery patients: incidence, predictors and clinical impact.
van Oort MJH, Al Amri I, de Weger A, Regeer MV, Jukema JW, Mertens BJA, Montero-Cabezas JM
Objectives: Coronary graft failure (CGF) may occur early after coronary bypass graft surgery (CABG). The study aimed to identify clinical and perioperative risk factors and to evaluate the long-term clinical impact of symptomatic early CGF. Methods: Patients who underwent clinically indicated coronary angiography (CAG) prior to post-CABG discharge between 2012 and 2022 were included. Symptomatic early CGF was defined as a dysfunctional coronary graft, evaluated on clinically indicated CAG, cause...
Abstract
Rheumatology advances in practice,
Volume 9, Issue 1, 20 3 2025, Pages rkaf010
Anti-citrullinated protein antibody detection by hemagglutination.
Kruis I, Kumari J, van der Heijden A, Weijn A, Vree Egberts W, Peeters IR, van Herwaarden N, Salden M, Pruijn GJM
Objectives: ACPAs play an important role in the classification of RA and can be detected by serological tests. Several ACPA detection assays are available for clinical use, which are all based on ELISA(-like) tests with citrullinated peptides (CCP2) or alternative citrullinated proteins/peptides. We aimed to facilitate ACPA detection in low-volume laboratories and resource-poor environments by developing a rapid and easy-to-perform test. Methods: We designed and generated an agglutination mediat...
Abstract
Respiratory research,
Volume 26, Issue 1, 18 3 2025, Pages 20
Radiation decreases bronchial epithelial progenitor function as assessed by organoid formation.
Kuipers ME, Ninaber DK, van Doorn-Wink KCJ, Slats AM, Hiemstra PS
Objective: Radiation-induced lung injury (RILI) is a serious side-effect of radiotherapy for lung cancer, in which effects on the normal lung epithelium may play a key role. Since these effects are incompletely understood, the aim of the present study was to evaluate the effect of ionizing radiation (IR) on cultured well-differentiated primary bronchial epithelial cells (PBEC) with a focus on cytotoxicity, barrier formation, inflammation and epithelial progenitor function. Materials and methods:...
Abstract
Brain : a journal of neurology,
16 3 2025, Pages awaf011
N-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference.
Weilnhammer V, Rothkirch M, Yilmaz D, Fritsch M, Ptasczynski LE, Reichenbach K, Rödiger L, Corlett P, Sterzer P
Perception integrates external sensory signals with internal predictions that reflect prior knowledge about the world. Previous research suggests that this integration is governed by slow alternations between an external mode, driven by sensory signals, and an internal mode, shaped by prior knowledge. Using a double-blind, placebo-controlled, cross-over experiment in healthy human participants, we investigated the effects of the N-Methyl-D-aspartate receptor (NMDAR) antagonist S-ketamine on the...
Abstract
Scientific reports,
Volume 15, Issue 1, 16 3 2025, Pages 2180
Iron metabolism in a mouse model of hepatocellular carcinoma.
Yilmaz D, Tharehalli U, Paganoni R, Knoop P, Gruber A, Chen Y, Dong R, Leithäuser F, Seufferlein T, Leopold K, Lechel A, Vujić Spasić M
Hepatocellular carcinoma (HCC) remains the most prevalent type of primary liver cancer worldwide. p53 is one of the most frequently mutated tumor-suppressor genes in HCC and its deficiency in hepatocytes triggers tumor formation in mice. To investigate iron metabolism during liver carcinogenesis, we employed a model of chronic carbon tetrachloride injections in liver-specific p53-deficient mice to induce liver fibrosis, cirrhosis and subsequent carcinogenesis. A transcriptome analysis of liver c...
Abstract
European heart journal. Cardiovascular Imaging,
15 3 2025, Pages jeaf014
The role of multi-modality imaging for the assessment of left atrium and left atrial appendage. A clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC).
Sade LE, Faletra FF, Pontone G, Gerber BLM, Muraru D, Edvardsen T, Cosyns B, Popescu BA, Klein A, Marwick TH, Cameli M, Saric M, Thomas L, Ajmone Marsan N, Fontes-Carvalho R, Podlesnikar T, Fontana M, La Gerche A, Petersen SE, Moharem-Elgamal S, Bittencourt MS, Vannan MA, Glikson M, Peichl P, Cochet H, Stankovic I, Donal E
Structural, architectural, contractile or electrophysiological alterations may occur in the left atrium (LA). The concept of LA cardiopathy is supported by accumulating scientific evidence demonstrating that LA remodeling has become a cornerstone diagnostic and prognostic marker. The structure and the function of LA and left atrial appendage (LAA) which is an integral part of the LA, are key elements for a better understanding of multiple clinical conditions, most notably atrial fibrillation (AF...
Abstract
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
13 2 2025
Angiographic Characterization and Sex-Related Anatomical Differences of Atrial Coronary Arteries Anatomy-A Proposal of Systematic Classification.
Marques-Antunes M, van Oort MJH, Oliveri F, Al Amri I, Bingen BO, Cruz-Ferreira R, Wouter Jukema J, Montero-Cabezas JM
Background: The coronary atrial circulation is the network of vessels that supply blood to the atria, originating from the left circumflex and right coronary arteries. Current descriptions of this arterial system are based on anatomical studies with a limited number of patients, predominantly male. In addition, there is a lack of consensus its angiographic nomenclature. Aims: This study aimed to evaluate the anatomical variations of coronary atrial branches (CAB) and investigate sex-related diff...
Abstract
Heart rhythm,
13 2 2025, Pages S1547-5271(25)00022-0
Application of artificial intelligence to analyze data from randomized controlled trials: An example from DECAAF II.
Mekhael M, Feng H, Akoum N, Sohns C, Sommer P, Mahnkopf C, Kholmovski E, Bax JJ, Sanders P, McGann C, Marchlinski F, Mansour M, Hindricks G, Wilber D, Calkins H, Jais P, Younes H, Assaf A, Noujaim C, Lim C, Huang C, Pandey A, Wazni O, Marrouche N
Background: Causal machine learning (ML) provides an efficient way of identifying heterogeneous treatment effect groups from hundreds of possible combinations, especially for randomized trial data. Objective: The aim of this paper is to illustrate the potential of applying causal ML on the DECAAF II trial data. We proposed a causal ML model to predict the treatment response heterogeneity. Methods: We applied causal tree learning to the DECAAF II trial data as an example of real applications, ide...
Abstract
The American journal of cardiology,
Volume 241, 11 2 2025, Pages 61-68
Arrhythmogenic Right Ventricular Cardiomyopathy: The Importance of Biventricular Strain in Risk-Stratification.
Chua AP, Laenens D, Sarrazyn C, Lopez-Santi MP, Nabeta T, Myagmardorj R, Bootsma M, Barge-Schaapveld DQCM, Bax JJ, Marsan NA
Despite arrhythmogenic right ventricular cardiomyopathy (ARVC) being predominantly a right ventricular (RV) disease, concomitant left ventricular (LV) involvement has been recognized. ARVC is diagnosed by the RV-centric 2010 Task Force Criteria(TFC) using routine echocardiography, but previous studies have suggested that strain imaging may be more sensitive to detect RV and LV dysfunction. No data however are available regarding the additional value of combining biventricular strain for risk str...
Abstract
American heart journal,
Volume 282, 9 2 2025, Pages 134-145
Increased prevalence of coronary atherosclerosis in cancer survivors: A retrospective matched cross-sectional study with coronary CT angiography.
Polomski EAS, Heemelaar JC, de Ronde MES, Al Jaff AAM, Mertens BJA, van Dijkman PRM, Jukema JW, Antoni ML
Background: Cancer and cancer treatment may accelerate the development of cardiovascular disease. With the improved prognosis of cancer survivors, cardiovascular events are increasing in this patient group. However, it is unknown whether the prevalence of coronary atherosclerosis is increased in patients with a history of cancer. This study aims to evaluate the prevalence and severity of coronary atherosclerosis in different age groups of cancer survivors compared to matched controls. Methods: C...
Abstract
Pharmacological research,
Volume 212, 9 2 2025, Pages 107575
GWAS of CRP response to statins further supports the role of APOE in statin response: A GIST consortium study.
Magavern EF, Deshmukh H, Asselin G, Theusch E, Trompet S, Li X, Noordam R, Chen YI, Seeman TE, Taylor KD, Post WS, Tardif JC, Paul DS, Benjamin EJ, Heard-Costa NL, Vasan RS, Rotter JI, Krauss RM, Jukema JW, Ridker PM, Munroe PB, Caulfield MJ, Chasman DI, Dubé MP, Hitman GA, Warren HR, Genomic Investigation of Statin Therapy Consortium (GIST)
Statins are first-line treatments in the primary and secondary prevention of cardiovascular disease. Clinical studies show statins act independently of lipid-lowering mechanisms to decrease C-reactive protein (CRP), an inflammation marker. We aim to elucidate genetic loci associated with CRP statin response. CRP statin response is the change in log-CRP between off-treatment and on-treatment measurements. Cohort-level Genome-Wide Association Studies (GWAS) of CRP response were performed using 100...
Abstract
JACC. Advances,
Volume 4, Issue 2, 8 2 2025, Pages 101535
Genetic Predisposition to Coronary Artery Disease: Evaluating Statin Therapy in Elder Populations From PROSPER.
Choi SH, Young R, Koyama S, Jukema JW, Trompet S, Ford I, Natarajan P, Peloso GM
Abstract
Langenbeck's archives of surgery,
Volume 410, Issue 1, 8 2 2025, Pages 28
Establishing reference curves for vital tissue perfusion using quantitative near-infrared fluorescence imaging with indocyanine green.
Tange FP, Peul RC, van den Hoven P, Koning S, Kruiswijk MW, Faber RA, Verduijn PS, van Rijswijk CSP, Galema HA, Hilling DE, van Dijk SPJ, van Ginhoven TM, Keereweer S, Mureau MAM, Feitsma EA, Noltes ME, Kruijff S, Driessen C, Achiam MP, Schepers A, van Schaik J, Mieog JSD, Vahrmeijer AL, Hamming JF, van der Vorst JR
Purpose: Assessment of tissue perfusion using near-infrared fluorescence (NIR) with indocyanine green (ICG) is gaining popularity, however reliable and objective interpretation remains a challenge. Therefore, this study aimed to establish reference curves for vital tissue perfusion across target tissues using this imaging modality. Methods: Data from five prospective study cohorts conducted in three Dutch academic medical centres between December 2018 and June 2023 was included. Quantitative ana...
Abstract
PloS one,
Volume 20, Issue 1, 8 2 2025, Pages e0313916
Decreased risk-proneness with increasing age in equally raised and kept wolves and dogs.
Jean-Joseph H, Kortekaas K, Range F, Kotrschal K
A basic mechanism of domestication is the selection for fearlessness and acceptance of humans as social partners, which may affect risk-taking behavior and the ability to use humans as social support, both at the behavioural and physiological levels. We combined behavioural observations with heart rate parameters (i.e., HR and heart rate variability, HRV) in equally raised and housed wolves and dogs to assess the responses to food offered in the vicinity of a potential stressor (an unknown spinn...
Abstract
