Publications
Below you can find a list of our published research.
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Below you can find a list of our published research.
7971 results
Cited 20 times since 2021 (4.7 per year) source: EuropePMC
ESC heart failure, Volume 8, Issue 2, 22 4 2021, Pages 1541-1551 Clinical and economic impact of HeartLogic™ compared with standard care in heart failure patients. Treskes RW, Beles M, Caputo ML, Cordon A, Biundo E, Maes E, Egorova AD, Schalij MJ, Van Bockstal K, Grazioli-Gauthier L, Vanderheyden M, Bartunek J, Auricchio A, Beeres SLMA, Heggermont WA
Aims: The implantable cardiac defibrillator/cardiac resynchronization therapy with defibrillator-based HeartLogic™ algorithm has recently been developed for early detection of impending decompensation in heart failure (HF) patients; but whether this novel algorithm can reduce HF hospitalizations has not been evaluated. We investigated if activation of the HeartLogic algorithm reduces the number of hospital admissions for decompensated HF in a 1 year post-activation period as compared with a 1 ye... Abstract
Cited 2 times since 2021 (0.5 per year) source: EuropePMC
European heart journal. Digital health, Volume 2, Issue 2, 22 4 2021, Pages 215-223 Potential of eHealth smart technology in optimization and monitoring of heart failure treatment in adults with systemic right ventricular failure. Nederend M, Zandstra TE, Kiès P, Jongbloed MRM, Vliegen HW, Treskes RW, Schalij MJ, Atsma DE, Egorova AD
Aims: Patients with a systemic right ventricle (sRV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA are prone to heart failure and arrhythmias. This study evaluated feasibility, patient adherence, and satisfaction of a smart technology-based care pathway for heart failure treatment optimization in these patients. Methods and results: Patients with symptomatic sRV failure eligible for initiation of sacubitril/valsartan were provided w... Abstract
Cited 2 times since 2021 (0.5 per year) source: EuropePMC
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, Volume 30, Issue 6, 19 3 2021, Pages 1605-1617 The impact of transvenous cardioverter-defibrillator implantation on quality of life, depression and optimism in dialysis patients: report on the secondary outcome of QOL in the randomized controlled ICD2 trial. Timal RJ, de Gucht V, Rotmans JI, Hensen LCR, Buiten MS, de Bie MK, Putter H, Schalij MJ, Rabelink TJ, Jukema JW
Rationale: The impact of prophylactic implantable cardioverter-defibrillator (ICD) implantation on the psychological well-being of patients on dialysis is unknown. Objective: We aimed to identify the effect of primary ICD implantation on quality of life (QoL), mood and dispositional optimism in patients undergoing dialysis. Methods and results: We performed a prespecified subanalysis of the randomized controlled ICD2 trial. In total, 177 patients on chronic dialysis, with an age of 55-81 years,... Abstract
Cited 6 times since 2021 (1.4 per year) source: EuropePMC
Trials, Volume 22, Issue 1, 19 3 2021, Pages 155 Intravenous immunoglobulin and intravenous methylprednisolone as optimal induction treatment in chronic inflammatory demyelinating polyradiculoneuropathy: protocol of an international, randomised, double-blind, placebo-controlled trial (OPTIC). Bus SRM, Zambreanu L, Abbas A, Rajabally YA, Hadden RDM, de Haan RJ, de Borgie CAJM, Lunn MP, van Schaik IN, Eftimov F, OPTIC study group
Background: International guidelines recommend either intravenous immunoglobulin (IVIg) or corticosteroids as first-line treatment for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). IVIg treatment usually leads to rapid improvement and is generally safe, but does not seem to lead to long-term remissions. Corticosteroids act more slowly and are associated with more side effects, but may induce long-term remissions. The hypothesis of this study is that combined IVIg and corticos... Abstract
Cited 5 times since 2021 (1.2 per year) source: EuropePMC
Frontiers in immunology, Volume 11, 19 3 2021, Pages 609624 Characterization and Monitoring of Antigen-Responsive T Cell Clones Using T Cell Receptor Gene Expression Analysis. Pollastro S, de Bourayne M, Balzaretti G, Jongejan A, van Schaik BDC, Niewold ITG, van Kampen AHC, Maillère B, de Vries N
High-throughput T-cell receptor repertoire sequencing constitutes a powerful tool to study T cell responses at the clonal level. However, it does not give information on the functional phenotype of the responding clones and lacks a statistical framework for quantitative evaluation. To overcome this, we combined datasets from different experiments, all starting from the same blood samples. We used a novel, sensitive, UMI-based protocol to perform repertoire analysis on experimental replicates. Ap... Abstract
Cited 3 times since 2021 (0.7 per year) source: EuropePMC
International journal of molecular sciences, Volume 22, Issue 4, 18 3 2021, Pages 2010 BMP Receptor Inhibition Enhances Tissue Repair in Endoglin Heterozygous Mice. Bakker W, Dingenouts CKE, Lodder K, Wiesmeijer KC, de Jong A, Kurakula K, Mager HJ, Smits AM, de Vries MR, Quax PHA, Goumans MJTH
Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a severe vascular disorder caused by mutations in the TGFβ/BMP co-receptor endoglin. Endoglin haploinsufficiency results in vascular malformations and impaired neoangiogenesis. Furthermore, HHT1 patients display an impaired immune response. To date it is not fully understood how endoglin haploinsufficient immune cells contribute to HHT1 pathology. Therefore, we investigated the immune response during tissue repair in Eng+/- mice, a model for... Abstract
Cited 11 times since 2021 (2.6 per year) source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 29, Issue 4, 18 3 2021, Pages 224-229 Emergency medical services evaluations for chest pain during first COVID-19 lockdown in Hollands-Midden, the Netherlands. de Koning ER, Boogers MJ, Bosch J, de Visser M, Schalij MJ, Beeres SLMA
Objective: To assess whether the COVID-19 lockdown in 2020 had negative indirect health effects, as people seem to have been reluctant to seek medical care. Methods: All emergency medical services (EMS) transports for chest pain or out-of-hospital cardiac arrest (OHCA) in the Dutch region Hollands-Midden (population served > 800,000) were evaluated during the initial 6 weeks of the COVID-19 lockdown and during the same time period in 2019. The primary endpoint was the number of evaluated ches... Abstract
JACC. Case reports, Volume 3, Issue 2, 17 3 2021, Pages 217-219 Björk-Fontan and the Restoration of Right-Sided Conduits. de Winter RJ, Koolbergen DR
Cited 3 times since 2021 (0.7 per year) source: EuropePMC
PloS one, Volume 16, Issue 2, 17 3 2021, Pages e0246455 A randomised experiment of health, cost and social norm message frames to encourage acceptance of swaps in a simulation online supermarket. Bunten A, Porter L, Sanders JG, Sallis A, Payne Riches S, Van Schaik P, González-Iraizoz M, Chadborn T, Forwood S
Offering lower-energy food swaps to customers of online supermarkets could help to decrease energy (kcal) purchased and consumed. However, acceptance rates of such food swaps tend to be low. This study aimed to see whether framing lower-energy food swaps in terms of cost savings or social norms could improve likelihood of acceptance relative to framing swaps in terms of health benefits. Participants (n = 900) were asked to shop from a 12-item shopping list in a simulation online supermarket. Whe... Abstract
Cited 6 times since 2021 (1.4 per year) source: EuropePMC
Pediatric diabetes, Volume 22, Issue 4, 16 3 2021, Pages 618-624 Bedside sonographic measurements of optic nerve sheath diameter in children with diabetic ketoacidosis. Şık N, Erbaş İM, Demir K, Yılmaz D, Duman M
Background: Bedside sonographic assessment of the optic nerve sheath has gained popularity for evaluating intracranial pressure in recent years. Objective: To investigate the bedside sonographic measurements of optic nerve sheath diameter (ONSD) and ONSD/eyeball diameter ratios, which are related with cerebral edema (CE), in children with diabetic ketoacidosis (DKA) before and after treatment. Methods: Children aged 12 months to 18 years, who were diagnosed with DKA were included. The ONSD was m... Abstract
Cited 39 times since 2021 (9.1 per year) source: EuropePMC
Archives of orthopaedic and trauma surgery, Volume 142, Issue 8, 15 3 2021, Pages 1775-1791 Safety and efficacy of outpatient hip and knee arthroplasty: a systematic review with meta-analysis. Bemelmans YFL, Keulen MHF, Heymans M, van Haaren EH, Boonen B, Schotanus MGM
Introduction: This systematic review aimed to assess the safety and efficacy of outpatient joint arthroplasty (OJA) pathways compared to inpatient pathways. Materials and methods: An electronic literature search was conducted to identify eligible studies. Studies comparing OJA with inpatient pathways-following hip and/or (partial) knee arthroplasty-were included. Included studies were assigned-based on OJA definition-to one of the following two groups: (1) outpatient surgery (OS); outpatient def... Abstract
Cited 5 times since 2021 (1.2 per year) source: EuropePMC
Sensors (Basel, Switzerland), Volume 21, Issue 4, 15 3 2021, Pages 1361 Early Detection of Fluid Retention in Patients with Advanced Heart Failure: A Review of a Novel Multisensory Algorithm, HeartLogic<sup>TM</sup>. Feijen M, Egorova AD, Beeres SLMA, Treskes RW
Heart failure (HF) hospitalisations due to decompensation are associated with shorter life expectancy and lower quality of life. These hospitalisations pose a significant burden on the patients, doctors and healthcare resources. Early detection of an upcoming episode of decompensation may facilitate timely optimisation of the ambulatory medical treatment and thereby prevent heart-failure-related hospitalisations. The HeartLogicTM algorithm combines data from five sensors of cardiac implantable e... Abstract
Cited 5 times since 2021 (1.2 per year) source: EuropePMC
Forensic science international, Volume 321, 13 2 2021, Pages 110722 Measuring calibration of likelihood-ratio systems: A comparison of four metrics, including a new metric devPAV. Vergeer P, van Schaik Y, Sjerps M
Numerical likelihood-ratio (LR) systems aim to calculate evidential strength for forensic evidence evaluation. Calibration of such LR-systems is essential: one does not want to over- or understate the strength of the evidence. Metrics that measure calibration differ in sensitivity to errors in calibration of such systems. In this paper we compare four calibration metrics by a simulation study based on Gaussian Log LR-distributions. Three calibration metrics are taken from the literature (Good, 1... Abstract
Cited 2 times since 2021 (0.5 per year) source: EuropePMC
The Annals of thoracic surgery, Volume 112, Issue 4, 13 2 2021, Pages e237-e239 Pneumothorax Due to a Nontraumatic Thoracic Wall Rupture Due to Steroid-Induced Muscle Wasting. van Schaik E, Ramnarain D, Pouwels S
Spontaneous pneumothorax can be classified into primary and secondary variants. A 58-year-old patient presented with a 7-week history of severe coughing and chest pain. He noticed progressive swelling of the face and the upper part of the body. His medical history revealed osteoporosis and severe rheumatoid arthritis treated with steroids and disease-modifying antirheumatic drugs. Computed tomography of the thorax revealed complete rupture of the thoracic wall through costae 9 and 10 with lung h... Abstract
Cited 19 times since 2021 (4.4 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 8, 12 2 2021, Pages 631985 Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem. Meerman M, Bracco Gartner TCL, Buikema JW, Wu SM, Siddiqi S, Bouten CVC, Grande-Allen KJ, Suyker WJL, Hjortnaes J
Radiation-induced cardiovascular disease is a well-known complication of radiation exposure. Over the last few years, planning for deep space missions has increased interest in the effects of space radiation on the cardiovascular system, as an increasing number of astronauts will be exposed to space radiation for longer periods of time. Research has shown that exposure to different types of particles found in space radiation can lead to the development of diverse cardiovascular disease via fibro... Abstract
Cited 7 times since 2021 (1.6 per year) source: EuropePMC
BMJ open, Volume 11, Issue 2, 12 2 2021, Pages e041553 Prehospital triage of patients with acute cardiac complaints: study protocol of HART-c, a multicentre prospective study. de Koning E, Biersteker TE, Beeres S, Bosch J, Backus BE, Kirchhof CJ, Alizadeh Dehnavi R, Silvius HA, Schalij M, Boogers MJ
Introduction: Emergency department (ED) overcrowding is a major healthcare problem associated with worse patient outcomes and increased costs. Attempts to reduce ED overcrowding of patients with cardiac complaints have so far focused on in-hospital triage and rapid risk stratification of patients with chest pain at the ED. The Hollands-Midden Acute Regional Triage-Cardiology (HART-c) study aimed to assess the amount of patients left at home in usual ambulance care as compared with the new prehos... Abstract
Cited 17 times since 2021 (4 per year) source: EuropePMC
Cancers, Volume 13, Issue 4, 12 2 2021, Pages 771 Clinical <i>CYP2D6</i> Genotyping to Personalize Adjuvant Tamoxifen Treatment in ER-Positive Breast Cancer Patients: Current Status of a Controversy. Mulder TAM, de With M, Del Re M, Danesi R, Mathijssen RHJ, van Schaik RHN
Tamoxifen is a major option for adjuvant endocrine treatment in estrogen receptor (ER) positive breast cancer patients. The conversion of the prodrug tamoxifen into the most active metabolite endoxifen is mainly catalyzed by the enzyme cytochrome P450 2D6 (CYP2D6). Genetic variation in the CYP2D6 gene leads to altered enzyme activity, which influences endoxifen formation and thereby potentially therapy outcome. The association between genetically compromised CYP2D6 activity and low endoxifen pla... Abstract
Cited 9 times since 2021 (2.1 per year) source: EuropePMC
Journal of magnetic resonance imaging : JMRI, Volume 54, Issue 2, 10 2 2021, Pages 411-420 Quantification of Myocardial Creatine and Triglyceride Content in the Human Heart: Precision and Accuracy of in vivo Proton Magnetic Resonance Spectroscopy. Bakermans AJ, Boekholdt SM, de Vries DK, Reckman YJ, Farag ES, de Heer P, Uthman L, Denis SW, Zuurbier CJ, Houtkooper RH, Koolbergen DR, Kluin J, Planken RN, Lamb HJ, Webb AG, Strijkers GJ, Beard DA, Jeneson JAL, Nederveen AJ
Background: Proton magnetic resonance spectroscopy (1 H-MRS) of the human heart is deemed to be a quantitative method to investigate myocardial metabolite content, but thorough validations of in vivo measurements against invasive techniques are lacking. Purpose: To determine measurement precision and accuracy for quantifications of myocardial total creatine and triglyceride content with localized 1 H-MRS. Study type: Test-retest repeatability and measurement validation study. Subjects: Sixteen v... Abstract
Cited 29 times since 2021 (6.7 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 14, Issue 6, 10 2 2021, Pages 1085-1095 Prognostic Implications of a Novel Algorithm to Grade Secondary Tricuspid Regurgitation. Fortuni F, Dietz MF, Prihadi EA, van der Bijl P, De Ferrari GM, Knuuti J, Bax JJ, Delgado V, Marsan NA
Objectives: A novel tricuspid regurgitation (TR) grading system, using vena contracta (VC) width and effective regurgitant orifice area (EROA), was proposed and validated based on its prognostic usefulness. Background: The clinical need of a new grading system for TR has recently been emphasized to depict the whole spectrum of TR severity, particularly beyond severe TR (massive or torrential). Methods: TR severity was characterized in 1,129 patients with moderate or severe secondary TR (STR). Re... Abstract
Cited 9 times since 2021 (2.1 per year) source: EuropePMC
Frontiers in cardiovascular medicine, Volume 8, 9 2 2021, Pages 638487 Multi-Modality Imaging for Interventions in Tricuspid Valve Disease. Fortuni F, Hirasawa K, Bax JJ, Delgado V, Ajmone Marsan N
Several studies have demonstrated that severe tricuspid regurgitation (TR) has a significant negative impact on morbidity and mortality. Nowadays, several therapeutic options to treat TR are available and patients at high surgical risk can also be treated with transcatheter procedures. For the management of patients with TR, an accurate assessment of the tricuspid valve and its surrounding structures is therefore of crucial importance and has gained significant interest in the medical community.... Abstract