6197 results
Family practice,
Volume 42, Issue 2, 1 1 2025, Pages cmae045
The effect and implementation of the COVID Box, a remote patient monitoring system for patients with a COVID-19 infection in primary care: a matched cohort study.
van Hattem NE, Mijnsbergen NJ, van Os HJA, Mertens BA, Eekhof JAH, Chavannes NH, Atsma DE, Bonten TN
At the onset of the COVID-19 pandemic, the pressure on hospitals increased tremendously. To alleviate this pressure, a remote patient monitoring system called the COVID Box was developed and implemented in primary care. The aim was to assess whether the COVID Box in primary care could reduce emergency department (ED) referrals due to a COVID-19 infection. A matched cohort study was performed between December 2020 and June 2021. Patients with a COVID-19 infection in need of intensive monitoring b...
Abstract
Cited 1 times since 2025 (3.8 per year)
source: EuropePMC
European journal of endocrinology,
Volume 192, Issue 2, 1 1 2025, Pages S1-S14
The effect of first intervention on cardiac parameters in patients with acromegaly: a systematic review.
Huynh KA, Al-Gully J, Montero-Cabezas JM, Scheffers LE, Verstegen MJT, Biermasz NR, Coopmans EC
Objective: Cardiovascular disease in acromegaly patients remains a major cause of morbidity and all-cause mortality. This systematic review investigates the effect of the first growth hormone-lowering intervention on cardiac parameters. Design: Systematic review. Methods: Studies evaluating cardiac parameters following the first intervention in acromegaly published up to February, 25, 2022 were included in this systematic review. Risk of bias was assessed using a modified Newcastle-Ottawa Scale...
Abstract
Cited 1 times since 2025 (3.8 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 2, 1 1 2025, Pages euaf003
Evoked delayed potential ablation for post-myocardial infarction ventricular tachycardia: results from a large prospective multicentre study.
de Riva M, Evertz R, Lukac P, Dekker LRC, Blaauw Y, Ter Bekke RMA, Kimura Y, Beukema RJ, Ouss A, Mulder BA, Vernooy K, Wijnmaalen AP, Zeppenfeld K
Aims: The optimal substrate ablation approach for post-myocardial infarction (MI) ventricular tachycardia (VT) is unknown. Proposed ablation targets are prone to individual interpretation making the ablation outcome potentially operator dependent. Evoked delayed potentials (EDPs) are a well-defined target. Evoked delayed potential ablation was effective in preventing post-MI VT recurrence in a prior study. The aims of this study were to assess long-term outcomes of EDP ablation in a large multic...
Abstract
Family practice,
Volume 42, Issue 2, 1 1 2025, Pages cmae050
Patient preferences for conservative treatment of shoulder pain: a discrete choice experiment.
Versloot AHC, Veldwijk J, Ottenheijm RPG, de Graaf M, van der Windt DA, Koes BW, Runhaar J, Schiphof D
Background: Shoulder pain is common amongst adults, but little is known about patients' preferences. Objective: The aim of this study was to determine patients' preferences for treatment options offered for shoulder pain in primary care. Methods: A discrete choice experiment was used to investigate these preferences. Adults with shoulder pain were asked to make 12 choices between two treatment options, or to opt-out. The attributes of the 12 treatment options were presented as varying...
Abstract
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology,
Volume 36, Issue 2, 1 1 2025, Pages e70040
Ocular surface disease in pediatric patients with moderate-to-severe atopic dermatitis.
van der Rijst LP, Veldhuis N, van der Kamp S, Achten RE, van Luijk CM, Voskuil-Kerkhof ESM, Haeck IM, de Bruin-Weller MS, de Graaf M
Abstract
Health education research,
Volume 40, Issue 2, 1 1 2025, Pages cyaf001
Implementation of a complex eHealth intervention by a public-private partnership in clinical practice: a qualitative multicentre analysis using CFIR.
IJzerman RVH, van der Vaart R, Breeman LD, Kraaijenhagen RA, Evers AWM, Scholte Op Reimer WJM, Janssen VR
Complex eHealth interventions-featuring multiple components within dynamic systems-are used for healthcare improvement. Public-private partnerships (PPPs), combining resources, expertise, and technology, are crucial in this context. Yet, integrating these interventions into practice remains challenging. This study identifies barriers and facilitators affecting implementation of the BENEFIT programme, a complex eHealth intervention targeting cardiovascular disease patients, by PPP within practice...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 67, Issue 2, 1 1 2025, Pages ezae442
Perioperative extracorporeal membrane oxygenation in neonates with transposition of the great arteries: 15 years of experience.
Weeda JA, Van Der Palen RLF, Bunker-Wiersma HE, Koers L, Van Es E, Hazekamp MG, Te Pas AB, Roeleveld PP
Objectives: Extracorporeal membrane oxygenation (ECMO) can act as a bridge to recovery in both pre- and postoperative patients with transposition of the great arteries (TGA). However, literature on its use in these patients is scarce. Methods: Retrospective single-centre cohort study encompassing all TGA patients who received ECMO between January 2009 and March 2024. Results: Twenty-two neonates received ECMO during the study period, with an overall median age and weight at time of ECMO cannulat...
Abstract
Molecular biology reports,
Volume 52, Issue 1, 31 5 2025, Pages 180
Upregulation of the MAP2K4 gene triggers endothelial-mesenchymal transition in COVID-19.
Yilmaz E, Yilmaz D, Yildiz CG, Cacan E
Background: SARS-CoV-2 infection is marked by an excessive inflammatory response, leading to elevated production of pro-inflammatory cytokines through activation of intracellular pathways like mitogen-activated protein kinase (MAPK). Viruses can use the MAPK signaling pathway to their advantage, but the relationship of this pathway to the severe SARS-CoV-2 period has not been fully elucidated. MAP2K4 is involved in the MAPK signaling pathway and affects cellular processes such as cell-cell junct...
Abstract
Open heart,
Volume 12, Issue 1, 30 5 2025, Pages e003009
Sacubitril/valsartan is associated with improvements in quality of life in adult congenital heart disease patients with systemic right ventricular failure.
Neijenhuis RML, Nederend M, van Groningen AE, Jongbloed MRM, Vliegen HW, Jukema JW, Kiès P, Egorova AD
Background: Short-term improvements in quality of life (QOL) have been reported in adult congenital heart disease patients with systemic right ventricle (sRV) failure after treatment with sacubitril/valsartan. This study aimed to evaluate the medium-term QOL changes in sRV failure patients treated with sacubitril/valsartan. Methods: In this single-centre, prospective cohort study, patients with symptomatic sRV failure completed the Netherlands Organisation for Applied Scientific Research/Academi...
Abstract
Clinical and translational radiation oncology,
Volume 52, 29 5 2025, Pages 100927
Effect of FLASH proton therapy on primary bronchial epithelial cell organoids.
Kuipers ME, van Liefferinge F, van der Wal E, Rovituso M, Slats AM, Hiemstra PS, Van Doorn-Wink KCJ
Purpose: The effects of conventional (CONV) and FLASH proton therapy on primary bronchial epithelial cell (PBEC) organoids from individuals with chronic obstructive pulmonary disease (COPD) were investigated. The primary objective was to compare the effect of FLASH and CONV on COPD PBEC organoids with a focus on DNA damage, organoid formation, and gene expression. Methods: PBECs were obtained from six COPD donors, cultured as three-dimensional (3D) organoids and exposed to 2 and 8 Gy CONV and FL...
Abstract
Cited 1 times since 2025 (3.6 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 14, Issue 3, 28 4 2025, Pages 859
From Survival to Recovery: Understanding the Life Impact of an Acute Aortic Dissection Through Activity, Sleep, and Quality of Life.
Bacour N, Grewal S, Theijsse RT, Klautz RJM, Grewal N
Background/Objectives: An acute aortic dissection (AAD) is a cardiovascular emergency with high mortality rates if left untreated. Survival has increased due to improvements in diagnosis and therapy. However, during their recovery, survivors frequently encounter major social, psychological, and physical challenges. This study aimed to evaluate the recovery experience of AAD survivors in The Netherlands. Insights on sleep quality, physical activity, and quality of life were collected from a uniqu...
Abstract
JTCVS techniques,
Volume 30, 28 4 2025, Pages 81-93
Intraoperative assessment of myocardial perfusion using near-infrared fluorescence and indocyanine green: A literature review.
Peul RC, Kharbanda RK, Koning S, Kruiswijk MW, Tange FP, van den Hoven P, Vahrmeijer AL, Klautz RJM, Hamming JF, Hjortnaes J, van der Vorst JR
Background: Coronary artery bypass grafting (CABG) is among the most commonly performed major surgical procedures worldwide. While flow measurements help assess graft patency during surgery, there are limited tools available for surgeons to objectively evaluate myocardial perfusion after graft placement. Near-infrared fluorescence (NIRF) imaging shows promise in this area, offering real-time visualization of flow and perfusion without the need for radiation or nephrotoxic contrast agents. This r...
Abstract
Journal of the European Academy of Dermatology and Venereology : JEADV,
22 4 2025
Increasing dosing intervals for biologics in atopic dermatitis-why, who, when and how?
Jacobson ME, Boesjes CM, de Bruin-Weller MS, de Graaf M, Morimoto RY, Simpson EL
Biologics approved and in development for atopic dermatitis offer life-changing clinical efficacy with a relatively banal long-term safety profile requiring no laboratory monitoring. Biologic therapies also have their drawbacks, including high payor cost and the need to be administered as every other week subcutaneous injections. Addressing these concerns, studies of longer dosing intervals have been performed in the formal clinical trial setting and during real-world clinical care. Here, we rev...
Abstract
Vascular medicine (London, England),
Volume 30, Issue 2, 21 3 2025, Pages 250-260
Prognostic performance of bedside tests for predicting ulcer healing and wound healing after minor amputation in patients prone to medial arterial calcification: A systematic review.
Willems SA, Nieuwstraten JA, Schepers A, van Schaik J, van den Hoven P, van der Vorst JR, Hamming JF, Brouwers JJ
Foot ulceration is a significant and growing health problem worldwide, particularly due to rises in diabetes mellitus (DM) and peripheral artery disease. The prediction of ulcer healing remains a major challenge. In patients with foot ulcers, medial arterial calcification (MAC) can be present as a result of concomitant DM or chronic kidney disease and is a prognostic factor for unfavorable outcome. This systematic review aimed to evaluate the prognostic reliability of bedside tests to predict ul...
Abstract
Open heart,
Volume 12, Issue 1, 21 3 2025, Pages e003055
Prognostic role of con-/discordant coronary flow reserve and microvascular resistance in coronary microvascular disease: a systematic review and network meta-analysis.
Al-Gully J, Oliveri F, Forouzanfar JP, Montero-Cabezas JM, Jukema JW, den Haan MC, Al Amri I, Bingen BO
Background: Coronary microvascular disease (CMD) is defined as impaired coronary flow reserve (CFR) and/or increased microvascular resistance (MR) without significant epicardial coronary stenosis. This definition allows for discordant CFR and MR values within patients with CMD. The aim of this meta-analysis is to characterise the prognostic value and pathophysiological backgrounds of CFR and MR con-/discordance. Methods: A systematic search (PROSPERO CRD42024573004) identified studies determinin...
Abstract
International journal of cardiology,
Volume 423, 21 3 2025, Pages 132996
Intravascular lithotripsy in calcified left main coronary artery: Procedural success and 1-year clinical outcomes.
Oliveri F, van Oort MJH, Phagu AAS, Al Amri I, Bingen BO, Claessen BEPM, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Intravascular lithotripsy (IVL) has an excellent efficacy and safety profile in the treatment of calcified coronary lesions during percutaneous coronary intervention (PCI). However, data regarding its use on left main (LM) lesions are still limited. Objective: We aimed to analyze the technical success and 1-year clinical outcomes in calcified LM lesions treated with IVL. Methods: Patients who underwent IVL from the ongoing prospective BENELUX registry were eligible for inclusion. Pat...
Abstract
Cited 1 times since 2025 (3.4 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 33, Issue 3, 20 3 2025, Pages 93-102
Symptomatic early coronary graft failure in bypass surgery patients: incidence, predictors and clinical impact.
van Oort MJH, Al Amri I, de Weger A, Regeer MV, Jukema JW, Mertens BJA, Montero-Cabezas JM
Objectives: Coronary graft failure (CGF) may occur early after coronary bypass graft surgery (CABG). The study aimed to identify clinical and perioperative risk factors and to evaluate the long-term clinical impact of symptomatic early CGF. Methods: Patients who underwent clinically indicated coronary angiography (CAG) prior to post-CABG discharge between 2012 and 2022 were included. Symptomatic early CGF was defined as a dysfunctional coronary graft, evaluated on clinically indicated CAG, cause...
Abstract
Rheumatology advances in practice,
Volume 9, Issue 1, 20 3 2025, Pages rkaf010
Anti-citrullinated protein antibody detection by hemagglutination.
Kruis I, Kumari J, van der Heijden A, Weijn A, Vree Egberts W, Peeters IR, van Herwaarden N, Salden M, Pruijn GJM
Objectives: ACPAs play an important role in the classification of RA and can be detected by serological tests. Several ACPA detection assays are available for clinical use, which are all based on ELISA(-like) tests with citrullinated peptides (CCP2) or alternative citrullinated proteins/peptides. We aimed to facilitate ACPA detection in low-volume laboratories and resource-poor environments by developing a rapid and easy-to-perform test. Methods: We designed and generated an agglutination mediat...
Abstract
Respiratory research,
Volume 26, Issue 1, 18 3 2025, Pages 20
Radiation decreases bronchial epithelial progenitor function as assessed by organoid formation.
Kuipers ME, Ninaber DK, van Doorn-Wink KCJ, Slats AM, Hiemstra PS
Objective: Radiation-induced lung injury (RILI) is a serious side-effect of radiotherapy for lung cancer, in which effects on the normal lung epithelium may play a key role. Since these effects are incompletely understood, the aim of the present study was to evaluate the effect of ionizing radiation (IR) on cultured well-differentiated primary bronchial epithelial cells (PBEC) with a focus on cytotoxicity, barrier formation, inflammation and epithelial progenitor function. Materials and methods:...
Abstract
Brain : a journal of neurology,
16 3 2025, Pages awaf011
N-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference.
Weilnhammer V, Rothkirch M, Yilmaz D, Fritsch M, Ptasczynski LE, Reichenbach K, Rödiger L, Corlett P, Sterzer P
Perception integrates external sensory signals with internal predictions that reflect prior knowledge about the world. Previous research suggests that this integration is governed by slow alternations between an external mode, driven by sensory signals, and an internal mode, shaped by prior knowledge. Using a double-blind, placebo-controlled, cross-over experiment in healthy human participants, we investigated the effects of the N-Methyl-D-aspartate receptor (NMDAR) antagonist S-ketamine on the...
Abstract
