6190 results
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
NPJ microgravity,
Volume 8, Issue 1, 17 3 2022, Pages 36
The influence of interparticle cohesion on rebounding slow impacts on rubble pile asteroids.
Joeris K, Schönau L, Keulen M, Born P, Kollmer JE
The ballistic sorting effect has been proposed to be a driver behind the observed size sorting on the rubble pile asteroid Itokawa. This effect depends on the inelasticity of slow collisions with granular materials. The inelasticity of a collision with a granular material, in turn, depends on grain size. Here we argue that determining the inelasticity of such collisions in an asteroid-like environment is a nontrivial task. We show non-monotonic dependency of the coefficient of restitution (COR)...
Abstract
Cited 4 times since 2022 (1.5 per year)
source: EuropePMC
European heart journal. Case reports,
Volume 6, Issue 8, 16 3 2022, Pages ytac345
Anomalous coronary artery from the pulmonary artery diagnosed in adulthood: a case series on variations of coronary anatomy and the diagnostic value of cardiac magnetic resonance imaging.
Talebian Yazdi M, Robbers-Visser D, van der Bilt IAC, Boekholdt SM, Koolbergen DR, Planken RN, Groenink M
Background: Anomalous coronary artery from the pulmonary artery is a rare congenital disorder with high mortality rates in infancy. Adult cases can present with life-threatening arrhythmias and sudden cardiac death. Case summary: We report three cases of adults with anomalous pulmonary origin of each of the main coronary branches. The first patient with an anomalous left coronary artery from the pulmonary artery presented with an out-of-hospital cardiac arrest. The second patient with an anomalo...
Abstract
Cited 4 times since 2022 (1.5 per year)
source: EuropePMC
Journal of pediatric hematology/oncology,
Volume 45, Issue 3, 16 3 2022, Pages e298-e303
Roles of Vitamin-K-dependent Factors Protein S and GAS6 With TAM Receptors and HMGB1 in Pediatric COVID-19 Disease.
Şik N, Duman M, Küme T, Gürsoy Doruk Ö, Yilmaz D, Ören H
Objective: This study was designed to evaluate serum high-mobility group box 1 (HMGB1), protein S (PS), growth arrest-specific gene 6 (GAS6), and TAM receptor (TYRO3, AXL, and MERTK) levels in children with COVID-19 disease. Methods: A prospective case-control study was conducted in our pediatric emergency department and 57 patients with SARS-CoV-2 polymerase chain reaction (PCR) positivity, 6 patients with multisystem inflammatory syndrome in children (MIS-C), and 17 healthy children were inclu...
Abstract
Cited 10 times since 2022 (3.7 per year)
source: EuropePMC
Molecular psychiatry,
Volume 27, Issue 11, 16 3 2022, Pages 4419-4431
Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.
Lahti J, Tuominen S, Yang Q, Pergola G, Ahmad S, Amin N, Armstrong NJ, Beiser A, Bey K, Bis JC, Boerwinkle E, Bressler J, Campbell A, Campbell H, Chen Q, Corley J, Cox SR, Davies G, De Jager PL, Derks EM, Faul JD, Fitzpatrick AL, Fohner AE, Ford I, Fornage M, Gerring Z, Grabe HJ, Grodstein F, Gudnason V, Simonsick E, Holliday EG, Joshi PK, Kajantie E, Kaprio J, Karell P, Kleineidam L, Knol MJ, Kochan NA, Kwok JB, Leber M, Lam M, Lee T, Li S, Loukola A, Luck T, Marioni RE, Mather KA, Medland S, Mirza SS, Nalls MA, Nho K, O'Donnell A, Oldmeadow C, Painter J, Pattie A, Reppermund S, Risacher SL, Rose RJ, Sadashivaiah V, Scholz M, Satizabal CL, Schofield PW, Schraut KE, Scott RJ, Simino J, Smith AV, Smith JA, Stott DJ, Surakka I, Teumer A, Thalamuthu A, Trompet S, Turner ST, van der Lee SJ, Villringer A, Völker U, Wilson RS, Wittfeld K, Vuoksimaa E, Xia R, Yaffe K, Yu L, Zare H, Zhao W, Ames D, Attia J, Bennett DA, Brodaty H, Chasman DI, Goldman AL, Hayward C, Ikram MA, Jukema JW, Kardia SLR, Lencz T, Loeffler M,
Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyse...
Abstract
Cited 6 times since 2022 (2.2 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 36, Issue 2, 14 2 2022, Pages 163-171
Effects of Atrial Ischemia on Left Atrial Remodeling in Patients with ST-Segment Elevation Myocardial Infarction.
Montero-Cabezas JM, Abou R, Chimed S, Fortuni F, Goedemans L, Ajmone Marsan N, Bax JJ, Delgado V
Background: Adverse left atrial (LA) remodeling after ST-segment elevation myocardial infarction (STEMI) has been associated with poor prognosis. Flow impairment in the dominant coronary atrial branch (CAB) may affect large areas of LA myocardium, potentially leading to adverse LA remodeling during follow-up. The aim of this study was to assess echocardiographic LA remodeling in patients with STEMI with impaired coronary flow in the dominant CAB. Methods: Of 897 patients with STEMI, 69 patients...
Abstract
Cited 12 times since 2022 (4.4 per year)
source: EuropePMC
Prehospital and disaster medicine,
Volume 37, Issue 5, 11 2 2022, Pages 600-608
Managing Hospital Capacity: Achievements and Lessons from the COVID-19 Pandemic.
de Koning ER, Boogers MJ, Beeres SL, Kramer ID, Dannenberg WJ, Schalij MJ
Introduction: The coronavirus disease 2019 (COVID-19) pandemic challenged health care systems in an unprecedented way. Due to the enormous amount of hospital ward and intensive care unit (ICU) admissions, regular care came to a standstill, thereby overcrowding ICUs and endangering (regular and COVID-19-related) critical care. Acute care coordination centers were set up to safely manage the influx of COVID-19 patients. Furthermore, treatments requiring ICU surveillance were postponed leading to i...
Abstract
Cited 6 times since 2022 (2.2 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 108, Issue 17, 11 2 2022, Pages 1401-1407
Prognostic implications of left ventricular diastolic dysfunction in moderate aortic stenosis.
Stassen J, Ewe SH, Butcher SC, Amanullah MR, Mertens BJ, Hirasawa K, Singh GK, Sin KY, Ding ZP, Pio SM, Sia CH, Chew N, Kong W, Poh KK, Cohen D, Généreux P, Leon MB, Ajmone Marsan N, Delgado V, Bax JJ
Objective: To investigate the prognostic impact of left ventricular (LV) diastolic dysfunction in patients with moderate aortic stenosis (AS) and preserved LV systolic function. Methods: Patients with a first diagnosis of moderate AS (aortic valve area >1.0 and ≤1.5 cm2) and preserved LV systolic function (LV ejection fraction ≥50%) were identified. LV diastolic function was evaluated using echocardiographic criteria according to the 2016 American Society of Echocardiography/European Associat...
Abstract
The international journal of cardiovascular imaging,
Volume 38, Issue 10, 8 2 2022, Pages 2141-2142
Progression of moderate to severe aortic stenosis: new insights into cardiac remodeling.
Stassen J, Singh GK, Butcher SC, Hirasawa K, Marsan NA, Delgado V, Bax JJ
Abstract
Cited 3 times since 2022 (1.1 per year)
source: EuropePMC
Frontiers in immunology,
Volume 13, 5 1 2022, Pages 958952
A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria.
Kreft L, Schepers A, Hils M, Swiontek K, Flatley A, Janowski R, Mirzaei MK, Dittmar M, Chakrapani N, Desai MS, Eyerich S, Deng L, Niessing D, Fischer K, Feederle R, Blank S, Schmidt-Weber CB, Hilger C, Biedermann T, Ohnmacht C
The alpha-Gal epitope (α-Gal) with the determining element galactose-α1,3-galactose can lead to clinically relevant allergic reactions and rejections in xenotransplantation. These immune reactions can develop because humans are devoid of this carbohydrate due to evolutionary loss of the enzyme α1,3-galactosyltransferase (GGTA1). In addition, up to 1% of human IgG antibodies are directed against α-Gal, but the stimulus for the induction of anti-α-Gal antibodies is still unclear. Commensal bacteri...
Abstract
Cited 4 times since 2022 (1.5 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 11, Issue 16, 5 1 2022, Pages e024168
Revealing Unforeseen Diagnostic Image Features With Deep Learning by Detecting Cardiovascular Diseases From Apical 4-Chamber Ultrasounds.
Cheng LH, Bosch PBJ, Hofman RFH, Brakenhoff TB, Bruggemans EF, van der Geest RJ, Holman ER
Background With the increase of highly portable, wireless, and low-cost ultrasound devices and automatic ultrasound acquisition techniques, an automated interpretation method requiring only a limited set of views as input could make preliminary cardiovascular disease diagnoses more accessible. In this study, we developed a deep learning method for automated detection of impaired left ventricular (LV) function and aortic valve (AV) regurgitation from apical 4-chamber ultrasound cineloops and inve...
Abstract
Cited 7 times since 2022 (2.6 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 11, Issue 16, 5 1 2022, Pages e024581
von Willebrand Factor: A Central Regulator of Arteriovenous Fistula Maturation Through Smooth Muscle Cell Proliferation and Outward Remodeling.
Laboyrie SL, de Vries MR, de Jong A, de Boer HC, Lalai RA, Martinez L, Vazquez-Padron RI, Rotmans JI
Background Arteriovenous fistula (AVF) maturation failure is a main limitation of vascular access. Maturation is determined by the intricate balance between outward remodeling and intimal hyperplasia, whereby endothelial cell dysfunction, platelet aggregation, and vascular smooth muscle cell (VSMC) proliferation play a crucial role. von Willebrand Factor (vWF) is an endothelial cell-derived protein involved in platelet aggregation and VSMC proliferation. We investigated AVF vascular remodeling i...
Abstract
Cited 2 times since 2022 (0.7 per year)
source: EuropePMC
Current cardiology reports,
Volume 24, Issue 10, 4 1 2022, Pages 1407-1416
Focus on Diagnosis and Prognosis to Guide Timing of Intervention in Valvular Heart Disease.
Stassen J, Galloo X, van der Bijl P, Bax JJ
Purpose of review: The present article reviews the role of multimodality imaging to improve risk stratification and timing of intervention in patients with valvular heart disease (VHD), and summarizes the latest developments in transcatheter valve interventions. Recent findings: Growing evidence suggests that intervention at an earlier stage may improve outcomes of patients with significant VHD. Multimodality imaging, including strain imaging and tissue characterization with cardiac magnetic res...
Abstract
Cited 2 times since 2022 (0.7 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 62, Issue 3, 1 1 2022, Pages ezac401
Obesity and outcomes after left ventricular assist device implantation: insights from the EUROMACS Registry.
Angleitner P, Kaider A, De By TMMH, Dimitrov K, Schlöglhofer T, Tops LF, Fiane AE, Rábago G, Laufer G, Zimpfer D
Objectives: The objective was to analyse associations between obesity and outcomes after left ventricular assist device (LVAD) implantation. Methods: A retrospective analysis of the EUROMACS Registry was performed. Adult patients undergoing primary implantation of a continuous-flow LVAD between 2006 and 2019 were included (Medtronic HeartWare® HVAD®, Abbott HeartMate II®, Abbott HeartMate 3™). Patients were classified into 4 different groups according to body mass index at the time of surgery (b...
Abstract
Mathematical biosciences and engineering : MBE,
Volume 19, Issue 11, 1 1 2022, Pages 10941-10962
Assessing the therapeutic response of tumors to hypoxia-targeted prodrugs with an in silico approach.
Yilmaz D, Tuzer M, Unlu MB
Tumor hypoxia is commonly recognized as a condition stimulating the progress of the aggressive phenotype of tumor cells. Hypoxic tumor cells inhibit the delivery of cytotoxic drugs, causing hypoxic areas to receive insufficient amounts of anticancer agents, which results in adverse treatment responses. Being such an obstruction to conventional therapies for cancer, hypoxia might be considered a target to facilitate the efficacy of treatments in the resistive environment of tumor sites. In this r...
Abstract
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,
Volume 32, Issue 8, 1 1 2022, Pages 1094-1095
Langerhans Cell Histiocytosis with an Undetected Ileal Polyp.
Kiyak M, Tanoglu A, Yilmaz D
Null.
Abstract
Cited 29 times since 2022 (10.5 per year)
source: EuropePMC
American journal of human genetics,
Volume 109, Issue 8, 1 1 2022, Pages 1366-1387
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL, Chesi A, Wells A, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu KH, Ntalla I, Hui Q, Klarin D, Hilliard AT, Wang Z, Xue C, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Hwang MY, Han S, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Havulinna AS, Veturi Y, Pacheco JA, Rosenthal EA, Lingren T, Feng Q, Kullo IJ, Narita A, Takayama J, Martin HC, Hunt KA, Trivedi B, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Rasheed A, Hindy G, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Choudhury A, Sengupta D, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Wood AR, Ji Y, Gao Z, Haworth S, Mitchell RE, Chai JF, Aadahl M, Bjerregaard AA, Yao J, Manichaikul A, Lee WJ, Hsiung CA, Warren HR, Ramirez J, Bork-Jensen J, Kårhu
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow...
Abstract
Cited 33 times since 2022 (12 per year)
source: EuropePMC
JACC. Cardiovascular interventions,
Volume 15, Issue 16, 1 1 2022, Pages 1664-1674
Impact of Moderate Aortic Stenosis on Long-Term Clinical Outcomes: A Systematic Review and Meta-Analysis.
Coisne A, Scotti A, Latib A, Montaigne D, Ho EC, Ludwig S, Modine T, Généreux P, Bax JJ, Leon MB, Bauters C, Granada JF
Background: The clinical course of patients with moderate aortic stenosis (AS) remains incompletely defined. Objectives: This study sought to analyze the clinical course of moderate AS and compare it with other stages of the disease. Methods: Multiple electronic databases were searched to identify studies on adult moderate AS. Random-effects models were used to derive pooled estimates. The primary endpoint was all-cause death. The secondary endpoints were cardiac death, heart failure, sudden dea...
Abstract
Cited 48 times since 2022 (17.4 per year)
source: EuropePMC
European heart journal,
Volume 43, Issue 32, 1 1 2022, Pages e1-e9
A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy.
Cadrin-Tourigny J, Bosman LP, Nozza A, Wang W, Tadros R, Bhonsale A, Bourfiss M, Fortier A, Lie ØH, Saguner AM, Svensson A, Andorin A, Tichnell C, Murray B, Zeppenfeld K, van den Berg MP, Asselbergs FW, Wilde AAM, Krahn AD, Talajic M, Rivard L, Chelko S, Zimmerman SL, Kamel IR, Crosson JE, Judge DP, Yap SC, van der Heijden JF, Tandri H, Jongbloed JDH, Guertin MC, van Tintelen JP, Platonov PG, Duru F, Haugaa KH, Khairy P, Hauer RNW, Calkins H, Te Riele ASJM, James CA
Aims: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients. Methods and results: Five hundred and twenty-eight patients with a definite diagnosis and no history of sustained VAs/SCD at baseline, aged 38.2 ± 15.5 years, 44.7% male, were enrolled from five registries in North America and Europe. Over 4.83 (interq...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 62, Issue 3, 1 1 2022, Pages ezac240
Mechanical circulatory support in the failing systemic right ventricle: a step towards better outcome.
Koolbergen DR
Abstract
Cited 37 times since 2022 (13.4 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 80, Issue 5, 1 1 2022, Pages 545-561
Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement: JACC State-of-the-Art Review.
Pibarot P, Herrmann HC, Wu C, Hahn RT, Otto CM, Abbas AE, Chambers J, Dweck MR, Leipsic JA, Simonato M, Rogers T, Sathananthan J, Guerrero M, Ternacle J, Wijeysundera HC, Sondergaard L, Barbanti M, Salaun E, Généreux P, Kaneko T, Landes U, Wood DA, Deeb GM, Sellers SL, Lewis J, Madhavan M, Gillam L, Reardon M, Bleiziffer S, O'Gara PT, Rodés-Cabau J, Grayburn PA, Lancellotti P, Thourani VH, Bax JJ, Mack MJ, Leon MB, Heart Valve Collaboratory
Bioprosthetic valve dysfunction (BVD) and bioprosthetic valve failure (BVF) may be caused by structural or nonstructural valve dysfunction. Both surgical and transcatheter bioprosthetic valves have limited durability because of structural valve deterioration. The main objective of this summary of experts participating in a virtual workshop was to propose standardized definitions for nonstructural and structural BVD and BVF following aortic or mitral biological valve replacement with the goal of...
Abstract
