Research

Publications

Below you can find a list of our published research.

9256 results

Cited 1 times since 2023 (0.5 per year) source: EuropePMC

Journal of visualized experiments : JoVE, Issue 196, 2 1 2023 Using a Combination of Indirect Calorimetry, Infrared Thermography, and Blood Glucose Levels to Measure Brown Adipose Tissue Thermogenesis in Humans. Van Schaik L, Kettle C, Green RA, Irving HR, Rathner JA

In mammals, brown adipose tissue (BAT) is activated rapidly in response to cold in order to maintain body temperature. Although BAT has been studied greatly in small animals, it is difficult to measure the activity of BAT in humans. Therefore, little is known about the heat-generating capacity and physiological significance of BAT in humans, including the degree to which components of the diet can activate BAT. This is due to the limitations in the currently most used method to assess the activa... Abstract

Cited 2 times since 2023 (1.1 per year) source: EuropePMC

Heart rhythm, Volume 20, Issue 8, 2 1 2023, Pages 1128-1135 Five-year safety and efficacy of leadless pacemakers in a Dutch cohort. Breeman KTN, Oosterwerff EFJ, de Graaf MA, Juffer A, Saleem-Talib S, Maass AH, Wilde AAM, Boersma LVA, Ramanna H, van Dijk VF, van Erven L, Delnoy PHM, Tjong FVY, Knops RE

Background: Adequate real-world safety and efficacy of leadless pacemakers (LPs) have been demonstrated up to 3 years after implantation. Longer-term data are warranted to assess the net clinical benefit of leadless pacing. Objective: The purpose of this study was to evaluate the long-term safety and efficacy of LP therapy in a real-world cohort. Methods: In this retrospective cohort study, all consecutive patients with a first LP implantation from December 21, 2012, to December 13, 2016, in 6 D... Abstract

Cited 3 times since 2023 (1.6 per year) source: EuropePMC

Microbial genomics, Volume 9, Issue 6, 1 1 2023 Noise reduction strategies in metagenomic chromosome confirmation capture to link antibiotic resistance genes to microbial hosts. McCallum GE, Rossiter AE, Quraishi MN, Iqbal TH, Kuehne SA, van Schaik W

The gut microbiota is a reservoir for antimicrobial resistance genes (ARGs). With current sequencing methods, it is difficult to assign ARGs to their microbial hosts, particularly if these ARGs are located on plasmids. Metagenomic chromosome conformation capture approaches (meta3C and Hi-C) have recently been developed to link bacterial genes to phylogenetic markers, thus potentially allowing the assignment of ARGs to their hosts on a microbiome-wide scale. Here, we generated a meta3C dataset of... Abstract

Cited 7 times since 2023 (3.7 per year) source: EuropePMC

European journal of preventive cardiology, Volume 30, Issue 8, 1 1 2023, Pages 624-633 Longitudinal association of electrocardiogram abnormalities with major adverse cardiac events in people with Type 2 diabetes: the Hoorn Diabetes Care System cohort. Harms PP, Elders PPJM, Rutters F, Lissenberg-Witte BI, Tan HL, Beulens JWJ, Nijpels G, van der Heijden AA, for ESCAPE-NET

Aims: To investigate the association of (changes in) electrocardiogram (ECG) abnormalities with incident major adverse cardiac events (MACE) in people with Type 2 diabetes (T2D) without pre-existing cardiovascular disease (CVD). Methods and results: A prospective longitudinal study of 11 993 people with T2D without known CVD from the Hoorn Diabetes Care System cohort. Annually repeated measurements (1998-2018), included cardiovascular risk factors, over 70 000 ECG, and self-reported cardiovascul... Abstract

Cited 3 times since 2023 (1.6 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 25, Issue 6, 1 1 2023, Pages euad139 The R″ wave in V1 and the negative terminal QRS vector in aVF combine to a novel 12-lead ECG algorithm to identify slow conducting anatomical isthmus 3 in patients with tetralogy of Fallot. Wallet J, Kimura Y, Blom NA, Man S, Jongbloed MRM, Zeppenfeld K, Zeppenfeld K

Aims: Patients with repaired tetralogy of Fallot (rTOF) have an increased risk of ventricular tachycardia (VT), with slow conducting anatomical isthmus (SCAI) 3 as dominant VT substrate. In patients with right bundle branch block (RBBB), SCAI 3 leads to local activation delay with a shift of terminal RV activation towards the lateral RV outflow tract which may be detected by terminal QRS vector changes on sinus rhythm electrocardiogram (ECG). Methods and results: Consecutive rTOF patients aged ≥... Abstract

European review for medical and pharmacological sciences, Volume 27, Issue 11, 1 1 2023, Pages 4942-4950 Temporal relationship between thromboembolic events and myeloproliferative neoplasm diagnosis: is it associated with mortality risk? Gulturk E, Yılmaz D, Bırce Sonmezoz G, Dırıl M

Objective: The aim of this study is to investigate the temporal relationship between the first occurrence of thromboembolic events (TEE) and the timing of myeloproliferative neoplasm (MPN) diagnosis and to determine risk factors for TEE-related mortality in MPN. Patients and methods: A total of 138 BCR-ABL-negative MPN patients with TEE, diagnosed from January 2010 to December 2019, were included in this retrospective cohort. Patients were compared according to mortality and subjects were classi... Abstract

Cited 2 times since 2023 (1.1 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 63, Issue 6, 1 1 2023, Pages ezad114 Extensive aortic root endocarditis with extension into the intervalvular fibrous body: an updated report of a mitral valve sparing approach. Tomšič A, Palmen M, de Jong ML, Hjortnaes J, Driessen AGH, Braun J, Marsan NA, Klautz RJM

Objectives: Aortic root abscess can spread to include adjacent cardiac structures, including the central or intervalvular fibrous body and mitral valve. After radical debridement, complex surgical correction is needed. We describe the results of our mitral valve sparing approach. Methods: Between January 2004 and December 2020, 60 patients underwent operation for infective endocarditis of the aortic root with extension towards the mitral valve at 2 centres in the Netherlands. Early and late clin... Abstract

Cited 8 times since 2023 (4.2 per year) source: EuropePMC

Nature, Volume 618, Issue 7965, 1 1 2023, Pages E19-E20 Author Correction: The power of genetic diversity in genome-wide association studies of lipids. Graham SE, Clarke SL, Wu KH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I, Vedantam S, Winkler TW, Locke AE, Marouli E, Hwang MY, Han S, Narita A, Choudhury A, Bentley AR, Ekoru K, Verma A, Trivedi B, Martin HC, Hunt KA, Hui Q, Klarin D, Zhu X, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Ruotsalainen SE, Havulinna AS, Veturi Y, Feng Q, Rosenthal EA, Lingren T, Pacheco JA, Pendergrass SA, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Hindy G, Rasheed A, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Willemsen G, Wood AR, Ji Y, Gao Z, Haworth S, Mitchell RE, Chai JF, Aadahl M, Yao J, Manichaikul A, Warren HR, Ramirez J, Bork-Jensen J, Kårhus LL, Goel A, Sabater-Lleal M, Noordam R, Sidore C, Fiorillo E, McD

Abstract

Cited 4 times since 2023 (2.1 per year) source: EuropePMC

Microbiology spectrum, Volume 11, Issue 4, 1 1 2023, Pages e0036223 Deconstructed Plastic Substrate Preferences of Microbial Populations from the Natural Environment. Putman LI, Schaerer LG, Wu R, Kulas DG, Zolghadr A, Ong RG, Shonnard DR, Techtmann SM

Over half of the world's plastic waste is landfilled, where it is estimated to take hundreds of years to degrade. Given the continued use and disposal of plastic products, it is vital that we develop fast and effective ways to utilize plastic waste. Here, we explore the potential of tandem chemical and biological processing to process various plastics quickly and effectively. Four samples of compost or sediment were used to set up enrichment cultures grown on mixtures of compounds, includin... Abstract

Cited 6 times since 2023 (3.2 per year) source: EuropePMC

Science translational medicine, Volume 15, Issue 698, 31 5 2023, Pages eade8732 Gene-edited and -engineered stem cell platform drives immunotherapy for brain metastatic melanomas. Kanaya N, Kitamura Y, Lopez Vazquez M, Franco A, Chen KS, van Schaik TA, Farzani TA, Borges P, Ichinose T, Seddiq W, Kuroda S, Boland G, Jahan N, Fisher D, Wakimoto H, Shah K

Oncolytic virus therapy has shown activity against primary melanomas; however, its efficacy in brain metastases remains challenging, mainly because of the delivery and immunosuppressive nature of tumors in the brain. To address this challenge, we first established PTEN-deficient melanoma brain metastasis mouse models and characterized them to be more immunosuppressive compared with primary melanoma, mimicking the clinical settings. Next, we developed an allogeneic twin stem cell (TSC) system com... Abstract

Cited 7 times since 2023 (3.7 per year) source: EuropePMC

World journal of urology, Volume 41, Issue 7, 31 5 2023, Pages 1837-1845 Low adherence to recommended use of neoadjuvant chemotherapy for muscle-invasive bladder cancer. van Hoogstraten LMC, Man CCO, Witjes JA, Meijer RP, Mulder SF, Smilde TJ, Ripping TM, Kiemeney LA, Aben KKH, BlaZIB Study Group

Purpose: To evaluate guideline adherence and variation in the recommended use of neoadjuvant chemotherapy (NAC) and the effects of this variation on survival in patients with non-metastatic muscle-invasive bladder cancer (MIBC). Patients and methods: In this nationwide, Netherlands Cancer Registry-based study, we identified 1025 patients newly diagnosed with non-metastatic MIBC between November 2017 and November 2019 who underwent radical cystectomy. Patients with ECOG performance status 0-1 and... Abstract

Cited 3 times since 2023 (1.6 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 39, Issue 8, 30 5 2023, Pages 1525-1533 Prognostic implications of left ventricular inward displacement assessed by cardiac magnetic resonance imaging in patients with myocardial infarction. Nabeta T, Meucci MC, Westenberg JJM, Reiber JH, Knuuti J, van der Bijl P, Marsan NA, Bax JJ

Risk stratification of patients with ischemic heart disease (IHD) still depends mainly on the left ventricular ejection fraction (LVEF). LV inward displacement (InD) is a novel parameter of LV systolic function, derived from feature tracking cardiac magnetic resonance (CMR) imaging. We aimed to investigate the prognostic impact of InD in patients with IHD and prior myocardial infarction. A total of 111 patients (mean age 57 ± 10, 86% male) with a history of myocardial infarction who underwent CM... Abstract

The Pediatric infectious disease journal, Volume 42, Issue 9, 30 5 2023, Pages e348-e349 HSV-1 Encephalitis Presenting with Diplopia: Effects of Infection or Autoimmunity? Elvan-Tuz A, Elvan-Tuz A, Kaya-Guner E, Sarioglu FC, Agrali-Eroz N, Baykan M, Karadag-Oncel E, Yilmaz D, Olgac-Dundar N

This report describes a case in which diplopia was developed as a finding of postinfectious anti- N -methyl- d -aspartate receptor encephalitis. Infectious encephalitis, especially herpes simplex virus, is essential as it is one of the triggers of autoimmune encephalitis. Even if the cases present unexpected clinical findings, we should be vigilant in terms of autoimmune processes, such as diplopia seen in our case. Abstract

Cited 2 times since 2023 (1.1 per year) source: EuropePMC

International journal of cardiology, Volume 387, 30 5 2023, Pages 131099 Outcomes of concomitant surgical ablation in patients undergoing surgical myectomy for hypertrophic obstructive cardiomyopathy: A systematic review and meta-analysis. Kharbanda RK, Ramdat Misier NL, Van den Eynde J, El Mathari S, Tomšič A, Palmen M, Klautz RJM

Objective: Studies investigating the efficacy of concomitant surgical atrial fibrillation (AF) ablation in hypertrophic obstructive cardiomyopathy (HOCM) patients undergoing myectomy are scarce and limited in terms of sample size. We aim to summarize current outcomes of concomitant surgical AF ablation in HOCM patients undergoing surgical myectomy. Methods: This systematic review and meta-analysis was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guide... Abstract

Parasites & vectors, Volume 16, Issue 1, 26 4 2023, Pages 170 Non-invasive investigation of Polychromophilus parasite infections in bat populations in Serbia using bat flies. Bajić B, Werb O, Budinski I, Blagojević J, Schaer J, van Schaik J

Background: Haemosporidian parasites of the genus Polychromophilus infect bats worldwide. They are vectored by obligate ectoparasitic bat flies of the family Nycteribiidae. Despite their global distribution, only five Polychromophilus morphospecies have been described to date. The two predominant species, Polychromophilus melanipherus and Polychromophilus murinus, are broadly distributed and mainly infect miniopterid and vespertilionid bats, respectively. In areas where species from different ba... Abstract

Cited 3 times since 2023 (1.6 per year) source: EuropePMC

Diabetologia, Volume 66, Issue 7, 26 4 2023, Pages 1260-1272 Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH. Li JH, Brenner LN, Kaur V, Figueroa K, Schroeder P, Huerta-Chagoya A, MAGIC Investigators, Diabetes Prevention Program (DPP) Research Group, Udler MS, Leong A, Mercader JM, Florez JC

Aims/hypothesis: Characterisation of genetic variation that influences the response to glucose-lowering medications is instrumental to precision medicine for treatment of type 2 diabetes. The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH) examined the acute response to metformin and glipizide in order to identify new pharmacogenetic associations for the response to common glucose-lowering medications in individuals at risk of type 2 diabet... Abstract

Cited 2 times since 2023 (1 per year) source: EuropePMC

Indian journal of thoracic and cardiovascular surgery, Volume 39, Issue Suppl 2, 25 4 2023, Pages 270-279 The role of transforming growth factor beta in bicuspid aortic valve aortopathy. Grewal N, Dolmaci O, Klautz A, Legue J, Driessen A, Klautz R, Poelmann R

A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac deformity, which is associated with an increased risk to develop a thoracic aortic aneurysm and/or an aortic dissection as compared to persons with a tricuspid aortic valve. Due to the high prevalence of a BAV in the general population and the associated life-long increased risk for adverse vascular events, BAV disease places a considerable burden on the public health. The aim of the present review is to discuss the role of t... Abstract

Cited 5 times since 2023 (2.6 per year) source: EuropePMC

Infection, Volume 51, Issue 6, 25 4 2023, Pages 1679-1694 Persistent symptoms and risk factors predicting prolonged time to symptom-free after SARS‑CoV‑2 infection: an analysis of the baseline examination of the German COVIDOM/NAPKON-POP cohort. Shi Y, Strobl R, Apfelbacher C, Bahmer T, Geisler R, Heuschmann P, Horn A, Hoven H, Keil T, Krawczak M, Krist L, Lemhöfer C, Lieb W, Lorenz-Depiereux B, Mikolajczyk R, Montellano FA, Reese JP, Schreiber S, Skoetz N, Störk S, Vehreschild JJ, Witzenrath M, Grill E, NAPKON Study Group

Purpose: We aimed to assess symptoms in patients after SARS-CoV-2 infection and to identify factors predicting prolonged time to symptom-free. Methods: COVIDOM/NAPKON-POP is a population-based prospective cohort of adults whose first on-site visits were scheduled ≥ 6 months after a positive SARS-CoV-2 PCR test. Retrospective data including self-reported symptoms and time to symptom-free were collected during the survey before a site visit. In the survival analyses, being symptom-free served as t... Abstract

Cited 3 times since 2023 (1.6 per year) source: EuropePMC

Neuroendocrinology, Volume 113, Issue 10, 25 4 2023, Pages 987-1007 Safety of Growth Hormone Replacement Therapy in Childhood-Onset Craniopharyngioma: A Systematic Review and Cohort Study. van Schaik J, Kormelink E, Kabak E, van Dalen EC, Schouten-van Meeteren AYN, de Vos-Kerkhof E, Bakker B, Fiocco M, Hoving EW, Tissing WJE, van Santen HM

Introduction: Survival of childhood-onset craniopharyngioma (cCP) is excellent; however, many survivors suffer from hypothalamic-pituitary dysfunction. Growth hormone replacement therapy (GHRT) is of high importance for linear growth and metabolic outcome. Optimal timing for initiation of GHRT in cCP is on debate because of concerns regarding tumor progression or recurrence. Methods: A systematic review and cohort studys were performed for the effect and timing of GHRT on overall mortality, tumo... Abstract

Cited 3 times since 2023 (1.6 per year) source: EuropePMC

Annals of vascular surgery, Volume 97, 25 4 2023, Pages 410-418 Use of Omniflow® II Biosynthetic Graft for the Treatment of Vascular Graft and Endograft Infections. Liesker DJ, Gareb B, Speijers MJ, van der Vorst JR, Salemans PB, Tutein Nolthenius RP, Zeebregts CJ, Saleem BR

Background: Vascular graft/endograft infection is a rare but life-threatening complication of cardiovascular surgery and remains a surgical challenge. Several different graft materials are available for the treatment of vascular graft/endograft infection, each having its own advantages and disadvantages. Biosynthetic vascular grafts have shown low reinfection rates and could be a potential second best after autologous veins in the treatment of vascular graft/endograft infection. Therefore, the a... Abstract