6128 results
Cited 33 times since 2020 (6.7 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 75, Issue 16, 1 1 2020, Pages 1869-1877
Age-Related Variations in Takotsubo Syndrome.
Cammann VL, Szawan KA, Stähli BE, Kato K, Budnik M, Wischnewsky M, Dreiding S, Levinson RA, Di Vece D, Gili S, Citro R, Bossone E, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Heiner S, D'Ascenzo F, Dichtl W, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Poledniková K, Toušek P, Winchester DE, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Shoji T, Ishibashi I, Takahara M, Himi T, Din J, Al-Shammari A, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm M, Maier LS, Pinto FJ, Widimský P, Felix SB, Braun-Dullaeus RC, Rottbauer W, Hasenfu
Background: Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients. Objectives: This study aimed to investigate age-related differences in TTS. Methods: Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age (younger: ≤50 years, middle-age: 51 to 74 years, elderly: ≥75 years). Baseline characteristics, hospital course, as...
Abstract
Cited 14 times since 2020 (2.8 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 21, Issue 4, 1 1 2020, Pages 363-374
Increased long-term mortality in women with high left ventricular ejection fraction: data from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) long-term registry.
Gebhard C, Maredziak M, Messerli M, Buechel RR, Lin F, Gransar H, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJW, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kim YJ, Leipsic J, Maffei E, Marques H, Gonçalves PA, Pontone G, Raff GL, Rubinshtein R, Shaw LJ, Villines TC, Lu Y, Jones EC, Peña JM, Min JK, Kaufmann PA
Aims: There are significant sex-specific differences in left ventricular ejection fraction (LVEF), with a higher LVEF being observed in women. We sought to assess the clinical relevance of an increased LVEF in women and men. Methods and results: A total of 4632 patients from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry (44.8% women; mean age 58.7 ± 13.2 years in men and 59.5 ± 13.3 years in women, P = 0.05), in whom LVEF was measur...
Abstract
JACC. Cardiovascular imaging,
Volume 13, Issue 4, 1 1 2020, Pages 1099
The Authors Reply: Computed Tomography Angiography-Based Risk Discrimination: An Established Bright Future for Prognostication.
van Rosendael AR, Min JK, Shaw LJ, Bax JJ
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Annals of surgery,
Volume 271, Issue 4, 1 1 2020, Pages 781-789
Variation in Surgical Treatment of Abdominal Aortic Aneurysms With Small Aortic Diameters in the Netherlands.
Karthaus EG, Vahl A, van der Werf LR, Elsman BHP, Van Herwaarden JA, Wouters MWJM, Hamming JF
Objective: To evaluate reasons to deviate from aneurysm diameter thresholds, and focus on the difference in how Dutch vascular surgical units (VSUs) perceive their deviation and their actual deviation. Background: Guidelines recommend surgical treatment for asymptomatic abdominal aortic aneurysms (AAAs) with a diameter of at least 55 mm for men and 50 mm for women. We evaluate reasons to deviate from these guidelines, and focus on the difference in how Dutch vascular surgical units (VSUs) percei...
Abstract
Cited 45 times since 2020 (9.1 per year)
source: EuropePMC
JAMA network open,
Volume 3, Issue 4, 1 1 2020, Pages e202165
Effect of Smartphone-Enabled Health Monitoring Devices vs Regular Follow-up on Blood Pressure Control Among Patients After Myocardial Infarction: A Randomized Clinical Trial.
Treskes RW, van Winden LAM, van Keulen N, van der Velde ET, Beeres SLMA, Atsma DE, Schalij MJ
Importance: Smart technology via smartphone-compatible devices might improve blood pressure (BP) regulation in patients after myocardial infarction. Objectives: To investigate whether smart technology in clinical practice can improve BP regulation and to evaluate the feasibility of such an intervention. Design, setting, and participants: This study was an investigator-initiated, single-center, nonblinded, feasibility, randomized clinical trial conducted at the Department of Cardiology of the Lei...
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
Annals of vascular surgery,
Volume 67, 1 1 2020, Pages 346-353
Vascular Surgeons' Views on Ejaculation Disorders After Abdominal Aortic Surgery: Results of a Dutch Survey.
van Schaik J, van der Vorst JR, Hamming JF, Elzevier HW, Nicolai MPJ
Background: The aim of this study is to evaluate vascular surgeons' knowledge and appreciation of ejaculatory dysfunction after open aortic aneurysm repair and the knowledge of possible nerve-preserving techniques. Methods: A Dutch national survey was conducted on sexual counseling in the case of open aortic surgery. For this purpose, a designed questionnaire based on a review of the literature in the field and on other surveys aiming to analyze care for sexual health by medical specialists...
Abstract
Cited 17 times since 2020 (3.5 per year)
source: EuropePMC
Cardiovascular research,
Volume 116, Issue 5, 1 1 2020, Pages 931-943
Stress-induced remodelling of the mitral valve: a model for leaflet thickening and superimposed tissue formation in mitral valve disease.
Kruithof BPT, Paardekooper L, Hiemstra YL, Goumans MJ, Palmen M, Delgado V, Klautz RJM, Ajmone Marsan N
Aims: In mitral valve prolapse (MVP), leaflet thickening has recently been suggested to be due, in addition to a myxomatous degeneration, to the presence of a superimposed tissue (SIT), defined as an additional fibrous layer on top of the original leaflet. The mechanisms of SIT formation are currently unknown. We hypothesized that SIT formation would result from excessive leaflet stress and we used a unique ex vivo model to assess the correlation between leaflet remodelling and the type and loca...
Abstract
Cited 19 times since 2020 (3.9 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 7, 31 5 2020, Pages 43
Multicellular <i>In vitro</i> Models of Cardiac Arrhythmias: Focus on Atrial Fibrillation.
van Gorp PRR, Trines SA, Pijnappels DA, de Vries AAF
Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice with a large socioeconomic impact due to its associated morbidity, mortality, reduction in quality of life and health care costs. Currently, antiarrhythmic drug therapy is the first line of treatment for most symptomatic AF patients, despite its limited efficacy, the risk of inducing potentially life-threating ventricular tachyarrhythmias as well as other side effects. Alternative, in-hospital treatment modalitie...
Abstract
Cited 61 times since 2020 (12.4 per year)
source: EuropePMC
Circulation,
Volume 141, Issue 20, 29 5 2020, Pages 1608-1617
Peripheral Artery Disease and Venous Thromboembolic Events After Acute Coronary Syndrome: Role of Lipoprotein(a) and Modification by Alirocumab: Prespecified Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial.
Schwartz GG, Steg PG, Szarek M, Bittner VA, Diaz R, Goodman SG, Kim YU, Jukema JW, Pordy R, Roe MT, White HD, Bhatt DL, ODYSSEY OUTCOMES Committees and Investigators*
Background: Patients with acute coronary syndrome are at risk for peripheral artery disease (PAD) events and venous thromboembolism (VTE). PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors reduce lipoprotein(a) and low-density lipoprotein cholesterol (LDL-C) levels. Our objective was to ascertain whether PCSK9 inhibition reduces the risk of PAD events or VTE after acute coronary syndrome, and if such effects are related to levels of lipoprotein(a) or LDL-C. Methods: This was a pre...
Abstract
JACC. Clinical electrophysiology,
Volume 6, Issue 4, 29 5 2020, Pages 461-462
Whole Heart Histology: A Method for the Direct Integration of Histology With Electrophysiological and Imaging Data.
Glashan CA, Tofig BJ, Tao Q, Blom SA, Sørensen JCH, Zeppenfeld K, Kristiansen SB
Abstract
Cited 7 times since 2020 (1.4 per year)
source: EuropePMC
Cells,
Volume 9, Issue 4, 29 5 2020, Pages E824
Loss of Endothelial Glycocalyx Hyaluronan Impairs Endothelial Stability and Adaptive Vascular Remodeling After Arterial Ischemia.
Wang G, de Vries MR, Sol WMPJ, van Oeveren-Rietdijk AM, de Boer HC, van Zonneveld AJ, Quax PHA, Rabelink TJ, van den Berg BM
We recently reported that loss of hyaluronan (HA) from the endothelial glycocalyx leads to loss of vessel stability in specific microcirculatory vascular beds. Here we hypothesized that such derangements in the glycocalyx may also impair the adaptive response to vascular ischemia. Endothelial specific conditional hyaluronan synthase 2-KO (Has2-cKO) mice revealed reduced endothelial HA expression and lower hindlimb perfusion at baseline compared to control mice. After a single ligation of the com...
Abstract
Cited 94 times since 2020 (19.1 per year)
source: EuropePMC
The New England journal of medicine,
Volume 382, Issue 18, 29 5 2020, Pages 1696-1707
Anticoagulation with or without Clopidogrel after Transcatheter Aortic-Valve Implantation.
Nijenhuis VJ, Brouwer J, Delewi R, Hermanides RS, Holvoet W, Dubois CLF, Frambach P, De Bruyne B, van Houwelingen GK, Van Der Heyden JAS, Toušek P, van der Kley F, Buysschaert I, Schotborgh CE, Ferdinande B, van der Harst P, Roosen J, Peper J, Thielen FWF, Veenstra L, Chan Pin Yin DRPP, Swaans MJ, Rensing BJWM, van 't Hof AWJ, Timmers L, Kelder JC, Stella PR, Baan J, Ten Berg JM
Background: The roles of anticoagulation alone or with an antiplatelet agent after transcatheter aortic-valve implantation (TAVI) have not been well studied. Methods: We performed a randomized trial of clopidogrel in patients undergoing TAVI who were receiving oral anticoagulation for appropriate indications. Patients were assigned before TAVI in a 1:1 ratio not to receive clopidogrel or to receive clopidogrel for 3 months. The two primary outcomes were all bleeding and non-procedure-related ble...
Abstract
Cited 5 times since 2020 (1 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 9, Issue 4, 26 4 2020, Pages E911
Ventricular Repolarization is Associated with Cognitive Function, but Not with Cognitive Decline and Brain Magnetic Resonance Imaging (MRI) Measurements in Older Adults.
Zonneveld MH, Noordam R, Grond JV, Sabayan B, Mooijaart SP, Mcfarlane PW, Jukema JW, Trompet S
We aimed to investigate the cross-sectional and longitudinal associations of electrocardiogram (ECG)-based QT, QTc, JT, JTc, and QRS intervals with cognitive function and brain magnetic resonance imaging (MRI) measurements in a cohort of older individuals at increased risk for cardiovascular disease, but free of known arrhythmias. We studied 4627 participants (54% female, mean age 75 years) enrolled in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Ten-second ECGs were co...
Abstract
Cited 20 times since 2020 (4.1 per year)
source: EuropePMC
Current opinion in cell biology,
Volume 64, 26 4 2020, Pages 58-66
How to maintain the genome in nuclear space.
Mitrentsi I, Yilmaz D, Soutoglou E
Genomic instability can be life-threatening. The fine balance between error-free and mutagenic DNA repair pathways is essential for maintaining genome integrity. Recent advances in DNA double-strand break induction and detection techniques have allowed the investigation of DNA damage and repair in the context of the highly complex nuclear structure. These studies have revealed that the 3D genome folding, nuclear compartmentalization and cytoskeletal components control the spatial distribution of...
Abstract
Cited 13 times since 2020 (2.6 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 9, Issue 4, 26 4 2020, Pages E908
The Development of the Ascending Aortic Wall in Tricuspid and Bicuspid Aortic Valve: A Process from Maturation to Degeneration.
Grewal N, Gittenberger-de Groot AC, Thusen JV, Wisse LJ, Bartelings MM, DeRuiter MC, Klautz RJM, Poelmann RE
Background: Patients with a bicuspid aortic valve (BAV) have an increased risk for aortic dilation and dissection. In this study, we provide a histological stratification of the developing aorta in the tricuspid aortic valve (TAV) and the BAV populations as a reference for future studies on aortopathy and related syndromes. Methods: Non-dilated TAV and BAV ascending aortic wall samples were collected, including 60 TAV (embryonic-70 years) and 32 BAV specimens (fetal-72 years, categorized in eigh...
Abstract
Cited 6 times since 2020 (1.2 per year)
source: EuropePMC
JACC. Basic to translational science,
Volume 5, Issue 4, 25 4 2020, Pages 360-373
Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular <sup>18</sup>F-FDG Uptake in Atherosclerotic Mice.
Ståhle M, Silvola JMU, Hellberg S, de Vries M, Quax PHA, Kroon J, Rinne P, de Jong A, Liljenbäck H, Savisto N, Wickman A, Stroes ESG, Ylä-Herttuala S, Saukko P, Abrahamsson T, Pettersson K, Knuuti J, Roivainen A, Saraste A
This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of 18F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies.
Abstract
Cited 9 times since 2020 (1.8 per year)
source: EuropePMC
Oral surgery, oral medicine, oral pathology and oral radiology,
Volume 130, Issue 2, 18 3 2020, Pages 209-216
Evaluation of a metal artifact reduction algorithm and an optimization filter in the estimation of peri-implant dehiscence defects by using cone beam computed tomography: an in-vitro study.
Bayrak S, Orhan K, Kursun Çakmak ES, Görürgöz C, Odabaşı O, Yilmaz D, Atakan C
Objectives: The aim of this study was to assess the effect of a metal artifact reduction (MAR) algorithm and the adaptive image noise optimizer (AINO) optimization filter in the detection of peri-implant dehiscences with cone beam computed tomography (CBCT). Study design: Nine implants (3 zirconium, 3 titanium, and 3 zirconium-titanium) were placed in 3 sheep heads. Dehiscences were created on the buccal and lingual/palatal surfaces. A total of 9 defects and 9 controls with no defects were evalu...
Abstract
Cited 3 times since 2020 (0.6 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 13, Issue 5, 18 3 2020, Pages 1133-1134
Individualized Patient Risk Stratification Using Machine Learning and Topological Data Analysis.
Ng ACT, Delgado V, Bax JJ
Abstract
Cited 4 times since 2020 (0.8 per year)
source: EuropePMC
International journal of cardiology. Heart & vasculature,
Volume 27, 17 3 2020, Pages 100499
Multifocal cardiovascular calcification in patients with established cardiovascular disease; prevalence, risk factors, and relation with recurrent cardiovascular disease.
van 't Klooster CC, Nathoe HM, Hjortnaes J, Bots ML, Isgum I, Lessmann N, van der Graaf Y, Leiner T, Visseren FLJ, UCC-SMART-study group
Aims: The aim is to investigate (multifocal) cardiovascular calcification in patients with established cardiovascular disease (CVD), regarding prevalence, risk factors, and relation with recurrent CVD or vascular interventions. Coronary artery calcification (CAC), thoracic aortic calcification (TAC) (including ascending aorta, aortic arch, descending aorta), mitral annular calcification (MAC), and aortic valve calcification (AVC) are studied. Methods: The study concerned 568 patients with establ...
Abstract
Cited 9 times since 2020 (1.8 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 162, Issue 6, 12 2 2020, Pages 1684-1695
Comparison of microstructural alterations in the proximal aorta between aortic stenosis and regurgitation.
Sequeira Gross TM, Lindner D, Ojeda FM, Neumann J, Grewal N, Kuntze T, Blankenberg S, Reichenspurner H, Westermann D, Girdauskas E
Objective: We aimed to analyze the association among flow patterns, gene expression, and histologic alterations of the proximal aorta in patients with aortic valve disease. Methods: A total of 131 patients referred for aortic valve replacement were grouped by valve dysfunction (aortic stenosis vs aortic regurgitation) and valve morphology (bicuspid vs tricuspid). On the basis of magnetic resonance imaging, aortic tissue from outer and inner curvature was collected for gene expression and histolo...
Abstract
