Research

Publications

Below you can find a list of our published research.

6139 results

Cited 23 times since 2011 (1.7 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 14, Issue 1, 13 2 2011, Pages 66-73 Prophylactic implantable cardioverter-defibrillator treatment in the elderly: therapy, adverse events, and survival gain. van Rees JB, Borleffs CJ, Thijssen J, de Bie MK, van Erven L, Cannegieter SC, Bax JJ, Schalij MJ

Aims: In elderly patients, obscurity remains regarding the benefit of implantable cardioverter-defibrillator (ICD) treatment as primary prevention of sudden cardiac death. This study assesses implant rates, therapy, adverse events, and survival gain in the elderly primary prevention ICD patient. Methods and results: A total of 1395 patients treated with an ICD for primary prevention of sudden cardiac death at the Leiden University Medical Center were included and allocated to three groups accord... Abstract

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 23, Issue 1, 13 2 2011, Pages 74-80 Toward magnetic resonance-guided electroanatomical voltage mapping for catheter ablation of scar-related ventricular tachycardia: a comparison of registration methods. Tao Q, Milles J, VAN Huls VAN Taxis C, Lamb HJ, Reiber JH, Zeppenfeld K, VAN DER Geest RJ

Introduction: Integration of preprocedural delayed enhanced magnetic resonance imaging (DE-MRI) with electroanatomical voltage mapping (EAVM) may provide additional high-resolution substrate information for catheter ablation of scar-related ventricular tachycardias (VT). Accurate and fast image integration of DE-MRI with EAVM is desirable for MR-guided ablation. Methods and results: Twenty-six VT patients with large transmural scar underwent catheter ablation and preprocedural DE-MRI. With diffe... Abstract

Cited 300 times since 2011 (22.2 per year) source: EuropePMC

Nature genetics, Volume 43, Issue 10, 11 2 2011, Pages 1005-1011 Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Johnson AD, Bochud M, Rice KM, Henneman P, Smith AV, Ehret GB, Amin N, Larson MG, Mooser V, Hadley D, Dörr M, Bis JC, Aspelund T, Esko T, Janssens AC, Zhao JH, Heath S, Laan M, Fu J, Pistis G, Luan J, Arora P, Lucas G, Pirastu N, Pichler I, Jackson AU, Webster RJ, Zhang F, Peden JF, Schmidt H, Tanaka T, Campbell H, Igl W, Milaneschi Y, Hottenga JJ, Vitart V, Chasman DI, Trompet S, Bragg-Gresham JL, Alizadeh BZ, Chambers JC, Guo X, Lehtimäki T, Kühnel B, Lopez LM, Polašek O, Boban M, Nelson CP, Morrison AC, Pihur V, Ganesh SK, Hofman A, Kundu S, Mattace-Raso FU, Rivadeneira F, Sijbrands EJ, Uitterlinden AG, Hwang SJ, Vasan RS, Wang TJ, Bergmann S, Vollenweider P, Waeber G, Laitinen J, Pouta A, Zitting P, McArdle WL, Kroemer HK, Völker U, Völzke H, Glazer NL, Taylor KD, Harris TB, Alavere H, Haller T, Keis A, Tammesoo ML, Aulchenko Y, Barroso I, Khaw KT, Galan P, Hercberg S, Lathrop M, Eyheramendy S, Org E, Org E, Sõber S, Lu X, Nolte IM, Penninx BW, Corre T,

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31... Abstract

Cited 51 times since 2011 (3.8 per year) source: EuropePMC

PloS one, Volume 6, Issue 9, 9 2 2011, Pages e24164 Human embryonic and fetal mesenchymal stem cells differentiate toward three different cardiac lineages in contrast to their adult counterparts. Ramkisoensing AA, Pijnappels DA, Askar SF, Passier R, Swildens J, Goumans MJ, Schutte CI, de Vries AA, Scherjon S, Mummery CL, Schalij MJ, Atsma DE

Mesenchymal stem cells (MSCs) show unexplained differences in differentiation potential. In this study, differentiation of human (h) MSCs derived from embryonic, fetal and adult sources toward cardiomyocytes, endothelial and smooth muscle cells was investigated. Labeled hMSCs derived from embryonic stem cells (hESC-MSCs), fetal umbilical cord, bone marrow, amniotic membrane and adult bone marrow and adipose tissue were co-cultured with neonatal rat cardiomyocytes (nrCMCs) or cardiac fibroblasts... Abstract

Cited 22 times since 2011 (1.6 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 24, Issue 11, 9 2 2011, Pages 1183-1190 Real-time three-dimensional echocardiography: segmental analysis of the right ventricle in patients with repaired tetralogy of fallot. van der Hulst AE, Roest AA, Holman ER, de Roos A, Blom NA, Bax JJ, Delgado V

Background: The accurate assessment of right ventricular (RV) function and dimensions has important prognostic implications in patients with repaired tetralogy of Fallot (ToF). Three-dimensional imaging is the preferred methodology to evaluate RV function. Novel postprocessing software applications to evaluate three-dimensional data have provided insight into RV function and dimensions by analyzing the various RV components (inlet, apical trabecular, outlet). The aim of this study was to charact... Abstract

Cited 8 times since 2011 (0.6 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 143, Issue 3, 9 2 2011, Pages 569-575 Exercise capacity and cardiac reserve in children and adolescents with corrected pulmonary atresia with intact ventricular septum after univentricular palliation and biventricular repair. Romeih S, Groenink M, Roest AA, van der Plas MN, Hazekamp MG, Mulder BJ, Blom NA

Objective: Management of pulmonary atresia with intact ventricular septum is challenging and depends on the severity of right ventricular hypoplasia. Clinical outcomes of biventricular repair seem favorable to univentricular palliation, but data on superiority of biventricular repair regarding exercise capacity are conflicting. We investigated the response to physical and pharmacologic stress in patients with surgically corrected pulmonary atresia with intact ventricular septum. Methods: Sixteen... Abstract

Cited 24 times since 2011 (1.8 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 52, Issue 10, 9 2 2011, Pages 1559-1565 Cardiac sympathetic dysfunction in genotyped patients with arrhythmogenic right ventricular cardiomyopathy and risk of recurrent ventricular tachyarrhythmias. Paul M, Wichter T, Kies P, Gerss J, Wollmann C, Rahbar K, Eckardt L, Breithardt G, Schober O, Schulze-Bahr E, Schäfers M

Unlabelled: Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) typically present with ventricular tachyarrhythmias preferentially triggered by an elevated sympathetic tone. Previous studies demonstrated an impairment of the presynaptic catecholamine reuptake as assessed by (123)I-labeled norepinephrine analog on metaiodobenzylguanidine ((123)I-MIBG) SPECT. Mutations in the gene encoding for plakophilin-2 (PKP-2) are the most common cause of autosomal dominant ARVC (ARVC-9). In... Abstract

Cited 14 times since 2011 (1 per year) source: EuropePMC

The American journal of cardiology, Volume 108, Issue 12, 8 2 2011, Pages 1689-1696 Prevalence of dyssynchrony and relation with long-term outcome in patients after acute myocardial infarction. Antoni ML, Boden H, Hoogslag GE, Ewe SH, Auger D, Holman ER, van der Wall EE, Schalij MJ, Bax JJ, Delgado V

The impact of left ventricular (LV) dyssynchrony on the long-term outcomes of patients with acute myocardial infarction (AMI) remains unknown. The purpose of the present study was to evaluate the prevalence of LV dyssynchrony after AMI and the potential relation with adverse events. A total of 976 consecutive patients admitted with AMI treated with primary percutaneous coronary intervention were evaluated. Two-dimensional echocardiography was performed Abstract

Cited 56 times since 2011 (4.1 per year) source: EuropePMC

Current opinion in virology, Volume 1, Issue 6, 3 1 2011, Pages 635-642 Predicting 'airborne' influenza viruses: (trans-) mission impossible? Sorrell EM, Schrauwen EJ, Linster M, De Graaf M, Herfst S, Fouchier RA

Repeated transmission of animal influenza viruses to humans has prompted investigation of the viral, host, and environmental factors responsible for transmission via aerosols or respiratory droplets. How do we determine-out of thousands of influenza virus isolates collected in animal surveillance studies each year-which viruses have the potential to become 'airborne', and hence pose a pandemic threat? Here, using knowledge from pandemic, zoonotic and epidemic viruses, we postulate that... Abstract

Cited 41 times since 2011 (3 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 92, Issue 3, 1 1 2011, Pages 973-979 Thirty-year experience with the arterial switch operation. Lalezari S, Bruggemans EF, Blom NA, Hazekamp MG

Background: We evaluated the results of the arterial switch operation (ASO) being performed at our institution for more than 30 years and identified risk factors for mortality and reoperation. Methods: Clinical outcome of 332 consecutive patients with transposition of the great arteries undergoing ASO was retrospectively analyzed, using surgical reports, medical charts, and latest follow-up echocardiography. Statistical analysis was performed using the Kaplan-Meier method and univariable and mul... Abstract

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Volume 6, Issue 9, 1 1 2011, Pages 1510-1515 Transesophageal ultrasound-guided fine-needle aspiration for the mediastinal restaging of non-small cell lung cancer. von Bartheld MB, Versteegh MI, Braun J, Willems LN, Rabe KF, Annema JT

Introduction: Selected patients with stage III (N2/N3) non-small cell lung cancer (NSCLC) who are downstaged to N0 by chemoradiation therapy might benefit from subsequent surgical resection of the tumor. How mediastinal lymph nodes can be best reevaluated is subject of debate. Transesophageal ultrasound-guided fine-needle aspiration (EUS-FNA) is a minimally invasive technique to sample mediastinal nodes. We assessed sensitivity and false-negative rate of EUS-FNA for the mediastinal restaging of... Abstract

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

Human molecular genetics, Volume 20, Issue 23, 30 5 2011, Pages 4748-4757 A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention. Sampietro ML, Trompet S, Verschuren JJ, Talens RP, Deelen J, Heijmans BT, de Winter RJ, Tio RA, Doevendans PA, Ganesh SK, Nabel EG, Westra HJ, Franke L, van den Akker EB, Westendorp RG, Zwinderman AH, Kastrati A, Koch W, Slagboom PE, de Knijff P, Jukema JW

Percutaneous coronary intervention (PCI) has become an effective therapy to treat obstructive coronary artery diseases (CAD). However, one of the major drawbacks of PCI is the occurrence of restenosis in 5-25% of all initially treated patients. Restenosis is defined as the re-narrowing of the lumen of the blood vessel, resulting in renewed symptoms and the need for repeated intervention. To identify genetic variants that are associated with restenosis, a genome-wide association study (GWAS) was... Abstract

Cited 97 times since 2011 (7.2 per year) source: EuropePMC

European heart journal, Volume 32, Issue 20, 30 5 2011, Pages 2541-2554 RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome. Steg PG, Mehta SR, Jukema JW, Lip GY, Gibson CM, Kovar F, Kala P, Garcia-Hernandez A, Renfurm RW, Granger CB, RUBY-1 Investigators

Aims: To establish the safety, tolerability and most promising regimen of darexaban (YM150), a novel, oral, direct factor Xa inhibitor, for prevention of ischaemic events in acute coronary syndrome (ACS). Methods: In a 26-week, multi-centre, double-blind, randomized, parallel-group study, 1279 patients with recent high-risk non-ST-segment or ST-segment elevation ACS received one of six darexaban regimens: 5 mg b.i.d., 10 mg o.d., 15 mg b.i.d., 30 mg o.d., 30 mg b.i.d., or 60 mg o.d. or placebo,... Abstract

Cited 25 times since 2011 (1.8 per year) source: EuropePMC

Intensive care medicine, Volume 37, Issue 10, 30 5 2011, Pages 1656-1663 Ventilator-associated pneumonia in children after cardiac surgery in The Netherlands. Roeleveld PP, Guijt D, Kuijper EJ, Hazekamp MG, de Wilde RB, de Jonge E

Purpose: We conducted a retrospective cohort study in an academic tertiary care center to characterize ventilator-associated pneumonia (VAP) in pediatric patients after cardiac surgery in The Netherlands. Methods: All patients following cardiac surgery and mechanically ventilated for ≥24 h were included. The primary outcome was development of VAP. Secondary outcomes were duration of mechanical ventilation and length of ICU stay. Results: A total of 125 patients were enrolled. Their mean age was... Abstract

Cited 20 times since 2011 (1.5 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 14, Issue 1, 27 4 2011, Pages 112-116 Trans-venous lead removal without the use of extraction sheaths, results of >250 removal procedures. de Bie MK, Fouad DA, Borleffs CJ, van Rees JB, Thijssen J, Trines SA, Bootsma M, Schalij MJ, van Erven L

Aims: The number of implanted cardiac rhythm devices has rapidly increased in the past decade. Subsequently, the need for lead extraction has also increased. Several techniques of lead removal have been documented from manual traction of the lead to lead extraction assisted with mechanical or laser sheaths. The goal of this study was to review our experience with lead removal using manual traction without the assistance of extraction sheaths. Methods and results: In the Leiden University Medical... Abstract

Cited 1859 times since 2011 (137 per year) source: EuropePMC

European heart journal, Volume 32, Issue 23, 26 4 2011, Pages 2999-3054 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Hamm CW, Bassand JP, Agewall S, Bax J, Boersma E, Bueno H, Caso P, Dudek D, Gielen S, Huber K, Ohman M, Petrie MC, Sonntag F, Uva MS, Storey RF, Wijns W, Zahger D, ESC Committee for Practice Guidelines

Abstract

Cited 13 times since 2011 (1 per year) source: EuropePMC

European journal of heart failure, Volume 13, Issue 10, 25 4 2011, Pages 1133-1139 The effect of cardiac resynchronization therapy on left ventricular diastolic function assessed with speckle-tracking echocardiography. Shanks M, Antoni ML, Hoke U, Bertini M, Ng AC, Auger D, Marsan NA, van Erven L, Holman ER, Schalij MJ, Bax JJ, Delgado V

Aims: Changes in left ventricular (LV) diastolic function after cardiac resynchronization therapy (CRT) in relation to LV reverse remodelling and heart failure aetiology have not been extensively characterized. The aims of the study were to evaluate changes in LV diastolic function with speckle-tracking echocardiography in relation to: (i) cardiac resynchronization therapy response (LV remodelling) and (ii) heart failure aetiology. Methods and results: A total of 192 heart failure patients under... Abstract

Cited 14 times since 2011 (1 per year) source: EuropePMC

BMC musculoskeletal disorders, Volume 12, 24 4 2011, Pages 196 Displaced midshaft fractures of the clavicle: non-operative treatment versus plate fixation (Sleutel-TRIAL). A multicentre randomised controlled trial. Stegeman SA, de Jong M, Sier CF, Krijnen P, Duijff JW, van Thiel TP, de Rijcke PA, Soesman NM, Hagenaars T, Boekhoudt FD, de Vries MR, Roukema GR, Tanka AF, van den Bremer J, van der Meulen HG, Bronkhorst MW, van Dijkman BA, van Zutphen SW, Vos DI, Schep NW, Eversdijk MG, van Olden GD, van den Brand JG, Hillen RJ, Frölke JP, Schipper IB

Background: The traditional view that the vast majority of midshaft clavicular fractures heal with good functional outcomes following non-operative treatment may be no longer valid for all midshaft clavicular fractures. Recent studies have presented a relatively high incidence of non-union and identified speciic limitations of the shoulder function in subgroups of patients with these injuries. Aim: A prospective, multicentre randomised controlled trial (RCT) will be conducted in 21 hospitals in... Abstract

Cited 46 times since 2011 (3.4 per year) source: EuropePMC

European heart journal, Volume 33, Issue 1, 22 4 2011, Pages 96-102 Relationship between discharge heart rate and mortality in patients after acute myocardial infarction treated with primary percutaneous coronary intervention. Antoni ML, Boden H, Delgado V, Boersma E, Fox K, Schalij MJ, Bax JJ

Aims: In patients with coronary artery disease, the prognostic value of heart rate has been mainly evaluated in patients with left ventricular dysfunction. Patients with ST-segment elevation acute myocardial infarction (STEMI) are currently treated with primary percutaneous coronary intervention (PCI) and in this contemporary population of patients, the relationship between heart rate and mortality during a follow-up >1 year has not been investigated. Methods and results: The population compr... Abstract

Cited 15 times since 2011 (1.1 per year) source: EuropePMC

BMC geriatrics, Volume 11, 21 3 2011, Pages 48 [Cost] effectiveness of withdrawal of fall-risk increasing drugs versus conservative treatment in older fallers: design of a multicenter randomized controlled trial (IMPROveFALL-study). Hartholt KA, Boyé ND, Van der Velde N, Van Lieshout EM, Polinder S, De Vries OJ, Kerver AJ, Ziere G, Bruijninckx MM, De Vries MR, Mattace-Raso FU, Uitterlinden AG, Van Beeck EF, Lips P, Patka P, Van der Cammen TJ

Background: Fall incidents represent an increasing public health problem in aging societies worldwide. A major risk factor for falls is the use of fall-risk increasing drugs. The primary aim of the study is to compare the effect of a structured medication assessment including the withdrawal of fall-risk increasing drugs on the number of new falls versus 'care as usual' in older adults presenting at the Emergency Department after a fall. Methods/design: A prospective, multi-center, rand... Abstract