Research

Publications

Below you can find a list of our published research.

6143 results

Cited 21 times since 2011 (1.6 per year) source: EuropePMC

Atherosclerosis, Volume 220, Issue 2, 21 3 2011, Pages 413-417 Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly. Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ

Our goal was to determine whether genetic variation at genes affecting statin metabolism or targets of statin therapy would influence low density lipoprotein (LDL) cholesterol lowering with pravastatin, baseline heart disease, or cardiac endpoints on trial. We examined associations of single nucleotide polymorphisms (SNPs) at the liver X receptor alpha (LXRA, rs12221497), and the solute carrier organic anion transporter (SLCO1B1, rs4149056 and rs2306283) gene loci with these variables. We studie... Abstract

Cited 65 times since 2011 (4.8 per year) source: EuropePMC

The breast journal, Volume 17, Issue 6, 21 3 2011, Pages 661-668 Methotrexate in the management of idiopathic granulomatous mastitis: review of 108 published cases and report of four cases. Akbulut S, Yilmaz D, Bakir S

This study aimed to discuss the role of agents, such as steroids and methotrexate (MTX), in the treatment of patients with idiopathic granulomatous mastitis (IGM). Using Pubmed and Google Scholar data bases, a retrospective study was carried out on IGM cases treated with steroids and/or MTX between 1972 and 2010. Four IGM cases treated with MTX at our clinic were also summarized in this study. A total of 541 IGM cases since 1972, including ours, were retrospectively analyzed. Steroid treatment 5... Abstract

Cited 23 times since 2011 (1.7 per year) source: EuropePMC

Blood, Volume 118, Issue 20, 21 3 2011, Pages 5613-5621 High BRE expression predicts favorable outcome in adult acute myeloid leukemia, in particular among MLL-AF9-positive patients. Noordermeer SM, Sanders MA, Gilissen C, Tönnissen E, van der Heijden A, Döhner K, Bullinger L, Jansen JH, Valk PJ, van der Reijden BA

Aberrations in protein ubiquitination have recently been identified in the pathogenesis of acute myeloid leukemia (AML). We studied whether expression changes of more than 1600 ubiquitination related genes correlated with clinical outcome in 525 adult AML patients. High expression of one of these genes, BRE, was observed in 3% of the cases and predicted favorable prognosis independently of known prognostic factors (5-year overall survival: 57%). Remarkably, unsupervised expression profiling show... Abstract

Cited 16 times since 2011 (1.2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 98, Issue 3, 13 2 2011, Pages 232-237 Age- and gender-specific differences in the prognostic value of CT coronary angiography. Yiu KH, de Graaf FR, Schuijf JD, van Werkhoven JM, Marsan NA, Veltman CE, de Roos A, Pazhenkottil A, Kroft LJ, Boersma E, Herzog B, Leung M, Maffei E, Leung DY, Kaufmann PA, Cademartiri F, Bax JJ, Jukema JW

Objective: To evaluate the potential age- and gender-specific differences in the incidence and prognostic value of coronary artery disease (CAD) in patients undergoing CT coronary angiography (CTA). Design and patients: In this multicentre prospective registry study, 2432 patients (mean age 57 ± 12, 56% male) underwent CTA for suspected CAD. Patients were stratified into four groups according to age Abstract

Cited 158 times since 2011 (11.7 per year) source: EuropePMC

Nature reviews. Cardiology, Volume 9, Issue 1, 13 2 2011, Pages 53-62 Restenosis after PCI. Part 1: pathophysiology and risk factors. Jukema JW, Verschuren JJ, Ahmed TA, Quax PH

Restenosis is a complex disease for which the pathophysiological mechanisms have not yet been fully elucidated, but are thought to include inflammation, proliferation, and matrix remodeling. Over the years, many predictive clinical, biological, (epi)genetic, lesion-related, and procedural risk factors for restenosis have been identified. These factors are not only useful in risk stratification of patients, they also contribute to our understanding of this condition. Furthermore, these factors pr... Abstract

Cited 23 times since 2011 (1.7 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 14, Issue 1, 13 2 2011, Pages 66-73 Prophylactic implantable cardioverter-defibrillator treatment in the elderly: therapy, adverse events, and survival gain. van Rees JB, Borleffs CJ, Thijssen J, de Bie MK, van Erven L, Cannegieter SC, Bax JJ, Schalij MJ

Aims: In elderly patients, obscurity remains regarding the benefit of implantable cardioverter-defibrillator (ICD) treatment as primary prevention of sudden cardiac death. This study assesses implant rates, therapy, adverse events, and survival gain in the elderly primary prevention ICD patient. Methods and results: A total of 1395 patients treated with an ICD for primary prevention of sudden cardiac death at the Leiden University Medical Center were included and allocated to three groups accord... Abstract

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 23, Issue 1, 13 2 2011, Pages 74-80 Toward magnetic resonance-guided electroanatomical voltage mapping for catheter ablation of scar-related ventricular tachycardia: a comparison of registration methods. Tao Q, Milles J, VAN Huls VAN Taxis C, Lamb HJ, Reiber JH, Zeppenfeld K, VAN DER Geest RJ

Introduction: Integration of preprocedural delayed enhanced magnetic resonance imaging (DE-MRI) with electroanatomical voltage mapping (EAVM) may provide additional high-resolution substrate information for catheter ablation of scar-related ventricular tachycardias (VT). Accurate and fast image integration of DE-MRI with EAVM is desirable for MR-guided ablation. Methods and results: Twenty-six VT patients with large transmural scar underwent catheter ablation and preprocedural DE-MRI. With diffe... Abstract

Cited 300 times since 2011 (22.2 per year) source: EuropePMC

Nature genetics, Volume 43, Issue 10, 11 2 2011, Pages 1005-1011 Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Johnson AD, Bochud M, Rice KM, Henneman P, Smith AV, Ehret GB, Amin N, Larson MG, Mooser V, Hadley D, Dörr M, Bis JC, Aspelund T, Esko T, Janssens AC, Zhao JH, Heath S, Laan M, Fu J, Pistis G, Luan J, Arora P, Lucas G, Pirastu N, Pichler I, Jackson AU, Webster RJ, Zhang F, Peden JF, Schmidt H, Tanaka T, Campbell H, Igl W, Milaneschi Y, Hottenga JJ, Vitart V, Chasman DI, Trompet S, Bragg-Gresham JL, Alizadeh BZ, Chambers JC, Guo X, Lehtimäki T, Kühnel B, Lopez LM, Polašek O, Boban M, Nelson CP, Morrison AC, Pihur V, Ganesh SK, Hofman A, Kundu S, Mattace-Raso FU, Rivadeneira F, Sijbrands EJ, Uitterlinden AG, Hwang SJ, Vasan RS, Wang TJ, Bergmann S, Vollenweider P, Waeber G, Laitinen J, Pouta A, Zitting P, McArdle WL, Kroemer HK, Völker U, Völzke H, Glazer NL, Taylor KD, Harris TB, Alavere H, Haller T, Keis A, Tammesoo ML, Aulchenko Y, Barroso I, Khaw KT, Galan P, Hercberg S, Lathrop M, Eyheramendy S, Org E, Org E, Sõber S, Lu X, Nolte IM, Penninx BW, Corre T,

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31... Abstract

Cited 51 times since 2011 (3.8 per year) source: EuropePMC

PloS one, Volume 6, Issue 9, 9 2 2011, Pages e24164 Human embryonic and fetal mesenchymal stem cells differentiate toward three different cardiac lineages in contrast to their adult counterparts. Ramkisoensing AA, Pijnappels DA, Askar SF, Passier R, Swildens J, Goumans MJ, Schutte CI, de Vries AA, Scherjon S, Mummery CL, Schalij MJ, Atsma DE

Mesenchymal stem cells (MSCs) show unexplained differences in differentiation potential. In this study, differentiation of human (h) MSCs derived from embryonic, fetal and adult sources toward cardiomyocytes, endothelial and smooth muscle cells was investigated. Labeled hMSCs derived from embryonic stem cells (hESC-MSCs), fetal umbilical cord, bone marrow, amniotic membrane and adult bone marrow and adipose tissue were co-cultured with neonatal rat cardiomyocytes (nrCMCs) or cardiac fibroblasts... Abstract

Cited 22 times since 2011 (1.6 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 24, Issue 11, 9 2 2011, Pages 1183-1190 Real-time three-dimensional echocardiography: segmental analysis of the right ventricle in patients with repaired tetralogy of fallot. van der Hulst AE, Roest AA, Holman ER, de Roos A, Blom NA, Bax JJ, Delgado V

Background: The accurate assessment of right ventricular (RV) function and dimensions has important prognostic implications in patients with repaired tetralogy of Fallot (ToF). Three-dimensional imaging is the preferred methodology to evaluate RV function. Novel postprocessing software applications to evaluate three-dimensional data have provided insight into RV function and dimensions by analyzing the various RV components (inlet, apical trabecular, outlet). The aim of this study was to charact... Abstract

Cited 8 times since 2011 (0.6 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 143, Issue 3, 9 2 2011, Pages 569-575 Exercise capacity and cardiac reserve in children and adolescents with corrected pulmonary atresia with intact ventricular septum after univentricular palliation and biventricular repair. Romeih S, Groenink M, Roest AA, van der Plas MN, Hazekamp MG, Mulder BJ, Blom NA

Objective: Management of pulmonary atresia with intact ventricular septum is challenging and depends on the severity of right ventricular hypoplasia. Clinical outcomes of biventricular repair seem favorable to univentricular palliation, but data on superiority of biventricular repair regarding exercise capacity are conflicting. We investigated the response to physical and pharmacologic stress in patients with surgically corrected pulmonary atresia with intact ventricular septum. Methods: Sixteen... Abstract

Cited 24 times since 2011 (1.8 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 52, Issue 10, 9 2 2011, Pages 1559-1565 Cardiac sympathetic dysfunction in genotyped patients with arrhythmogenic right ventricular cardiomyopathy and risk of recurrent ventricular tachyarrhythmias. Paul M, Wichter T, Kies P, Gerss J, Wollmann C, Rahbar K, Eckardt L, Breithardt G, Schober O, Schulze-Bahr E, Schäfers M

Unlabelled: Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) typically present with ventricular tachyarrhythmias preferentially triggered by an elevated sympathetic tone. Previous studies demonstrated an impairment of the presynaptic catecholamine reuptake as assessed by (123)I-labeled norepinephrine analog on metaiodobenzylguanidine ((123)I-MIBG) SPECT. Mutations in the gene encoding for plakophilin-2 (PKP-2) are the most common cause of autosomal dominant ARVC (ARVC-9). In... Abstract

Cited 14 times since 2011 (1 per year) source: EuropePMC

The American journal of cardiology, Volume 108, Issue 12, 8 2 2011, Pages 1689-1696 Prevalence of dyssynchrony and relation with long-term outcome in patients after acute myocardial infarction. Antoni ML, Boden H, Hoogslag GE, Ewe SH, Auger D, Holman ER, van der Wall EE, Schalij MJ, Bax JJ, Delgado V

The impact of left ventricular (LV) dyssynchrony on the long-term outcomes of patients with acute myocardial infarction (AMI) remains unknown. The purpose of the present study was to evaluate the prevalence of LV dyssynchrony after AMI and the potential relation with adverse events. A total of 976 consecutive patients admitted with AMI treated with primary percutaneous coronary intervention were evaluated. Two-dimensional echocardiography was performed Abstract

Cited 56 times since 2011 (4.1 per year) source: EuropePMC

Current opinion in virology, Volume 1, Issue 6, 3 1 2011, Pages 635-642 Predicting 'airborne' influenza viruses: (trans-) mission impossible? Sorrell EM, Schrauwen EJ, Linster M, De Graaf M, Herfst S, Fouchier RA

Repeated transmission of animal influenza viruses to humans has prompted investigation of the viral, host, and environmental factors responsible for transmission via aerosols or respiratory droplets. How do we determine-out of thousands of influenza virus isolates collected in animal surveillance studies each year-which viruses have the potential to become 'airborne', and hence pose a pandemic threat? Here, using knowledge from pandemic, zoonotic and epidemic viruses, we postulate that... Abstract

Cited 41 times since 2011 (3 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 92, Issue 3, 1 1 2011, Pages 973-979 Thirty-year experience with the arterial switch operation. Lalezari S, Bruggemans EF, Blom NA, Hazekamp MG

Background: We evaluated the results of the arterial switch operation (ASO) being performed at our institution for more than 30 years and identified risk factors for mortality and reoperation. Methods: Clinical outcome of 332 consecutive patients with transposition of the great arteries undergoing ASO was retrospectively analyzed, using surgical reports, medical charts, and latest follow-up echocardiography. Statistical analysis was performed using the Kaplan-Meier method and univariable and mul... Abstract

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Volume 6, Issue 9, 1 1 2011, Pages 1510-1515 Transesophageal ultrasound-guided fine-needle aspiration for the mediastinal restaging of non-small cell lung cancer. von Bartheld MB, Versteegh MI, Braun J, Willems LN, Rabe KF, Annema JT

Introduction: Selected patients with stage III (N2/N3) non-small cell lung cancer (NSCLC) who are downstaged to N0 by chemoradiation therapy might benefit from subsequent surgical resection of the tumor. How mediastinal lymph nodes can be best reevaluated is subject of debate. Transesophageal ultrasound-guided fine-needle aspiration (EUS-FNA) is a minimally invasive technique to sample mediastinal nodes. We assessed sensitivity and false-negative rate of EUS-FNA for the mediastinal restaging of... Abstract

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

Human molecular genetics, Volume 20, Issue 23, 30 5 2011, Pages 4748-4757 A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention. Sampietro ML, Trompet S, Verschuren JJ, Talens RP, Deelen J, Heijmans BT, de Winter RJ, Tio RA, Doevendans PA, Ganesh SK, Nabel EG, Westra HJ, Franke L, van den Akker EB, Westendorp RG, Zwinderman AH, Kastrati A, Koch W, Slagboom PE, de Knijff P, Jukema JW

Percutaneous coronary intervention (PCI) has become an effective therapy to treat obstructive coronary artery diseases (CAD). However, one of the major drawbacks of PCI is the occurrence of restenosis in 5-25% of all initially treated patients. Restenosis is defined as the re-narrowing of the lumen of the blood vessel, resulting in renewed symptoms and the need for repeated intervention. To identify genetic variants that are associated with restenosis, a genome-wide association study (GWAS) was... Abstract

Cited 97 times since 2011 (7.1 per year) source: EuropePMC

European heart journal, Volume 32, Issue 20, 30 5 2011, Pages 2541-2554 RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome. Steg PG, Mehta SR, Jukema JW, Lip GY, Gibson CM, Kovar F, Kala P, Garcia-Hernandez A, Renfurm RW, Granger CB, RUBY-1 Investigators

Aims: To establish the safety, tolerability and most promising regimen of darexaban (YM150), a novel, oral, direct factor Xa inhibitor, for prevention of ischaemic events in acute coronary syndrome (ACS). Methods: In a 26-week, multi-centre, double-blind, randomized, parallel-group study, 1279 patients with recent high-risk non-ST-segment or ST-segment elevation ACS received one of six darexaban regimens: 5 mg b.i.d., 10 mg o.d., 15 mg b.i.d., 30 mg o.d., 30 mg b.i.d., or 60 mg o.d. or placebo,... Abstract

Cited 25 times since 2011 (1.8 per year) source: EuropePMC

Intensive care medicine, Volume 37, Issue 10, 30 5 2011, Pages 1656-1663 Ventilator-associated pneumonia in children after cardiac surgery in The Netherlands. Roeleveld PP, Guijt D, Kuijper EJ, Hazekamp MG, de Wilde RB, de Jonge E

Purpose: We conducted a retrospective cohort study in an academic tertiary care center to characterize ventilator-associated pneumonia (VAP) in pediatric patients after cardiac surgery in The Netherlands. Methods: All patients following cardiac surgery and mechanically ventilated for ≥24 h were included. The primary outcome was development of VAP. Secondary outcomes were duration of mechanical ventilation and length of ICU stay. Results: A total of 125 patients were enrolled. Their mean age was... Abstract

Cited 20 times since 2011 (1.5 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 14, Issue 1, 27 4 2011, Pages 112-116 Trans-venous lead removal without the use of extraction sheaths, results of >250 removal procedures. de Bie MK, Fouad DA, Borleffs CJ, van Rees JB, Thijssen J, Trines SA, Bootsma M, Schalij MJ, van Erven L

Aims: The number of implanted cardiac rhythm devices has rapidly increased in the past decade. Subsequently, the need for lead extraction has also increased. Several techniques of lead removal have been documented from manual traction of the lead to lead extraction assisted with mechanical or laser sheaths. The goal of this study was to review our experience with lead removal using manual traction without the assistance of extraction sheaths. Methods and results: In the Leiden University Medical... Abstract