Research

Publications

Below you can find a list of our published research.

6143 results

Cited 32 times since 2010 (2.2 per year) source: EuropePMC

Atherosclerosis, Volume 214, Issue 2, 13 2 2010, Pages 295-300 Atorvastatin inhibits plaque development and adventitial neovascularization in ApoE deficient mice independent of plasma cholesterol levels. Bot I, Jukema JW, Lankhuizen IM, van Berkel TJ, Biessen EA

Excessive adventitial neovascularization is one of the hallmarks of atherosclerotic plaque progression and is associated with an increased plaque burden by facilitating leukocyte influx and perivascular inflammation. Statins act atheroprotective by reducing plasma cholesterol levels and by quenching inflammation, but recent studies suggest that they may also affect neovascularization. In this study, we aimed to investigate this notion in apoE(-/-) mice. Advanced carotid artery lesions were induc... Abstract

Cited 385 times since 2010 (26.8 per year) source: EuropePMC

Circulation. Heart failure, Volume 4, Issue 1, 12 2 2010, Pages 44-52 Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction. Westermann D, Lindner D, Kasner M, Zietsch C, Savvatis K, Escher F, von Schlippenbach J, Skurk C, Steendijk P, Riad A, Poller W, Schultheiss HP, Tschöpe C

Background: The pathophysiology of heart failure with normal ejection fraction (HFNEF) is still under discussion. Here we report the influence of cardiac inflammation on extracellular matrix (ECM) remodeling in patients with HFNEF. Methods and results: We investigated left ventricular systolic and diastolic function in 20 patients with HFNEF and 8 control patients by conductance catheter methods and echocardiography. Endomyocardial biopsy samples were also obtained, and ECM proteins as well as c... Abstract

Cited 18 times since 2010 (1.3 per year) source: EuropePMC

BMC musculoskeletal disorders, Volume 11, 12 2 2010, Pages 263 Functional treatment versus plaster for simple elbow dislocations (FuncSiE): a randomized trial. de Haan J, den Hartog D, Tuinebreijer WE, Iordens GI, Breederveld RS, Bronkhorst MW, Bruijninckx MM, De Vries MR, Dwars BJ, Eygendaal D, Haverlag R, Meylaerts SA, Mulder JW, Ponsen KJ, Roerdink WH, Roukema GR, Schipper IB, Schouten MA, Sintenie JB, Sivro S, Van den Brand JG, Van der Meulen HG, Van Thiel TP, Van Vugt AB, Verleisdonk EJ, Vroemen JP, Waleboer M, Willems WJ, Polinder S, Patka P, van Lieshout EM, Schep NW

Background: Elbow dislocations can be classified as simple or complex. Simple dislocations are characterized by the absence of fractures, while complex dislocations are associated with fractures. After reduction of a simple dislocation, treatment options include immobilization in a static plaster for different periods of time or so-called functional treatment. Functional treatment is characterized by early active motion within the limits of pain with or without the use of a sling or hinged brace... Abstract

Cited 2 times since 2010 (0.1 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 97, Issue 1, 11 2 2010, Pages 1-3 Can cardiac [123I]m-iodobenzylguanidine imaging be used for risk stratification of patients with acute myocardial infarction? Boogers MJ, Bax JJ

Abstract

Cited 13 times since 2010 (0.9 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 97, Issue 2, 8 2 2010, Pages 143-150 Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies. Pons D, Trompet S, de Craen AJ, Thijssen PE, Quax PH, de Vries MR, Wierda RJ, van den Elsen PJ, Monraats PS, Ewing MM, Heijmans BT, Slagboom PE, Zwinderman AH, Doevendans PA, Tio RA, de Winter RJ, de Maat MP, Iakoubova OA, Sattar N, Shepherd J, Westendorp RG, Jukema JW, PROSPER study group, WOSCOPS study group, GENDER study group

Aims: This study was designed to investigate the counterbalancing influence of genetic variation in the promoter of the gene encoding P300/CBP associated factor (PCAF), a lysine acetyltransferase (KAT), on coronary heart disease (CHD) and mortality. Methods and results: The association of genetic variation in the PCAF-gene with CHD, restenosis and mortality was investigated in three large cohorts. The results were combined to examine overall effects on CHD mortality and on restenosis risk. Compa... Abstract

Cited 26 times since 2010 (1.8 per year) source: EuropePMC

The American journal of cardiology, Volume 106, Issue 12, 4 1 2010, Pages 1675-1679 Impact of clinical presentation and pretest likelihood on the relation between calcium score and computed tomographic coronary angiography. van Werkhoven JM, de Boer SM, Schuijf JD, Cademartiri F, Maffei E, Jukema JW, Boogers MJ, Kroft LJ, de Roos A, Bax JJ

The purpose of the present study was to assess the impact of clinical presentation and pretest likelihood on the relation between coronary calcium score (CCS) and computed tomographic coronary angiography (CTA) to determine the role of CCS as a gatekeeper to CTA in patients presenting with chest pain. In 576 patients with suspected coronary artery disease (CAD), CCS and CTA were performed. CCS was categorized as 0, 1 to 400, and >400. On CT angiogram the presence of significant CAD (≥50% lumi... Abstract

Cited 29 times since 2010 (2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 96, Issue 21, 1 1 2010, Pages 1737-1743 Left ventricular rotational mechanics in patients with coronary artery disease: differences in subendocardial and subepicardial layers. Bertini M, Delgado V, Nucifora G, Ajmone Marsan N, Ng AC, Shanks M, Antoni ML, van de Veire NR, van Bommel RJ, Rapezzi C, Schalij MJ, Bax JJ

Objective: Subendocardial and subepicardial layers have opposite orientation of the myofibres and they are differently affected by coronary artery disease. This study investigated the differences in subendocardial and subepicardial left ventricular (LV) twist in patients with coronary artery disease. Methods: 214 patients were included in the study: 60 with first ST elevation myocardial infarction (STEMI), 111 with chronic ischaemic heart failure (HF) and 43 normal subjects. Real-time three-dime... Abstract

Cited 5 times since 2010 (0.3 per year) source: EuropePMC

Nature reviews. Cardiology, Volume 7, Issue 11, 1 1 2010, Pages 604-606 Cardiomyopathies: Myocardial fibrosis assessed by CMR to predict events in HCM. Ajmone Marsan N, Bax JJ

Abstract

Cited 30 times since 2010 (2.1 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 6, Issue 5, 1 1 2010, Pages 643-652 Multimodality imaging in transcatheter aortic valve implantation: key steps to assess procedural feasibility. Delgado V, Ewe SH, Ng AC, van der Kley F, Marsan NA, Schuijf JD, Schalij MJ, Bax JJ

Transcatheter aortic valve implantation (TAVI) has been an important breakthrough in the treatment of patients with symptomatic, severe aortic stenosis and contraindications for surgical aortic valve replacement. Accurate aortic root measurements and evaluation of spatial relationships with the coronary ostia are crucial in pre-operative TAVI assessment. In addition, characterisation of the peripheral artery anatomy and aorta is an important key step in the procedural feasibility evaluation. The... Abstract

Cited 14 times since 2010 (1 per year) source: EuropePMC

Haemophilia : the official journal of the World Federation of Hemophilia, Volume 16, Issue 6, 1 1 2010, Pages 888-891 A single centre experience in circumcision of haemophilia patients: Izmir protocol. Yilmaz D, Akin M, Ay Y, Balkan C, Celik A, Ergün O, Kavakli K

Haemophiliacs and their families consider that circumcision is a very important step to become a member of society and it is a social obligation for men in Turkey. Although bleeding risk is high, almost all haemophiliacs would like to be circumcised in Turkish society. The aim of this study was to evaluate our experience in circumcision of haemophilia patients and define efficacy, safety and complication rates of our protocol, called 'Izmir protocol'. In this study, we retrospectivel... Abstract

Cited 10 times since 2010 (0.7 per year) source: EuropePMC

American heart journal, Volume 160, Issue 5, 1 1 2010, Pages 812-818 Rationale and design of a trial on the effect of angiotensin II receptor blockers on the function of the systemic right ventricle. van der Bom T, Winter MM, Bouma BJ, Groenink M, Vliegen HW, Pieper PG, van Dijk AP, Sieswerda GT, Roos-Hesslink JW, Zwinderman AH, Mulder BJ

Background: Angiotensin II receptor blockers have been proven to be beneficial in left ventricular failure. In patients with a morphologic right ventricle supporting the systemic circulation, its efficacy has not yet been established. Methods: We designed a multicenter, prospective, randomized, double-blind, placebo-controlled trial studying the effect of valsartan in patients with a systemic right ventricle due to a congenitally or surgically corrected transposition of the great arteries. The p... Abstract

Cited 25 times since 2010 (1.7 per year) source: EuropePMC

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons, Volume 49, Issue 6, 1 1 2010, Pages 541-545 Chopart joint injury: a study of outcome and morbidity. van Dorp KB, de Vries MR, van der Elst M, Schepers T

Injuries involving the Chopart joint complex are relatively rare and frequently missed or misdiagnosed, often leading to a poor functional outcome. This study was performed to determine the outcome and morbidity in patients with Chopart joint injuries, and to increase awareness of this severe injury. Patients with a Chopart dislocation or fracture-dislocation, treated between January 2004 and January 2010, were identified using the appropriate diagnosis code and reviewing all radiographs of pati... Abstract

Cited 18 times since 2010 (1.3 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 21, Issue 11, 1 1 2010, Pages 1284-1292 Electrical activation of sinus venosus myocardium and expression patterns of RhoA and Isl-1 in the chick embryo. Vicente-Steijn R, Kolditz DP, Mahtab EA, Askar SF, Bax NA, VAN DER Graaf LM, Wisse LJ, Passier R, Pijnappels DA, Schalij MJ, Poelmann RE, Gittenberger-DE Groot AC, Jongbloed MR

Unlabelled: Electrical Activity and RhoA in the Embryo. Introduction: Myocardium at the venous pole (sinus venosus) of the heart has gained clinical interest as arrhythmias can be initiated from this area. During development, sinus venosus myocardium is incorporated to the primary heart tube and expresses different markers than primary myocardium. We aimed to elucidate the development of sinus venosus myocardium, including the sinoatrial node (SAN), by studying expression patterns of RhoA in rel... Abstract

Cited 29 times since 2010 (2 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 56, Issue 23, 1 1 2010, Pages 1922-1929 Timing of pre-operative Beta-blocker treatment in vascular surgery patients: influence on post-operative outcome. Flu WJ, van Kuijk JP, Chonchol M, Winkel TA, Verhagen HJ, Bax JJ, Poldermans D

Objectives: This study evaluated timing of β-blocker initiation before surgery and its relationship with: 1) pre-operative heart rate and high-sensitivity C-reactive-protein (hs-CRP) levels; and 2) post-operative outcome. Background: Perioperative guidelines recommend β-blocker initiation days to weeks before surgery, on the basis of expert opinions. Methods: In 940 vascular surgery patients, pre-operative heart rate and hs-CRP levels were recorded, next to timing of β-blocker initiation before... Abstract

Cited 16 times since 2010 (1.1 per year) source: EuropePMC

The American journal of medicine, Volume 123, Issue 11, 1 1 2010, Pages 978-986 Clinical relevance of hibernating myocardium in ischemic left ventricular dysfunction. Schinkel AF, Bax JJ, Delgado V, Poldermans D, Rahimtoola SH

Patients with chronic ischemic left ventricular dysfunction may have a substantial amount of viable, hibernating myocardium, which is a state of chronic contractile dysfunction with reduced blood flow at rest. Coronary revascularization in these patients may result in improvement of left ventricular function; in the absence of viability, left ventricular function will not improve postrevascularization. Various noninvasive imaging techniques are available for detection of viable myocardium, inclu... Abstract

Cited 40 times since 2010 (2.8 per year) source: EuropePMC

Respiratory medicine, Volume 104, Issue 11, 1 1 2010, Pages 1744-1749 Prevalence and potential determinants of exertional dyspnea after acute pulmonary embolism. Klok FA, van Kralingen KW, van Dijk AP, Heyning FH, Vliegen HW, Huisman MV

Background: The exact prevalence and etiology of exertional dyspnea in the clinical course of acute pulmonary embolism (PE) have not yet been established. Methods: A large cohort of consecutive patients diagnosed with acute PE was subjected to a dyspnea questionnaire and invited for cardiopulmonary work-up including the 6-min walk test, spirometry and echocardiography. The prevalence, severity, determinants and underlying diseases of exertional dyspnea were evaluated. Results: Of the registered... Abstract

Cited 19 times since 2010 (1.3 per year) source: EuropePMC

Pain medicine (Malden, Mass.), Volume 11, Issue 11, 1 1 2010, Pages 1628-1634 Pain symptoms accompanying chronic poststernotomy pain: a pilot study. van Leersum NJ, van Leersum RL, Verwey HF, Klautz RJ

Objective: Despite the technical developments in surgical procedures, chronic poststernotomy pain (CPSP) is still very common. Many theories for its cause have been proposed in the literature, but the etiology is still not clear. Pain along the sternal scar and in the upper extremities (sometimes accompanied with paresthesia) persists in about 30% of cases. These symptoms have been regarded as two separate complications. This study investigated all pain symptoms in patients following sternotomy.... Abstract

Cited 12 times since 2010 (0.8 per year) source: EuropePMC

The American journal of cardiology, Volume 106, Issue 10, 1 1 2010, Pages 1404-1409 Left ventricular muscle and fluid mechanics in acute myocardial infarction. Nucifora G, Delgado V, Bertini M, Marsan NA, Van de Veire NR, Ng AC, Siebelink HM, Schalij MJ, Holman ER, Sengupta PP, Bax JJ

Left ventricular (LV) diastolic filling is characterized by the formation of intraventricular rotational bodies of fluid (termed "vortex rings") that optimize the efficiency of LV ejection. The aim of the present study was to evaluate the morphology and dynamics of LV diastolic vortex ring formation early after acute myocardial infarction (AMI), in relation to LV diastolic function and infarct size. A total of 94 patients with a first ST-segment elevation AMI (59 ± 11 years; 78% men) w... Abstract

Cited 229 times since 2010 (15.9 per year) source: EuropePMC

JAMA, Volume 304, Issue 20, 1 1 2010, Pages 2245-2252 Mediastinoscopy vs endosonography for mediastinal nodal staging of lung cancer: a randomized trial. Annema JT, van Meerbeeck JP, Rintoul RC, Dooms C, Deschepper E, Dekkers OM, De Leyn P, Braun J, Carroll NR, Praet M, de Ryck F, Vansteenkiste J, Vermassen F, Versteegh MI, Veseliç M, Nicholson AG, Rabe KF, Tournoy KG

Context: Mediastinal nodal staging is recommended for patients with resectable non-small cell lung cancer (NSCLC). Surgical staging has limitations, which results in the performance of unnecessary thoracotomies. Current guidelines acknowledge minimally invasive endosonography followed by surgical staging (if no nodal metastases are found by endosonography) as an alternative to immediate surgical staging. Objective: To compare the 2 recommended lung cancer staging strategies. Design, setting, and... Abstract

Cited 18 times since 2010 (1.3 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 56, Issue 19, 1 1 2010, Pages 1567-1575 Effect of biventricular pacing on diastolic dyssynchrony. Shanks M, Bertini M, Delgado V, Ng AC, Nucifora G, van Bommel RJ, Borleffs CJ, Holman ER, van de Veire NR, Schalij MJ, Bax JJ

Objectives: This study sought to examine the changes in diastolic dyssynchrony with cardiac resynchronization therapy (CRT). Background: Little is known about the effect of CRT on diastolic dyssynchrony. Methods: Consecutive heart failure patients (n = 266, age 65.7 ± 10.0 years) underwent color-coded tissue Doppler imaging at baseline, 48 h, and 6 months after CRT. Systolic and diastolic dyssynchrony were defined as maximal time delay in peak systolic and early diastolic velocities, respectivel... Abstract