Research

Publications

Below you can find a list of our published research.

6555 results

Cited 169 times since 2008 (9.8 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 51, Issue 1, 1 1 2008, Pages 37-45 Statins for secondary prevention in elderly patients: a hierarchical bayesian meta-analysis. Afilalo J, Duque G, Steele R, Jukema JW, de Craen AJ, Eisenberg MJ

Objectives: This study was designed to determine whether statins reduce all-cause mortality in elderly patients with coronary heart disease. Background: Statins continue to be underutilized in elderly patients because evidence has not consistently shown that they reduce mortality. Methods: We searched 5 electronic databases, the Internet, and conference proceedings to identify relevant trials. In addition, we obtained unpublished data for the elderly patient subgroups from 4 trials and for the s... Abstract

Cited 19 times since 2008 (1.1 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 1, Issue 1, 1 1 2008, Pages 94-106 Noncoronary applications of cardiac multidetector row computed tomography. Tops LF, Krishnàn SC, Schuijf JD, Schalij MJ, Bax JJ

Multidetector row computed tomography (MDCT) has a high diagnostic accuracy to evaluate coronary artery stenoses. Additionally, the 4-dimensional aspect of cardiac MDCT allows a comprehensive evaluation of cardiac structure and function. Left ventricular volumes and systolic function can be accurately assessed with MDCT, and imaging of myocardial infarction is a promising application of cardiac MDCT. In addition, MDCT may provide anatomical visualization of heart valves. Also, evaluation of anat... Abstract

Cited 6 times since 2008 (0.3 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 16, Issue 1, 1 1 2008, Pages 30-32 Epigenetic histone acetylation modifiers in vascular remodelling - new targets for therapy in cardiovascular disease. Pons D, Jukema JW

Abstract

Cited 1 times since 2008 (0.1 per year) source: EuropePMC

Multimedia manual of cardiothoracic surgery : MMCTS, Volume 2008, Issue 915, 1 1 2008, Pages mmcts.2006.002329 Surgery for supravalvular aortic stenosis - the three-patch technique. Arnáiz E, Koolbergen D, Adsuar A, Hazekamp MG

The objective of this paper is to describe the three-patch technique for repair of supravalvular aortic stenosis (SVAS). Supravalvular aortic stenosis is a rare malformation as a result of an abnormal thickening of the aortic wall. SVAS may present in two forms: a localized form (affecting only the aortic sinotubular junction) and a diffuse form, where the aortic arch and its side branches are also affected. Since 1960, multiple surgical techniques have been described with the aim of relieving t... Abstract

Cited 3 times since 2008 (0.2 per year) source: EuropePMC

Mayo Clinic proceedings, Volume 83, Issue 1, 1 1 2008, Pages 10-12 Can coronary calcification define the warranty period of a normal myocardial perfusion study? Bax JJ, Schuijf JD

Abstract

Cited 57 times since 2008 (3.3 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 15, Issue 1, 1 1 2008, Pages 127-136 Assessment of left ventricular mechanical dyssynchrony by phase analysis of ECG-gated SPECT myocardial perfusion imaging. Chen J, Henneman MM, Trimble MA, Bax JJ, Borges-Neto S, Iskandrian AE, Nichols KJ, Garcia EV

Cardiac resynchronization therapy (CRT) has shown benefits in patients with severe heart failure. However, at least 30% of patients selected for CRT by use of traditional criteria (New York Heart Association class III or IV, depressed left ventricular [LV] ejection fraction, and prolonged QRS duration) do not respond to CRT. Recent studies with tissue Doppler imaging have shown that the presence of LV dyssynchrony is an important predictor of response to CRT. Phase analysis has been developed to... Abstract

Cited 40 times since 2008 (2.3 per year) source: EuropePMC

The American journal of cardiology, Volume 101, Issue 1, 1 1 2008, Pages 122-126 Influence of renal function on the usefulness of N-terminal pro-B-type natriuretic peptide as a prognostic cardiac risk marker in patients undergoing noncardiac vascular surgery. Goei D, Schouten O, Boersma E, Welten GM, Dunkelgrun M, Lindemans J, van Gestel YR, Hoeks SE, Bax JJ, Poldermans D

N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is related to stress-induced myocardial ischemia and/or volume overload, both common in patients with renal dysfunction. This might compromise the prognostic usefulness of NT-pro-BNP in patients with renal impairment before vascular surgery. We assessed the prognostic value of NT-pro-BNP in the entire strata of renal function. In 356 patients (median age 69 years, 77% men), cardiac history, glomerular filtration rate (GFR, ml/min/1.73 m(2)),... Abstract

Cited 35 times since 2007 (2 per year) source: EuropePMC

Atherosclerosis, Volume 200, Issue 1, 27 4 2007, Pages 161-167 High HDL cholesterol does not protect against coronary artery disease when associated with combined cholesteryl ester transfer protein and hepatic lipase gene variants. van Acker BA, Botma GJ, Zwinderman AH, Kuivenhoven JA, Dallinga-Thie GM, Sijbrands EJ, Boer JM, Seidell JC, Jukema JW, Kastelein JJ, Jansen H, Verhoeven AJ, REGRESS Study Group

Cholesteryl ester transfer protein (CETP) and hepatic lipase (HL) are two HDL modifying proteins that have both pro- and anti-atherogenic properties. We hypothesized that CETP and HL synergistically affect HDL cholesterol and atherosclerotic risk. To test our hypothesis, we analysed the genotype frequencies of CETP Taq1B (rs708272) and LIPC-514C/T (rs1800588) polymorphisms in male coronary artery disease patients (CAD; n=792) and non-symptomatic controls (n=539). Cases and controls had similar a... Abstract

Cited 33 times since 2007 (1.9 per year) source: EuropePMC

Tuberculosis (Edinburgh, Scotland), Volume 88, Issue 3, 26 4 2007, Pages 249-261 Double-blind randomized Phase I study comparing rdESAT-6 to tuberculin as skin test reagent in the diagnosis of tuberculosis infection. Arend SM, Franken WP, Aggerbeck H, Prins C, van Dissel JT, Thierry-Carstensen B, Tingskov PN, Weldingh K, Andersen P

Limited specificity of the tuberculin skin test incited the development of in vitro assays based on Mycobacterium tuberculosis-specific antigens such as ESAT-6 that are lacking in Bacillus Calmette Guérin (BCG). In animal studies, intradermal ESAT-6 was safe and induced specific skin test responses. The aim of the study was to assess the safety of intradermal recombinant dimer ESAT-6 (rdESAT-6) compared with tuberculin and to determine the human dose. The study design was a double-blind Phase I... Abstract

Cited 79 times since 2007 (4.6 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 19, Issue 4, 20 3 2007, Pages 392-399 Real-time three-dimensional echocardiography permits quantification of left ventricular mechanical dyssynchrony and predicts acute response to cardiac resynchronization therapy. Marsan NA, Bleeker GB, Ypenburg C, Ghio S, van de Veire NR, Holman ER, van der Wall EE, Tavazzi L, Schalij MJ, Bax JJ

Objective: To evaluate the value of real-time three-dimensional echocardiography (RT3DE) to predict acute response to cardiac resynchronization therapy (CRT). Methods: Sixty consecutive heart failure patients scheduled for CRT were included. RT3DE was performed before and within 48 hours after pacemaker implantation to calculate both left ventricular (LV) volumes and LV dyssynchrony. LV dyssynchrony was defined as the standard deviation of the time taken to reach the minimum systolic volume for... Abstract

Cited 43 times since 2007 (2.5 per year) source: EuropePMC

Biochemical and biophysical research communications, Volume 366, Issue 4, 18 3 2007, Pages 910-916 Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity. Pols TW, Ottenhoff R, Vos M, Levels JH, Quax PH, Meijers JC, Pannekoek H, Groen AK, de Vries CJ

NR4A nuclear receptors are induced in the liver upon fasting and regulate hepatic gluconeogenesis. Here, we studied the role of nuclear receptor Nur77 (NR4A1) in hepatic lipid metabolism. We generated mice expressing hepatic Nur77 using adenoviral vectors, and demonstrate that these mice exhibit a modulation of the plasma lipid profile and a reduction in hepatic triglyceride. Expression analysis of >25 key genes involved in lipid metabolism revealed that Nur77 inhibits SREBP1c expression. Thi... Abstract

Cited 2 times since 2007 (0.1 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 35, Issue 3, 18 3 2007, Pages 687 Discrepancy between glucose metabolism and sympathetic nerve terminals in a patient with metastatic paraganglioma. Rahbar K, Kies P, Stegger L, Juergens KU, Weckesser M

Abstract

Cited 292 times since 2007 (17 per year) source: EuropePMC

European heart journal, Volume 29, Issue 4, 15 3 2007, Pages 531-556 Cardiac computed tomography: indications, applications, limitations, and training requirements: report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT of the European Society of Cardiology and the European Council of Nuclear Cardiology. Schroeder S, Achenbach S, Bengel F, Burgstahler C, Cademartiri F, de Feyter P, George R, Kaufmann P, Kopp AF, Knuuti J, Ropers D, Schuijf J, Tops LF, Bax JJ, Working Group Nuclear Cardiology and Cardiac CT, European Society of Cardiology, European Council of Nuclear Cardiology

As a consequence of improved technology, there is growing clinical interest in the use of multi-detector row computed tomography (MDCT) for non-invasive coronary angiography. Indeed, the accuracy of MDCT to detect or exclude coronary artery stenoses has been high in many published studies. This report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT (WG 5) of the European Society of Cardiology and the European Council of Nuclear Cardiology summarizes the present... Abstract

Cited 23 times since 2007 (1.3 per year) source: EuropePMC

Journal of applied physiology (Bethesda, Md. : 1985), Volume 104, Issue 2, 13 2 2007, Pages 446-450 Long-term cardiovascular effects of neonatal dexamethasone treatment: hemodynamic follow-up by left ventricular pressure-volume loops in rats. Bal MP, de Vries WB, van Oosterhout MF, Baan J, van der Wall EE, van Bel F, Steendijk P

Dexamethasone is clinically applied in preterm infants to treat or prevent chronic lung disease. However, concern has emerged about adverse side effects. The cardiovascular short-term side effects of neonatal dexamethasone treatment are well documented, but long-term consequences are unknown. Previous studies showed suppressed mitosis during dexamethasone treatment, leading to reduced ventricular weight, depressed systolic function, and compensatory dilatation in prepubertal rats. In addition, r... Abstract

Cited 12 times since 2007 (0.7 per year) source: EuropePMC

Radiology, Volume 246, Issue 2, 4 1 2007, Pages 394-400 MR imaging of right ventricular function after the Ross procedure for aortic valve replacement: initial experience. Grotenhuis HB, de Roos A, Ottenkamp J, Schoof PH, Vliegen HW, Kroft LJ

Purpose: To prospectively assess right ventricular (RV) function after the Ross procedure by using magnetic resonance (MR) imaging. Materials and methods: The local ethics committee approved the study and informed consent was obtained from all participants prior to enrollment in the study. Seventeen patients (15 male, two female; mean age +/- standard deviation, 19 years +/- 3.9; imaging performed 8.3 years after surgery +/- 3.2) and 17 matched controls (15 male, two female; mean age +/- standar... Abstract

Cited 2 times since 2007 (0.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 50, Issue 25, 1 1 2007, Pages 2421-2430 Highlights of the 2007 scientific sessions of the European Society of Cardiology Vienna, Austria, September 1-5, 2007. Kristensen SD, Baumgartner H, Drexler H, Eeckhout E, Filippatos G, Gitt AK, Linde C, Pierard LA, Poldermans D, Schunkert H, Sipido KR, van der Wall EE, Fox K, Bax JJ, European Society of Cardiology

Abstract

Cited 47 times since 2007 (2.7 per year) source: EuropePMC

Archives of internal medicine, Volume 167, Issue 22, 1 1 2007, Pages 2482-2489 A prognostic risk index for long-term mortality in patients with peripheral arterial disease. Feringa HH, Bax JJ, Hoeks S, van Waning VH, Elhendy A, Karagiannis S, Vidakovic R, Schouten O, Boersma E, Poldermans D

Background: Prognostic information in peripheral arterial disease (PAD) may provide the basis for optimal management strategies at an early stage. This study aimed to develop a prognostic risk index for long-term mortality in patients with PAD. Methods: In a single-center observational cohort study, 2642 patients with an ankle-brachial index of 0.90 or lower were randomly divided into derivation (n = 1332) and validation (n = 1310) cohorts. Cox regression analysis with stepwise backward eliminat... Abstract

Cited 5 times since 2007 (0.3 per year) source: EuropePMC

Coronary artery disease, Volume 18, Issue 8, 1 1 2007, Pages 645-651 Baseline natriuretic peptide levels in relation to myocardial ischemia, troponin T release and heart rate variability in patients undergoing major vascular surgery. Feringa HH, Vidakovic R, Karagiannis SE, de Jonge R, Lindemans J, Goei D, Schouten O, Bax JJ, Poldermans D

Background: This study was conducted to determine the association between baseline N-terminal pro-B-type natriuretic peptide (NT-proBNP) and myocardial ischemia, troponin T release and heart rate variability (HRV) in patients undergoing major vascular surgery. Methods: In a prospective study, 182 vascular surgery patients were evaluated by clinical risk factors, dobutamine stress echocardiography and baseline NT-proBNP levels. Myocardial ischemia was detected by continuous 12-lead electrocardiog... Abstract

Cited 36 times since 2007 (2.1 per year) source: EuropePMC

Current opinion in lipidology, Volume 18, Issue 6, 1 1 2007, Pages 645-649 Opportunities and challenges for mesenchymal stem cell-mediated heart repair. Atsma DE, Fibbe WE, Rabelink TJ

Purpose of review: Mesenchymal stem cells (or multipotent stromal cells) are emerging as a potent cell type for cardiac cell therapy. This review describes the potential of cardiac mesenchymal stem cell therapy, but also highlights some recently discovered less favorable mesenchymal stem cell characteristics. Recent findings: Mesenchymal stem cells exert a beneficial effect on cardiac function upon administration to the ischemic myocardium. The mode of action does not seem to involve differentia... Abstract

Cited 39 times since 2007 (2.3 per year) source: EuropePMC

Clinical orthopaedics and related research, Volume 465, 1 1 2007, Pages 23-32 The 2007 Otto Aufranc Award. Ceramic-on-metal hip arthroplasties: a comparative in vitro and in vivo study. Williams S, Schepers A, Isaac G, Hardaker C, Ingham E, van der Jagt D, Breckon A, Fisher J

The performance of novel ceramic-on-metal bearing couples has been compared with metal-on-metal and ceramic-on-ceramic bearing couples in laboratory and short-term clinical studies. Laboratory studies compared ceramic-on-metal with metal-on-metal and ceramic-on-ceramic bearings with diameters of 28 and 36 mm under standard conditions and under adverse conditions with head loading on the rim of the cup. Clinical studies compared metal ion levels in ceramic-on-metal with metal-on-metal, ceramic-on... Abstract