6177 results
Cited 7 times since 2022 (2.6 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 11, Issue 16, 5 1 2022, Pages e024581
von Willebrand Factor: A Central Regulator of Arteriovenous Fistula Maturation Through Smooth Muscle Cell Proliferation and Outward Remodeling.
Laboyrie SL, de Vries MR, de Jong A, de Boer HC, Lalai RA, Martinez L, Vazquez-Padron RI, Rotmans JI
Background Arteriovenous fistula (AVF) maturation failure is a main limitation of vascular access. Maturation is determined by the intricate balance between outward remodeling and intimal hyperplasia, whereby endothelial cell dysfunction, platelet aggregation, and vascular smooth muscle cell (VSMC) proliferation play a crucial role. von Willebrand Factor (vWF) is an endothelial cell-derived protein involved in platelet aggregation and VSMC proliferation. We investigated AVF vascular remodeling i...
Abstract
Cited 2 times since 2022 (0.7 per year)
source: EuropePMC
Current cardiology reports,
Volume 24, Issue 10, 4 1 2022, Pages 1407-1416
Focus on Diagnosis and Prognosis to Guide Timing of Intervention in Valvular Heart Disease.
Stassen J, Galloo X, van der Bijl P, Bax JJ
Purpose of review: The present article reviews the role of multimodality imaging to improve risk stratification and timing of intervention in patients with valvular heart disease (VHD), and summarizes the latest developments in transcatheter valve interventions. Recent findings: Growing evidence suggests that intervention at an earlier stage may improve outcomes of patients with significant VHD. Multimodality imaging, including strain imaging and tissue characterization with cardiac magnetic res...
Abstract
Cited 2 times since 2022 (0.7 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 62, Issue 3, 1 1 2022, Pages ezac401
Obesity and outcomes after left ventricular assist device implantation: insights from the EUROMACS Registry.
Angleitner P, Kaider A, De By TMMH, Dimitrov K, Schlöglhofer T, Tops LF, Fiane AE, Rábago G, Laufer G, Zimpfer D
Objectives: The objective was to analyse associations between obesity and outcomes after left ventricular assist device (LVAD) implantation. Methods: A retrospective analysis of the EUROMACS Registry was performed. Adult patients undergoing primary implantation of a continuous-flow LVAD between 2006 and 2019 were included (Medtronic HeartWare® HVAD®, Abbott HeartMate II®, Abbott HeartMate 3™). Patients were classified into 4 different groups according to body mass index at the time of surgery (b...
Abstract
Mathematical biosciences and engineering : MBE,
Volume 19, Issue 11, 1 1 2022, Pages 10941-10962
Assessing the therapeutic response of tumors to hypoxia-targeted prodrugs with an in silico approach.
Yilmaz D, Tuzer M, Unlu MB
Tumor hypoxia is commonly recognized as a condition stimulating the progress of the aggressive phenotype of tumor cells. Hypoxic tumor cells inhibit the delivery of cytotoxic drugs, causing hypoxic areas to receive insufficient amounts of anticancer agents, which results in adverse treatment responses. Being such an obstruction to conventional therapies for cancer, hypoxia might be considered a target to facilitate the efficacy of treatments in the resistive environment of tumor sites. In this r...
Abstract
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,
Volume 32, Issue 8, 1 1 2022, Pages 1094-1095
Langerhans Cell Histiocytosis with an Undetected Ileal Polyp.
Kiyak M, Tanoglu A, Yilmaz D
Null.
Abstract
Cited 29 times since 2022 (10.6 per year)
source: EuropePMC
American journal of human genetics,
Volume 109, Issue 8, 1 1 2022, Pages 1366-1387
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL, Chesi A, Wells A, Bhatti KF, Vedantam S, Winkler TW, Locke AE, Marouli E, Zajac GJM, Wu KH, Ntalla I, Hui Q, Klarin D, Hilliard AT, Wang Z, Xue C, Thorleifsson G, Helgadottir A, Gudbjartsson DF, Holm H, Olafsson I, Hwang MY, Han S, Akiyama M, Sakaue S, Terao C, Kanai M, Zhou W, Brumpton BM, Rasheed H, Havulinna AS, Veturi Y, Pacheco JA, Rosenthal EA, Lingren T, Feng Q, Kullo IJ, Narita A, Takayama J, Martin HC, Hunt KA, Trivedi B, Haessler J, Giulianini F, Bradford Y, Miller JE, Campbell A, Lin K, Millwood IY, Rasheed A, Hindy G, Faul JD, Zhao W, Weir DR, Turman C, Huang H, Graff M, Choudhury A, Sengupta D, Mahajan A, Brown MR, Zhang W, Yu K, Schmidt EM, Pandit A, Gustafsson S, Yin X, Luan J, Zhao JH, Matsuda F, Jang HM, Yoon K, Medina-Gomez C, Pitsillides A, Hottenga JJ, Wood AR, Ji Y, Gao Z, Haworth S, Mitchell RE, Chai JF, Aadahl M, Bjerregaard AA, Yao J, Manichaikul A, Lee WJ, Hsiung CA, Warren HR, Ramirez J, Bork-Jensen J, Kårhu
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow...
Abstract
Cited 33 times since 2022 (12.1 per year)
source: EuropePMC
JACC. Cardiovascular interventions,
Volume 15, Issue 16, 1 1 2022, Pages 1664-1674
Impact of Moderate Aortic Stenosis on Long-Term Clinical Outcomes: A Systematic Review and Meta-Analysis.
Coisne A, Scotti A, Latib A, Montaigne D, Ho EC, Ludwig S, Modine T, Généreux P, Bax JJ, Leon MB, Bauters C, Granada JF
Background: The clinical course of patients with moderate aortic stenosis (AS) remains incompletely defined. Objectives: This study sought to analyze the clinical course of moderate AS and compare it with other stages of the disease. Methods: Multiple electronic databases were searched to identify studies on adult moderate AS. Random-effects models were used to derive pooled estimates. The primary endpoint was all-cause death. The secondary endpoints were cardiac death, heart failure, sudden dea...
Abstract
Cited 48 times since 2022 (17.6 per year)
source: EuropePMC
European heart journal,
Volume 43, Issue 32, 1 1 2022, Pages e1-e9
A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy.
Cadrin-Tourigny J, Bosman LP, Nozza A, Wang W, Tadros R, Bhonsale A, Bourfiss M, Fortier A, Lie ØH, Saguner AM, Svensson A, Andorin A, Tichnell C, Murray B, Zeppenfeld K, van den Berg MP, Asselbergs FW, Wilde AAM, Krahn AD, Talajic M, Rivard L, Chelko S, Zimmerman SL, Kamel IR, Crosson JE, Judge DP, Yap SC, van der Heijden JF, Tandri H, Jongbloed JDH, Guertin MC, van Tintelen JP, Platonov PG, Duru F, Haugaa KH, Khairy P, Hauer RNW, Calkins H, Te Riele ASJM, James CA
Aims: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by ventricular arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients. Methods and results: Five hundred and twenty-eight patients with a definite diagnosis and no history of sustained VAs/SCD at baseline, aged 38.2 ± 15.5 years, 44.7% male, were enrolled from five registries in North America and Europe. Over 4.83 (interq...
Abstract
Cited 1 times since 2022 (0.4 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 62, Issue 3, 1 1 2022, Pages ezac240
Mechanical circulatory support in the failing systemic right ventricle: a step towards better outcome.
Koolbergen DR
Abstract
Cited 37 times since 2022 (13.6 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 80, Issue 5, 1 1 2022, Pages 545-561
Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement: JACC State-of-the-Art Review.
Pibarot P, Herrmann HC, Wu C, Hahn RT, Otto CM, Abbas AE, Chambers J, Dweck MR, Leipsic JA, Simonato M, Rogers T, Sathananthan J, Guerrero M, Ternacle J, Wijeysundera HC, Sondergaard L, Barbanti M, Salaun E, Généreux P, Kaneko T, Landes U, Wood DA, Deeb GM, Sellers SL, Lewis J, Madhavan M, Gillam L, Reardon M, Bleiziffer S, O'Gara PT, Rodés-Cabau J, Grayburn PA, Lancellotti P, Thourani VH, Bax JJ, Mack MJ, Leon MB, Heart Valve Collaboratory
Bioprosthetic valve dysfunction (BVD) and bioprosthetic valve failure (BVF) may be caused by structural or nonstructural valve dysfunction. Both surgical and transcatheter bioprosthetic valves have limited durability because of structural valve deterioration. The main objective of this summary of experts participating in a virtual workshop was to propose standardized definitions for nonstructural and structural BVD and BVF following aortic or mitral biological valve replacement with the goal of...
Abstract
Cited 17 times since 2022 (6.2 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 80, Issue 5, 1 1 2022, Pages 527-544
Bioprosthetic Aortic Valve Hemodynamics: Definitions, Outcomes, and Evidence Gaps: JACC State-of-the-Art Review.
Herrmann HC, Pibarot P, Wu C, Hahn RT, Tang GHL, Abbas AE, Playford D, Ruel M, Jilaihawi H, Sathananthan J, Wood DA, De Paulis R, Bax JJ, Rodes-Cabau J, Cameron DE, Chen T, Del Nido PJ, Dweck MR, Kaneko T, Latib A, Moat N, Modine T, Popma JJ, Raben J, Smith RL, Tchetche D, Thomas MR, Vincent F, Yoganathan A, Zuckerman B, Mack MJ, Leon MB, Heart Valve Collaboratory
A virtual workshop was organized by the Heart Valve Collaboratory to identify areas of expert consensus, areas of disagreement, and evidence gaps related to bioprosthetic aortic valve hemodynamics. Impaired functional performance of bioprosthetic aortic valve replacement is associated with adverse patient outcomes; however, this assessment is complicated by the lack of standardization for labelling, definitions, and measurement techniques, both after surgical and transcatheter valve replacement....
Abstract
Cited 14 times since 2022 (5.1 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 80, Issue 7, 1 1 2022, Pages 666-676
Prevalence and Prognostic Implications of Discordant Grading and Flow-Gradient Patterns in Moderate Aortic Stenosis.
Stassen J, Ewe SH, Singh GK, Butcher SC, Hirasawa K, Amanullah MR, Pio SM, Sin KYK, Ding ZP, Sia CH, Chew NWS, Kong WKF, Poh KK, Leon MB, Pibarot P, Delgado V, Marsan NA, Bax JJ
Background: The prognostic implications of discordant grading in severe aortic stenosis (AS) are well known. However, the prevalence of different flow-gradient patterns and their prognostic implications in moderate AS are unknown. Objectives: The purpose of this study was to investigate the occurrence and prognostic implications of different flow-gradient patterns in patients with moderate AS. Methods: Patients with moderate AS (aortic valve area >1.0 and ≤1.5 cm2) were identified and divided...
Abstract
Cited 26 times since 2022 (9.5 per year)
source: EuropePMC
Allergy,
Volume 77, Issue 11, 29 5 2022, Pages 3398-3407
Patient-centered dupilumab dosing regimen leads to successful dose reduction in persistently controlled atopic dermatitis.
Spekhorst LS, Bakker D, Drylewicz J, Rispens T, Loeff F, Boesjes CM, Thijs J, Romeijn GLE, Loman L, Schuttelaar ML, van Wijk F, de Graaf M, de Bruin-Weller MS
Background: At present, no real-world studies are available on different dupilumab dosing regimens in controlled atopic dermatitis (AD). The aim of this study was to clinically evaluate a patient-centered dupilumab dosing regimen in patients with controlled AD and to relate this to serum drug levels and serum biomarkers. Methods: Ninety adult AD patients from the prospective BioDay registry were included based on their dupilumab administration interval according to a predefined patient-centered...
Abstract
Cited 3 times since 2022 (1.1 per year)
source: EuropePMC
JMIR formative research,
Volume 6, Issue 7, 28 4 2022, Pages e38263
COVID-box Experiences of Patients and Health Care Professionals (COVID-box Project): Single-Center, Retrospective, Observational Study.
Dirikgil E, Brons K, Duindam M, Groeneveld GH, Geelhoed JJM, Heringhaus C, van der Boog PJM, Rabelink TJ, Bos WJW, Chavannes NH, Atsma DE, Teng YKO
Background: During the COVID-19 pandemic, several home monitoring programs have described the success of reducing hospital admissions, but only a few studies have investigated the experiences of patients and health care professionals. Objective: The objective of our study was to determine patients' and health care professionals' experiences and satisfaction with employing the COVID-box. Methods: In this single-center, retrospective, observational study, patients and health care profess...
Abstract
Cited 2 times since 2022 (0.7 per year)
source: EuropePMC
Journal of internal medicine,
Volume 292, Issue 6, 27 4 2022, Pages 892-903
Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism: A pooled analysis of two randomized controlled trials.
Lyko C, Blum MR, Abolhassani N, Stuber MJ, Del Giovane C, Feller M, Moutzouri E, Oberle J, Jungo KT, Collet TH, den Elzen WPJ, Poortvliet RKE, Du Puy RS, Dekkers OM, Trompet S, Jukema JW, Aujesky D, Quinn T, Westendorp R, Kearney PM, Gussekloo J, Van Heemst D, Mooijaart SP, Bauer DC, Rodondi N
Background: Antithyroid antibodies increase the likelihood of developing overt hypothyroidism, but their clinical utility remains unclear. No large randomized controlled trial (RCT) has assessed whether older adults with subclinical hypothyroidism (SHypo) caused by autoimmune thyroid disease derive more benefits from levothyroxine treatment (LT4). Objective: To determine whether older adults with SHypo and positive antibodies derive more clinical benefits from LT4 than those with negative antibo...
Abstract
Cited 3 times since 2022 (1.1 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 31, Issue 1, 27 4 2022, Pages 16-20
The Netherlands Heart Tissue Bank : Strengthening the cardiovascular research infrastructure with an open access Cardiac Tissue Repository.
Henkens MTHM, van Ast JF, Te Riele ASJM, Houweling AC, Amin AS, Nijveldt R, Antoni ML, Li X, Wehrens SMT, von der Thüsen JH, Damman K, Ter Horst EN, Manintveld OC, Abma-Schouten RY, Niessen HWM, Silljé HHW, Jukema JW, Doevendans PA
Aim: Cardiac diseases remain a leading cause of cardiovascular disease (CVD) related hospitalisation and mortality. That is why research to improve our understanding of pathophysiological processes underlying cardiac diseases is of great importance. There is a strong need for healthy and diseased human cardiac tissue and related clinical data to accomplish this, since currently used animal and in vitro disease models do not fully grasp the pathophysiological processes observed in humans. This de...
Abstract
Cited 6 times since 2022 (2.2 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 115, Issue 6, 21 3 2022, Pages 1396-1402
The Aortic Root in Acute Type A Dissection: Repair or Replace?
Arabkhani B, Verhoef J, Tomšič A, van Brakel TJ, Hjortnaes J, Klautz RJM
Background: The effect of an "aggressive" approach on the aortic root in acute type A aortic dissection (ATAAD) remains insufficiently explored. Methods: Retrospective analysis was conducted between 1992 and 2020 of a single-center, prospective cohort of consecutive patients aged ≥18 years diagnosed with ATAAD. Patients were divided into 2 groups: aortic root replacement (ARR; prosthetic or valve-sparing root replacement, n = 141) and conservative root approach (CRA; root sparing of pa...
Abstract
Cited 9 times since 2022 (3.3 per year)
source: EuropePMC
International journal of cardiology. Heart & vasculature,
Volume 42, 19 3 2022, Pages 101086
Dyspnea in patients with atrial fibrillation: Mechanisms, assessment and an interdisciplinary and integrated care approach.
van der Velden RMJ, Hermans ANL, Pluymaekers NAHA, Gawalko M, Elliott A, Hendriks JM, Franssen FME, Slats AM, van Empel VPM, Van Gelder IC, Thijssen DHJ, Eijsvogels TMH, Leue C, Crijns HJGM, Linz D, Simons SO
Atrial fibrillation (AF) is the most common sustained heart rhythm disorder and is often associated with symptoms that can significantly impact quality of life and daily functioning. Palpitations are the cardinal symptom of AF and many AF therapies are targeted towards relieving this symptom. However, up to two-third of patients also complain of dyspnea as a predominant self-reported symptom. In clinical practice it is often challenging to ascertain whether dyspnea represents an AF-related sympt...
Abstract
Cited 2 times since 2022 (0.7 per year)
source: EuropePMC
Urologie (Heidelberg, Germany),
Volume 61, Issue 12, 19 3 2022, Pages 1365-1372
[Acceptance and status of digitalization in clinics and practices : Current assessment in German urology].
Borkowetz A, Leitsmann M, Baunacke M, Borgmann H, Boehm K, Groeben C, Roigas J, Schneider AW, Speck T, Schroeder-Printzen I, Zillich S, Volkmer B, Witzsch U, Huber J, Arbeitskreis Versorgungsforschung, Qualität und Ökonomie der Deutschen Gesellschaft für Urologie e V, Arbeitskreis Informationstechnologie und Dokumentation der Deutschen Gesellschaft für Urologie e V
Background: Digitalization of patient documentation and introduction of the electronic patient record (ePA) pose challenges to everyday clinical practice. Objectives: We investigated the acceptance and status of the digitalization of patient data and the introduction of the ePA among German urologists. Materials and methods: A questionnaire with 30 questions about the acceptance and status of digitalization of patient documentation and ePA was sent out via the newsletter of the German Society of...
Abstract
The international journal of cardiovascular imaging,
Volume 38, Issue 12, 19 3 2022, Pages 2771-2779
Left ventricular assist device and pump thrombosis: the importance of the inflow cannula position.
Kortekaas KA, de Graaf MA, Palmen M, Braun J, Mertens BJA, Tops LF, Beeres SLMA
Pump thrombosis is a devastating complication after left ventricular assist device implantation. This study aims to elucidate the relation between left ventricular assist device implantation angle and risk of pump thrombosis. Between November 2010 and March 2020, 53 left ventricular assist device-patients underwent a computed tomography scan. Using a 3-dimensional multiplanar reformation the left ventricular axis was reconstructed to measure the implantation angle of the inflow cannula. All pati...
Abstract
