6882 results
Cited 80 times since 2013 (6.6 per year)
source: EuropePMC
International journal of cardiology,
Volume 168, Issue 3, 23 4 2013, Pages 1965-1974
T-cell co-stimulation by CD28-CD80/86 and its negative regulator CTLA-4 strongly influence accelerated atherosclerosis development.
Ewing MM, Karper JC, Abdul S, de Jong RC, Peters HA, de Vries MR, Redeker A, Kuiper J, Toes RE, Arens R, Jukema JW, Quax PH
Objective: T-cells are central to the immune response responsible for native atherosclerosis. The objective of this study is to investigate T-cell contribution to post-interventional accelerated atherosclerosis development, as well as the role of the CD28-CD80/86 co-stimulatory and Cytotoxic T-Lymphocyte Antigen (CTLA)-4 co-inhibitory pathways controlling T-cell activation status in this process. Methods and results: The role of T-cells and the CD28-CD80/86 co-stimulatory and CTLA-4 co-inhibitor...
Abstract
Cited 8 times since 2013 (0.7 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 15, Issue 5, 22 4 2013, Pages 690-696
Duty-cycled bipolar/unipolar radiofrequency ablation for symptomatic atrial fibrillation induces significant pulmonary vein narrowing at long-term follow-up.
Compier MG, Leong DP, Marsan NA, Delgado V, Zeppenfeld K, Schalij MJ, Trines SA
Aims: A novel duty-cycled bipolar/unipolar ablation catheter pulmonary vein ablation catheter (PVAC) has been developed to achieve pulmonary vein (PV) isolation in patients with atrial fibrillation (AF). Ablation with PVAC was recently found to induce PV narrowing at 3 months follow-up. The long-term effects of this catheter on PV dimensions are however unknown and were evaluated with this study. Methods and results: Patients (n = 62, 71% male, age 60 ± 7 years) with drug-refractory AF scheduled...
Abstract
Cited 36 times since 2013 (3 per year)
source: EuropePMC
Journal of behavioral medicine,
Volume 37, Issue 2, 19 3 2013, Pages 308-321
A self-regulation lifestyle program for post-cardiac rehabilitation patients has long-term effects on exercise adherence.
Janssen V, De Gucht V, van Exel H, Maes S
As maintenance of lifestyle change and risk factor modification following completion of cardiac rehabilitation has been shown to be notoriously difficult, we developed a brief self-regulation lifestyle program for post-cardiac rehabilitation patients. Randomized-controlled trial. Following completion of cardiac rehabilitation 210 patients were randomized to receive either a lifestyle maintenance program (n = 112) or standard care (n = 98). The program was based on self-regulation principles and...
Abstract
Cited 25 times since 2013 (2.1 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 145, Issue 6, 16 3 2013, Pages 1611-6, 1616.e1-4
Antifibrinolytics attenuate inflammatory gene expression after cardiac surgery.
Later AF, Sitniakowsky LS, van Hilten JA, van de Watering L, Brand A, Smit NP, Klautz RJ
Objectives: Anti-inflammatory effects of tranexamic acid and aprotinin, used to abate perioperative blood loss, are reported and might be of substantial clinical relevance. The study of messenger ribonucleic acid synthesis provides a valuable asset in evaluating the inflammatory pathways involved. Methods: Whole-blood messenger ribonucleic acid expression of 114 inflammatory genes was compared pre- and postoperatively in 35 patients randomized to receive either placebo, tranexamic acid, or aprot...
Abstract
Cited 54 times since 2013 (4.4 per year)
source: EuropePMC
Journal of immunology (Baltimore, Md. : 1950),
Volume 190, Issue 4, 14 2 2013, Pages 1659-1671
An unbiased genome-wide Mycobacterium tuberculosis gene expression approach to discover antigens targeted by human T cells expressed during pulmonary infection.
Commandeur S, van Meijgaarden KE, Prins C, Pichugin AV, Dijkman K, van den Eeden SJ, Friggen AH, Franken KL, Dolganov G, Kramnik I, Schoolnik GK, Oftung F, Korsvold GE, Geluk A, Ottenhoff TH
Mycobacterium tuberculosis is responsible for almost 2 million deaths annually. Mycobacterium bovis bacillus Calmette-Guérin, the only vaccine available against tuberculosis (TB), induces highly variable protection against TB, and better TB vaccines are urgently needed. A prerequisite for candidate vaccine Ags is that they are immunogenic and expressed by M. tuberculosis during infection of the primary target organ, that is, the lungs of susceptible individuals. In search of new TB vaccine candi...
Abstract
Cited 669 times since 2013 (55.1 per year)
source: EuropePMC
Stem cell research,
Volume 10, Issue 3, 14 2 2013, Pages 301-312
Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury.
Arslan F, Lai RC, Smeets MB, Akeroyd L, Choo A, Aguor EN, Timmers L, van Rijen HV, Doevendans PA, Pasterkamp G, Lim SK, de Kleijn DP
We have previously identified exosomes as the paracrine factor secreted by mesenchymal stem cells. Recently, we found that the key features of reperfusion injury, namely loss of ATP/NADH, increased oxidative stress and cell death were underpinned by proteomic deficiencies in ischemic/reperfused myocardium, and could be ameliorated by proteins in exosomes. To test this hypothesis in vivo, mice (C57Bl6/J) underwent 30 min ischemia, followed by reperfusion (I/R injury). Purified exosomes or saline...
Abstract
Cited 28 times since 2013 (2.3 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 99, Issue 10, 12 2 2013, Pages 722-728
Right ventricular function and survival following cardiac resynchronisation therapy.
Leong DP, Höke U, Delgado V, Auger D, Witkowski T, Thijssen J, van Erven L, Bax JJ, Schalij MJ, Marsan NA
Objectives: Right ventricular (RV) function is an important prognostic marker in heart failure. However, its impact on all-cause mortality following cardiac resynchronisation therapy (CRT) independent of confounding factors has not been evaluated. Furthermore, evidence concerning the effect of CRT on RV function is limited. The study's aims were to: (1) assess the prognostic importance of RV function among CRT recipients, and (2) characterise RV functional change following CRT and its deter...
Abstract
Cited 14 times since 2013 (1.2 per year)
source: EuropePMC
American journal of physiology. Lung cellular and molecular physiology,
Volume 304, Issue 4, 4 1 2013, Pages L264-75
Ambrisentan reduces pulmonary arterial hypertension but does not stimulate alveolar and vascular development in neonatal rats with hyperoxic lung injury.
Wagenaar GT, Laghmani el H, de Visser YP, Sengers RM, Steendijk P, Baelde HJ, Walther FJ
Ambrisentan, an endothelin receptor type A antagonist, may be a novel therapeutic agent in neonatal chronic lung disease (CLD) by blocking the adverse effects of the vasoconstrictor endothelin-1, especially pulmonary arterial hypertension (PAH)-induced right ventricular hypertrophy (RVH). We determined the cardiopulmonary effects of ambrisentan treatment (1-20 mg·kg(-1)·day(-1)) in neonatal rats with CLD in 2 models: early treatment during continuous exposure to hyperoxia for 10 days and late tr...
Abstract
Cited 64 times since 2013 (5.3 per year)
source: EuropePMC
International orthopaedics,
Volume 37, Issue 3, 4 1 2013, Pages 489-494
The timing of ankle fracture surgery and the effect on infectious complications; a case series and systematic review of the literature.
Schepers T, De Vries MR, Van Lieshout EM, Van der Elst M
Purpose: Information about the influence of delayed surgery on infectious wound complications is ambiguous. A clinical audit was performed to test the hypothesis that early surgery lowers the rate of infectious wound complications. Secondly we looked at the influence of surgical delay and complications on patient reported functional outcome. Methods: All consecutive, closed distal fibular fractures treated surgically with a plate were included and retrospectively analysed for the delay in operat...
Abstract
Cited 24 times since 2013 (2 per year)
source: EuropePMC
Trends in cardiovascular medicine,
Volume 23, Issue 3, 3 1 2013, Pages 71-79
Visualizing novel concepts of cardiovascular calcification.
Hjortnaes J, New SE, Aikawa E
Cardiovascular calcification is currently viewed as an active disease process similar to embryonic bone formation. Cardiovascular calcification mainly affects the aortic valve and arteries and is associated with increased mortality risk. Aortic valve and arterial calcification share similar risk factors, including age, gender, diabetes, chronic renal disease, and smoking. However, the exact cellular and molecular mechanism of cardiovascular calcification is unknown. Late-stage cardiovascular cal...
Abstract
Cited 1 times since 2013 (0.1 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 61, Issue 3, 1 1 2013, Pages 357-385
Highlights of the year in JACC 2012.
DeMaria AN, Bax JJ, Feld GK, Greenberg BH, Hall JL, Hlatky MA, Lew WY, Lima JA, Mahmud E, Maisel AS, Narayan SM, Nissen SE, Sahn DJ, Tsimikas S
Abstract
Studies in health technology and informatics,
Volume 194, 1 1 2013, Pages 126-132
How to co-develop services, work, and information systems in healthcare: the daisy approach.
Korpela M, Ikävalko P, Luukkonen I, Martikainen S, Palmén M, Tiihonen T, Toivanen M, Vainikainen V
Information systems in healthcare need to be designed and developed in a collaborative way. However, existing collaborative methodologies for the parallel development of healthcare work and information systems are vague and fragmented. Furthermore, they neither address people-centred healthcare nor limited-resource contexts. In this paper we introduce an emerging holistic approach, based on a unifying theoretical basis, for co-developing the services, work and information systems in healthcare....
Abstract
Cited 1 times since 2013 (0.1 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 8, Issue 9, 1 1 2013, Pages 1103-1109
How should I treat acute aortic annulus rupture during transcatheter aortic valve implantation?
Debonnaire P, Van Herck PL, Katsanos S, van der Kley F, de Weger A, Palmen M, Marsan NA, Schalij MJ, Delgado V
Abstract
Cited 11 times since 2013 (0.9 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 21, Issue 1, 1 1 2013, Pages 6-13
Myocardial bridging: what have we learned in the past and will new diagnostic modalities provide new insights?
Bruschke AV, Veltman CE, de Graaf MA, Vliegen HW
The clinical significance of myocardial bridging has been a subject of discussion and controversy since the introduction of coronary arteriography (CAG) in the early 1960s. More recently computed tomography coronary angiography (CTCA) has made it possible to visualise the overlying muscular bands and appears to have a higher sensitivity for detecting myocardial bridging than CAG. Combining CTCA with invasive techniques such as CAG should make it possible to improve our understanding of the patho...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 157, Issue 23, 1 1 2013, Pages A6354
[Feedback during laparoscopic training].
Spruit EN, Band GP, Hamming JF
A recent Danish study showed that instructor feedback significantly reduced the duration of training time needed for acquiring laparoscopic skills. While there is a clear advantage to trainees reaching a predetermined expert level of performance more rapidly, this does not necessarily imply that the skills were also acquired more efficiently. Experiencing continual feedback while undergoing a training task could reduce the level of difficulty in performing it; the presence of an instructor can a...
Abstract
Cited 1 times since 2013 (0.1 per year)
source: EuropePMC
Nederlands tijdschrift voor geneeskunde,
Volume 157, Issue 7, 1 1 2013, Pages A5928
[Adhesiolysis during abdominal surgery: substantial risks].
Hamming JF, Bonsing BA
Surgeons from the Dutch St. Radboud University Medical Centre recently presented the results of a prospective study on adhesiolysis in abdominal surgery. In this methodologically sound study, the authors provided substantial data on the consequences of adhesiolysis. Most patients who have undergone an abdominal operation in the past appear to have adhesions. During an adhesiolysis procedure, 10% of patients suffer intestinal damage, the operating time is prolonged and blood loss is more severe....
Abstract
Cited 18 times since 2013 (1.5 per year)
source: EuropePMC
Thrombosis research,
Volume 131 Suppl 1, 1 1 2013, Pages S39-41
Venous thromboembolism in neonates and children--update 2013.
Nowak-Göttl U, Janssen V, Manner D, Kenet G
Thromboses (VTE) in children were associated with medical diseases with and without acquired or inherited thrombophilic risk factors (IT). Disease recurrence rates vary between 3% in children with a first event during the neonatal period and 21% in children with idiopathic VTE. Recently reported systematic reviews showed significant associations between VTE and factor V G1691A or factor II G20210A mutations, protein C, protein S and antithrombin deficiency, more pronounced when combined IT were...
Abstract
Cited 36 times since 2013 (3 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 6, Issue 1, 1 1 2013, Pages 42-52
Real-time integration of MDCT-derived coronary anatomy and epicardial fat: impact on epicardial electroanatomic mapping and ablation for ventricular arrhythmias.
van Huls van Taxis CF, Wijnmaalen AP, Piers SR, van der Geest RJ, Schalij MJ, Zeppenfeld K
Objectives: This study aimed to evaluate the feasibility and accuracy of real-time integration of multidetector computed tomography (MDCT) derived coronary anatomy and epicardial fat distribution and its impact on electroanatomical mapping and ablation. Background: Epicardial catheter ablation for ventricular arrhythmias (VA) is an important therapeutic option in patients after endocardial ablation failure. However, epicardial mapping and ablation are limited by the presence of coronary arteries...
Abstract
Cited 17 times since 2013 (1.4 per year)
source: EuropePMC
The journal of gene medicine,
Volume 15, Issue 1, 1 1 2013, Pages 1-11
Development of an AdEasy-based system to produce first- and second-generation adenoviral vectors with tropism for CAR- or CD46-positive cells.
Janssen JM, Liu J, Skokan J, Gonçalves MA, de Vries AA
Background: The AdEasy system has acquired preeminence amongst the various methods for producing first-generation, early region 1 (E1)-deleted human adenovirus (HAdV) vectors (AdVs) as a result of the fast and reproducible recovery of full-length AdV genomes via homologous recombination in Escherichia coli. Methods: From the classical AdEasy system, a new production platform was derived to assemble first- and second-generation [i.e. E1- plus early region 2A (E2A)-deleted] AdVs displaying on thei...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 157, Issue 51, 1 1 2013, Pages A7059
[The bionic heart patient: care about aftercare].
Schalij MJ
During the last few decades, care for heart patients has significantly improved. The enormous increase in the number of diagnostic and therapeutic options has resulted in a much better prognosis for many patients with cardiovascular disorders. Implantable cardioverter defibrillators (ICDs) and resynchronization therapy combined with ICDs decrease the risk of sudden death due to ventricular arrhythmias and improve symptoms related to cardiovascular failure. Percutaneous valve implants and percuta...
Abstract
