Research

Publications

Below you can find a list of our published research.

6128 results

Cited 35 times since 2007 (2 per year) source: EuropePMC

Atherosclerosis, Volume 200, Issue 1, 27 4 2007, Pages 161-167 High HDL cholesterol does not protect against coronary artery disease when associated with combined cholesteryl ester transfer protein and hepatic lipase gene variants. van Acker BA, Botma GJ, Zwinderman AH, Kuivenhoven JA, Dallinga-Thie GM, Sijbrands EJ, Boer JM, Seidell JC, Jukema JW, Kastelein JJ, Jansen H, Verhoeven AJ, REGRESS Study Group

Cholesteryl ester transfer protein (CETP) and hepatic lipase (HL) are two HDL modifying proteins that have both pro- and anti-atherogenic properties. We hypothesized that CETP and HL synergistically affect HDL cholesterol and atherosclerotic risk. To test our hypothesis, we analysed the genotype frequencies of CETP Taq1B (rs708272) and LIPC-514C/T (rs1800588) polymorphisms in male coronary artery disease patients (CAD; n=792) and non-symptomatic controls (n=539). Cases and controls had similar a... Abstract

Cited 33 times since 2007 (1.9 per year) source: EuropePMC

Tuberculosis (Edinburgh, Scotland), Volume 88, Issue 3, 26 4 2007, Pages 249-261 Double-blind randomized Phase I study comparing rdESAT-6 to tuberculin as skin test reagent in the diagnosis of tuberculosis infection. Arend SM, Franken WP, Aggerbeck H, Prins C, van Dissel JT, Thierry-Carstensen B, Tingskov PN, Weldingh K, Andersen P

Limited specificity of the tuberculin skin test incited the development of in vitro assays based on Mycobacterium tuberculosis-specific antigens such as ESAT-6 that are lacking in Bacillus Calmette Guérin (BCG). In animal studies, intradermal ESAT-6 was safe and induced specific skin test responses. The aim of the study was to assess the safety of intradermal recombinant dimer ESAT-6 (rdESAT-6) compared with tuberculin and to determine the human dose. The study design was a double-blind Phase I... Abstract

Cited 79 times since 2007 (4.6 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 19, Issue 4, 20 3 2007, Pages 392-399 Real-time three-dimensional echocardiography permits quantification of left ventricular mechanical dyssynchrony and predicts acute response to cardiac resynchronization therapy. Marsan NA, Bleeker GB, Ypenburg C, Ghio S, van de Veire NR, Holman ER, van der Wall EE, Tavazzi L, Schalij MJ, Bax JJ

Objective: To evaluate the value of real-time three-dimensional echocardiography (RT3DE) to predict acute response to cardiac resynchronization therapy (CRT). Methods: Sixty consecutive heart failure patients scheduled for CRT were included. RT3DE was performed before and within 48 hours after pacemaker implantation to calculate both left ventricular (LV) volumes and LV dyssynchrony. LV dyssynchrony was defined as the standard deviation of the time taken to reach the minimum systolic volume for... Abstract

Cited 43 times since 2007 (2.5 per year) source: EuropePMC

Biochemical and biophysical research communications, Volume 366, Issue 4, 18 3 2007, Pages 910-916 Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity. Pols TW, Ottenhoff R, Vos M, Levels JH, Quax PH, Meijers JC, Pannekoek H, Groen AK, de Vries CJ

NR4A nuclear receptors are induced in the liver upon fasting and regulate hepatic gluconeogenesis. Here, we studied the role of nuclear receptor Nur77 (NR4A1) in hepatic lipid metabolism. We generated mice expressing hepatic Nur77 using adenoviral vectors, and demonstrate that these mice exhibit a modulation of the plasma lipid profile and a reduction in hepatic triglyceride. Expression analysis of >25 key genes involved in lipid metabolism revealed that Nur77 inhibits SREBP1c expression. Thi... Abstract

Cited 2 times since 2007 (0.1 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 35, Issue 3, 18 3 2007, Pages 687 Discrepancy between glucose metabolism and sympathetic nerve terminals in a patient with metastatic paraganglioma. Rahbar K, Kies P, Stegger L, Juergens KU, Weckesser M

Abstract

Cited 292 times since 2007 (17 per year) source: EuropePMC

European heart journal, Volume 29, Issue 4, 15 3 2007, Pages 531-556 Cardiac computed tomography: indications, applications, limitations, and training requirements: report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT of the European Society of Cardiology and the European Council of Nuclear Cardiology. Schroeder S, Achenbach S, Bengel F, Burgstahler C, Cademartiri F, de Feyter P, George R, Kaufmann P, Kopp AF, Knuuti J, Ropers D, Schuijf J, Tops LF, Bax JJ, Working Group Nuclear Cardiology and Cardiac CT, European Society of Cardiology, European Council of Nuclear Cardiology

As a consequence of improved technology, there is growing clinical interest in the use of multi-detector row computed tomography (MDCT) for non-invasive coronary angiography. Indeed, the accuracy of MDCT to detect or exclude coronary artery stenoses has been high in many published studies. This report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT (WG 5) of the European Society of Cardiology and the European Council of Nuclear Cardiology summarizes the present... Abstract

Cited 23 times since 2007 (1.3 per year) source: EuropePMC

Journal of applied physiology (Bethesda, Md. : 1985), Volume 104, Issue 2, 13 2 2007, Pages 446-450 Long-term cardiovascular effects of neonatal dexamethasone treatment: hemodynamic follow-up by left ventricular pressure-volume loops in rats. Bal MP, de Vries WB, van Oosterhout MF, Baan J, van der Wall EE, van Bel F, Steendijk P

Dexamethasone is clinically applied in preterm infants to treat or prevent chronic lung disease. However, concern has emerged about adverse side effects. The cardiovascular short-term side effects of neonatal dexamethasone treatment are well documented, but long-term consequences are unknown. Previous studies showed suppressed mitosis during dexamethasone treatment, leading to reduced ventricular weight, depressed systolic function, and compensatory dilatation in prepubertal rats. In addition, r... Abstract

Cited 12 times since 2007 (0.7 per year) source: EuropePMC

Radiology, Volume 246, Issue 2, 4 1 2007, Pages 394-400 MR imaging of right ventricular function after the Ross procedure for aortic valve replacement: initial experience. Grotenhuis HB, de Roos A, Ottenkamp J, Schoof PH, Vliegen HW, Kroft LJ

Purpose: To prospectively assess right ventricular (RV) function after the Ross procedure by using magnetic resonance (MR) imaging. Materials and methods: The local ethics committee approved the study and informed consent was obtained from all participants prior to enrollment in the study. Seventeen patients (15 male, two female; mean age +/- standard deviation, 19 years +/- 3.9; imaging performed 8.3 years after surgery +/- 3.2) and 17 matched controls (15 male, two female; mean age +/- standar... Abstract

Cited 2 times since 2007 (0.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 50, Issue 25, 1 1 2007, Pages 2421-2430 Highlights of the 2007 scientific sessions of the European Society of Cardiology Vienna, Austria, September 1-5, 2007. Kristensen SD, Baumgartner H, Drexler H, Eeckhout E, Filippatos G, Gitt AK, Linde C, Pierard LA, Poldermans D, Schunkert H, Sipido KR, van der Wall EE, Fox K, Bax JJ, European Society of Cardiology

Abstract

Cited 47 times since 2007 (2.7 per year) source: EuropePMC

Archives of internal medicine, Volume 167, Issue 22, 1 1 2007, Pages 2482-2489 A prognostic risk index for long-term mortality in patients with peripheral arterial disease. Feringa HH, Bax JJ, Hoeks S, van Waning VH, Elhendy A, Karagiannis S, Vidakovic R, Schouten O, Boersma E, Poldermans D

Background: Prognostic information in peripheral arterial disease (PAD) may provide the basis for optimal management strategies at an early stage. This study aimed to develop a prognostic risk index for long-term mortality in patients with PAD. Methods: In a single-center observational cohort study, 2642 patients with an ankle-brachial index of 0.90 or lower were randomly divided into derivation (n = 1332) and validation (n = 1310) cohorts. Cox regression analysis with stepwise backward eliminat... Abstract

Cited 5 times since 2007 (0.3 per year) source: EuropePMC

Coronary artery disease, Volume 18, Issue 8, 1 1 2007, Pages 645-651 Baseline natriuretic peptide levels in relation to myocardial ischemia, troponin T release and heart rate variability in patients undergoing major vascular surgery. Feringa HH, Vidakovic R, Karagiannis SE, de Jonge R, Lindemans J, Goei D, Schouten O, Bax JJ, Poldermans D

Background: This study was conducted to determine the association between baseline N-terminal pro-B-type natriuretic peptide (NT-proBNP) and myocardial ischemia, troponin T release and heart rate variability (HRV) in patients undergoing major vascular surgery. Methods: In a prospective study, 182 vascular surgery patients were evaluated by clinical risk factors, dobutamine stress echocardiography and baseline NT-proBNP levels. Myocardial ischemia was detected by continuous 12-lead electrocardiog... Abstract

Cited 36 times since 2007 (2.1 per year) source: EuropePMC

Current opinion in lipidology, Volume 18, Issue 6, 1 1 2007, Pages 645-649 Opportunities and challenges for mesenchymal stem cell-mediated heart repair. Atsma DE, Fibbe WE, Rabelink TJ

Purpose of review: Mesenchymal stem cells (or multipotent stromal cells) are emerging as a potent cell type for cardiac cell therapy. This review describes the potential of cardiac mesenchymal stem cell therapy, but also highlights some recently discovered less favorable mesenchymal stem cell characteristics. Recent findings: Mesenchymal stem cells exert a beneficial effect on cardiac function upon administration to the ischemic myocardium. The mode of action does not seem to involve differentia... Abstract

Cited 39 times since 2007 (2.3 per year) source: EuropePMC

Clinical orthopaedics and related research, Volume 465, 1 1 2007, Pages 23-32 The 2007 Otto Aufranc Award. Ceramic-on-metal hip arthroplasties: a comparative in vitro and in vivo study. Williams S, Schepers A, Isaac G, Hardaker C, Ingham E, van der Jagt D, Breckon A, Fisher J

The performance of novel ceramic-on-metal bearing couples has been compared with metal-on-metal and ceramic-on-ceramic bearing couples in laboratory and short-term clinical studies. Laboratory studies compared ceramic-on-metal with metal-on-metal and ceramic-on-ceramic bearings with diameters of 28 and 36 mm under standard conditions and under adverse conditions with head loading on the rim of the cup. Clinical studies compared metal ion levels in ceramic-on-metal with metal-on-metal, ceramic-on... Abstract

Cited 41 times since 2007 (2.4 per year) source: EuropePMC

Journal of clinical pharmacology, Volume 47, Issue 12, 1 1 2007, Pages 1555-1569 A randomized, placebo-controlled trial to evaluate the efficacy, safety, and pharmacodynamic interaction of coadministered amlodipine and atorvastatin in 1660 patients with concomitant hypertension and dyslipidemia: the respond trial. Preston RA, Harvey P, Herfert O, Dykstra G, Jukema JW, Sun F, Gillen D

Guidelines stress the importance of the simultaneous management of multiple cardiovascular risk factors. This can in part be achieved by coadministration of lipid-lowering and antihypertensive treatments. Potential pharmacodynamic interaction between drugs should be investigated as part of developing single-pill combinations. The Respond trial assessed whether combining amlodipine to treat hypertension and atorvastatin to treat dyslipidemia affected the action of either monotherapy. A total of 1... Abstract

Cited 21 times since 2007 (1.2 per year) source: EuropePMC

Journal of hypertension, Volume 25, Issue 12, 1 1 2007, Pages 2454-2462 Olmesartan and pravastatin additively reduce development of atherosclerosis in APOE*3Leiden transgenic mice. van der Hoorn JW, Kleemann R, Havekes LM, Kooistra T, Princen HM, Jukema JW

Aim: This study was designed to investigate the effect of the angiotensin II receptor blocker olmesartan alone, or in combination with standard treatment with a statin, pravastatin, on atherosclerosis development in APOE*3Leiden transgenic mice. Methods and results: Four groups of 15 mice received an atherogenic diet alone (plasma cholesterol 17.4 +/- 2.7 mmol/l) or supplemented with either 0.008% (w/w) olmesartan (9.3 mg/kg per day) (plasma cholesterol 16.4 +/- 3.9 mmol/l), 0.03% (w/w) pravasta... Abstract

Clinical nuclear medicine, Volume 32, Issue 12, 1 1 2007, Pages 927-929 Intermittent ST-segment depressions during adenosine stress test. van der Hiel B, Scholte AJ, Stokkel MP

ST-segment depression during adenosine stress testing is usually a 1-time event during or after the test and is often related to ischemia due to severe 3-vessel disease. In this case report we describe a patient with severe 3-vessel disease who had intermittent ST-segment depression on the electrocardiogram during a myocardial perfusion stress test with adenosine. These intermittent ST depressions could be explained by possible adenosine-induced coronary spasm. Abstract

Cited 24 times since 2007 (1.4 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 48, Issue 12, 1 1 2007, Pages 2001-2010 Nuclear imaging in cardiac resynchronization therapy. Henneman MM, van der Wall EE, Ypenburg C, Bleeker GB, van de Veire NR, Marsan NA, Chen J, Garcia EV, Westenberg JJ, Schalij MJ, Bax JJ

Recently, cardiac resynchronization therapy (CRT) has become implemented in the treatment of patients with severe heart failure. Although the improvement in systolic function after CRT implantation can be considerable, 20%-30% of patients do not respond to CRT. Evidence is accumulating that the presence of left ventricular (LV) dyssynchrony is mandatory for a response to CRT. Since the early 1980s attempts have been made to assess cardiac dyssynchrony with nuclear imaging, and it has been report... Abstract

Cited 6 times since 2007 (0.3 per year) source: EuropePMC

Thrombosis and haemostasis, Volume 98, Issue 6, 1 1 2007, Pages 1323-1328 The influence of established genetic variation in the haemostatic system on clinical restenosis after percutaneous coronary interventions. Pons D, Monraats PS, de Maat MP, Pires NM, Quax PH, van Vlijmen BJ, Rosendaal FR, Zwinderman AH, Doevendans PA, Waltenberger J, de Winter RJ, Tio RA, Frants RR, van der Laarse A, van der Wall EE, Jukema JW

Since activation of the haemostatic system is an important feature of the wound healing response triggered by arterial injury, variations in genes involved in thrombus formation may play a role in restenosis after percutaneous coronary interventions (PCI). Therefore, our aim was to examine the relationship between polymorphisms that are known to play a role in the haemostatic system and the risk of clinical restenosis in the GENetic DEterminants of Restenosis (GENDER) study, a multicenter prospe... Abstract

Journal of the American College of Cardiology, Volume 50, Issue 24, 26 4 2007, Pages 2336-2343 Highlights of the 2007 scientific sessions of the American Society of Nuclear Cardiology San Diego, California, September 6-9, 2007. Russell RR, Abbott BG, Arrighi JA, Bengel FM, Cohen MC, Garcia EV, Hendel RC, Holly TA, Mieres JH, Shaw LJ, Thomas GS, Thompson RC, Wackers FJ, Bax JJ

Abstract

Cited 38 times since 2007 (2.2 per year) source: EuropePMC

The American journal of cardiology, Volume 101, Issue 1, 26 4 2007, Pages 40-45 Anatomic correlates of a normal perfusion scan using 64-slice computed tomographic coronary angiography. van Werkhoven JM, Schuijf JD, Jukema JW, Kroft LJ, Stokkel MP, Dibbets-Schneider P, Pundziute G, Scholte AJ, van der Wall EE, Bax JJ

Both myocardial perfusion imaging (MPI) and multislice computed tomography (MSCT) are currently used to detect coronary artery disease (CAD). However, MSCT permits early detection of atherosclerosis while myocardial perfusion is still normal. In addition, MPI results can be normal despite the presence of high-risk CAD (left main and balanced 3-vessel CAD). In this study, the range of anatomic findings using MSCT in patients with normal MPI results was evaluated. In 180 patients presenting with c... Abstract