Research

Publications

Below you can find a list of our published research.

6393 results

Frontiers in digital health, Volume 7, 1 1 2025, Pages 1528860 Content evaluation of the inclusive eHealth guide: how to develop interventions for people with a lower socioeconomic position? Al-Dhahir I, Breeman LD, Faber JS, Wentzel J, van den Berg-Emons RJG, Kraal JJ, Janssen VR, Kraaijenhagen RA, Visch VT, Chavannes NH, Evers AWM

Objectives: eHealth interventions favor those with higher socio-economic positions (SEPs). This can widen disparities, as people with lower SEPs may lack resources and face digital or financial barriers, making tailored solutions necessary. This study evaluates professionals' perceptions of the Inclusive eHealth Guide (IeG) regarding its content. The aim was to ensure it meets the needs of professionals and the targeted lower SEP demographic, thereby enhancing the effectiveness of eHealth i... Abstract

Therapeutic advances in medical oncology, Volume 17, 1 1 2025, Pages 17588359251379665 Predicting response and survival to first-line treatment with baseline [18F]FDG-PET-CT in patients with small-cell lung cancer: an integrated diagnostic approach. Ventura D, Schindler P, Kies P, Bleckmann A, Mohr M, Lenz G, Schäfers M, Roll W, Evers G

Background: Small-cell lung cancer (SCLC) is a highly malignant disease with a propensity for early progression and high mortality. The prognostic value of treatment response and survival has been verified for solely established imaging, clinical, and biochemical markers. There is a lack of evidence for the combination of those parameters with machine learning and integrated models, particularly in the context of molecular imaging. Objectives: The aim of this study was to predict early disease p... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 27, Issue 11, 1 1 2025, Pages euaf276 The SIDECAR 2.0 (S-ICD registry in European paediatric and young adult patients with congenital heart defects 2.0): an analysis of European S-ICD clinical practice and its evolution in paediatric patients. Silvetti MS, Bruyndonckx L, Waldmann V, Gebauer R, Környei L, Ksiazczyk T, Illikova V, Tavacova T, Roses-Noguer F, Kwiatkowska J, Pazzano V, Wilkin M, Paech C, Fésüs G, Egorova AD, Wieniawski P, Rivas-Gandara N, Kempa M, Battipaglia I, Klehs S, Chalupka M, Maltret A, Knops RE, Janousek J, Blom NA, Lovecchio M, Valsecchi S, Drago F

Aims: Subcutaneous implantable cardioverter-defibrillators (S-ICDs) are effective in patients who require protection from sudden cardiac death while avoiding the long-term risks associated with transvenous leads. However, data on their real-world performance in paediatric and young patients remain limited. This study aims to evaluate the safety and efficacy of S-ICDs in a large, multicentre cohort of paediatric and young patients across Europe, with a focus on contemporary implantation practices... Abstract

Cited 1 times since 2025 (5.6 per year) source: EuropePMC

Family practice, Volume 42, Issue 6, 1 1 2025, Pages cmaf081 Cost-effectiveness of a corticosteroid injection versus exercise therapy for shoulder pain in general practice (SIX-Shoulder Study): a randomized controlled trial. Versloot AHC, Toy M, Schiphof D, Bindels P, Ottenheijm RPG, de Graaf M, van der Windt DA, van Ochten JM, Koes BW, Runhaar J

Background: Shoulder pain often results in functional limitations leading to substantial societal and healthcare costs. Guidelines recommend a corticosteroid injection or exercise therapy, but long-term comparative cost-effectiveness remains unclear. This study examined the cost-effectiveness of these two treatments over 12 months in patients with shoulder pain presenting in Dutch primary care. Methods: A randomized controlled trial was conducted with patients consulting for a new episode of sho... Abstract

Aims: In non-ischaemic cardiomyopathy (NICM), late gadolinium enhancement (LGE) detected by cardiovascular magnetic resonance is related to ventricular arrhythmia (VA) and sudden cardiac death (SCD) risk. The incremental prognostic value of quantifying LGE volume or mass beyond its mere presence, however, remains unresolved. The aim was to evaluate whether LGE quantification improves the prediction of SCD. Methods and results: PubMed, Embase, and Web of Science were searched on 20 November 2024... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 27, Issue 10, 1 1 2025, Pages euaf240 Evolution of implantable cardioverter-defibrillator shock therapy in children in the era of optimized ICD programming and remote monitoring. Bertels RA, Boersma E, Zeggelaar MD, van Dongen SAF, Ten Harkel ADJ, van Erven L, Smeding C, Bartelds B, van den Berg G, Boesaard EP, Bhagwandien RE, Yap SC, Knops RE, Blom NA, Kammeraad JAE

Aims: Implantable cardioverter defibrillator (ICD) therapy is effective in preventing sudden cardiac death in children. Unnecessary shocks should be avoided. ICD programming strategies and remote monitoring have been proven to be effective in preventing ICD shock therapy in adults; the present study evaluates the effectiveness in children. Methods and results: Retrospective multi-centre study, including children with transvenous or epicardial ICD implantation. During follow-up data on ICD shocks... Abstract

Interdisciplinary cardiovascular and thoracic surgery, 30 5 2025, Pages ivaf231 A European survey on non-technical skills in robotic thoracic surgery for lung resections. Shahin GMM, Verhagen MJ, Hutteman M, Wink J, Stamenkovic SA, Durand M, Baste JM, Melfi F, Braun J

Objectives: In robotic surgery, interaction between team-members differs from that in open surgery, which impacts the team-members' tasks and responsibilities. Training for robot-assisted thoracic surgery (RATS) is primarily focused on technical skills. However, non-technical skills (NOTECHS) are equally important for safe and high-quality surgery. There is debate whether NOTECHS require adjustments to meet specific needs of RATS. The aim of this study is to evaluate how NOTECHS-domains are... Abstract

Arteriosclerosis, thrombosis, and vascular biology, Volume 45, Issue 11, 25 4 2025, Pages 2111-2123 Multiplex Apolipoprotein Panel Improves Cardiovascular Event Prediction and Cardiovascular Outcome by Identifying Patients Who Benefit From Targeted PCSK9 Inhibitor Therapy. Reijnders E, Bossuyt PM, Jukema JW, Ruhaak LR, Romijn FPHTM, Szarek M, Trompet S, Bhatt DL, Bittner VA, Diaz R, Fazio S, Stevanovic I, Goodman SG, Harrington RA, White HD, Steg PG, Schwartz GG, Cobbaert CM

Background: Residual cardiovascular risk remains, despite achieving low-density lipoprotein cholesterol targets with high-intensity statins. Traditional risk scores are suboptimal. This study evaluated the prognostic utility of a 9-plex apolipoprotein panel in recent patients with acute coronary syndrome on statins and its role in predicting treatment benefit by alirocumab, a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor, enabling precision medicine. Methods: Baseline serum sam... Abstract

Allergy, 24 4 2025 Biologics to Treat Atopic Dermatitis: Effectiveness, Safety, and Future Directions. de Bruin-Weller MS, Boesjes CM, Achten RA, Beck LA, Irvine AD, Vestergaard C, de Graaf M, van Wijk F, Bakker DS, Weidinger S

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide. The clinical presentation of AD is heterogeneous and is characterized by a relapsing and remitting course. Most patients suffer from mild AD while approximately 5% to 20% experience severe disease activity, which often requires systemic treatment. Before 2017, systemic treatment options were limited to broad immunosuppressants, which often had significant toxicity and limited effectiveness. Advances in... Abstract

The Canadian journal of cardiology, 23 4 2025, Pages S0828-282X(25)01178-X New Cardiovascular Damage Staging Classification for Chronic Significant Aortic Regurgitation. Bergeron A, Lopez Santi P, Bernard J, Hecht S, Fleury MA, Jacob S, Marchand C, Clavel MA, Côté N, Bax JJ, Marsan NA, Pibarot P

Background: Current recommendations for management of chronic aortic regurgitation (AR) are based on AR severity, symptoms and repercussions on the left ventricle (LV), only providing modest risk stratification value in patients with AR. The objective was to assess the prognostic value of a new staging classification characterizing the extent of cardiovascular damage for risk stratification in patients with chronic AR. Methods: According to cardiovascular damages at echocardiography, 619 patient... Abstract

BMJ open, Volume 15, Issue 9, 23 4 2025, Pages e097306 Comparison of cardiovascular risk profiles of patients with type A aortic dissection and thoracic aortic aneurysm: a retrospective multicentre study. Tirpan AU, Dolmaci OB, Jansen EK, Twisk JWR, Klautz RJM, Grewal N

Objective: A thoracic aortic aneurysm (TAA) is often considered a precursor to an acute type A aortic dissection (ATAAD), a life-threatening condition requiring immediate surgical intervention. While both conditions share histopathological similarities, less is known about their overlap in clinical cardiovascular risk factors. This study aimed to map the cardiovascular disease burden in patients with ATAAD and compare it with patients with TAA. Design: A multicentre retrospective study. Setting:... Abstract

Scientific reports, Volume 15, Issue 1, 19 3 2025, Pages 32618 (Cardiac) complexity needs interaction. De Coster T

The heart exemplifies a complex system where electrical, mechanical, and biochemical processes interact dynamically. Understanding cardiac complexity requires exploring these interactions across multiple levels, from cellular dynamics to organ-wide behavior. This collection examines key interactions in cardiology, including excitation-contraction coupling, arrhythmia quantification, electromechanical modeling, and imaging advances. By integrating mathematical, computational, and clinical perspec... Abstract

NeuroImage. Clinical, Volume 48, 19 3 2025, Pages 103881 Brain age gap reduction following exercise mirrors clinical improvements in schizophrenia spectrum disorders. Yilmaz D, Papiol S, Keeser D, Cole JH, Malchow B, Walter H, Meyer-Lindenberg A, Hirjak D, Schmitt A, Falkai P, Maurus I, Roell L

Schizophrenia spectrum disorders (SSD) are associated with accelerated brain aging, reflected in an increased brain age gap. This gap serves as a biomarker, indicating poorer brain health, cognitive deficits, and greater severity in specific symptom domains. Exercise holds promise as an adjunct therapy to mitigate these deficits by potentially promoting brain recovery. However, the extent of overall improvements in brain health following exercise, along with their predictors and relationships to... Abstract

Applied and environmental microbiology, Volume 91, Issue 10, 19 3 2025, Pages e0082225 Evidence of ESBL plasmid transfer and selective persistence of multiple host-associated Escherichia coli isolates in a chicken cecal fermentation model. Leng J, Ferrandis-Vila M, Oldenkamp R, Mehat JW, Fivian-Hughes AS, Kumar Tiwari S, Van der Putten B, Trung Nguyen V, Bethe A, Clark J, Singh P, Semmler T, Schwarz S, Alvarez J, Hoa NT, Bootsma M, Menge C, Berens C, Schultsz C, Ritchie JM, La Ragione RM

The guts of animals and humans harbor diverse microbial communities that are regularly exposed to bacteria originating from food, water, and their surroundings. Species such as Escherichia coli are adept at colonizing multiple hosts, along with surviving in the environment. By encoding pathogenic traits and transmissible forms of antimicrobial resistance (AMR), E. coli can also pose a zoonotic risk. Our understanding of the factors that govern host residency is limited. Here, we used a chicken c... Abstract

American journal of clinical dermatology, Volume 26, Issue 6, 19 3 2025, Pages 1031-1043 Systemic Treatments in Moderate-to-Severe Atopic Dermatitis in Pediatric Patients up to 12 Years of Age: Real-World Treatment Outcomes from the PEDISTAD Registry. Paller AS, Marcoux D, Ramien M, Baselga E, Carvalho VO, Ardusso LRF, de Graaf M, Pasmans S, Toledo-Bahena M, Rubin C, Joyce JC, Lee LW, Gupta R, Adams B, Ardeleanu M, Zhang A

Background: Atopic dermatitis (AD), a chronic systemic disease, can cause intense skin itching and negatively impact sleep, mood, and quality of life (QoL) for patients and families. Methods: PEDISTAD is an ongoing, 10-year, observational registry describing disease characteristics, atopic comorbidities, and treatment patterns in pediatric patients (aged Abstract

Microbiology spectrum, Volume 13, Issue 10, 18 3 2025, Pages e0176225 Activity of HOCl-generating e-bandage with clinically available hydrogels against Staphylococcus aureus and Acinetobacter baumannii biofilms. Dagsuyu E, Kies P, Karau MJ, Patel R, Beyenal H

Biofilms hinder wound infection healing, making wound infections a healthcare challenge for which innovative treatments are needed. A 1.77 cm2 electrochemical bandage (e-bandage), which generates the biocide hypochlorous acid (HOCl), has shown promising anti-biofilm activity in vitro, ex vivo, and in vivo. The e-bandage is a three-electrode system operationalized by a hydrogel. In addition to providing a conductive electrolyte for the electrodes, the hydrogel provides a protective barrier for th... Abstract

Signal transduction and targeted therapy, Volume 10, Issue 1, 18 3 2025, Pages 311 Reversion of aortic valve cells calcification by activation of Notch signalling via histone acetylation induction. Garoffolo G, Ferrari S, De Martino S, Pizzo E, Candino V, Curini L, Macrì F, Kruithof BPT, Mongelli A, Grillo M, Fanotti N, Fejzaj P, Casaburo M, Alanazi A, Marsan NA, Khaliel F, Alsulbud A, Agrifoglio M, Colombo GI, Chiesa M, Farsetti A, Gaetano C, Raucci A, Pesce M

Calcification of the aortic valve is a prevalent cardiovascular pathology in the aging population. Traditionally linked to inflammation, lipid accumulation, and risk conditions, this disease remains poorly understood, and effective treatments to halt its progression are not yet available. We hypothesized that calcification of the human valve interstitial cells (VICs) is associated with cellular senescence and alterations in the epigenetic setup, like in arteries. To verify this hypothesis, we ex... Abstract

Annals of vascular surgery, Volume 122, 17 3 2025, Pages 774-779 Diagnostic Accuracy of Elastic Deformation for Detecting High Aneurysm Sac Pressure After Endovascular Aneurysm Repair. van Rijn K, van Genderen OS, Putter H, Eiberg JP, van Wissen RC, Hamming JF, van Schaik J, van der Vorst JR

Objectives: Elastic deformation (ED) is a novel noninvasive follow-up modality after endovascular aortic repair (EVAR). ED is defined as the percentage of diameter change of the aneurysm sac after application of a controlled ultrasound transducer pressure. It is hypothesized that low aneurysm sac deformation indicates high sac pressure. The current study aims to determine the ideal cutoff value of ED and analyze the corresponding diagnostic accuracy. Methods: A prospective cohort study was perfo... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 33, Issue 11, 17 3 2025, Pages 335-342 Radiofrequency ablation of supraventricular tachyarrhythmias in newborns and infants: why, when, and how? Palma A, Bertels RA, de Riva M, Zeppenfeld K, Blom NA

Supraventricular tachyarrhythmias (SVTs) in newborns and infants ( Abstract

Transfusion, Volume 65, Issue 11, 17 3 2025, Pages 2034-2044 Storage duration of platelet concentrates and clinical outcomes in cardiac surgery patients. van Hout FMA, Caram-Deelder C, Pors A, Middelburg RA, Klautz RJM, Rosseel PMJ, Helmerhorst HJF, van de Watering LMG, Kerkhoffs JL, Palmen M, van der Bom JG

Background: The changes in platelet structure and function arising from its collection and storage are collectively called "platelet storage lesion." In patients this might potentially be associated with impaired hemostasis and adverse events. We performed a hypothesis-generating retrospective study in cardiac surgery patients transfused with platelets in two hospitals between 2005 and 2017. Study design and methods: We explored whether longer storage duration of platelets is associate... Abstract