Research

Publications

Below you can find a list of our published research.

9315 results

Cited 8 times since 2020 (1.5 per year) source: EuropePMC

Wiley interdisciplinary reviews. Cognitive science, Volume 11, Issue 4, 16 3 2020, Pages e1527 Must all signals be evolved? A proposal for a new classification of communicative acts. Fröhlich M, van Schaik CP

While signals in evolutionary biology are usually defined as "acts or traits that have evolved because of their effect on others", work on gestures and vocalizations in various animal taxa have revealed population- or even individual-specific meanings of social signals. These results strongly suggest that communicative acts that are like signals with regard to both form and function (meaning) can also be acquired ontogenetically, and we discuss direct evidence for such plasticity in ca... Abstract

Cited 28 times since 2020 (5.3 per year) source: EuropePMC

Journal of diabetes science and technology, Volume 15, Issue 3, 16 3 2020, Pages 655-663 Validation of Automated Screening for Referable Diabetic Retinopathy With an Autonomous Diagnostic Artificial Intelligence System in a Spanish Population. Shah A, Clarida W, Amelon R, Hernaez-Ortega MC, Navea A, Morales-Olivas J, Dolz-Marco R, Verbraak F, Jorda PP, van der Heijden AA, Peris Martinez C

Purpose: The purpose of this study is to compare the diagnostic performance of an autonomous artificial intelligence (AI) system for the diagnosis of referable diabetic retinopathy (RDR) to manual grading by Spanish ophthalmologists. Methods: Subjects with type 1 and 2 diabetes participated in a diabetic retinopathy (DR) screening program in 2011 to 2012 in Valencia (Spain), and two images per eye were collected according to their standard protocol. Mydriatic drops were used in all patients. Ret... Abstract

Cited 10 times since 2020 (1.9 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 162, Issue 6, 12 2 2020, Pages 1684-1695 Comparison of microstructural alterations in the proximal aorta between aortic stenosis and regurgitation. Sequeira Gross TM, Lindner D, Ojeda FM, Neumann J, Grewal N, Kuntze T, Blankenberg S, Reichenspurner H, Westermann D, Girdauskas E

Objective: We aimed to analyze the association among flow patterns, gene expression, and histologic alterations of the proximal aorta in patients with aortic valve disease. Methods: A total of 131 patients referred for aortic valve replacement were grouped by valve dysfunction (aortic stenosis vs aortic regurgitation) and valve morphology (bicuspid vs tricuspid). On the basis of magnetic resonance imaging, aortic tissue from outer and inner curvature was collected for gene expression and histolo... Abstract

Cited 44 times since 2020 (8.2 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 13, Issue 3, 12 2 2020, Pages e009750 Impact of Clinical Characteristics and Statins on Coronary Plaque Progression by Serial Computed Tomography Angiography. Smit JM, van Rosendael AR, El Mahdiui M, Neglia D, Knuuti J, Saraste A, Buechel RR, Teresinska A, Pizzi MN, Roque A, Poddighe R, Mertens BJ, Caselli C, Rocchiccioli S, Parodi O, Pelosi G, Scholte AJ

Background Progression of coronary artery disease using serial coronary computed tomography angiography (CTA) is of clinical interest. Our primary aim was to prospectively assess the impact of clinical characteristics and statin use on quantitatively assessed coronary plaque progression in a low-risk study population during long-term follow-up. Methods Patients who previously underwent coronary CTA for suspected coronary artery disease were prospectively included to undergo follow-up coronary CT... Abstract

Cited 19 times since 2020 (3.6 per year) source: EuropePMC

Cells, Volume 9, Issue 3, 12 2 2020, Pages E701 Local Mast Cell Activation Promotes Neovascularization. Bot I, Velden DV, Bouwman M, Kröner MJ, Kuiper J, Quax PHA, de Vries MR

Mast cells have been associated with arteriogenesis and collateral formation. In advanced human atherosclerotic plaques, mast cells have been shown to colocalize with plaque neovessels, and mast cells have also been associated with tumor vascularization. Based on these associations, we hypothesize that mast cells promote angiogenesis during ischemia. In human ischemic muscle tissue from patients with end-stage peripheral artery disease, we observed activated mast cells, predominantly located aro... Abstract

Cited 21 times since 2020 (3.9 per year) source: EuropePMC

mSphere, Volume 5, Issue 2, 11 2 2020, Pages e00143-20 Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates. Janssen AB, Bartholomew TL, Marciszewska NP, Bonten MJM, Willems RJL, Bengoechea JA, van Schaik W

Infections by multidrug-resistant Gram-negative bacteria are increasingly common, prompting the renewed interest in the use of colistin. Colistin specifically targets Gram-negative bacteria by interacting with the anionic lipid A moieties of lipopolysaccharides, leading to membrane destabilization and cell death. Here, we aimed to uncover the mechanisms of colistin resistance in nine colistin-resistant Escherichia coli strains and one Escherichia albertii strain. These were the only colistin-res... Abstract

Cited 10 times since 2020 (1.9 per year) source: EuropePMC

mSystems, Volume 5, Issue 2, 10 2 2020, Pages e00607-19 Carbon Assimilation Strategies in Ultrabasic Groundwater: Clues from the Integrated Study of a Serpentinization-Influenced Aquifer. Seyler LM, Brazelton WJ, McLean C, Putman LI, Hyer A, Kubo MDY, Hoehler T, Cardace D, Schrenk MO

Serpentinization is a low-temperature metamorphic process by which ultramafic rock chemically reacts with water. Such reactions provide energy and materials that may be harnessed by chemosynthetic microbial communities at hydrothermal springs and in the subsurface. However, the biogeochemistry mediated by microbial populations that inhabit these environments is understudied and complicated by overlapping biotic and abiotic processes. We applied metagenomics, metatranscriptomics, and untargeted m... Abstract

Cited 12 times since 2020 (2.2 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 47, Issue 6, 9 2 2020, Pages 1518-1526 Prevalence of hyperfunctioning thyroid nodules among those in need of fine needle aspiration cytology according to ATA 2015, EU-TIRADS, and ACR-TIRADS. Noto B, Eveslage M, Pixberg M, Gonzalez Carvalho JM, Schäfers M, Riemann B, Kies P

Purpose: Given the large number of patients with thyroid nodules, improvement of the specificity of current ultrasound-based thyroid nodule classification systems (ATA, EU-TIRADS, and ACR-TIRADS) is warranted to reduce the number of diagnostic thyroidectomies. Thyroid scintigraphy has been shown to demonstrate hyperfunctional nodules, associated with a low malignancy risk, in euthyroid patients. However, it is not known if thyroid scintigraphy could improve specificity of current classification... Abstract

Frontiers in veterinary science, Volume 7, 6 1 2020, Pages 67 The Comparison of Three Statistical Models for Syndromic Surveillance in Cattle Using Milk Production Data. Veldhuis AMB, Swart WAJM, Brouwer-Middelesch H, Stegeman JA, Mars MH, van Schaik G

Two vector-borne infections have emerged and spread throughout the north-western part of Europe in the last decade: Bluetongue virus serotype-8 (BTV-8) and the Schmallenberg virus (SBV). The objective of the current study was to compare three statistical methods when applied in a syndromic surveillance context for the early detection of emerging diseases in cattle in the Netherlands. Since BTV-8 and SBV both have a negative effect on milk production in dairy cattle, routinely collected bulk milk... Abstract

Cited 5 times since 2020 (0.9 per year) source: EuropePMC

European journal of obstetrics, gynecology, and reproductive biology, Volume 248, 6 1 2020, Pages 150-155 Evaluation of mode of birth in pregnant women with heart disease. Petrus AHJ, Jongert BL, Kiès P, Sueters M, Jongbloed MRM, Vliegen HW, Schalij MJ, van Lith J, van den Akker T

Objective: Maternal heart disease (HD) complicates 1-4 % of pregnancies and is associated with adverse maternal and fetal outcomes. Although vaginal birth is generally recommended in the guidelines, cesarean section (CS) rates in women with HD are often high. Aim of the present study was to evaluate mode of birth and pregnancy outcomes in women with HD in a tertiary care hospital in the Netherlands. Study design: The study population consisted of 128 consecutive pregnancies in 99 women with HD,... Abstract

Cited 13 times since 2020 (2.4 per year) source: EuropePMC

BMC nephrology, Volume 21, Issue 1, 5 1 2020, Pages 81 The association of kidney function and cognitive decline in older patients at risk of cardiovascular disease: a longitudinal data analysis. Zijlstra LE, Trompet S, Mooijaart SP, van Buren M, Sattar N, Stott DJ, Jukema JW

Background: Chronic kidney disease (CKD) has been identified as a significant direct marker for cognitive decline, but controversy exists regarding the magnitude of the association of kidney function with cognitive decline across the different CKD stages. Therefore, the aim of this study was to investigate the association of kidney function with cognitive decline in older patients at high risk of cardiovascular disease, using data from the PROspective Study of Pravastatin in the Elderly at Risk... Abstract

Cited 12 times since 2020 (2.2 per year) source: EuropePMC

Journal of dairy science, Volume 103, Issue 5, 5 1 2020, Pages 4654-4671 A description and qualitative comparison of the elements of heterogeneous bovine viral diarrhea control programs that influence confidence of freedom. van Roon AM, Santman-Berends IMGA, Graham D, More SJ, Nielen M, van Duijn L, Mercat M, Fourichon C, Madouasse A, Gethmann J, Sauter-Louis C, Frössling J, Lindberg A, Correia-Gomes C, Gunn GJ, Henry MK, van Schaik G

For endemic infections in cattle that are not regulated at the European Union level, such as bovine viral diarrhea virus (BVDV), European Member States have implemented control or eradication programs (CEP) tailored to their specific situations. Different methods are used to assign infection-free status in CEP; therefore, the confidence of freedom associated with the "free" status generated by different CEP are difficult to compare, creating problems for the safe trade of cattle betwee... Abstract

Cited 1 times since 2020 (0.2 per year) source: EuropePMC

Journal of critical care, Volume 57, 4 1 2020, Pages 203-207 Pharmacogenomic response of low dose haloperidol in critically ill adults with delirium. Trogrlić Z, van der Jagt M, Osse RJ, Devlin JW, Nieboer D, Koch BCP, van Schaik RHN, Hunfeld NGM

Purpose: To characterize the pharmacogenomic response of low-dose haloperidol for delirium treatment in critically ill adults. Materials and methods: Single-center, pilot study of a convenience sample of ICU adults with delirium treated with low-dose IV haloperidol. Patients were evaluated for delirium with the ICDSC every 8 h. Serum haloperidol concentrations were collected on ICU days 2-6, CYP2D6 and CYP3A4 genotypes were characterized and patients were categorized as extensive (EM), intermedi... Abstract

Cited 36 times since 2020 (6.7 per year) source: EuropePMC

The journal of allergy and clinical immunology. In practice, Volume 8, Issue 6, 3 1 2020, Pages 1972-1979.e8 Effectiveness of myAirCoach: A mHealth Self-Management System in Asthma. Khusial RJ, Honkoop PJ, Usmani O, Soares M, Simpson A, Biddiscombe M, Meah S, Bonini M, Lalas A, Polychronidou E, Koopmans JG, Moustakas K, Snoeck-Stroband JB, Ortmann S, Votis K, Tzovaras D, Chung KF, Fowler S, Sont JK, myAirCoach study group

Background: Self-management programs have beneficial effects on asthma control, but their implementation in clinical practice is poor. Mobile health (mHealth) could play an important role in enhancing self-management. Objective: To assess the clinical effectiveness and technology acceptance of myAirCoach-supported self-management on top of usual care in patients with asthma using inhalation medication. Methods: Patients were recruited in 2 separate studies. The myAirCoach system consisted of an... Abstract

Cited 6 times since 2020 (1.1 per year) source: EuropePMC

International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation, Volume 43, Issue 1, 1 1 2020, Pages 82-89 The most important activities of daily functioning: the opinion of persons with lower limb amputation and healthcare professionals differ considerably. van Schaik L, Hoeksema S, Huvers LF, Geertzen JHB, Dijkstra PU, Dekker R

The aim of this study is to determine the 15 most important daily activities according to persons with lower limb amputation (LLA) and healthcare professionals. Persons with LLA (n = 125) and healthcare professionals (n = 44) filled in a questionnaire. Participants had to select 10 items out of a list of 40 items on the domains activity and/or participation. Selection criterion was what they considered to be most important to perform independently and order the selected 10 items from most to lea... Abstract

New directions for child and adolescent development, Volume 2020, Issue 170, 1 1 2020, Pages 113-141 Parents, Preschools, and the Developmental Niches of Young Children: A Study in Four Western Cultures. Harkness S, Super CM, Bonichini S, Bermudez MR, Mavridis C, van Schaik SDM, Tomkunas A, Palacios J

Recent years have witnessed increasing attention to early childhood education and care as a foundation for children's successful development in school and beyond. The great majority of children in postindustrial societies now attend preschools or daycare, making this setting a major part of their culturally constructed developmental niches. Although an extensive literature demonstrates the importance of parental involvement or engagement in their children's schools, relationships betwe... Abstract

Cited 21 times since 2020 (3.9 per year) source: EuropePMC

Journal for immunotherapy of cancer, Volume 8, Issue 1, 1 1 2020, Pages e000251 T cell receptor repertoire characteristics both before and following immunotherapy correlate with clinical response in mesothelioma. Vroman H, Balzaretti G, Belderbos RA, Klarenbeek PL, van Nimwegen M, Bezemer K, Cornelissen R, Niewold ITG, van Schaik BD, van Kampen AH, Aerts JGJV, de Vries N, Hendriks RW

Background: Malignant pleural mesothelioma (MPM) is a highly lethal malignancy in need for new treatment options. Although immunotherapies have been shown to boost a tumor-specific immune response, not all patients respond and prognostic biomarkers are scarce. In this study, we determined the peripheral blood T cell receptor β (TCRβ) chain repertoire of nine MPM patients before and 5 weeks after the start of dendritic cell (DC)-based immunotherapy. Materials and methods: We separately profiled P... Abstract

Cited 30 times since 2020 (5.6 per year) source: EuropePMC

Autophagy, Volume 17, Issue 3, 1 1 2020, Pages 706-722 <i>Coxiella</i> effector protein CvpF subverts RAB26-dependent autophagy to promote vacuole biogenesis and virulence. Siadous FA, Cantet F, Van Schaik E, Burette M, Allombert J, Lakhani A, Bonaventure B, Goujon C, Samuel J, Bonazzi M, Martinez E

Coxiella burnetii, the etiological agent of the zoonosis Q fever, replicates inside host cells within a large vacuole displaying autolysosomal characteristics. The development of this compartment is mediated by bacterial effectors, which interfere with a number of host membrane trafficking pathways. By screening a Coxiella transposon mutant library, we observed that transposon insertions in cbu0626 led to intracellular replication and vacuole biogenesis defects. Here, we demonstrate that CBU0626... Abstract

Cited 13 times since 2020 (2.4 per year) source: EuropePMC

The Journal of antimicrobial chemotherapy, Volume 75, Issue 3, 1 1 2020, Pages 709-717 Increased risk of acquisition and transmission of ESBL-producing Enterobacteriaceae in malnourished children exposed to amoxicillin. Maataoui N, Langendorf C, Berthe F, Bayjanov JR, van Schaik W, Isanaka S, Grais RF, Clermont O, Andremont A, Armand-Lefèvre L, Woerther PL

Objectives: Routine amoxicillin for children with uncomplicated severe acute malnutrition raises concerns of increasing antibiotic resistance. We performed an ancillary study nested within a double-blind, placebo-controlled trial in Niger testing the role of routine 7 day amoxicillin therapy in nutritional recovery of children 6 to 59 months of age with uncomplicated severe acute malnutrition. Methods: We screened 472 children for rectal carriage of ESBL-producing Enterobacteriaceae (ESBL-E) as... Abstract

Cited 6 times since 2020 (1.1 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 22, Issue 3, 1 1 2020, Pages 394-400 High haemoglobin A1c level is a possible risk factor for ventricular fibrillation in sudden cardiac arrest among non-diabetic individuals in the general population. van Dongen LH, Blom MT, Bardai A, Homma PCM, Beulens JWJ, van der Heijden AA, Elders P, Tan HL

Aims: This study aimed to establish whether higher levels of glycated haemoglobin (HbA1c) are associated with increased sudden cardiac arrest (SCA) risk in non-diabetic individuals. Methods and results: Case-control study in non-diabetic individuals (HbA1c Abstract