8635 results
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
International journal of molecular sciences,
Volume 21, Issue 13, 30 5 2020, Pages E4643
Bis(maltolato)oxovanadium(IV) Induces Angiogenesis via Phosphorylation of VEGFR2.
Parma L, Peters HAB, Johansson ME, Gutiérrez S, Meijerink H, de Kimpe S, de Vries MR, Quax PHA
VEGFR2 and VEGF-A play a pivotal role in the process of angiogenesis. VEGFR2 activation is regulated by protein tyrosine phosphatases (PTPs), enzymes that dephosphorylate the receptor and reduce angiogenesis. We aim to study the effect of PTPs blockade using bis(maltolato)oxovanadium(IV) (BMOV) on in vivo wound healing and in vitro angiogenesis. BMOV significantly improves in vivo wound closure by 45% in C57BL/6JRj mice. We found that upon VEGFR2 phosphorylation induced by endogenously produced...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
Volume 163, Issue 6, 30 5 2020, Pages 1202-1208
Glycoprotein Nonmetastatic Melanoma Protein B as Potential Imaging Marker in Posttherapeutic Metastatic Head and Neck Cancer.
van Schaik JE, Hanemaaijer SH, Halmos GB, Witjes MJH, van der Laan BFAM, van der Vegt B, Plaat BEC
Objective: To evaluate expression of potential molecular imaging targets epidermal growth factor receptor (EGFR), glycoprotein nonmetastatic melanoma protein B (GPNMB), and vascular endothelial growth factor (VEGF) in lymph nodes (LNs) with or without head and neck squamous cell carcinoma (HNSCC) metastases after (chemo)radiation. Study design: Retrospective study comparing receptor expression in paired lymph nodes after initial treatment. Setting: A tertiary referral hospital. Subjects and meth...
Abstract
Cited 26 times since 2020 (4.8 per year)
source: EuropePMC
American heart journal,
Volume 228, 30 5 2020, Pages 27-35
Rationale and design of a prospective, randomized, controlled, multicenter study to evaluate the safety and efficacy of transcatheter heart valve replacement in female patients with severe symptomatic aortic stenosis requiring aortic valve intervention (Randomized researcH in womEn all comers wIth Aortic stenosis [RHEIA] trial).
Eltchaninoff H, Bonaros N, Prendergast B, Nietlispach F, Vasa-Nicotera M, Chieffo A, Pibarot P, Bramlage P, Sykorova L, Kurucova J, Bax JJ, Windecker S, Dumonteil N, Tchetche D
Background: Limited data suggest that transcatheter (TAVR) as compared with surgical aortic valve replacement (SAVR) may be more effective in female than male patients. To date, most evidence is derived from subgroup analyses of large trials, and a dedicated randomized trial evaluating whether there is a difference in outcomes between these interventions in women is warranted. The RHEIA trial will compare the safety and efficacy of TAVR with SAVR in women with severe symptomatic aortic stenosis...
Abstract
Cited 28 times since 2020 (5.1 per year)
source: EuropePMC
European urology oncology,
Volume 3, Issue 4, 27 4 2020, Pages 424-432
European Association of Urology Guidelines on Primary Urethral Carcinoma-2020 Update.
Gakis G, Bruins HM, Cathomas R, Compérat EM, Cowan NC, van der Heijden AG, Hernández V, Linares Espinós EE, Lorch A, Neuzillet Y, Ribal MJ, Rouanne M, Thalmann GN, Veskimäe E, Witjes AJ
Context: Primary urethral carcinoma (PUC) is a rare cancer accounting for
Abstract
Cited 35 times since 2020 (6.4 per year)
source: EuropePMC
Progress in cardiovascular diseases,
Volume 63, Issue 4, 27 4 2020, Pages 452-456
Sex differences in bicuspid aortic valve disease.
Kong WKF, Bax JJ, Michelena HI, Delgado V
Bicuspid aortic valve (BAV), the most frequent congenital heart disease, is characterized by an uneven distribution between sexes. BAV is three to four times more frequent in men than in women which could be associated with a reduced dosage of X chromosome genes. In addition, BAV has a multifactorial inheritance, low penetrance and variable phenotypes that may lead to different form of valve degeneration and dysfunction over time as well as different incidence of aortic valve and vascular compli...
Abstract
Cited 7 times since 2020 (1.3 per year)
source: EuropePMC
Autonomic neuroscience : basic & clinical,
Volume 227, 26 4 2020, Pages 102696
Association between reduced heart rate variability components and supraventricular tachyarrhythmias in patients with a systemic right ventricle.
Zandstra T, Kiès P, Maan A, Man SC, Bootsma M, Vliegen H, Egorova A, Mertens B, Holman E, Schalij M, Jongbloed M
Background: Patients with a systemic right ventricle are prone to develop heart failure. Abnormal heart rate variability (HRV), a measure of autonomic dysfunction, is associated with morbidity and mortality in patients with left ventricular failure. The association between HRV and supraventricular arrhythmias (SVTs), which are associated with adverse events in this population, was assessed. Methods: 24-Hour Holter recordings of patients with a systemic right ventricle and healthy controls were a...
Abstract
Cited 24 times since 2020 (4.4 per year)
source: EuropePMC
Progress in cardiovascular diseases,
Volume 63, Issue 4, 26 4 2020, Pages 419-424
Speaking a common language: Introduction to a standard terminology for the bicuspid aortic valve and its aortopathy.
Michelena HI, Della Corte A, Evangelista A, Maleszewski JJ, Enriquez-Sarano M, Bax JJ, Otto CM, Schäfers HJ
There is a growing need to develop a common language when referring to a frequent and heterogeneous condition such as the congenital bicuspid aortic valve and its aortopathy. The following short manuscript serves as an introduction to a standard terminology for the bicuspid aortic valve and its aortopathy.
Abstract
Cited 13 times since 2020 (2.4 per year)
source: EuropePMC
Journal of inherited metabolic disease,
Volume 43, Issue 5, 25 4 2020, Pages 1070-1081
Cognitive functioning and depressive symptoms in Fabry disease: A follow-up study.
Körver S, Geurtsen GJ, Hollak CEM, van Schaik IN, Longo MGF, Lima MR, Dijkgraaf MGW, Langeveld M
Patients with Fabry disease (FD) have a high prevalence of depressive symptoms and can suffer from cognitive impairment, negatively affecting their life. The course of cognitive functioning and depressive symptoms in FD is unknown. The aim of this prospective cohort study was to describe changes in cognitive functioning and depressive symptoms and to identify related variables in patients with FD over 1 year. Assessments were conducted twice, using a neuropsychological test battery and the Centr...
Abstract
Cited 3 times since 2020 (0.6 per year)
source: EuropePMC
International journal of cardiology,
Volume 318, 24 4 2020, Pages 7-13
Blood transfusion and ischaemic outcomes according to anemia and bleeding in patients with non-ST-segment elevation acute coronary syndromes: Insights from the TAO randomized clinical trial.
Deharo P, Ducrocq G, Bode C, Cohen M, Cuisset T, Mehta SR, Pollack CV, Wiviott SD, Rao SV, Jukema JW, Erglis A, Moccetti T, Elbez Y, Steg PG
Background: The benefits and risks of blood transfusion in patients with acute myocardial infarction who are anemic or who experience bleeding are debated. We sought to study the association between blood transfusion and ischemic outcomes according to haemoglobin nadir and bleeding status in patients with NST-elevation myocardial infarction (NSTEMI). Methods: The TAO trial randomized patients with NSTEMI and coronary angiogram scheduled within 72h to heparin plus eptifibatide versus otamixaban....
Abstract
Cited 18 times since 2020 (3.3 per year)
source: EuropePMC
JMIR human factors,
Volume 7, Issue 2, 23 4 2020, Pages e17147
Perspectives of Patients and Professionals on Information and Education After Myocardial Infarction With Insight for Mixed Reality Implementation: Cross-Sectional Interview Study.
Hilt AD, Mamaqi Kapllani K, Hierck BP, Kemp AC, Albayrak A, Melles M, Schalij MJ, Scherptong RWC
Background: Patient education is crucial in the secondary prevention of cardiovascular disease. Novel technologies such as augmented reality or mixed reality expand the possibilities for providing visual support in this process. Mixed reality creates interactive digital three-dimensional (3D) projections overlaying virtual objects on the real-world environment. While augmented reality only overlays objects, mixed reality not just overlays but anchors virtual objects to the real world. However, r...
Abstract
Cited 38 times since 2020 (7 per year)
source: EuropePMC
European respiratory review : an official journal of the European Respiratory Society,
Volume 29, Issue 156, 23 4 2020, Pages 190139
COPD and acute myocardial infarction.
Goedemans L, Bax JJ, Delgado V
COPD is strongly associated with cardiovascular disease, in particular acute myocardial infarction (AMI). Besides shared risk factors, COPD-related factors, such as systemic inflammation and hypoxia, underlie the pathophysiological interaction between COPD and AMI. The prevalence of COPD amongst AMI populations ranges from 7% to 30%, which is possibly even an underestimation due to underdiagnoses of COPD in general. Following the acute event, patients with COPD have an increased risk of mortalit...
Abstract
Cited 19 times since 2020 (3.5 per year)
source: EuropePMC
One health outlook,
Volume 2, 22 4 2020, Pages 14
Novel opportunities for NGS-based one health surveillance of foodborne viruses.
Desdouits M, de Graaf M, Strubbia S, Oude Munnink BB, Kroneman A, Le Guyader FS, Koopmans MPG
Foodborne viral infections rank among the top 5 causes of disease, with noroviruses and hepatitis A causing the greatest burden globally. Contamination of foods by infected food handlers or through environmental pollution are the main sources of foodborne illness, with a lesser role for consumption of products from infected animals. Viral partial genomic sequencing has been used for more than two decades to track foodborne outbreaks and whole genome or metagenomics next-generation-sequencing (NG...
Abstract
Cited 21 times since 2020 (3.8 per year)
source: EuropePMC
Cardiology and therapy,
Volume 9, Issue 2, 20 3 2020, Pages 307-321
Optical Coherence Tomography: Current Applications for the Assessment of Coronary Artery Disease and Guidance of Percutaneous Coronary Interventions.
Oosterveer TTM, van der Meer SM, Scherptong RWC, Jukema JW
Introduction: Coronary angiography (CAG) is the standard modality for assessment of coronary stenoses and intraprocedural guidance of percutaneous coronary interventions (PCI). However, the limitations of CAG are well recognized. Intracoronary imaging (ICI) can potentially overcome these limitations. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are the main ICI techniques utilized in clinical practice. Aim: This narrative literature review addresses the current clinical...
Abstract
Cited 1 times since 2020 (0.2 per year)
source: EuropePMC
Nederlands tijdschrift voor geneeskunde,
Volume 164, 18 3 2020, Pages D4940
[Moral case deliberation in complex euthanasia requests].
Metselaar S, van Schaik MV, Molewijk AC, Widdershoven GAM
Dealing with euthanasia requests can be a complex matter for a doctor. How to determine whether the due diligence criteria of the Dutch Euthanasia Act are met in cases that are not straightforward? We argue that moral case deliberation (MCD), methodically structured reflective discussions on concrete moral dilemmas, can provide support in dealing with complex euthanasia requests. In this article, we discuss a case that was talked about during a MCD (in particular the CURA method, where CURA stan...
Abstract
Cited 5 times since 2020 (0.9 per year)
source: EuropePMC
The journal of physical chemistry. B,
Volume 124, Issue 25, 17 3 2020, Pages 5311-5322
Simulations of the Biodegradation of Citrate-Based Polymers for Artificial Scaffolds Using Accelerated Reactive Molecular Dynamics.
Dasgupta N, Yilmaz DE, van Duin A
In this study, we investigate the reactivity and mechanical properties of poly(1,6-hexanediol-co-citric acid) via ReaxFF molecular dynamics simulations. We implement an accelerated scheme within the ReaxFF framework to study the hydrolysis reaction of the polymer which is provided with a sufficient amount of energy known as the restrain energy after a suitable pretransition-state configuration is obtained to overcome the activation energy barrier and the desired product is obtained. The validity...
Abstract
Cited 4 times since 2020 (0.7 per year)
source: EuropePMC
European journal of preventive cardiology,
Volume 28, Issue 10, 17 3 2020, Pages 1155-1159
Screening for coronary artery calcium in a high-risk population: the ROBINSCA trial.
Denissen SJAM, van der Aalst CM, Vonder M, Gratama JWC, Adriaansen HJ, Kuijpers D, Roeters van Lennep JE, Vliegenthart R, van der Harst P, Braam RL, van Dijkman PRM, Oudkerk M, de Koning HJ
Abstract
Cited 14 times since 2020 (2.6 per year)
source: EuropePMC
Journal of cardiovascular translational research,
Volume 14, Issue 1, 16 3 2020, Pages 100-109
The Role of Immunomodulation in Vein Graft Remodeling and Failure.
Baganha F, de Jong A, Jukema JW, Quax PHA, de Vries MR
Obstructive arterial disease is a major cause of morbidity and mortality in the developed world. Venous bypass graft surgery is one of the most frequently used revascularization strategies despite its considerable short and long time failure rate. Due to vessel wall remodeling, inflammation, intimal hyperplasia, and accelerated atherosclerosis, vein grafts may (ultimately) fail to revascularize tissues downstream to occlusive atherosclerotic lesions. In the past decades, little has changed in th...
Abstract
Cited 2 times since 2020 (0.4 per year)
source: EuropePMC
Annals of vascular surgery,
Volume 69, 15 3 2020, Pages 332-344
Patients with a Ruptured Abdominal Aortic Aneurysm Are Better Informed in Hospitals with an "EVAR-preferred" Strategy: An Instrumental Variable Analysis of the Dutch Surgical Aneurysm Audit.
Karthaus EG, Lijftogt N, Vahl A, van der Willik EM, Amodio S, van Zwet EW, Hamming JF, Dutch Society for Vascular Surgery, the Steering Committee of the Dutch Surgical Aneurysm Audit and the Dutch Institute for Clinical Auditing
Background: While several observational studies suggested a lower postoperative mortality after minimal invasive endovascular aneurysm repair (EVAR) in patients with a ruptured abdominal aortic aneurysm (RAAA) compared to conventional open surgical repair (OSR), landmark randomized controlled trials have not been able to prove the superiority of EVAR over OSR. Randomized controlled trials contain a selected, homogeneous population, influencing external validity. Observational studies are biased...
Abstract
Cited 75 times since 2020 (13.7 per year)
source: EuropePMC
Circulation,
Volume 141, Issue 24, 15 3 2020, Pages 2004-2025
Resource and Infrastructure-Appropriate Management of ST-Segment Elevation Myocardial Infarction in Low- and Middle-Income Countries.
Chandrashekhar Y, Alexander T, Mullasari A, Kumbhani DJ, Alam S, Alexanderson E, Bachani D, Wilhelmus Badenhorst JC, Baliga R, Bax JJ, Bhatt DL, Bossone E, Botelho R, Chakraborthy RN, Chazal RA, Dhaliwal RS, Gamra H, Harikrishnan SP, Jeilan M, Kettles DI, Mehta S, Mohanan PP, Kurt Naber C, Naik N, Ntsekhe M, Otieno HA, Pais P, Piñeiro DJ, Prabhakaran D, Reddy KS, Redha M, Roy A, Sharma M, Shor R, Adriaan Snyders F, Weii Chieh Tan J, Valentine CM, Wilson BH, Yusuf S, Narula J
The 143 low- and middle-income countries (LMICs) of the world constitute 80% of the world's population or roughly 5.86 billion people with much variation in geography, culture, literacy, financial resources, access to health care, insurance penetration, and healthcare regulation. Unfortunately, their burden of cardiovascular disease in general and acute ST-segment-elevation myocardial infarction (STEMI) in particular is increasing at an unprecedented rate. Compounding the problem, outcomes...
Abstract
Cited 30 times since 2020 (5.5 per year)
source: EuropePMC
The Journal of physiology,
Volume 598, Issue 15, 14 2 2020, Pages 3129-3153
CaMKII activity contributes to homeometric autoregulation of the heart: A novel mechanism for the Anrep effect.
Reil JC, Reil GH, Kovács Á, Sequeira V, Waddingham MT, Lodi M, Herwig M, Ghaderi S, Kreusser MM, Papp Z, Voigt N, Dobrev D, Meyhöfer S, Langer HF, Maier LS, Linz D, Mügge A, Hohl M, Steendijk P, Hamdani N
Key points: The Anrep effect represents the alteration of left ventricular (LV) contractility to acutely enhanced afterload in a few seconds, thereby preserving stroke volume (SV) at constant preload. As a result of the missing preload stretch in our model, the Anrep effect differs from the slow force response and has a different mechanism. The Anrep effect demonstrated two different phases. First, the sudden increased afterload was momentary equilibrated by the enhanced LV contractility as a re...
Abstract
