8684 results
Cited 21 times since 2021 (4.9 per year)
source: EuropePMC
Clinical pharmacology and therapeutics,
Volume 110, Issue 1, 23 4 2021, Pages 169-178
Avoiding Tacrolimus Underexposure and Overexposure with a Dosing Algorithm for Renal Transplant Recipients: A Single Arm Prospective Intervention Trial.
Francke MI, Andrews LM, Le HL, van de Wetering J, Clahsen-van Groningen MC, van Gelder T, van Schaik RHN, van der Holt B, de Winter BCM, Hesselink DA
Bodyweight-based tacrolimus dosing followed by therapeutic drug monitoring is standard clinical care after renal transplantation. However, after transplantation, a meager 38% of patients are on target at first steady-state and it can take up to 3 weeks to reach the target tacrolimus predose concentration (C0 ). Tacrolimus underexposure and overexposure is associated with an increased risk of rejection and drug-related toxicity, respectively. To minimize subtherapeutic and supratherapeutic tacrol...
Abstract
Cited 30 times since 2021 (7 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 8, Issue 2, 22 4 2021, Pages 23
Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow's Disease.
van Wijngaarden AL, Kruithof BPT, Vinella T, Barge-Schaapveld DQCM, Ajmone Marsan N
Degenerative mitral valve disease causing mitral valve prolapse is the most common cause of primary mitral regurgitation, with two distinct phenotypes generally recognized with some major differences, i.e., fibroelastic deficiency (FED) and Barlow's disease. The aim of this review was to describe the main histological, clinical and echocardiographic features of patients with FED and Barlow's disease, highlighting the differences in diagnosis, risk stratification and patient management,...
Abstract
Cited 24 times since 2021 (5.6 per year)
source: EuropePMC
Neurology,
Volume 96, Issue 8, 22 4 2021, Pages e1110-e1123
Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke: Meta-analysis From 7 Prospective Cohorts.
Vojinovic D, Kalaoja M, Trompet S, Fischer K, Shipley MJ, Li S, Havulinna AS, Perola M, Salomaa V, Yang Q, Sattar N, Jousilahti P, Amin N, Satizabal CL, Taba N, Sabayan B, Vasan RS, Ikram MA, Stott DJ, Ala-Korpela M, Jukema JW, Seshadri S, Kettunen J, Kivimaki M, Esko T, van Duijn CM
Objective: To conduct a comprehensive analysis of circulating metabolites and incident stroke in large prospective population-based settings. Methods: We investigated the association of metabolites with risk of stroke in 7 prospective cohort studies including 1,791 incident stroke events among 38,797 participants in whom circulating metabolites were measured by nuclear magnetic resonance technology. The relationship between metabolites and stroke was assessed with Cox proportional hazards regres...
Abstract
Cited 16 times since 2021 (3.7 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 10, Issue 5, 22 4 2021, Pages e018565
Clinical Course Long After Atrial Switch: A Novel Risk Score for Major Clinical Events.
Woudstra OI, Zandstra TE, Vogel RF, van Dijk APJ, Vliegen HW, Kiès P, Jongbloed MRM, Egorova AD, Doevendans PAFM, Konings TC, Mulder BJM, Tanck MWT, Meijboom FJ, Bouma BJ
Background Patients with transposition of the great arteries corrected by an atrial switch operation experience major clinical events during adulthood, mainly heart failure (HF) and arrhythmias, but data on the emerging risks remain scarce. We assessed the risk for events during the clinical course in adulthood, and provided a novel risk score for event-free survival. Methods and Results This multicenter study observed 167 patients with transposition of the great arteries corrected by an atrial...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
European journal of applied physiology,
Volume 121, Issue 5, 22 4 2021, Pages 1405-1418
Biventricular function in exercise during autonomic (thoracic epidural) block.
Wink J, Steendijk P, Tsonaka R, de Wilde RBP, Friedericy HJ, Braun J, Veering BT, Aarts LPHJ, Wouters PF
Background: Blockade of cardiac sympathetic fibers by thoracic epidural anesthesia (TEA) was previously shown to reduce right and left ventricular systolic function and effective pulmonary arterial elastance. At conditions of constant paced heart rate, cardiac output and systemic hemodynamics were unchanged. In this study, we further investigated the effect of cardiac sympathicolysis during physical stress and increased oxygen demand. Methods: In a cross-over design, 12 patients scheduled to und...
Abstract
Cited 20 times since 2021 (4.7 per year)
source: EuropePMC
ESC heart failure,
Volume 8, Issue 2, 22 4 2021, Pages 1541-1551
Clinical and economic impact of HeartLogic™ compared with standard care in heart failure patients.
Treskes RW, Beles M, Caputo ML, Cordon A, Biundo E, Maes E, Egorova AD, Schalij MJ, Van Bockstal K, Grazioli-Gauthier L, Vanderheyden M, Bartunek J, Auricchio A, Beeres SLMA, Heggermont WA
Aims: The implantable cardiac defibrillator/cardiac resynchronization therapy with defibrillator-based HeartLogic™ algorithm has recently been developed for early detection of impending decompensation in heart failure (HF) patients; but whether this novel algorithm can reduce HF hospitalizations has not been evaluated. We investigated if activation of the HeartLogic algorithm reduces the number of hospital admissions for decompensated HF in a 1 year post-activation period as compared with a 1 ye...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
European heart journal. Digital health,
Volume 2, Issue 2, 22 4 2021, Pages 215-223
Potential of eHealth smart technology in optimization and monitoring of heart failure treatment in adults with systemic right ventricular failure.
Nederend M, Zandstra TE, Kiès P, Jongbloed MRM, Vliegen HW, Treskes RW, Schalij MJ, Atsma DE, Egorova AD
Aims: Patients with a systemic right ventricle (sRV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA are prone to heart failure and arrhythmias. This study evaluated feasibility, patient adherence, and satisfaction of a smart technology-based care pathway for heart failure treatment optimization in these patients. Methods and results: Patients with symptomatic sRV failure eligible for initiation of sacubitril/valsartan were provided w...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation,
Volume 30, Issue 6, 19 3 2021, Pages 1605-1617
The impact of transvenous cardioverter-defibrillator implantation on quality of life, depression and optimism in dialysis patients: report on the secondary outcome of QOL in the randomized controlled ICD2 trial.
Timal RJ, de Gucht V, Rotmans JI, Hensen LCR, Buiten MS, de Bie MK, Putter H, Schalij MJ, Rabelink TJ, Jukema JW
Rationale: The impact of prophylactic implantable cardioverter-defibrillator (ICD) implantation on the psychological well-being of patients on dialysis is unknown. Objective: We aimed to identify the effect of primary ICD implantation on quality of life (QoL), mood and dispositional optimism in patients undergoing dialysis. Methods and results: We performed a prespecified subanalysis of the randomized controlled ICD2 trial. In total, 177 patients on chronic dialysis, with an age of 55-81 years,...
Abstract
Cited 7 times since 2021 (1.6 per year)
source: EuropePMC
Trials,
Volume 22, Issue 1, 19 3 2021, Pages 155
Intravenous immunoglobulin and intravenous methylprednisolone as optimal induction treatment in chronic inflammatory demyelinating polyradiculoneuropathy: protocol of an international, randomised, double-blind, placebo-controlled trial (OPTIC).
Bus SRM, Zambreanu L, Abbas A, Rajabally YA, Hadden RDM, de Haan RJ, de Borgie CAJM, Lunn MP, van Schaik IN, Eftimov F, OPTIC study group
Background: International guidelines recommend either intravenous immunoglobulin (IVIg) or corticosteroids as first-line treatment for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). IVIg treatment usually leads to rapid improvement and is generally safe, but does not seem to lead to long-term remissions. Corticosteroids act more slowly and are associated with more side effects, but may induce long-term remissions. The hypothesis of this study is that combined IVIg and corticos...
Abstract
Cited 5 times since 2021 (1.2 per year)
source: EuropePMC
Frontiers in immunology,
Volume 11, 19 3 2021, Pages 609624
Characterization and Monitoring of Antigen-Responsive T Cell Clones Using T Cell Receptor Gene Expression Analysis.
Pollastro S, de Bourayne M, Balzaretti G, Jongejan A, van Schaik BDC, Niewold ITG, van Kampen AHC, Maillère B, de Vries N
High-throughput T-cell receptor repertoire sequencing constitutes a powerful tool to study T cell responses at the clonal level. However, it does not give information on the functional phenotype of the responding clones and lacks a statistical framework for quantitative evaluation. To overcome this, we combined datasets from different experiments, all starting from the same blood samples. We used a novel, sensitive, UMI-based protocol to perform repertoire analysis on experimental replicates. Ap...
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
International journal of molecular sciences,
Volume 22, Issue 4, 18 3 2021, Pages 2010
BMP Receptor Inhibition Enhances Tissue Repair in Endoglin Heterozygous Mice.
Bakker W, Dingenouts CKE, Lodder K, Wiesmeijer KC, de Jong A, Kurakula K, Mager HJ, Smits AM, de Vries MR, Quax PHA, Goumans MJTH
Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a severe vascular disorder caused by mutations in the TGFβ/BMP co-receptor endoglin. Endoglin haploinsufficiency results in vascular malformations and impaired neoangiogenesis. Furthermore, HHT1 patients display an impaired immune response. To date it is not fully understood how endoglin haploinsufficient immune cells contribute to HHT1 pathology. Therefore, we investigated the immune response during tissue repair in Eng+/- mice, a model for...
Abstract
Cited 11 times since 2021 (2.6 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 29, Issue 4, 18 3 2021, Pages 224-229
Emergency medical services evaluations for chest pain during first COVID-19 lockdown in Hollands-Midden, the Netherlands.
de Koning ER, Boogers MJ, Bosch J, de Visser M, Schalij MJ, Beeres SLMA
Objective: To assess whether the COVID-19 lockdown in 2020 had negative indirect health effects, as people seem to have been reluctant to seek medical care. Methods: All emergency medical services (EMS) transports for chest pain or out-of-hospital cardiac arrest (OHCA) in the Dutch region Hollands-Midden (population served > 800,000) were evaluated during the initial 6 weeks of the COVID-19 lockdown and during the same time period in 2019. The primary endpoint was the number of evaluated ches...
Abstract
JACC. Case reports,
Volume 3, Issue 2, 17 3 2021, Pages 217-219
Björk-Fontan and the Restoration of Right-Sided Conduits.
de Winter RJ, Koolbergen DR
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
PloS one,
Volume 16, Issue 2, 17 3 2021, Pages e0246455
A randomised experiment of health, cost and social norm message frames to encourage acceptance of swaps in a simulation online supermarket.
Bunten A, Porter L, Sanders JG, Sallis A, Payne Riches S, Van Schaik P, González-Iraizoz M, Chadborn T, Forwood S
Offering lower-energy food swaps to customers of online supermarkets could help to decrease energy (kcal) purchased and consumed. However, acceptance rates of such food swaps tend to be low. This study aimed to see whether framing lower-energy food swaps in terms of cost savings or social norms could improve likelihood of acceptance relative to framing swaps in terms of health benefits. Participants (n = 900) were asked to shop from a 12-item shopping list in a simulation online supermarket. Whe...
Abstract
Cited 6 times since 2021 (1.4 per year)
source: EuropePMC
Pediatric diabetes,
Volume 22, Issue 4, 16 3 2021, Pages 618-624
Bedside sonographic measurements of optic nerve sheath diameter in children with diabetic ketoacidosis.
Şık N, Erbaş İM, Demir K, Yılmaz D, Duman M
Background: Bedside sonographic assessment of the optic nerve sheath has gained popularity for evaluating intracranial pressure in recent years. Objective: To investigate the bedside sonographic measurements of optic nerve sheath diameter (ONSD) and ONSD/eyeball diameter ratios, which are related with cerebral edema (CE), in children with diabetic ketoacidosis (DKA) before and after treatment. Methods: Children aged 12 months to 18 years, who were diagnosed with DKA were included. The ONSD was m...
Abstract
Cited 42 times since 2021 (9.8 per year)
source: EuropePMC
Archives of orthopaedic and trauma surgery,
Volume 142, Issue 8, 15 3 2021, Pages 1775-1791
Safety and efficacy of outpatient hip and knee arthroplasty: a systematic review with meta-analysis.
Bemelmans YFL, Keulen MHF, Heymans M, van Haaren EH, Boonen B, Schotanus MGM
Introduction: This systematic review aimed to assess the safety and efficacy of outpatient joint arthroplasty (OJA) pathways compared to inpatient pathways. Materials and methods: An electronic literature search was conducted to identify eligible studies. Studies comparing OJA with inpatient pathways-following hip and/or (partial) knee arthroplasty-were included. Included studies were assigned-based on OJA definition-to one of the following two groups: (1) outpatient surgery (OS); outpatient def...
Abstract
Cited 5 times since 2021 (1.2 per year)
source: EuropePMC
Sensors (Basel, Switzerland),
Volume 21, Issue 4, 15 3 2021, Pages 1361
Early Detection of Fluid Retention in Patients with Advanced Heart Failure: A Review of a Novel Multisensory Algorithm, HeartLogic<sup>TM</sup>.
Feijen M, Egorova AD, Beeres SLMA, Treskes RW
Heart failure (HF) hospitalisations due to decompensation are associated with shorter life expectancy and lower quality of life. These hospitalisations pose a significant burden on the patients, doctors and healthcare resources. Early detection of an upcoming episode of decompensation may facilitate timely optimisation of the ambulatory medical treatment and thereby prevent heart-failure-related hospitalisations. The HeartLogicTM algorithm combines data from five sensors of cardiac implantable e...
Abstract
Cited 5 times since 2021 (1.2 per year)
source: EuropePMC
Forensic science international,
Volume 321, 13 2 2021, Pages 110722
Measuring calibration of likelihood-ratio systems: A comparison of four metrics, including a new metric devPAV.
Vergeer P, van Schaik Y, Sjerps M
Numerical likelihood-ratio (LR) systems aim to calculate evidential strength for forensic evidence evaluation. Calibration of such LR-systems is essential: one does not want to over- or understate the strength of the evidence. Metrics that measure calibration differ in sensitivity to errors in calibration of such systems. In this paper we compare four calibration metrics by a simulation study based on Gaussian Log LR-distributions. Three calibration metrics are taken from the literature (Good, 1...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 112, Issue 4, 13 2 2021, Pages e237-e239
Pneumothorax Due to a Nontraumatic Thoracic Wall Rupture Due to Steroid-Induced Muscle Wasting.
van Schaik E, Ramnarain D, Pouwels S
Spontaneous pneumothorax can be classified into primary and secondary variants. A 58-year-old patient presented with a 7-week history of severe coughing and chest pain. He noticed progressive swelling of the face and the upper part of the body. His medical history revealed osteoporosis and severe rheumatoid arthritis treated with steroids and disease-modifying antirheumatic drugs. Computed tomography of the thorax revealed complete rupture of the thoracic wall through costae 9 and 10 with lung h...
Abstract
Cited 19 times since 2021 (4.4 per year)
source: EuropePMC
Frontiers in cardiovascular medicine,
Volume 8, 12 2 2021, Pages 631985
Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem.
Meerman M, Bracco Gartner TCL, Buikema JW, Wu SM, Siddiqi S, Bouten CVC, Grande-Allen KJ, Suyker WJL, Hjortnaes J
Radiation-induced cardiovascular disease is a well-known complication of radiation exposure. Over the last few years, planning for deep space missions has increased interest in the effects of space radiation on the cardiovascular system, as an increasing number of astronauts will be exposed to space radiation for longer periods of time. Research has shown that exposure to different types of particles found in space radiation can lead to the development of diverse cardiovascular disease via fibro...
Abstract
