6205 results
Cited 125 times since 2014 (11.9 per year)
source: EuropePMC
Proceedings of the National Academy of Sciences of the United States of America,
Volume 111, Issue 50, 1 1 2014, Pages E5383-92
Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue.
Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M
Jervell and Lange-Nielsen syndrome (JLNS) is one of the most severe life-threatening cardiac arrhythmias. Patients display delayed cardiac repolarization, associated high risk of sudden death due to ventricular tachycardia, and congenital bilateral deafness. In contrast to the autosomal dominant forms of long QT syndrome, JLNS is a recessive trait, resulting from homozygous (or compound heterozygous) mutations in KCNQ1 or KCNE1. These genes encode the α and β subunits, respectively, of the ion c...
Abstract
Cited 23 times since 2014 (2.2 per year)
source: EuropePMC
European heart journal,
Volume 35, Issue 48, 1 1 2014, Pages 3417-3425
Non-invasive cardiac imaging evaluation of patients with chronic systolic heart failure: a report from the European Association of Cardiovascular Imaging (EACVI).
Gimelli A, Lancellotti P, Badano LP, Lombardi M, Gerber B, Plein S, Neglia D, Edvardsen T, Kitsiou A, Scholte AJ, Schröder S, Cosyns B, Gargiulo P, Zamorano JL, Perrone-Filardi P
Abstract
Cited 21 times since 2014 (2 per year)
source: EuropePMC
Lung cancer (Amsterdam, Netherlands),
Volume 87, Issue 2, 29 5 2014, Pages 201-203
Tumor flare after start of RAF inhibition in KRAS mutated NSCLC: a case report.
Mellema WW, Burgers SA, Smit EF
Here we describe a case of striking tumor flare after start of treatment with sorafenib and metformin as part of a phase II clinical trial. Previous reports have described a paradoxal activation of the MAPK pathway after treatment with a weak RAF inhibitor. This mechanism is based on inhibition of a negative feedback loop to upstream effectors of RAF and subsequently increased stimulation of the RAS-RAF-MEK-ERK (MAPK) pathway. We suggest that sorafenib may contribute to tumor progression through...
Abstract
Cited 75 times since 2014 (7.1 per year)
source: EuropePMC
European journal of heart failure,
Volume 17, Issue 1, 27 4 2014, Pages 51-62
Subclinical left ventricular dysfunction by echocardiographic speckle-tracking strain analysis relates to outcome in sarcoidosis.
Joyce E, Ninaber MK, Katsanos S, Debonnaire P, Kamperidis V, Bax JJ, Taube C, Delgado V, Ajmone Marsan N
Aims: Limited data exist on the risk of developing cardiac sarcoidosis (CS) and/or adverse events in sarcoidosis patients. Using LV global longitudinal strain (GLS), an emerging sensitive parameter of LV function, we evaluated the prevalence of subclinical cardiac dysfunction in sarcoidosis and investigated whether LVGLS predicts adverse outcomes in this population. Methods and results: A total of 130 patients with proven sarcoidosis undergoing echocardiography at our referral centre were identi...
Abstract
Cited 2 times since 2014 (0.2 per year)
source: EuropePMC
Journal of chromatography. A,
Volume 1374, 27 4 2014, Pages 224-230
Impurity profiling of trinitrotoluene using vacuum-outlet gas chromatography-mass spectrometry.
Brust H, Willemse S, Zeng T, van Asten A, Koeberg M, van der Heijden A, Bolck A, Schoenmakers P
In this work, a reliable and robust vacuum-outlet gas chromatography-mass spectrometry (GC-MS) method is introduced for the identification and quantification of impurities in trinitrotoluene (TNT). Vacuum-outlet GC-MS allows for short analysis times; the analysis of impurities in TNT was performed in 4min. This study shows that impurity profiling of TNT can be used to investigate relations between TNT samples encountered in forensic casework. A wide variety of TNT samples were analyzed with the...
Abstract
Cited 56 times since 2014 (5.3 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 8, Issue 1, 24 4 2014, Pages 102-109
Re-entry using anatomically determined isthmuses: a curable ventricular tachycardia in repaired congenital heart disease.
Kapel GF, Reichlin T, Wijnmaalen AP, Piers SR, Holman ER, Tedrow UB, Schalij MJ, Stevenson WG, Zeppenfeld K
Background: Ventricular tachycardia (VT) is an important cause of late morbidity and mortality in repaired congenital heart disease. The substrate often includes anatomic isthmuses that can be transected by radiofrequency catheter ablation similar to isthmus block for atrial flutter. This study evaluates the long-term efficacy of isthmus block for treatment of re-entry VT in adults with repaired congenital heart disease. Methods and results: Thirty-four patients (49±13 years; 74% male) with repa...
Abstract
Cited 56 times since 2014 (5.3 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 118, Issue 1, 23 4 2014, Pages 80-92
Housing and management factors associated with indicators of dairy cattle welfare.
de Vries M, Bokkers EA, van Reenen CG, Engel B, van Schaik G, Dijkstra T, de Boer IJ
Knowledge of potential synergies and trade-offs between housing and management factors for different aspects of animal welfare is essential for farmers who aim to improve the level of welfare in their herds. The aim of this research was to identify and compare housing and management factors associated with prevalence of lameness, prevalence of lesions or swellings, prevalence of dirty hindquarters, and frequency of displacements (social behavior) in dairy herds in free-stall housing. Seven obser...
Abstract
Cited 17 times since 2014 (1.6 per year)
source: EuropePMC
Atherosclerosis,
Volume 238, Issue 1, 22 4 2014, Pages 132-139
RP105 deficiency attenuates early atherosclerosis via decreased monocyte influx in a CCR2 dependent manner.
Wezel A, van der Velden D, Maassen JM, Lagraauw HM, de Vries MR, Karper JC, Kuiper J, Bot I, Quax PH
Objective: Toll like receptor 4 (TLR4) plays a key role in inflammation and previously it was established that TLR4 deficiency attenuates atherosclerosis. RadioProtective 105 (RP105) is a structural homolog of TLR4 and an important regulator of TLR4 signaling, suggesting that RP105 may also be an important effector in atherosclerosis. We thus aimed to determine the role of RP105 in atherosclerotic lesion development using RP105 deficient mice on an atherosclerotic background. Methods and results...
Abstract
Cited 24 times since 2014 (2.3 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 101, Issue 2, 20 3 2014, Pages 94-100
Non-invasive imaging in atrial fibrillation: focus on prognosis and catheter ablation.
Bax JJ, Marsan NA, Delgado V
Imaging identifies patients with high-risk phenotype among the general population with atrial fibrillation, such as the presence of structural and valvular heart disease, which are both related to adverse outcome. Imaging is also potentially important for prediction of success of catheter ablation. Specifically, patients with larger left atrial size, reduced left atrial function and increased left atrial fibrosis content are more likely to experience atrial fibrillation recurrences after ablatio...
Abstract
Cited 14 times since 2014 (1.3 per year)
source: EuropePMC
Journal of magnetic resonance imaging : JMRI,
Volume 42, Issue 2, 19 3 2014, Pages 390-399
Automated left ventricle segmentation in late gadolinium-enhanced MRI for objective myocardial scar assessment.
Tao Q, Piers SR, Lamb HJ, van der Geest RJ
Purpose: To develop and validate an objective and reproducible left ventricle (LV) segmentation method for late gadolinium enhanced (LGE) magnetic resonance imaging (MRI), which can facilitate accurate myocardial scar assessment. Materials and methods: A cohort of 25 ischemic patients and 25 nonischemic patients were included. A four-step algorithm was proposed: first, the Cine-MRI and LGE-MRI volume were globally registered; second, the registered Cine-MRI contours were fitted to each LGE-MRI s...
Abstract
Cited 45 times since 2014 (4.3 per year)
source: EuropePMC
Proceedings of the National Academy of Sciences of the United States of America,
Volume 111, Issue 48, 17 3 2014, Pages 17170-17175
Global structural changes of an ion channel during its gating are followed by ion mobility mass spectrometry.
Konijnenberg A, Yilmaz D, Ingólfsson HI, Dimitrova A, Marrink SJ, Li Z, Vénien-Bryan C, Sobott F, Koçer A
Mechanosensitive ion channels are sensors probing membrane tension in all species; despite their importance and vital role in many cell functions, their gating mechanism remains to be elucidated. Here, we determined the conditions for releasing intact mechanosensitive channel of large conductance (MscL) proteins from their detergents in the gas phase using native ion mobility-mass spectrometry (IM-MS). By using IM-MS, we could detect the native mass of MscL from Escherichia coli, determine vario...
Abstract
Cited 30 times since 2014 (2.9 per year)
source: EuropePMC
The Journal of clinical investigation,
Volume 124, Issue 12, 17 3 2014, Pages 5159-5174
Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1.
Ali ZA, de Jesus Perez V, Yuan K, Orcholski M, Pan S, Qi W, Chopra G, Adams C, Kojima Y, Leeper NJ, Qu X, Zaleta-Rivera K, Kato K, Yamada Y, Oguri M, Kuchinsky A, Hazen SL, Jukema JW, Ganesh SK, Nabel EG, Channon K, Leon MB, Charest A, Quertermous T, Ashley EA
Angioplasty and stenting is the primary treatment for flow-limiting atherosclerosis; however, this strategy is limited by pathological vascular remodeling. Using a systems approach, we identified a role for the network hub gene glutathione peroxidase-1 (GPX1) in pathological remodeling following human blood vessel stenting. Constitutive deletion of Gpx1 in atherosclerotic mice recapitulated this phenotype of increased vascular smooth muscle cell (VSMC) proliferation and plaque formation. In an i...
Abstract
Cited 4 times since 2014 (0.4 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 11, 12 2 2014, Pages e112129
Molecular epidemiology of seal parvovirus, 1988-2014.
Bodewes R, Hapsari R, Rubio García A, Sánchez Contreras GJ, van de Bildt MW, de Graaf M, Kuiken T, Osterhaus AD
A novel parvovirus was discovered recently in the brain of a harbor seal (Phoca vitulina) with chronic meningo-encephalitis. Phylogenetic analysis of this virus indicated that it belongs to the genus Erythroparvovirus, to which also human parvovirus B19 belongs. In the present study, the prevalence, genetic diversity and clinical relevance of seal parvovirus (SePV) infections was evaluated in both harbor and grey seals (Halichoerus grypus) that lived in Northwestern European coastal waters from...
Abstract
Cited 12 times since 2014 (1.1 per year)
source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 85, Issue 3, 12 2 2014, Pages 480-487
Position of Edwards SAPIEN transcatheter valve in the aortic root in relation with the coronary ostia: implications for percutaneous coronary interventions.
Katsanos S, Debonnaire P, van der Kley F, van Rosendael PJ, Joyce E, de Graaf MA, Schalij MJ, Scholte AJ, Bax JJ, Ajmone Marsan N, Delgado V
Objectives: To determine the implications of stable coverage of the coronary ostia by the Edwards SAPIEN valve frame in terms of myocardial ischemia and subsequent percutaneous coronary intervention (PCI), following transcatheter aortic valve implantation (TAVI). Background: Edwards SAPIEN frame is frequently deployed relatively higher than recommended and may overlap the coronary ostia. Methods: A total of 142 patients (age 81 ± 7 years, male 49%) treated with Edwards SAPIEN valve and with mult...
Abstract
Cited 14 times since 2014 (1.3 per year)
source: EuropePMC
Heart rhythm,
Volume 12, Issue 3, 7 1 2014, Pages 533-539
Epicardial leads in adult cardiac resynchronization therapy recipients: a study on lead performance, durability, and safety.
Buiten MS, van der Heijden AC, Klautz RJM, Schalij MJ, van Erven L
Background: Transvenous left ventricular (LV) lead placement for cardiac resynchronization therapy-defibrillator (CRT-D) delivery is unsuccessful in 8% to 10% of cases. These patients might benefit from an epicardial lead. However, data on long-term epicardial lead performance are scarce. Furthermore, extracting an epicardial lead requires a rethoracotomy. Objective: The purpose of this study was to determine data on almost a decade of experience with epicardial leads and investigate the safety...
Abstract
Cited 4 times since 2014 (0.4 per year)
source: EuropePMC
Hamostaseologie,
Volume 35, Issue 2, 7 1 2014, Pages 113-120
The role of mast cells in atherosclerosis.
Wezel A, Quax PH, Kuiper J, Bot I
Rupture of an atherosclerotic plaque is the major underlying cause of adverse cardiovascular events such as myocardial infarction or stroke. Therapeutic interventions should therefore be directed towards inhibiting growth of atherosclerotic lesions as well as towards prevention of lesion destabilization. Interestingly, the presence of mast cells has been demonstrated in both murine and human plaques, and multiple interventional murine studies have pointed out a direct role for mast cells in earl...
Abstract
Cited 17 times since 2014 (1.6 per year)
source: EuropePMC
Nutrition and cancer,
Volume 67, Issue 1, 5 1 2014, Pages 137-144
Mechanism of inhibition of CYP1A1 and glutathione S-transferase activities in fish liver by quercetin, resveratrol, naringenin, hesperidin, and rutin.
Arinç E, Yilmaz D, Bozcaarmutlu A
Quercetin, resveratrol, naringenin, hesperidin, and rutin are phenolic compounds/flavonoids that may have roles in the reduction of cancer susceptibility. In this study, in vitro modulatory effects of them were studied on liver CYP1A1 associated 7-ethoxyresorufin-O-deethylase (EROD) activity and glutathione S-transferase (GST) activity of leaping mullet (Liza saliens). All of the phenolic compounds/flavonoids used exerted an inhibitory effect on both EROD and GST activities of fish. Quercetin, r...
Abstract
The Journal of thoracic and cardiovascular surgery,
Volume 148, Issue 5, 4 1 2014, Pages 2440-2442
Reply to the editor.
Grewal N, Gittenberger-de Groot AC, DeRuiter MC
Abstract
Cited 4 times since 2014 (0.4 per year)
source: EuropePMC
JMIR research protocols,
Volume 3, Issue 4, 3 1 2014, Pages e52
Treatment of Infantile Hemangioma in Regional Hospitals With eHealth Support: Evaluation of Feasibility and Acceptance by Parents and Doctors.
de Graaf M, Totté JE, van Os-Medendorp H, van Renselaar W, Breugem CC, Pasmans SG
Background: Since beta blockers became the preferred treatment for infantile hemangiomas (IH), the number of patients eligible for treatment is increasing. Currently treatment of IH with beta blockers is mainly reserved for expert centers, where wait times are lengthening. This demonstrated the need for development of a more efficient and accessible way of providing care for children needing treatment for IH. An eHealth intervention, Hemangioma Treatment Plan (HTP), was developed to treat IH in...
Abstract
Cited 34 times since 2014 (3.2 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 16, Issue 3, 2 1 2014, Pages 290-299
Leaflet remodelling in functional mitral valve regurgitation: characteristics, determinants, and relation to regurgitation severity.
Debonnaire P, Al Amri I, Leong DP, Joyce E, Katsanos S, Kamperidis V, Schalij MJ, Bax JJ, Marsan NA, Delgado V
Background: Recently, it has been hypothesized that mitral leaflet remodelling may play a role in the pathophysiology of functional mitral regurgitation (FMR). We investigated the characteristics, determinants, and relation of mitral leaflet remodelling to FMR severity. Methods and results: Three-dimensional transoesophageal echocardiographic data of the mitral valve (MV) were studied in 30 patients with FMR ≥ grade 3 (≥3), 24 patients with FMR < grade 3 (
Abstract
