Research

Publications

Below you can find a list of our published research.

9618 results

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Volume 55, Issue 5, 18 3 2025, Pages 391-402 Dupilumab-Associated Ocular Surface Disease in Paediatric Atopic Dermatitis Patients: Results From the BioDay Registry. van der Rijst LP, van Luijk CM, van der Kamp S, Zuithoff NPA, de Boer JH, de Bruin-Weller MS, de Graaf M

Background: Dupilumab-associated ocular surface disease (DAOSD) is a common side effect in paediatric atopic dermatitis (AD) patients treated with dupilumab. However, long-term real-world safety data is limited. Therefore, this study investigates the incidence of DAOSD in paediatric AD patients treated with dupilumab and identifies associated risk factors. Methods: This prospective study included paediatric AD patients (aged 3-17 years) treated with dupilumab. Ocular symptoms were assessed every... Abstract

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, Volume 33, Issue 4, 18 3 2025, Pages 295 Physical activity, health-related fitness, and physical performance in children with acquired hypothalamic dysfunction. Van Roessel IMAA, Van Schaik J, Kleinlugtenbelt LB, van Duijn SN, Burghard M, Takken T, Tissing WJE, Bekkering WP, van Santen HM

Purpose: Survivors of a pediatric suprasellar tumor may suffer from hypothalamic-pituitary dysfunction (HD), which may result in hypothalamic obesity (HO). The first step in HO treatment is lifestyle intervention (e.g. exercise). Our aim was to assess physical activity (PA), health-related fitness (HRF) and physical performance (PP) in a cohort of children with a suprasellar tumor. Methods: Retrospective study on a national cohort including all children with a suprasellar tumor who were referred... Abstract

International journal of cardiology. Heart & vasculature, Volume 58, 17 3 2025, Pages 101654 Association of indexed aortic dimensions with the presence and extent of coronary artery ectasia in patients with acute coronary syndrome. van Oort MJH, Oliveri F, de Lange FWJ, Regeer MV, Bingen BO, Jukema JW, van der Kley F, Al Amri I, Montero-Cabezas JM

Background: Conflicting findings have been reported on the potential association between CAE and aortic dilatation. This study aimed to investigate the relationship between CAE extent and aortic dimensions in patients with acute coronary syndrome (ACS). Methods: This retrospective cohort study included 448 adult patients who underwent coronary angiography for ACS between 2004 and 2015. The cohort was divided into 224 patients with CAE and 224 control patients without CAE, matched for age, sex, a... Abstract

Frontiers in psychiatry, Volume 16, 17 3 2025, Pages 1511841 Determinants of victimization in patients with severe mental illness: results from a nation-wide cross-sectional survey in the Netherlands. Kamperman AM, Zarchev M, Henrichs J, Willemsen SP, Lesaffre EMEH, Swildens WE, Nijssen Y, Kroon H, van Schaik ADJF, van der Gaag M, Delespaul PAEG, van Weeghel J, van de Mheen D, Bogaerts S, Mulder CL

Objective: To examine determinants of the prevalence and frequency of criminal victimization (i.e. both personal and property crime victimization) in outpatients with severe mental illness. Methods: Data was collected using a multisite epidemiological survey including a random sample of 956 adult outpatients with SMI. Data were collected between 2010 and 2012. Data on 12-month victimization prevalence and frequency were obtained using the victimization scale of the Dutch Crime and Victimization... Abstract

British journal of clinical pharmacology, Volume 91, Issue 8, 13 2 2025, Pages 2327-2339 Pharmacokinetics of betamethasone in pre-eclampsia: An in vivo and ex vivo study. Schoenmakers S, Li L, Kluivers ACM, Broekhuizen M, Harhangi MS, Danser AHJ, Reiss I, Allegaert K, van den Berg SAA, van Zelst BD, van Schaik RHN, DeKoninck PLJ, Ronde E, Sassen SDT, Simons SHP, Koch BCP

Aims: To enhance understanding of betamethasone and its metabolites' pharmacokinetics in pregnancy, specifically early-onset pre-eclampsia, through a population pharmacokinetic model. Additionally, to investigate the placental metabolism and transfer of betamethasone and its main metabolites. Methods: A prospective, single-centre pharmacokinetic study was conducted in pregnant women (n = 28) with imminent preterm birth treated with intramuscular betamethasone. Betamethasone serum concentrat... Abstract

Cited 1 times since 2025 (2.3 per year) source: EuropePMC

Pediatric cardiology, 13 2 2025 Fontan-Associated Liver Disease (FALD) in the EUROFontan Experience. An Insight into European Awareness. Gozzi A, Vedovelli L, Bergonzoni E, Cao I, Angeli E, Zanoni R, Biffanti R, Butera G, Dimopoulos K, Rocafort AG, Hazekamp MG, Kansky A, Lenoir M, Martens T, Meliota G, Meyns B, Nosal M, Napoleone CP, Rijnberg FM, Dolzer ES, Scrascia G, Vairo U, Van Puyvelde J, Di Salvo G, Montanaro C, Padalino MA

Fontan-Associated Liver Disease (FALD) is a dramatically emerging problem even if not precisely defined in term of debated diagnosis and surveillance protocols. We analyze FALD prevalence, clinical impact and implications in a European cohort of patients. It's a retrospective observational multicenter study including Fontan patients operated between 1990 and 2022. Anatomical, clinical, surgical and liver-related data were collected, defining FALD as a spectrum of time-related structural-fun... Abstract

Arteriosclerosis, thrombosis, and vascular biology, Volume 45, Issue 5, 13 2 2025, Pages 576-584 Role of Perivascular Adipose Tissue in Vein Remodeling. Kruit N, Sluiter TJ, de Vries MR

Perivascular adipose tissue (PVAT) plays a crucial, yet underexplored, role in vein remodeling, which occurs after bypass surgery using a venous graft or creation of arteriovenous fistulae for hemodialysis access. PVAT exhibits significant heterogeneity in phenotype and tissue composition depending on the vascular bed, as well as its anatomic location within the vasculature. Through the excretion of adipokines, cytokines, and chemokines, PVAT can shape the vascular response to local and systemic... Abstract

Journal of lipid research, Volume 66, Issue 4, 13 2 2025, Pages 100778 Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease. Ao L, van Heemst D, Jukema JW, Rensen PCN, Willems van Dijk K, Noordam R

Plasma 1H-NMR metabolomic measures have yielded significant insight into the pathophysiology of cardiometabolic disease, but their inter-related nature complicates causal inference and clinical interpretation. This study aimed to investigate the associations of unrelated 1H-NMR metabolomic profiles with coronary artery disease (CAD) and ischemic stroke (IS). Principal component (PC) analysis was performed on 168 1H-NMR metabolomic measures in 56,712 unrelated European participants from UK Bioban... Abstract

JACC. Clinical electrophysiology, Volume 11, Issue 6, 12 2 2025, Pages 1193-1204 The Relevance of the Type of Ventricular Arrhythmia in Titin-Related Dilated Cardiomyopathy: A Multicenter Study. Ebert M, de Riva M, Wijnmaalen AP, Barge-Schaapveld DQCM, Bootsma M, Hoogendoorn J, Husser D, van Tintelen JP, Jongbloed JDH, Richter S, Berruezo A, Hindricks G, Stevenson WG, Zeppenfeld K

Background: Truncating titin variants (TTNtvs) are the most prevalent cause of inherited dilated cardiomyopathy. Occurrence of different ventricular arrhythmia (VA) subtypes, including premature ventricular complexes (PVCs), nonsustained ventricular tachycardia (NSVT), and sustained monomorphic VT (SMVT), has been reported. Objectives: The aim of this study was to analyze the prognostic relevance of distinct VA subtypes among TTNtv carriers and their underlying arrhythmogenic substrates. Methods... Abstract

eLife, Volume 14, 12 2 2025, Pages e103728 A systematic review and embryological perspective of pluripotent stem cell-derived autonomic postganglionic neuron differentiation for human disease modeling. Bos TA, Polyakova E, van Gils JM, de Vries AAF, Goumans MJ, Freund C, DeRuiter MC, Jongbloed MRM

Human autonomic neuronal cell models are emerging as tools for modeling diseases such as cardiac arrhythmias. In this systematic review, we compared 33 articles applying 14 different protocols to generate sympathetic neurons and 3 different procedures to produce parasympathetic neurons. All methods involved the differentiation of human pluripotent stem cells, and none employed permanent or reversible cell immortalization. Almost all protocols were reproduced in multiple pluripotent stem cell lin... Abstract

Preventive veterinary medicine, Volume 239, 12 2 2025, Pages 106512 The use of data for health and welfare management of farmed salmons in Norway, Scotland, and Ireland. Zhou X, Boerlage AS, Jensen BB, Gismervik K, Oliveira VHS, Hutchinson I, Burrell A, Graham DA, Doidge C, Kaler J, van Schaik G, Siegrist M, Bearth A

Data-driven solutions can support stakeholders' decision-making when managing health and welfare in Atlantic salmon production. While many different types of data are being collected, knowledge about stakeholders' use and needs regarding this data and data tools in their day-to-day work is limited. The current study explores the status quo of using data and data tools in salmon health management and needs of the stakeholders. Fourteen focus group discussions and three in-depth intervie... Abstract

Cited 1 times since 2025 (2.3 per year) source: EuropePMC

JDS communications, Volume 6, Issue 3, 12 2 2025, Pages 394-399 No indication of highly pathogenic avian influenza infections in Dutch cows. Fabri ND, Santman-Berends IMGA, Roos CAJ, van Schaik G, Het Lam J, Germeraad EA, Mars MH, Mars MH

In March 2024, an infection with highly pathogenic avian influenza (HPAI) virus subtype H5N1 of the HA clade 2.3.4.4b was detected in dairy cows in Texas. Following this first detection, the virus was identified in multiple states in the United States, with spillover into other mammals. This raised concerns in the Netherlands that despite having an effective monitoring and surveillance system, H5N1 virus infections in Dutch cattle could have occurred. The aim of this study was therefore to retro... Abstract

The Pediatric infectious disease journal, Volume 44, Issue 4, 10 2 2025, Pages 281-286 The Prevalence, Serogroup Distribution and Risk Factors of Meningococcal Carriage in Children, Adolescents and Young Adults in Turkey Meningo-Carr-TR Study PART 3: COVID-19 Pandemic Situation. Kizil MC, Kara Y, Karbuz A, Oz FN, Ciftci E, Kurugol Z, Iseri Nepesov M, Celebi S, Cetin BS, Yilmaz D, Dinleyici M, Kizmaz Isancli D, Kilicaslan O, Ozdemir H, Inceli BH, Penezoglu DN, Dortkardesler B, Sezer Yamanel RG, Aksoy FD, Tekin Can S, Agrali Eröz N, Kaya M, Kilic O, Dinleyici EC

Background: The prevalence of meningococcal carriage and serogroup distribution is crucial for assessing the epidemiology of invasive meningococcal disease, forecasting outbreaks and formulating potential immunization strategies. Following the meningococcal carriage studies conducted in Turkey in 2016 and 2018, we planned to re-evaluate meningococcal carriage in children, adolescents and young adults during the COVID-19 pandemic period. Methods: In the MENINGO-CARR-3 study, we collected nasophar... Abstract

Patient education and counseling, Volume 136, 8 2 2025, Pages 108716 Implementation of a patient decision aid for discharge planning of hospitalized patients with stroke: aprocess evaluation using a mixed-methods approach. Prick JCM, Engelhardt EG, Lansink Rotgerink FK, Deijle IA, van Schaik SM, Garvelink MM, Dahmen R, Brouwers PJAM, van Uden IWM, van der Wees PJ, Van den Berg-Vos RM, van Uden-Kraan CF, Santeon VBHC STROKE group

Objectives: To promote shared decision-making (SDM) during discharge planning of patients with stroke, a patient decision aid (PtDA) was implemented in seven Dutch hospitals. This mixed-methods process evaluation assessed: 1) PtDA use, 2) the SDM process, 3) facilitators and barriers influencing health care professional (HCP) adoption of the PtDA, and 4) HCP experiences with the PtDA. Methods: Rates of PtDA use were derived from hospital registries and PtDA log data. SDM levels in consultations... Abstract

Cited 6 times since 2025 (13.4 per year) source: EuropePMC

Nature genetics, Volume 57, Issue 3, 6 1 2025, Pages 539-547 Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases. Roselli C, Surakka I, Olesen MS, Sveinbjornsson G, Marston NA, Choi SH, Holm H, Chaffin M, Gudbjartsson D, Hill MC, Aegisdottir H, Albert CM, Alonso A, Anderson CD, Arking DE, Arnar DO, Barnard J, Benjamin EJ, Braunwald E, Brumpton B, Campbell A, Chami N, Chasman DI, Cho K, Choi EK, Christophersen IE, Chung MK, Conen D, Crijns HJ, Cutler MJ, Czuba T, Damrauer SM, Dichgans M, Dörr M, Dudink E, Duong T, Erikstrup C, Esko T, Fatkin D, Faul JD, Ferreira M, Freitag DF, Ganesh SK, Gaziano JM, Geelhoed B, Ghouse J, Gieger C, Giulianini F, Graham SE, Gudnason V, Guo X, Haggerty C, Hayward C, Heckbert SR, Hveem K, Ito K, Johnson R, Jukema JW, Jurgens SJ, Kääb S, Kane JP, Kany S, Kardia SLR, Kavousi M, Khurshid S, Kamanu FK, Kirchhof P, Kleber ME, Knight S, Komuro I, Krieger JE, Launer LJ, Li D, Lin H, Lin HJ, Loos RJF, Lotta L, Lubitz SA, Lunetta KL, Macfarlane PW, Magnusson PKE, Malik R, Mantineo H, Marcus GM, März W, McManus DD, Melander O, Melloni GEM, Meyre PB, Miyazawa K, Mohanty S, Monfort LM, Müller-Nurasyid M,

Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause of heart failure and stroke. This large-scale meta-analysis of genome-wide association studies increased the power to detect single-nucleotide variant associations and found more than 350 AF-associated genetic loci. We identified candidate genes related to muscle contractility, cardiac muscle development and cell-cell communication at 139 loci. Furthermore, we assayed chromatin accessibility using assay f... Abstract

Cited 1 times since 2025 (2.2 per year) source: EuropePMC

Gut, Volume 74, Issue 4, 6 1 2025, Pages 547-556 Surveillance in inflammatory bowel disease: white light endoscopy with segmental re-inspection versus dye-based chromoendoscopy - a multi-arm randomised controlled trial (HELIOS). Te Groen M, Wijnands AM, den Broeder N, de Jong DJ, van Dop WA, Duijvestein M, Fidder HH, van Schaik F, Hirdes MMC, van der Meulen-de Jong AE, Maljaars PWJ, Voorneveld PW, de Boer KHN, Peters CP, Oldenburg B, Hoentjen F, Dutch Initiative on Crohn and Colitis

Background: It remains unclear if the increased colorectal neoplasia detection rate in inflammatory bowel disease (IBD) by high-definition (HD) dye-based chromoendoscopy compared with HD white-light endoscopy is due to enhanced contrast or increased inspection times. Longer withdrawal times may yield similar neoplasia detection rates as found by HD chromoendoscopy. Objective: To compare colorectal neoplasia detection rates for HD white-light endoscopy with segmental re-inspection and HD chromoen... Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 105, Issue 6, 4 1 2025, Pages 1418-1426 Clinical and Technical Predictors of Treatment Success After Coronary Intravascular Lithotripsy in Calcific Coronary Lesions. van Oort MJH, Bingen BO, Oliveri F, Al Amri I, Phagu AAS, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Girgis H, van der Kley F, Jukema JW, Montero-Cabezas JM

Background: Intravascular lithotripsy (IVL) is increasingly used to treat coronary artery calcification (CAC). This study aimed to identify clinical and procedural factors associated with IVL treatment success. Methods: This retrospective analysis included 454 patients (73 ± 9 years, 75% male) treated with IVL from the multicenter BENELUX-IVL registry (May 2019 to February 2024). Treatment success was defined as achieving residual coronary diameter stenosis Abstract

Radiation and environmental biophysics, Volume 64, Issue 2, 4 1 2025, Pages 275-289 Commissioning and performance assessment of diodes and MOSFETs in in-vivo dosimetry for external beam radiation therapy. Al Kharusi O, Al Mamari R, Al Hosni B, Al Amri I, Al Fishawy M, Boulassel MR, Bouchareb Y

The precision of radiation therapy treatment depends on several calibration and quality assurance processes. In-vivo dosimetry (IVD) is used in external beam radiotherapy to evaluate the delivered versus planned dose as a patient-specific quality assurance verification procedure. This study aimed at assessing the performance of diodes (EDP-103G and EDP-203G) and metal oxide semiconductor field-effect transistors (MOSFETs) and corresponding correction factors followed by IVD evaluation in differe... Abstract

Cited 2 times since 2025 (4.4 per year) source: EuropePMC

Nature genetics, Volume 57, Issue 4, 4 1 2025, Pages 815-828 Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes. Henry A, Mo X, Finan C, Chaffin MD, Speed D, Issa H, Denaxas S, Ware JS, Zheng SL, Malarstig A, Gratton J, Bond I, Roselli C, Miller D, Chopade S, Schmidt AF, Abner E, Adams L, Andersson C, Aragam KG, Ärnlöv J, Asselin G, Raja AA, Backman JD, Bartz TM, Biddinger KJ, Biggs ML, Bloom HL, Boersma E, Brandimarto J, Brown MR, Brunak S, Bruun MT, Buckbinder L, Bundgaard H, Carey DJ, Chasman DI, Chen X, Cook JP, Czuba T, de Denus S, Dehghan A, Delgado GE, Doney AS, Dörr M, Dowsett J, Dudley SC, Engström G, Erikstrup C, Esko T, Farber-Eger EH, Felix SB, Finer S, Ford I, Ghanbari M, Ghasemi S, Ghouse J, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gui H, Gutmann R, Hägg S, Haggerty CM, Hedman ÅK, Helgadottir A, Hemingway H, Hillege H, Hyde CL, Aagaard Jensen B, Jukema JW, Kardys I, Karra R, Kavousi M, Kizer JR, Kleber ME, Køber L, Koekemoer A, Kuchenbaecker K, Lai YP, Lanfear D, Langenberg C, Lin H, Lind L, Lindgren CM, Liu PP, London B, Lowery BD, Luan J, Lubitz SA, Magnusson P, Margulies KB,

Heart failure (HF) is a major contributor to global morbidity and mortality. While distinct clinical subtypes, defined by etiology and left ventricular ejection fraction, are well recognized, their genetic determinants remain inadequately understood. In this study, we report a genome-wide association study of HF and its subtypes in a sample of 1.9 million individuals. A total of 153,174 individuals had HF, of whom 44,012 had a nonischemic etiology (ni-HF). A subset of patients with ni-HF were st... Abstract

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, Volume 34, Issue 5, 4 1 2025, Pages 1801-1809 Analysis of the factors associated with sexual health improvement in patients who underwent surgical management for adult spine deformity. van Schaik D, Baroncini A, Boissiere L, Larrieu D, Goudman L, Pizones J, Pellise F, Alanay A, Kleinstück F, Bourghli A, Obeid I, European Spine Study Group

Background: Spinal deformity can have a severe impact on the patient's sexual health. Eventually, this can lead to depression and relationship distress. Spinal surgical management is suggested to improve sexual function, however, the literature concerning these aspects is still scarce. This study evaluated which factors predicted improvement in sexual health in patients with adult spinal deformity (ASD) who underwent surgical treatment. Methods: Multicentric retrospective study based on a p... Abstract