9618 results
Open heart,
Volume 12, Issue 1, 30 5 2025, Pages e003009
Sacubitril/valsartan is associated with improvements in quality of life in adult congenital heart disease patients with systemic right ventricular failure.
Neijenhuis RML, Nederend M, van Groningen AE, Jongbloed MRM, Vliegen HW, Jukema JW, Kiès P, Egorova AD
Background: Short-term improvements in quality of life (QOL) have been reported in adult congenital heart disease patients with systemic right ventricle (sRV) failure after treatment with sacubitril/valsartan. This study aimed to evaluate the medium-term QOL changes in sRV failure patients treated with sacubitril/valsartan. Methods: In this single-centre, prospective cohort study, patients with symptomatic sRV failure completed the Netherlands Organisation for Applied Scientific Research/Academi...
Abstract
Clinical and translational radiation oncology,
Volume 52, 29 5 2025, Pages 100927
Effect of FLASH proton therapy on primary bronchial epithelial cell organoids.
Kuipers ME, van Liefferinge F, van der Wal E, Rovituso M, Slats AM, Hiemstra PS, Van Doorn-Wink KCJ
Purpose: The effects of conventional (CONV) and FLASH proton therapy on primary bronchial epithelial cell (PBEC) organoids from individuals with chronic obstructive pulmonary disease (COPD) were investigated. The primary objective was to compare the effect of FLASH and CONV on COPD PBEC organoids with a focus on DNA damage, organoid formation, and gene expression. Methods: PBECs were obtained from six COPD donors, cultured as three-dimensional (3D) organoids and exposed to 2 and 8 Gy CONV and FL...
Abstract
Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology,
Volume 53, Issue 3, 28 4 2025, Pages 311-320
Metagenomics education in a modular CURE format positively affects students' scientific discovery perception and data analytical skills.
Morsink MC, van Schaik EN, Bossers K, Duijker DA, Speksnijder AGCL
Targeted metagenomics is a rapidly expanding technology to analyze complex biological samples and genetic monitoring of environmental samples. In this research field, data analytical aspects play a crucial role. In order to teach targeted metagenomics data analysis, we developed a 4-week inquiry-driven modular course-based undergraduate research experience (mCURE) using publicly available Australian coral microbiome DNA sequencing data and associated metadata. Since an enormous amount of metadat...
Abstract
Cited 1 times since 2025 (1.8 per year)
source: EuropePMC
Journal of clinical medicine,
Volume 14, Issue 3, 28 4 2025, Pages 859
From Survival to Recovery: Understanding the Life Impact of an Acute Aortic Dissection Through Activity, Sleep, and Quality of Life.
Bacour N, Grewal S, Theijsse RT, Klautz RJM, Grewal N
Background/Objectives: An acute aortic dissection (AAD) is a cardiovascular emergency with high mortality rates if left untreated. Survival has increased due to improvements in diagnosis and therapy. However, during their recovery, survivors frequently encounter major social, psychological, and physical challenges. This study aimed to evaluate the recovery experience of AAD survivors in The Netherlands. Insights on sleep quality, physical activity, and quality of life were collected from a uniqu...
Abstract
Cited 1 times since 2025 (1.8 per year)
source: EuropePMC
JTCVS techniques,
Volume 30, 28 4 2025, Pages 81-93
Intraoperative assessment of myocardial perfusion using near-infrared fluorescence and indocyanine green: A literature review.
Peul RC, Kharbanda RK, Koning S, Kruiswijk MW, Tange FP, van den Hoven P, Vahrmeijer AL, Klautz RJM, Hamming JF, Hjortnaes J, van der Vorst JR
Background: Coronary artery bypass grafting (CABG) is among the most commonly performed major surgical procedures worldwide. While flow measurements help assess graft patency during surgery, there are limited tools available for surgeons to objectively evaluate myocardial perfusion after graft placement. Near-infrared fluorescence (NIRF) imaging shows promise in this area, offering real-time visualization of flow and perfusion without the need for radiation or nephrotoxic contrast agents. This r...
Abstract
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics,
Volume 198, Issue 5, 27 4 2025, Pages e33024
Pharmacogenetic Testing for Predicting Methylphenidate Treatment Outcomes in Childhood Attention Deficit Hyperactivity Disorder in Turkey: Focus on Carboxylesterase 1, Latrophilin-3, and Catechol-O-Methyltransferase.
Suzer Gamli I, Van Veggel A, Karaaslan RS, Kuerec AH, Marzoukah Z, Adak I, Bulut G, Tunc H, Hizel CP, Parlayan C, Ekinci O, Van Schaik R, Akin D
Pharmacogenetic studies involving Carboxylesterase 1 (CES1), Latrophilin-3 (LPHN3), and Catechol-O-methyltransferase (COMT) revealed individual differences regarding therapeutic response in children with attention deficit hyperactivity disorder (ADHD) under methylphenidate (MPH) treatment. This study aimed to evaluate MPH's association with the adverse effect status in children and its relationship with CES1, LPHN3, and COMT in the Turkish population. The study included 102 children and ado...
Abstract
BJU international,
25 4 2025
Fluid intake and recurrence and progression risk of patients with non-muscle-invasive bladder cancer.
Beeren I, Meijer H, van der Heijden AG, Aben KKH, Witjes JA, Kiemeney LALM, Vrieling A
Objectives: To evaluate the association of pre- and post-diagnosis fluid intake with non-muscle-invasive bladder cancer (NMIBC) recurrence and progression risk. Patients and methods: Data were used from the multicentre prospective cohort study UroLife. Participants reported pre-diagnosis fluid intake at 6 weeks (food frequency questionnaire [FFQ]) (n = 1322) and post-diagnosis fluid intake at 3 and 15 months (FFQ and 4-day 24-h fluid diaries) (n = 1275) after diagnosis. Multivariable proportiona...
Abstract
Cited 5 times since 2025 (8.8 per year)
source: EuropePMC
European urology,
Volume 87, Issue 4, 22 4 2025, Pages 444-452
Intravesical Instillation of Chemotherapy Before Radical Surgery for Upper Urinary Tract Urothelial Carcinoma: The REBACARE Trial.
van Doeveren T, Remmers S, Boevé ER, Cornel EB, van der Heijden AG, Hendricksen K, Cauberg ECC, Jacobs R, Kroon BK, Leliveld AM, Meijer RP, van Melick H, Merks B, Oddens JR, Pradere B, Roelofs LAJ, Somford DM, de Vries P, Wijsman B, Windt WAKM, Yska M, Zwaan PJ, Aben KKH, van Leeuwen PJ, Boormans JL
Background and objective: Intravesical instillation of chemotherapy (IIC) after radical surgery for upper urinary tract urothelial carcinoma (UTUC) reduces the risk of intravesical recurrence (IVR). However, compliance is low because of possible extravesical leakage after bladder cuff excision. The aim of this study was to evaluate the efficacy of preoperative IIC in reducing the risk of IVR. Methods: In this prospective, single-arm, multi-institutional, phase 2 clinical trial, 190 chemonaïve pa...
Abstract
Cited 1 times since 2025 (1.8 per year)
source: EuropePMC
Journal of the European Academy of Dermatology and Venereology : JEADV,
Volume 39, Issue 6, 22 4 2025, Pages 1099-1107
Increasing dosing intervals for biologics in atopic dermatitis-why, who, when and how?
Jacobson ME, Boesjes CM, de Bruin-Weller MS, de Graaf M, Morimoto RY, Simpson EL
Biologics approved and in development for atopic dermatitis offer life-changing clinical efficacy with a relatively banal long-term safety profile requiring no laboratory monitoring. Biologic therapies also have their drawbacks, including high payor cost and the need to be administered as every other week subcutaneous injections. Addressing these concerns, studies of longer dosing intervals have been performed in the formal clinical trial setting and during real-world clinical care. Here, we rev...
Abstract
Vascular medicine (London, England),
Volume 30, Issue 2, 21 3 2025, Pages 250-260
Prognostic performance of bedside tests for predicting ulcer healing and wound healing after minor amputation in patients prone to medial arterial calcification: A systematic review.
Willems SA, Nieuwstraten JA, Schepers A, van Schaik J, van den Hoven P, van der Vorst JR, Hamming JF, Brouwers JJ
Foot ulceration is a significant and growing health problem worldwide, particularly due to rises in diabetes mellitus (DM) and peripheral artery disease. The prediction of ulcer healing remains a major challenge. In patients with foot ulcers, medial arterial calcification (MAC) can be present as a result of concomitant DM or chronic kidney disease and is a prognostic factor for unfavorable outcome. This systematic review aimed to evaluate the prognostic reliability of bedside tests to predict ul...
Abstract
Open heart,
Volume 12, Issue 1, 21 3 2025, Pages e003055
Prognostic role of con-/discordant coronary flow reserve and microvascular resistance in coronary microvascular disease: a systematic review and network meta-analysis.
Al-Gully J, Oliveri F, Forouzanfar JP, Montero-Cabezas JM, Jukema JW, den Haan MC, Al Amri I, Bingen BO
Background: Coronary microvascular disease (CMD) is defined as impaired coronary flow reserve (CFR) and/or increased microvascular resistance (MR) without significant epicardial coronary stenosis. This definition allows for discordant CFR and MR values within patients with CMD. The aim of this meta-analysis is to characterise the prognostic value and pathophysiological backgrounds of CFR and MR con-/discordance. Methods: A systematic search (PROSPERO CRD42024573004) identified studies determinin...
Abstract
International journal of cardiology,
Volume 423, 21 3 2025, Pages 132996
Intravascular lithotripsy in calcified left main coronary artery: Procedural success and 1-year clinical outcomes.
Oliveri F, van Oort MJH, Phagu AAS, Al Amri I, Bingen BO, Claessen BEPM, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Intravascular lithotripsy (IVL) has an excellent efficacy and safety profile in the treatment of calcified coronary lesions during percutaneous coronary intervention (PCI). However, data regarding its use on left main (LM) lesions are still limited. Objective: We aimed to analyze the technical success and 1-year clinical outcomes in calcified LM lesions treated with IVL. Methods: Patients who underwent IVL from the ongoing prospective BENELUX registry were eligible for inclusion. Pat...
Abstract
Cited 1 times since 2025 (1.7 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 33, Issue 3, 20 3 2025, Pages 93-102
Symptomatic early coronary graft failure in bypass surgery patients: incidence, predictors and clinical impact.
van Oort MJH, Al Amri I, de Weger A, Regeer MV, Jukema JW, Mertens BJA, Montero-Cabezas JM
Objectives: Coronary graft failure (CGF) may occur early after coronary bypass graft surgery (CABG). The study aimed to identify clinical and perioperative risk factors and to evaluate the long-term clinical impact of symptomatic early CGF. Methods: Patients who underwent clinically indicated coronary angiography (CAG) prior to post-CABG discharge between 2012 and 2022 were included. Symptomatic early CGF was defined as a dysfunctional coronary graft, evaluated on clinically indicated CAG, cause...
Abstract
Rheumatology advances in practice,
Volume 9, Issue 1, 20 3 2025, Pages rkaf010
Anti-citrullinated protein antibody detection by hemagglutination.
Kruis I, Kumari J, van der Heijden A, Weijn A, Vree Egberts W, Peeters IR, van Herwaarden N, Salden M, Pruijn GJM
Objectives: ACPAs play an important role in the classification of RA and can be detected by serological tests. Several ACPA detection assays are available for clinical use, which are all based on ELISA(-like) tests with citrullinated peptides (CCP2) or alternative citrullinated proteins/peptides. We aimed to facilitate ACPA detection in low-volume laboratories and resource-poor environments by developing a rapid and easy-to-perform test. Methods: We designed and generated an agglutination mediat...
Abstract
Respiratory research,
Volume 26, Issue 1, 18 3 2025, Pages 20
Radiation decreases bronchial epithelial progenitor function as assessed by organoid formation.
Kuipers ME, Ninaber DK, van Doorn-Wink KCJ, Slats AM, Hiemstra PS
Objective: Radiation-induced lung injury (RILI) is a serious side-effect of radiotherapy for lung cancer, in which effects on the normal lung epithelium may play a key role. Since these effects are incompletely understood, the aim of the present study was to evaluate the effect of ionizing radiation (IR) on cultured well-differentiated primary bronchial epithelial cells (PBEC) with a focus on cytotoxicity, barrier formation, inflammation and epithelial progenitor function. Materials and methods:...
Abstract
Cited 2 times since 2025 (3.4 per year)
source: EuropePMC
Scientific reports,
Volume 15, Issue 1, 16 3 2025, Pages 2180
Iron metabolism in a mouse model of hepatocellular carcinoma.
Yilmaz D, Tharehalli U, Paganoni R, Knoop P, Gruber A, Chen Y, Dong R, Leithäuser F, Seufferlein T, Leopold K, Lechel A, Vujić Spasić M
Hepatocellular carcinoma (HCC) remains the most prevalent type of primary liver cancer worldwide. p53 is one of the most frequently mutated tumor-suppressor genes in HCC and its deficiency in hepatocytes triggers tumor formation in mice. To investigate iron metabolism during liver carcinogenesis, we employed a model of chronic carbon tetrachloride injections in liver-specific p53-deficient mice to induce liver fibrosis, cirrhosis and subsequent carcinogenesis. A transcriptome analysis of liver c...
Abstract
Cited 1 times since 2025 (1.7 per year)
source: EuropePMC
Journal of translational medicine,
Volume 23, Issue 1, 15 3 2025, Pages 73
Development of autonomic innervation at the venous pole of the heart: bridging the gap from mice to human.
Zwanenburg F, Bos TA, Ten Harkel ADJ, Haak MC, Hahurij ND, Poelmann RE, van Munsteren CJ, Wisse LJ, Blom NA, DeRuiter MC, Jongbloed MRM
Background: Prenatal development of autonomic innervation of sinus venosus-related structures might be related to atrial arrhythmias later in life. Most of the pioneering studies providing embryological background are conducted in animal models. To date, a detailed comparison with the human cardiac autonomic nervous system (cANS) is lacking. The aim of this study was to compare the morphological and functional development of the cANS between mouse and human, specifically aimed at the venous pole...
Abstract
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 105, Issue 4, 13 2 2025, Pages 951-958
Angiographic Characterization and Sex-Related Anatomical Differences of Atrial Coronary Arteries Anatomy-A Proposal of Systematic Classification.
Marques-Antunes M, van Oort MJH, Oliveri F, Al Amri I, Bingen BO, Cruz-Ferreira R, Wouter Jukema J, Montero-Cabezas JM
Background: The coronary atrial circulation is the network of vessels that supply blood to the atria, originating from the left circumflex and right coronary arteries. Current descriptions of this arterial system are based on anatomical studies with a limited number of patients, predominantly male. In addition, there is a lack of consensus its angiographic nomenclature. Aims: This study aimed to evaluate the anatomical variations of coronary atrial branches (CAB) and investigate sex-related diff...
Abstract
Heart rhythm,
13 2 2025, Pages S1547-5271(25)00022-0
Application of artificial intelligence to analyze data from randomized controlled trials: An example from DECAAF II.
Mekhael M, Feng H, Akoum N, Sohns C, Sommer P, Mahnkopf C, Kholmovski E, Bax JJ, Sanders P, McGann C, Marchlinski F, Mansour M, Hindricks G, Wilber D, Calkins H, Jais P, Younes H, Assaf A, Noujaim C, Lim C, Huang C, Pandey A, Wazni O, Marrouche N
Background: Causal machine learning (ML) provides an efficient way of identifying heterogeneous treatment effect groups from hundreds of possible combinations, especially for randomized trial data. Objective: The aim of this paper is to illustrate the potential of applying causal ML on the DECAAF II trial data. We proposed a causal ML model to predict the treatment response heterogeneity. Methods: We applied causal tree learning to the DECAAF II trial data as an example of real applications, ide...
Abstract
Cited 1 times since 2025 (1.7 per year)
source: EuropePMC
Cellular and molecular biology (Noisy-le-Grand, France),
Volume 70, Issue 12, 12 2 2025, Pages 52-58
Inhibition of RIPK1-driven necroptosis ameliorates inflammatory hyperalgesia caused by lipopolysaccharide: involvement of TLR-, NLRP3-, and caspase-11-mediated signaling pathways.
Kurt S, Senol SP, Yilmaz DE, Bahceli O, Ozgen B, Sabrie Z, Ahmed-Reda Elosman M, Tunctan B
Increasing evidence suggests that inhibition of receptor-interacting serine/threonine-protein kinase (RIPK) 1/RIPK3/mixed lineage kinase domain-like pseudokinase (MLKL) necrosome has protective effects in vivo models of painful conditions seen in humans associated with inflammation and demyelination in the central nervous system. However, the contribution of RIPK1-driven necroptosis to inflammatory pain remains unknown. Therefore, this study aims to determine the effect of necrostatin (Nec) -1s,...
Abstract
