9618 results
Cited 9 times since 2024 (10.2 per year)
source: EuropePMC
JAMA dermatology,
Volume 160, Issue 10, 1 1 2024, Pages 1044-1055
Long-Term Effectiveness and Reasons for Discontinuation of Dupilumab in Patients With Atopic Dermatitis.
Boesjes CM, Kamphuis E, de Graaf M, Spekhorst LS, Haeck I, van der Gang LF, Loman L, Zuithoff NPA, Dekkers C, van der Rijst LP, Romeijn GLE, Oosting AJ, Gostynksi A, van Lynden-van Nes AMT, Tupker RA, van Tuyll van Serooskerken AM, Flinterman A, Politiek K, Touwslager WRH, Christoffers WA, Stewart SM, Kamsteeg M, Schuttelaar MA, de Bruin-Weller MS
Importance: Limited data are available on the long-term effectiveness and safety of dupilumab for atopic dermatitis (AD) in daily practice. Objective: To evaluate clinical effectiveness and reasons for discontinuation of dupilumab treatment in children, adults, and older adults with AD with up to 5 years of treatment in daily practice. Design, setting, and participants: This prospective multicenter cohort study was conducted using the BioDay registry (4 academic and 10 nonacademic hospitals in t...
Abstract
Cited 9 times since 2024 (10.2 per year)
source: EuropePMC
European journal of preventive cardiology,
Volume 31, Issue 14, 1 1 2024, Pages 1690-1699
Prediction of individual lifetime cardiovascular risk and potential treatment benefit: development and recalibration of the LIFE-CVD2 model to four European risk regions.
Hageman SHJ, Kaptoge S, de Vries TI, Lu W, Kist JM, van Os HJA, Numans ME, Läll K, Bobak M, Pikhart H, Kubinova R, Malyutina S, Pająk A, Tamosiunas A, Erbel R, Stang A, Schmidt B, Schramm S, Bolton TR, Spackman S, Bakker SJL, Blaha M, Boer JMA, Bonnefond A, Brenner H, Brunner EJ, Cook NR, Davidson K, Dennison E, Donfrancesco C, Dörr M, Floyd JS, Ford I, Fu M, Gansevoort RT, Giampaoli S, Gillum RF, Gómez-de-la-Cámara A, Håheim LL, Hansson PO, Harms P, Humphries SE, Ikram MK, Jukema JW, Kavousi M, Kiechl S, Kucharska-Newton A, Pablos DL, Matsushita K, Meyer HE, Moons KGM, Mortensen MB, Muilwijk M, Nordestgaard BG, Packard C, Pamieri L, Panagiotakos D, Peters A, Potier L, Providencia R, Psaty BM, Ridker PM, Rodriguez B, Rosengren A, Sattar N, Schöttker B, Schwartz JE, Shea S, Shipley MJ, Sofat R, Thorand B, Verschuren WMM, Völzke H, Wareham NJ, Westbury L, Willeit P, Zhou B, Danesh J, Visseren FLJ, Di Angelantonio E, Pennells L, Dorresteijn JAN
Aims: The 2021 European Society of Cardiology prevention guidelines recommend the use of (lifetime) risk prediction models to aid decisions regarding initiation of prevention. We aimed to update and systematically recalibrate the LIFEtime-perspective CardioVascular Disease (LIFE-CVD) model to four European risk regions for the estimation of lifetime CVD risk for apparently healthy individuals. Methods and results: The updated LIFE-CVD (i.e. LIFE-CVD2) models were derived using individual partici...
Abstract
Echocardiography (Mount Kisco, N.Y.),
Volume 41, Issue 10, 1 1 2024, Pages e70006
Evolution and Prognostic Impact of Left Ventricular Myocardial Work Indices After Transcatheter Aortic Valve Replacement in Patients With Severe Aortic Stenosis.
Wu HW, Fortuni F, Muzafarova T, Sarrazyn C, Lopez Santi P, Chua APA, Butcher SC, van der Kley F, de Weger A, Jukema JW, Bax JJ, Ajmone Marsan N
Purpose: Left ventricular myocardial work (LVMW) has been shown to better characterize LV function in patients with severe aortic stenosis by correcting LV afterload. The aim of this study was to evaluate the evolution in LVMW indices after transcatheter aortic valve replacement (TAVR) and their prognostic value. Methods: The following LVMW indices were calculated before and immediately after TAVR in 255 patients (median age 82 years, 51% male): global work index (GWI), global constructive work...
Abstract
Cited 368 times since 2024 (417.6 per year)
source: EuropePMC
European heart journal,
Volume 45, Issue 38, 1 1 2024, Pages 3912-4018
2024 ESC Guidelines for the management of elevated blood pressure and hypertension.
McEvoy JW, McCarthy CP, Bruno RM, Brouwers S, Canavan MD, Ceconi C, Christodorescu RM, Daskalopoulou SS, Ferro CJ, Gerdts E, Hanssen H, Harris J, Lauder L, McManus RJ, Molloy GJ, Rahimi K, Regitz-Zagrosek V, Rossi GP, Sandset EC, Scheenaerts B, Staessen JA, Uchmanowicz I, Volterrani M, Touyz RM, ESC Scientific Document Group
Abstract
Cited 53 times since 2024 (60.1 per year)
source: EuropePMC
European heart journal,
Volume 45, Issue 38, 1 1 2024, Pages 4063-4098
Obesity and cardiovascular disease: an ESC clinical consensus statement.
Koskinas KC, Van Craenenbroeck EM, Antoniades C, Blüher M, Gorter TM, Hanssen H, Marx N, McDonagh TA, Mingrone G, Rosengren A, Prescott EB, ESC Scientific Document Group
The global prevalence of obesity has more than doubled over the past four decades, currently affecting more than a billion individuals. Beyond its recognition as a high-risk condition that is causally linked to many chronic illnesses, obesity has been declared a disease per se that results in impaired quality of life and reduced life expectancy. Notably, two-thirds of obesity-related excess mortality is attributable to cardiovascular disease. Despite the increasingly appreciated link between obe...
Abstract
Cited 2 times since 2024 (2.3 per year)
source: EuropePMC
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,
Volume 29, Issue 40, 1 1 2024
Attribution of invasive group A streptococcal infections (iGAS) to predisposing viral infections, the Netherlands, 2010 to 2023.
de Gier B, van de Kassteele J, van Asten L, Schoffelen AF, ISIS-AR study group, Hooiveld M, Te Wierik MJ, van Sorge NM, de Melker HE, Members of the ISIS-AR study group
BackgroundAfter most COVID-19 pandemic control measures were lifted in 2022, many infectious diseases re-emerged. An increase in invasive group A streptococcal (iGAS) infections among adults and young children was reported by several countries. Viral infections including influenza and varicella, known risk factors for iGAS infection, also increased.AimTo estimate the proportion of GAS skin and soft tissue infections (SSTI) and pneumonia/sepsis in children (≤ 5 years) attributable to varicella, a...
Abstract
Cells,
Volume 13, Issue 19, 30 5 2024, Pages 1636
Pulmonary and Systemic Immune Profiles Following Lung Volume Reduction Surgery and Allogeneic Mesenchymal Stromal Cell Treatment in Emphysema.
Jia L, Li N, van Unen V, Zwaginga JJ, Braun J, Hiemstra PS, Koning F, Khedoe PPSJ, Stolk J
Emphysema in patients with chronic obstructive pulmonary disease (COPD) is characterized by progressive inflammation. Preclinical studies suggest that lung volume reduction surgery (LVRS) and mesenchymal stromal cell (MSC) treatment dampen inflammation. We investigated the effects of bone marrow-derived MSC (BM-MSC) and LVRS on circulating and pulmonary immune cell profiles in emphysema patients using mass cytometry. Blood and resected lung tissue were collected at the first LVRS (L1). Following...
Abstract
Cited 3 times since 2024 (3.3 per year)
source: EuropePMC
JACC. Clinical electrophysiology,
Volume 10, Issue 12, 25 4 2024, Pages 2613-2624
Ventricular Tachycardia Substrates in Children and Young Adults With Repaired Tetralogy of Fallot.
Wallet J, Kimura Y, Blom NA, Jongbloed MRM, Bertels RA, Hazekamp MG, Zeppenfeld K
Background: Patients with repaired tetralogy of Fallot (rTOF) have a time-dependent increased risk of ventricular tachycardia (VT). Slow conducting anatomical isthmuses (SCAIs) are the dominant VT substrates in adults with rTOF. It is unknown if they are present at younger age. Objectives: This study aimed to characterize VT substrates in patients with rTOF
Abstract
Cited 1 times since 2024 (1.1 per year)
source: EuropePMC
Therapeutic drug monitoring,
Volume 47, Issue 1, 25 4 2024, Pages 4-31
Everolimus Personalized Therapy: Second Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.
Masuda S, Lemaitre F, Barten MJ, Bergan S, Shipkova M, van Gelder T, Vinks S, Wieland E, Bornemann-Kolatzki K, Brunet M, de Winter B, Dieterlen MT, Elens L, Ito T, Johnson-Davis K, Kunicki PK, Lawson R, Lloberas N, Marquet P, Millan O, Mizuno T, Moes DJAR, Noceti O, Oellerich M, Pattanaik S, Pawinski T, Seger C, van Schaik R, Venkataramanan R, Walson P, Woillard JB, Langman LJ
Abstract: The Immunosuppressive Drugs Scientific Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology established the second consensus report to guide therapeutic drug monitoring (TDM) of everolimus (EVR) and its optimal use in clinical practice 7 years after the first version was published in 2016. This version provides information focused on new developments that have arisen in the last 7 years. For the general aspects of the pharmacology and TDM of...
Abstract
Medical science educator,
Volume 35, Issue 1, 25 4 2024, Pages 43-46
The Development and Implementation of a Parallel, Multi-Campus Medical Anatomy Curriculum Delivered with and without Cadavers.
Harvey W, Van Schaik L, Frizzell H, Wright J, Rank MM
A parallel, multi-campus anatomy curriculum was developed that could be delivered with or without body donor cadaveric teaching resources. This blended program includes asynchronous lectures, e-Learning modules, formative self-assessment, independent study, and synchronous hands-on practical sessions. Practical sessions at the metropolitan campus utilise professionally prepared body donor cadaveric teaching resources, whereas rural campus practical sessions use a combination of non-cadaveric res...
Abstract
Cited 1 times since 2024 (1.1 per year)
source: EuropePMC
The EMBO journal,
Volume 43, Issue 21, 25 4 2024, Pages 5260-5287
Chromatin protein complexes involved in gene repression in lamina-associated domains.
Manzo SG, Mazouzi A, Leemans C, van Schaik T, Neyazi N, van Ruiten MS, Rowland BD, Brummelkamp TR, van Steensel B
Lamina-associated domains (LADs) are large chromatin regions that are associated with the nuclear lamina (NL) and form a repressive environment for transcription. The molecular players that mediate gene repression in LADs are currently unknown. Here, we performed FACS-based whole-genome genetic screens in human cells using LAD-integrated fluorescent reporters to identify such regulators. Surprisingly, the screen identified very few NL proteins, but revealed roles for dozens of known chromatin re...
Abstract
Cited 1 times since 2024 (1.1 per year)
source: EuropePMC
European journal of heart failure,
24 4 2024
Sexual dimorphism in the relationships between intramyocardial fat, myocardial fibrosis, and exercise intolerance in heart failure with preserved ejection fraction.
Ng ACT, Dong X, Koepp KE, Obokata M, Sorimachi H, Galloway G, Araoz P, Delgado V, Bax JJ, Borlaug BA
Abstract
Cited 1 times since 2024 (1.1 per year)
source: EuropePMC
Biosensors & bioelectronics,
Volume 267, 24 4 2024, Pages 116791
Dual action electrochemical bandage operated by a programmable multimodal wearable potentiostat.
Bozyel I, Fleming D, Won-Jun K, Rosen PF, Gelston S, Ozdemir D, Kies P, Koscianski C, Karau M, Ay SU, Patel R, Beyenal H
We have developed electrochemical bandage (e-bandage) prototypes that generate the reactive oxygen species hypochlorous acid (HOCl) or hydrogen peroxide (H2O2) for potential use to treat biofilm-infected wounds in humans. We have shown that both e-bandage-generated HOCl and H2O2 kill biofilms in vitro and in infected wounds on mice, with the former being more active in vitro. The H2O2-generating e-bandage, more so than the HOCl-generating e-bandage, was associated with improved healing of infect...
Abstract
Cited 4 times since 2024 (4.4 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 69, Issue 2, 24 4 2024, Pages 272-281
Editor's Choice - Role of Antiplatelet Therapy in Patients Managed for Complex Aortic Aneurysms using Fenestrated or Branched Endovascular Repair.
Nana P, Spanos K, Tsilimparis N, Haulon S, Sobocinski J, Gallitto E, Dias N, Eilenberg W, Wanhainen A, Mani K, Böckler D, Bertoglio L, van Rijswijk C, Modarai B, Seternes A, Enzmann FK, Giannoukas A, Gargiulo M, Kölbel T, APT-F/BEVAR Study Contributors
Objective: Despite the increasing number of fenestrated and branched endovascular aortic repair (F/B-EVAR) procedures, evidence on post-operative antiplatelet therapy is very limited. This study aimed to investigate the role of single antiplatelet therapy (SAPT) vs. double antiplatelet therapy (DAPT) after F/B-EVAR in 30 day and follow up outcomes. Methods: A multicentre retrospective analysis was conducted, including F/B-EVAR patients managed from 1 January 2018 to 31 December 2022. Comparative...
Abstract
Cited 3 times since 2024 (3.3 per year)
source: EuropePMC
JCI insight,
Volume 9, Issue 18, 24 4 2024, Pages e183674
Clinical cell-surface targets in metastatic and primary solid cancers.
Sharifi MN, Shi Y, Chrostek MR, Callahan SC, Shang T, Berg TJ, Helzer KT, Bootsma ML, Sjöström M, Josefsson A, Feng FY, Huffman LB, Schulte C, Blitzer GC, Sodji QH, Morris ZS, Ma VT, Meimetis L, Kosoff D, Taylor AK, LeBeau AM, Lang JM, Zhao SG
Therapies against cell-surface targets (CSTs) represent an emerging treatment class in solid malignancies. However, high-throughput investigations of CST expression across cancer types have been reliant on data sets of mostly primary tumors, despite therapeutic use most commonly in metastatic disease. We identified a total of 818 clinical trials of CST therapies with 78 CSTs. We assembled a data set spanning RNA-seq and microarrays in 7,927 benign samples, 16,866 primary tumor samples, and 6,124...
Abstract
Cited 1 times since 2024 (1.1 per year)
source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 104, Issue 5, 23 4 2024, Pages 881-890
Procedural and clinical impact of intracoronary lithotripsy in heavily calcified aorto-ostial coronary lesions.
Oliveri F, Meijer M, Van Oort MJH, Al Amri I, Bingen BO, Claessen BE, Dimitriu-Leen AC, Kefer J, Girgis H, Vossenberg T, Van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Percutaneous coronary intervention of calcified aorto-ostial lesions (AOL) pose unique challenges due to anatomical propensity for recoil, leading to poorer outcomes compared to non-AOL. Although intravascular lithotripsy (IVL) has shown excellent success and safety in heavily calcified plaques, evidence specific to AOL is limited. This study aims to evaluate the efficacy and safety of IVL in AOL versus non-AOL. Methods: Patients treated with IVL between 2019 and 2023 from an ongoing...
Abstract
Cited 20 times since 2024 (22.1 per year)
source: EuropePMC
Circulation,
Volume 150, Issue 24, 23 4 2024, Pages 1931-1943
Interatrial Shunt Treatment for Heart Failure: The Randomized RELIEVE-HF Trial.
Stone GW, Lindenfeld J, Rodés-Cabau J, Anker SD, Zile MR, Kar S, Holcomb R, Pfeiffer MP, Bayes-Genis A, Bax JJ, Bank AJ, Costanzo MR, Verheye S, Roguin A, Filippatos G, Núñez J, Lee EC, Laufer-Perl M, Moravsky G, Litwin SE, Prihadi E, Gada H, Chung ES, Price MJ, Thohan V, Schewel D, Kumar S, Kische S, Shah KS, Donovan DJ, Zhang Y, Eigler NL, Abraham WT, RELIEVE-HF Investigators
Background: An interatrial shunt may provide an autoregulatory mechanism to decrease left atrial pressure and improve heart failure (HF) symptoms and prognosis. Methods: Patients with symptomatic HF with any left ventricular ejection fraction (LVEF) were randomized 1:1 to transcatheter shunt implantation versus a placebo procedure, stratified by reduced (≤40%) versus preserved (>40%) LVEF. The primary safety outcome was a composite of device-related or procedure-related major adverse cardiova...
Abstract
European heart journal open,
Volume 4, Issue 5, 23 4 2024, Pages oeae080
Short-term impact of cardiovascular screening by traditional risk assessment or coronary artery calcium score on health-related quality of life: the ROBINSCA trial.
Moldovanu D, de Koning HJ, Vonder M, Gratama JWC, Adriaansen HJ, Roeters van Lennep JE, Vliegenthart R, van der Harst P, Braam RL, van Dijkman PRM, Oudkerk M, van der Aalst CM
Aims: Evidence on the impact of screening for cardiovascular diseases (CVDs) on health-related quality of life (HRQoL) is important for policy decisions about screening implementation and to uncover teachable moments to motivate healthy lifestyle choices. It is unknown whether screening by cardiac computed tomography (CT) scan has a stronger impact on HRQoL than screening by traditional risk prediction models. The study aims to investigate differences in HRQoL across the screening process betwee...
Abstract
Cited 2 times since 2024 (2.2 per year)
source: EuropePMC
Frontiers in aging,
Volume 5, 20 3 2024, Pages 1365716
Unveiling frailty: comprehensive and sex-specific characterization in prematurely aging PolgA mice.
Yılmaz D, Singh A, Wehrle E, Kuhn GA, Mathavan N, Müller R
Frailty, a geriatric syndrome, is assessed using the frailty phenotype (FP) and frailty index (FI). While these approaches have been applied to aging mice, their effectiveness in prematurely aging mouse models such as PolgAD257A/D257A (PolgA) has not been completely explored. We demonstrated that frailty became evident in PolgA mice around 40 weeks, validated through body weight loss, reduced walking speed, decreased physical activity, and weaker grip strength. Moreover, we also identified sex d...
Abstract
Immunopharmacology and immunotoxicology,
Volume 46, Issue 6, 18 3 2024, Pages 805-814
Galantamine and wedelolactone combined treatment suppresses LPS-induced NLRP3 inflammasome activation in microglial cells.
Saker D, Sencar L, Coskun G, Sapmaz Ercakalli T, Yilmaz DM, Polat S
Context: Inflammasome NLR family pyrin domain-containing 3 (NLRP3) is associated with neurological disorders. Neuroinflammation can be suppressed by inhibiting NLRP3 inflammasome activation, decreasing neurodegenerative disorder progression. We devised a therapeutic technique that can reduce neuroinflammation induced by microglial activation, avoiding neurodegeneration. We aimed to investigate the mechanisms underlying the pharmacological effects of galantamine and wedelolactone by evaluating th...
Abstract
