8892 results
Cited 55 times since 2014 (4.9 per year)
source: EuropePMC
Advanced healthcare materials,
Volume 4, Issue 1, 24 4 2014, Pages 121-130
Directing valvular interstitial cell myofibroblast-like differentiation in a hybrid hydrogel platform.
Hjortnaes J, Camci-Unal G, Hutcheson JD, Jung SM, Schoen FJ, Kluin J, Aikawa E, Khademhosseini A
Three dimensional (3D) hydrogel platforms are powerful tools, providing controllable, physiologically relevant microenvironments that could aid in understanding how various environmental factors direct valvular interstitial cell (VIC) phenotype. Continuous activation of VICs and their transformation from quiescent fibroblast to activated myofibroblast phenotype is considered to be an initiating event in the onset of valve disease. However, the relative contribution VIC phenotypes is poorly under...
Abstract
Cited 55 times since 2014 (4.9 per year)
source: EuropePMC
Nature methods,
Volume 11, Issue 8, 22 4 2014, Pages 868-874
Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics.
Lundby A, Rossin EJ, Steffensen AB, Acha MR, Newton-Cheh C, Pfeufer A, Lynch SN, QT Interval International GWAS Consortium (QT-IGC), Olesen SP, Brunak S, Ellinor PT, Jukema JW, Trompet S, Ford I, Macfarlane PW, Krijthe BP, Hofman A, Uitterlinden AG, Stricker BH, Nathoe HM, Spiering W, Daly MJ, Asselbergs FW, van der Harst P, Milan DJ, de Bakker PI, Lage K, Olsen JV
Genome-wide association studies (GWAS) have identified thousands of loci associated with complex traits, but it is challenging to pinpoint causal genes in these loci and to exploit subtle association signals. We used tissue-specific quantitative interaction proteomics to map a network of five genes involved in the Mendelian disorder long QT syndrome (LQTS). We integrated the LQTS network with GWAS loci from the corresponding common complex trait, QT-interval variation, to identify candidate gene...
Abstract
Cited 26 times since 2014 (2.3 per year)
source: EuropePMC
The Journal of allergy and clinical immunology,
Volume 134, Issue 5, 20 3 2014, Pages 1051-6.e2
Predictors for the development of progressive severity in new-onset adult asthma.
Westerhof GA, Vollema EM, Weersink EJ, Reinartz SM, de Nijs SB, Bel EH
Background: A proportion of patients with adult-onset asthma have severe disease. Risk factors for an increase in asthma severity are poorly known. Objective: We sought to identify predictors for the development of severe asthma in adults. Methods: A cohort of 200 adults with new-onset asthma was prospectively followed for 2 years. At baseline, patients underwent a comprehensive assessment of clinical, functional, and inflammatory parameters. After 2 years, change in asthma severity was assessed...
Abstract
Cited 21 times since 2014 (1.9 per year)
source: EuropePMC
The American journal of cardiology,
Volume 114, Issue 5, 19 3 2014, Pages 763-768
New insights on Carpentier I mitral regurgitation from multidetector row computed tomography.
van Rosendael PJ, Katsanos S, Kamperidis V, Roos CJ, Scholte AJ, Schalij MJ, Ajmone Marsan N, Bax JJ, Delgado V
The underlying mechanism of mitral regurgitation (MR) because of isolated annulus dilation (Carpentier type I) remains controversial in patients with atrial fibrillation (AF). The present study evaluated changes in mitral valve geometry of patients with AF and structurally and functionally normal left ventricles and mitral leaflets. Grade of MR and left ventricular (LV) function was evaluated with echocardiography. Changes in mitral valve geometry were evaluated with multidetector row computed t...
Abstract
Cited 23 times since 2014 (2 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 6, 19 3 2014, Pages e99882
TLR4 accessory molecule RP105 (CD180) regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model.
Bastiaansen AJ, Karper JC, Wezel A, de Boer HC, Welten SM, de Jong RC, Peters EA, de Vries MR, van Oeveren-Rietdijk AM, van Zonneveld AJ, Hamming JF, Nossent AY, Quax PH
Aims: We investigated the role of the TLR4-accessory molecule RP105 (CD180) in post-ischemic neovascularization, i.e. arteriogenesis and angiogenesis. TLR4-mediated activation of pro-inflammatory Ly6Chi monocytes is crucial for effective neovascularization. Immunohistochemical analyses revealed that RP105+ monocytes are present in the perivascular space of remodeling collateral arterioles. As RP105 inhibits TLR4 signaling, we hypothesized that RP105 deficiency would lead to an unrestrained TLR4-...
Abstract
Cited 7 times since 2014 (0.6 per year)
source: EuropePMC
Surgery,
Volume 156, Issue 2, 19 3 2014, Pages 492-502
Treatment planning for peripheral arterial disease based on duplex ultrasonography and computed tomography angiography: consistency, confidence and the value of additional imaging.
de Vos MS, Bol BJ, Gravereaux EC, Hamming JF, Nguyen LL
Background: Duplex ultrasonography (DUS) can be used for treatment planning for lower extremity peripheral arterial disease (PAD), but has not replaced contrast-enhanced imaging such as computed tomography angiography (CTA). We assessed DUS-based treatment planning for consistency, confidence, and the value of additional CTA among multinational surgeons. Methods: Data from 12 patients with PAD were reviewed by 2 American vascular surgeons individually and 1 Dutch vascular department by consensus...
Abstract
Cited 28 times since 2014 (2.5 per year)
source: EuropePMC
Journal of virology,
Volume 88, Issue 17, 18 3 2014, Pages 9963-9975
Murine cytomegalovirus virion-associated protein M45 mediates rapid NF-κB activation after infection.
Krause E, de Graaf M, Fliss PM, Dölken L, Brune W
Unlabelled: Murine cytomegalovirus (MCMV) rapidly induces activation of nuclear factor κB (NF-κB) upon infection of host cells. After a transient phase of activation, the MCMV M45 protein blocks all canonical NF-κB-activating pathways by inducing the degradation of the gamma subunit of the inhibitor of κB kinase complex (IKKγ; commonly referred to as the NF-κB essential modulator [NEMO]). Here we show that the viral M45 protein also mediates rapid NF-κB activation immediately after infection. MC...
Abstract
Cited 191 times since 2014 (16.8 per year)
source: EuropePMC
ACS chemical biology,
Volume 9, Issue 8, 17 3 2014, Pages 1788-1798
Phytochemicals perturb membranes and promiscuously alter protein function.
Ingólfsson HI, Thakur P, Herold KF, Hobart EA, Ramsey NB, Periole X, de Jong DH, Zwama M, Yilmaz D, Hall K, Maretzky T, Hemmings HC, Blobel C, Marrink SJ, Koçer A, Sack JT, Andersen OS
A wide variety of phytochemicals are consumed for their perceived health benefits. Many of these phytochemicals have been found to alter numerous cell functions, but the mechanisms underlying their biological activity tend to be poorly understood. Phenolic phytochemicals are particularly promiscuous modifiers of membrane protein function, suggesting that some of their actions may be due to a common, membrane bilayer-mediated mechanism. To test whether bilayer perturbation may underlie this diver...
Abstract
Cited 15 times since 2014 (1.3 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 6, 17 3 2014, Pages e100135
Risk factors for malformations and impact on reproductive performance and mortality rates of Schmallenberg virus in sheep flocks in the Netherlands.
Luttikholt S, Veldhuis A, van den Brom R, Moll L, Lievaart-Peterson K, Peperkamp K, van Schaik G, Vellema P
In Northwestern Europe, an epizootic outbreak of congenital malformations in newborn lambs due to infection with Schmallenberg virus (SBV) started at the end of 2011. The objectives of this study were to describe clinical symptoms of SBV infection, the effect of infection on mortality rates, and reproductive performance in sheep, as well as to identify and quantify flock level risk factors for SBV infections resulting in malformations in newborn lambs. A case-control study design was used, with...
Abstract
Cited 64 times since 2014 (5.6 per year)
source: EuropePMC
Scientific reports,
Volume 4, 16 3 2014, Pages 5309
Extending the viability of acute brain slices.
Buskila Y, Breen PP, Tapson J, van Schaik A, Barton M, Morley JW
The lifespan of an acute brain slice is approximately 6-12 hours, limiting potential experimentation time. We have designed a new recovery incubation system capable of extending their lifespan to more than 36 hours. This system controls the temperature of the incubated artificial cerebral spinal fluid (aCSF) while continuously passing the fluid through a UVC filtration system and simultaneously monitoring temperature and pH. The combination of controlled temperature and UVC filtering maintains b...
Abstract
Cited 91 times since 2014 (8 per year)
source: EuropePMC
Biomaterials,
Volume 35, Issue 27, 16 3 2014, Pages 7774-7785
Tri-layered elastomeric scaffolds for engineering heart valve leaflets.
Masoumi N, Annabi N, Assmann A, Larson BL, Hjortnaes J, Alemdar N, Kharaziha M, Manning KB, Mayer JE, Khademhosseini A
Tissue engineered heart valves (TEHVs) that can grow and remodel have the potential to serve as permanent replacements of the current non-viable prosthetic valves particularly for pediatric patients. A major challenge in designing functional TEHVs is to mimic both structural and anisotropic mechanical characteristics of the native valve leaflets. To establish a more biomimetic model of TEHV, we fabricated tri-layered scaffolds by combining electrospinning and microfabrication techniques. These c...
Abstract
Cited 4 times since 2014 (0.4 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 67, Issue 8, 14 2 2014, Pages 674-675
Delayed positive response to a flecainide test in a patient with suspected Brugada syndrome: a worrisome finding.
de-Riva-Silva M, Montero-Cabezas JM, Fontenla-Cerezuela A, Salguero-Bodes R, López-Gil M, Arribas-Ynsaurriaga F
Abstract
Cited 27 times since 2014 (2.4 per year)
source: EuropePMC
European heart journal,
Volume 36, Issue 17, 13 2 2014, Pages 1023-1030
Influence of coronary vessel dominance on short- and long-term outcome in patients after ST-segment elevation myocardial infarction.
Veltman CE, van der Hoeven BL, Hoogslag GE, Boden H, Kharbanda RK, de Graaf MA, Delgado V, van Zwet EW, Schalij MJ, Bax JJ, Scholte AJ
Aims: Prognostic importance of coronary vessel dominance in patients with ST-elevation myocardial infarction (STEMI) remains uncertain. The aim of this study was to assess influence of coronary vessel dominance on the short- and long-term outcome after STEMI. Methods and results: Coronary angiographic images of consecutive patients presenting with first STEMI were retrospectively reviewed to assess coronary vessel dominance. Patients were followed after STEMI during a median period of 48 (IQR38-...
Abstract
Cited 8 times since 2014 (0.7 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 101, Issue 5, 12 2 2014, Pages 397-407
Potential role of fibrosis imaging in severe valvular heart disease.
Debonnaire P, Delgado V, Bax JJ
Abstract
Cited 13 times since 2014 (1.1 per year)
source: EuropePMC
Mutation research. Genetic toxicology and environmental mutagenesis,
Volume 770, 6 1 2014, Pages 72-79
Radio-protective effect of cinnamic acid, a phenolic phytochemical, on genomic instability induced by X-rays in human blood lymphocytes in vitro.
Cinkilic N, Tüzün E, Çetintaş SK, Vatan Ö, Yılmaz D, Çavaş T, Tunç S, Özkan L, Bilaloğlu R
The present study was designed to determine the protective activity of cinnamic acid against induction by X-rays of genomic instability in normal human blood lymphocytes. This radio-protective activity was assessed by use of the cytokinesis-block micronucleus test and the alkaline comet assay, with human blood lymphocytes isolated from two healthy donors. A Siemens Mevatron MD2 (Siemens AG, USA, 1994) linear accelerator was used for the irradiation with 1 or 2 Gy. Treatment of the lymphocytes wi...
Abstract
Cited 6 times since 2014 (0.5 per year)
source: EuropePMC
The aging male : the official journal of the International Society for the Study of the Aging Male,
Volume 17, Issue 4, 5 1 2014, Pages 248-255
L-arginine and tetrahydrobiopterin, but not sodium nitrite partially restored erectile dysfunction in aged rats.
Un O, Yilmaz D, Bayatli N, Kaya E, Gur S
Aging is associated with erectile dysfunction (ED), in which nitric oxide synthase (NOS) activity and NO bioavailability are reduced due to deficiencies of NOS cofactor (tetrahydrobiopterin, BH(4)) and substrate (L-arginine). We determined whether the prolonged treatment with sodium nitrite (NaNO(2)) as a storage form of NO ameliorates ED in aged rats. Male Sprague-Dawley rats were divided: younger, aged and NaNO(2)-treated (20 mg/kg per day) aged groups. The erectile (intracavernosal pressure [...
Abstract
Cited 82 times since 2014 (7.2 per year)
source: EuropePMC
European journal of human genetics : EJHG,
Volume 22, Issue 11, 4 1 2014, Pages 1321-1326
Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'.
Deelen P, Menelaou A, van Leeuwen EM, Kanterakis A, van Dijk F, Medina-Gomez C, Francioli LC, Hottenga JJ, Karssen LC, Estrada K, Kreiner-Møller E, Rivadeneira F, van Setten J, Gutierrez-Achury J, Westra HJ, Franke L, van Enckevort D, Dijkstra M, Byelas H, van Duijn CM, Genome of Netherlands Consortium, de Bakker PI, Wijmenga C, Swertz MA
Although genome-wide association studies (GWAS) have identified many common variants associated with complex traits, low-frequency and rare variants have not been interrogated in a comprehensive manner. Imputation from dense reference panels, such as the 1000 Genomes Project (1000G), enables testing of ungenotyped variants for association. Here we present the results of imputation using a large, new population-specific panel: the Genome of The Netherlands (GoNL). We benchmarked the performance o...
Abstract
Cited 2 times since 2014 (0.2 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 6, 4 1 2014, Pages e98820
The CD200-CD200 receptor inhibitory axis controls arteriogenesis and local T lymphocyte influx.
van den Borne P, Rygiel TP, Hoogendoorn A, Westerlaken GH, Boon L, Quax PH, Pasterkamp G, Hoefer IE, Meyaard L
The role of the CD200 ligand-CD200 receptor (CD200-CD200R) inhibitory axis is highly important in controlling myeloid cell function. Since the activation of myeloid cells is crucial in arteriogenesis, we hypothesized that disruption of the CD200-CD200R axis promotes arteriogenesis in a murine hindlimb ischemia model. Female Cd200-/- and wildtype (C57Bl/6J) mice underwent unilateral femoral artery ligation. Perfusion recovery was monitored over 7 days using Laser-Doppler analysis and was increase...
Abstract
Cited 7 times since 2014 (0.6 per year)
source: EuropePMC
Fetal diagnosis and therapy,
Volume 36, Issue 1, 4 1 2014, Pages 59-68
Bicuspid aortic valve morphology and associated cardiovascular abnormalities in fetal Turner syndrome: a pathomorphological study.
van Engelen K, Bartelings MM, Gittenberger-de Groot AC, Baars MJ, Postma AV, Bijlsma EK, Mulder BJ, Jongbloed MR
Introduction: Bicuspid aortic valve (BAV) is common in Turner syndrome (TS). In adult TS, 82-95% of BAVs have fusion of the right and left coronary leaflets. Data in fetal stages are scarce. The purpose of this study was to gain insight into aortic valve morphology and associated cardiovascular abnormalities in a fetal TS cohort with adverse outcome early in development. Material and methods: We studied post-mortem heart specimens of 36 TS fetuses and 1 TS newborn. Results: BAV was present in 28...
Abstract
Cited 13 times since 2014 (1.1 per year)
source: EuropePMC
Clinical transplantation,
Volume 28, Issue 6, 3 1 2014, Pages 649-655
Genetic polymorphisms in IL-2, IL-10, TGF-β1, and IL-2RB and acute rejection in renal transplant patients.
Chen Z, Bouamar R, Van Schaik RH, De Fijter JW, Hartmann A, Zeier M, Budde K, Kuypers DR, Weimar W, Hesselink DA, Van Gelder T
Acute rejection (AR) remains a concern for kidney transplantation. Cytokines are key mediators in the induction and effector phases of all immune and inflammatory responses. Single nucleotide polymorphisms (SNPs) in cytokines and their receptors may relate to AR. We investigated the relation between AR and SNPs in the genes encoding for IL-2(-330G>T), IL-10(-592C>A and -1082G>A), TGF-β1(915G>C), and IL-2RB(rs228942 C>A and rs228953 C>T) in 325 renal transplant patients during t...
Abstract
