Research

Publications

Below you can find a list of our published research.

9618 results

Cited 25 times since 2013 (2.1 per year) source: EuropePMC

Diabetes care, Volume 36, Issue 10, 15 3 2013, Pages 3054-3061 Stratified patient-centered care in type 2 diabetes: a cluster-randomized, controlled clinical trial of effectiveness and cost-effectiveness. Slingerland AS, Herman WH, Redekop WK, Dijkstra RF, Jukema JW, Niessen LW

Objective: Diabetes treatment should be effective and cost-effective. HbA1c-associated complications are costly. Would patient-centered care be more (cost-) effective if it was targeted to patients within specific HbA1c ranges? Research design and methods: This prospective, cluster-randomized, controlled trial involved 13 hospitals (clusters) in the Netherlands and 506 patients with type 2 diabetes randomized to patient-centered (n=237) or usual care (controls) (n=269). Primary outcomes were cha... Abstract

Cited 10 times since 2013 (0.8 per year) source: EuropePMC

Physiological measurement, Volume 34, Issue 9, 14 2 2013, Pages 991-1012 Towards true unipolar ECG recording without the Wilson central terminal (preliminary results). Gargiulo GD, McEwan AL, Bifulco P, Cesarelli M, Jin C, Tapson J, Thiagalingam A, van Schaik A

We present an innovative bio-potential front-end capable of recording true unipolar ECG leads for the first time without making use of the Wilson central terminal. In addition to the convenience in applications such as continuous monitoring and rapid diagnosis, the information in unipolar recordings may yield unique diagnostic information as it avoids the need to essentially subtract data or make use of the averaging effect imposed from the Wilson central terminal. The system also allows direct,... Abstract

Cited 16 times since 2013 (1.3 per year) source: EuropePMC

The American journal of cardiology, Volume 112, Issue 10, 14 2 2013, Pages 1533-1539 In-hospital major bleeding and its clinical relevance in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention. Boden H, Velders MA, van der Hoeven BL, Cannegieter SC, Schalij MJ

Advances in antithrombotic therapy for ST elevation myocardial infarction (STEMI) enhance the risk of bleeding. Therefore, the incidence, determinants, and prognostic implications of in-hospital major bleeding after primary percutaneous coronary intervention for STEMI were investigated. In 963 consecutive patients, the incidence of bleeding was evaluated according to commonly used classifications including Can Rapid risk stratification of Unstable angina patients Suppress Adverse outcomes with E... Abstract

Cited 56 times since 2013 (4.7 per year) source: EuropePMC

Virus research, Volume 178, Issue 1, 13 2 2013, Pages 15-20 Transmission of influenza A/H5N1 viruses in mammals. Imai M, Herfst S, Sorrell EM, Schrauwen EJ, Linster M, De Graaf M, Fouchier RA, Kawaoka Y

Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans and cause severe respiratory disease and fatalities. Currently, these viruses are not efficiently transmitted from person to person, although limited human-to-human transmission may have occurred. Nevertheless, further adaptation of avian H5N1 influenza A viruses to humans and/or reassortment with human influenza A viruses may result in aerosol transmissible viruses with pandemic potential. Although the full range of fac... Abstract

Cited 48 times since 2013 (4 per year) source: EuropePMC

Journal of dairy science, Volume 96, Issue 10, 9 2 2013, Pages 6264-6273 Evaluating results of the Welfare Quality multi-criteria evaluation model for classification of dairy cattle welfare at the herd level. de Vries M, Bokkers EA, van Schaik G, Botreau R, Engel B, Dijkstra T, de Boer IJ

The Welfare Quality multi-criteria evaluation (WQ-ME) model aggregates scores of single welfare measures into an overall assessment for the level of animal welfare in dairy herds. It assigns herds to 4 welfare classes: unacceptable, acceptable, enhanced, or excellent. The aim of this study was to demonstrate the relative importance of single welfare measures for WQ-ME classification of a selected sample of Dutch dairy herds. Seven trained observers quantified 63 welfare measures of the Welfare Q... Abstract

Cited 7 times since 2013 (0.6 per year) source: EuropePMC

PloS one, Volume 8, Issue 8, 9 2 2013, Pages e70676 Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene. Verschuren JJ, Trompet S, Sampietro ML, Heijmans BT, Koch W, Kastrati A, Houwing-Duistermaat JJ, Slagboom PE, Quax PH, Jukema JW

Background: Coronary restenosis after percutaneous coronary intervention (PCI) still remains a significant limitation of the procedure. The causative mechanisms of restenosis have not yet been fully identified. The goal of the current study was to perform gene-set analysis of biological pathways related to inflammation, proliferation, vascular function and transcriptional regulation on coronary restenosis to identify novel genes and pathways related to this condition. Methods: The GENetic DEterm... Abstract

Cited 157 times since 2013 (13 per year) source: EuropePMC

Nature, Volume 501, Issue 7468, 7 1 2013, Pages 560-563 Limited airborne transmission of H7N9 influenza A virus between ferrets. Richard M, Schrauwen EJ, de Graaf M, Bestebroer TM, Spronken MI, van Boheemen S, de Meulder D, Lexmond P, Linster M, Herfst S, Smith DJ, van den Brand JM, Burke DF, Kuiken T, Rimmelzwaan GF, Osterhaus AD, Fouchier RA

Wild waterfowl form the main reservoir of influenza A viruses, from which transmission occurs directly or indirectly to various secondary hosts, including humans. Direct avian-to-human transmission has been observed for viruses of subtypes A(H5N1), A(H7N2), A(H7N3), A(H7N7), A(H9N2) and A(H10N7) upon human exposure to poultry, but a lack of sustained human-to-human transmission has prevented these viruses from causing new pandemics. Recently, avian A(H7N9) viruses were transmitted to humans, cau... Abstract

Cited 8 times since 2013 (0.7 per year) source: EuropePMC

PloS one, Volume 8, Issue 8, 7 1 2013, Pages e72285 A LacI-family regulator activates maltodextrin metabolism of Enterococcus faecium. Zhang X, Rogers M, Bierschenk D, Bonten MJ, Willems RJ, van Schaik W

Enterococcus faecium is a gut commensal of humans and animals. In the intestinal tract, E. faecium will have access to a wide variety of carbohydrates, including maltodextrins and maltose, which are the sugars that result from the enzymatic digestion of starch by host-derived and microbial amylases. In this study, we identified the genetic determinants for maltodextrin utilization of E. faecium E1162. We generated a deletion mutant of the mdxABCD-pulA gene cluster that is homologous to maltodext... Abstract

Cited 176 times since 2013 (14.6 per year) source: EuropePMC

Epigenetics & chromatin, Volume 6, Issue 1, 6 1 2013, Pages 26 Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array. Slieker RC, Bos SD, Goeman JJ, Bovée JV, Talens RP, van der Breggen R, Suchiman HE, Lameijer EW, Putter H, van den Akker EB, Zhang Y, Jukema JW, Slagboom PE, Meulenbelt I, Heijmans BT

Background: DNA methylation has been recognized as a key mechanism in cell differentiation. Various studies have compared tissues to characterize epigenetically regulated genomic regions, but due to differences in study design and focus there still is no consensus as to the annotation of genomic regions predominantly involved in tissue-specific methylation. We used a new algorithm to identify and annotate tissue-specific differentially methylated regions (tDMRs) from Illumina 450k chip data for... Abstract

Cited 20 times since 2013 (1.7 per year) source: EuropePMC

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 19, Issue 18, 5 1 2013, Pages 5210-5217 A pharmacogenetic predictive model for paclitaxel clearance based on the DMET platform. de Graan AJ, Elens L, Smid M, Martens JW, Sparreboom A, Nieuweboer AJ, Friberg LE, Elbouazzaoui S, Wiemer EA, van der Holt B, Verweij J, van Schaik RH, Mathijssen RH

Purpose: Paclitaxel is used in the treatment of solid tumors and displays high interindividual variation in exposure. Low paclitaxel clearance could lead to increased toxicity during treatment. We present a genetic prediction model identifying patients with low paclitaxel clearance, based on the drug-metabolizing enzyme and transporter (DMET)-platform, capable of detecting 1,936 genetic variants in 225 metabolizing enzyme and drug transporter genes. Experimental design: In 270 paclitaxel-treated... Abstract

Journal of molecular and cellular cardiology, Volume 63, 2 1 2013, Pages 118-121 Mediators of inflammation after cardiac ischemia: the role of invariant natural killer T (iNKT) cells. Arslan F

Abstract

Cited 6 times since 2013 (0.5 per year) source: EuropePMC

Cardiovascular & hematological disorders drug targets, Volume 13, Issue 2, 1 1 2013, Pages 111-122 Anti-apoptotic serpins as therapeutics in cardiovascular diseases. Kuiper J, Quax PH, Bot I

Acute cardiovascular syndromes such as myocardial infarction and stroke are a major cause of death in the Western society and are generally caused by rupture of an atherosclerotic plaque. Treatment of atherosclerosis, the main underlying cause of acute cardiovascular syndromes, is still inadequate for most of the patients. Therefore, there is a need for new therapeutic strategies in addition to the existing lipid-lowering drugs such as statins. Lipid accumulation, inflammation and matrix degrada... Abstract

Cited 49 times since 2013 (4.1 per year) source: EuropePMC

Lancet (London, England), Volume 382, Issue 9892, 1 1 2013, Pages 644-657 Future treatment strategies in ST-segment elevation myocardial infarction. Windecker S, Bax JJ, Myat A, Stone GW, Marber MS

Over the past five decades, management of acute ST-segment elevation myocardial infarction (STEMI) has evolved substantially. Current treatment encompasses a systematic chain of network activation, antithrombotic drugs, and rapid instigation of mechanical reperfusion, although pharmacoinvasive strategies remain relevant. Secondary prevention with drugs and lifestyle modifications completes the contemporary management package. Despite a tangible improvement in outcomes, STEMI remains a frequent c... Abstract

Cited 13 times since 2013 (1.1 per year) source: EuropePMC

Pharmacogenomics, Volume 14, Issue 11, 1 1 2013, Pages 1295-1304 Genetic variation in the PPARA gene is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study. de Keyser CE, Becker ML, Uitterlinden AG, Hofman A, Lous JJ, Elens L, Visser LE, van Schaik RH, Stricker BH

Aim: Recently, minor alleles of two strongly linked polymorphisms in the PPARA gene, rs4253728 G>A and rs4823613 A>G, were related to decreased CYP3A4 expression and activity. We studied whether they were associated with the cholesterol-lowering effect of simvastatin. Materials & methods: We identified 123 incident users with cholesterol measurements before and after starting statin therapy in a prospective population-based cohort study. Associations between PPARA polymorphisms and cha... Abstract

Cited 29 times since 2013 (2.4 per year) source: EuropePMC

Therapeutic drug monitoring, Volume 35, Issue 4, 1 1 2013, Pages 459-465 Genetic polymorphisms in ABCB1 influence the pharmacodynamics of tacrolimus. Vafadari R, Bouamar R, Hesselink DA, Kraaijeveld R, van Schaik RH, Weimar W, Baan CC, van Gelder T

Introduction: Tacrolimus has a large interindividual pharmacokinetic variability, and quantification of its effect is difficult. It is a substrate of ABCB1, an efflux pump expressed more on CD8 T cells than on CD4 T cells. The ABCB1 3435C>T single-nucleotide polymorphism (SNP) has been associated with interindividual differences in ABCB1 activity and may influence drug efficacy. Here the influence of this SNP on the biological effect of tacrolimus was studied. Methods: Rhodamine (Rh123) efflu... Abstract

Cited 32 times since 2013 (2.7 per year) source: EuropePMC

Future microbiology, Volume 8, Issue 8, 1 1 2013, Pages 993-1010 The cell wall architecture of Enterococcus faecium: from resistance to pathogenesis. Hendrickx AP, van Schaik W, Willems RJ

The cell wall of Gram-positive bacteria functions as a surface organelle that continuously interacts with its environment through a plethora of cell wall-associated molecules. Enterococcus faecium is a normal inhabitant of the GI tract of mammals, but has recently become an important etiological agent of hospital-acquired infections in debilitated patients. Insights into the assembly and function of enterococcal cell wall components and their interactions with the host during colonization and in... Abstract

Cited 16 times since 2013 (1.3 per year) source: EuropePMC

Journal of clinical psychopharmacology, Volume 33, Issue 4, 1 1 2013, Pages 546-550 Association between genetic variation in the ABCB1 gene and switching, discontinuation, and dosage of antidepressant therapy: results from the Rotterdam Study. Noordam R, Aarts N, Hofman A, van Schaik RH, Stricker BH, Visser LE

The objective of this study was to investigate whether polymorphisms in the ABCB1 gene were associated with switching, with discontinuation of antidepressants within 45 days after starting therapy, and/or with dose change in a large prospective population-based cohort study. Between April 1, 1991, and December 31, 2007, there were 1257 incident users of antidepressants with known ABCB1 genotypes (1236C>T, 2677G>T/A, 3435C>T) in the population-based Rotterdam Study. Logistic regression m... Abstract

Cited 7 times since 2013 (0.6 per year) source: EuropePMC

Spine, Volume 38, Issue 18, 1 1 2013, Pages 1590-1594 An evaluation of web sites recommended by UK NHS consultants to patients with adolescent idiopathic scoliosis at the first point of diagnosis. Wellburn S, Bettany-Saltikov J, van Schaik P

Study design: An Internet-based evaluation of Web sites using a validated assessment tool. Objective: To evaluate the quality of information on scoliosis Web sites recommended by UK NHS consultants. Summary of background data: One of the most common sources of inquiry on the Web is for the purposes of health-related information. The number of Web sites in the field of scoliosis has increased, yet the quality of information is reported to continue to be of poor quality. The 2 previous studies in... Abstract

Cited 8 times since 2013 (0.7 per year) source: EuropePMC

Kidney international, Volume 85, Issue 1, 31 5 2013, Pages 94-102 Ankyrin-3 is a novel binding partner of the voltage-gated potassium channel Kv1.1 implicated in renal magnesium handling. San-Cristobal P, Lainez S, Dimke H, de Graaf MJ, Hoenderop JG, Bindels RJ

The voltage-gated potassium channel, Kv1.1, was recently identified as a causative gene in isolated dominant hypomagnesemia. The channel is situated in the distal convoluted tubule, where it participates in maintaining a favorable electrical gradient for driving magnesium ion into the cell through the transient receptor potential melastatin 6 channel. Pull-down experiments coupled to mass spectrometry using the carboxy-terminal domain of Kv1.1 as bait were used in mouse kidney lysates. Ankyrin-3... Abstract

Cited 83 times since 2013 (6.9 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 62, Issue 21, 31 5 2013, Pages 1966-1976 Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study. Holmes MV, Simon T, Exeter HJ, Folkersen L, Asselbergs FW, Guardiola M, Cooper JA, Palmen J, Hubacek JA, Carruthers KF, Horne BD, Brunisholz KD, Mega JL, van Iperen EPA, Li M, Leusink M, Trompet S, Verschuren JJW, Hovingh GK, Dehghan A, Nelson CP, Kotti S, Danchin N, Scholz M, Haase CL, Rothenbacher D, Swerdlow DI, Kuchenbaecker KB, Staines-Urias E, Goel A, van 't Hooft F, Gertow K, de Faire U, Panayiotou AG, Tremoli E, Baldassarre D, Veglia F, Holdt LM, Beutner F, Gansevoort RT, Navis GJ, Mateo Leach I, Breitling LP, Brenner H, Thiery J, Dallmeier D, Franco-Cereceda A, Boer JMA, Stephens JW, Hofker MH, Tedgui A, Hofman A, Uitterlinden AG, Adamkova V, Pitha J, Onland-Moret NC, Cramer MJ, Nathoe HM, Spiering W, Klungel OH, Kumari M, Whincup PH, Morrow DA, Braund PS, Hall AS, Olsson AG, Doevendans PA, Trip MD, Tobin MD, Hamsten A, Watkins H, Koenig W, Nicolaides AN, Teupser D, Day INM, Carlquist JF, Gaunt TR, Ford I, Sattar N, Tsimikas S, Schwartz GG, Lawlor DA, Morris RW, Sandhu MS, Poledne R, Maitland-van der

Objectives: This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in cardiovascular disease. Background: Higher circulating levels of sPLA2-IIA mass or sPLA2 enzyme activity have been associated with increased risk of cardiovascular events. However, it is not clear if this association is causal. A recent phase III clinical trial of an sPLA2 inhibitor (varespladib) was stopped prematurely for lack of efficacy. Methods: We conducted a Mendelian randomization meta-anal... Abstract