9618 results
Cited 192 times since 2013 (15.8 per year)
source: EuropePMC
Cancer,
Volume 119, Issue 18, 21 3 2013, Pages 3411-3418
Near-infrared fluorescence-guided resection of colorectal liver metastases.
van der Vorst JR, Schaafsma BE, Hutteman M, Verbeek FP, Liefers GJ, Hartgrink HH, Smit VT, Löwik CW, van de Velde CJ, Frangioni JV, Vahrmeijer AL
Background: The fundamental principle of oncologic surgery is the complete resection of malignant cells. However, small tumors are often difficult to find during surgery using conventional techniques. The objectives of this study were to determine if optical imaging, using a contrast agent already approved for other indications, could improve hepatic metastasectomy with curative intent, to optimize dose and timing, and to determine the mechanism of contrast agent accumulation. Methods: The high...
Abstract
Cited 18 times since 2013 (1.5 per year)
source: EuropePMC
Intensive care medicine,
Volume 39, Issue 9, 21 3 2013, Pages 1610-1617
Autonomic dysfunction in ICU-acquired weakness: a prospective observational pilot study.
Wieske L, Chan Pin Yin DR, Verhamme C, Schultz MJ, van Schaik IN, Horn J
Purpose: Intensive care unit-acquired weakness (ICU-AW) is a frequent complication of critical illness. It is unknown if patients with ICU-AW also have autonomic dysfunction, another frequent neurological complication of critical illness. We hypothesized that patients who develop ICU-AW also develop autonomic dysfunction. Furthermore, we hypothesized that patients with ICU-AW are more prone to develop autonomic dysfunction compared to patients without ICU-AW. Methods: This was an observational c...
Abstract
Cited 45 times since 2013 (3.7 per year)
source: EuropePMC
Arteriosclerosis, thrombosis, and vascular biology,
Volume 33, Issue 8, 20 3 2013, Pages 1902-1910
Lysine acetyltransferase PCAF is a key regulator of arteriogenesis.
Bastiaansen AJ, Ewing MM, de Boer HC, van der Pouw Kraan TC, de Vries MR, Peters EA, Welten SM, Arens R, Moore SM, Faber JE, Jukema JW, Hamming JF, Nossent AY, Quax PH
Objective: Therapeutic arteriogenesis, that is, expansive remodeling of preexisting collaterals, using single-action factor therapies has not been as successful as anticipated. Modulation of factors that act as a master switch for relevant gene programs may prove more effective. Transcriptional coactivator p300-CBP-associated factor (PCAF) has histone acetylating activity and promotes transcription of multiple inflammatory genes. Because arteriogenesis is an inflammation-driven process, we hypot...
Abstract
Cited 31 times since 2013 (2.5 per year)
source: EuropePMC
PloS one,
Volume 8, Issue 6, 19 3 2013, Pages e66467
Niacin Reduces Atherosclerosis Development in APOE*3Leiden.CETP Mice Mainly by Reducing NonHDL-Cholesterol.
Kühnast S, Louwe MC, Heemskerk MM, Pieterman EJ, van Klinken JB, van den Berg SA, van den Berg SA, Smit JW, Havekes LM, Rensen PC, van der Hoorn JW, Princen HM, Jukema JW
Objective: Niacin potently lowers triglycerides, mildly decreases LDL-cholesterol, and largely increases HDL-cholesterol. Despite evidence for an atheroprotective effect of niacin from previous small clinical studies, the large outcome trials, AIM-HIGH and HPS2-THRIVE did not reveal additional beneficial effects of niacin (alone or in combination with laropiprant) on top of statin treatment. We aimed to address this apparent discrepancy by investigating the effects of niacin without and with sim...
Abstract
Cited 2696 times since 2013 (221.2 per year)
source: EuropePMC
European heart journal,
Volume 34, Issue 28, 14 2 2013, Pages 2159-2219
2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC).
Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM, Schmieder RE, Sirnes PA, Sleight P, Viigimaa M, Waeber B, Zannad F, Redon J, Dominiczak A, Narkiewicz K, Nilsson PM, Burnier M, Viigimaa M, Ambrosioni E, Caufield M, Coca A, Olsen MH, Schmieder RE, Tsioufis C, van de Borne P, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Clement DL, Coca A, Gillebert TC, Tendera M, Rosei EA, Ambrosioni E, Anker SD, Bauersachs J, Hitij JB, Caulfield M, De Buyzere M, De Geest S, Derumeaux GA, Erdine S, Farsang C, Funck-Brentano C, Gerc V, Germano G, Gielen S, Haller H, Hoes AW, Jordan J, Kahan T, Komajda M, Lovic D
Abstract
Cited 18 times since 2013 (1.5 per year)
source: EuropePMC
International journal of geriatric psychiatry,
Volume 29, Issue 2, 13 2 2013, Pages 182-190
Cost-effectiveness of a stepped care programme to prevent depression and anxiety in residents in homes for the older people: a randomised controlled trial.
Bosmans JE, Dozeman E, van Marwijk HW, van Schaik DJ, Stek ML, Beekman AT, van der Horst HE
Background: Depression and anxiety are common in residents of elderly homes. Both disorders have negative effects on functioning, well-being and health-care utilisation. Besides treatment, prevention can be an option to reduce the burden of mental disorders. The objective of this study was to evaluate the cost-effectiveness of a stepped care programme to prevent the onset of depression and anxiety disorders in residents of elderly homes compared with usual care from a societal perspective. Metho...
Abstract
Cited 57 times since 2013 (4.7 per year)
source: EuropePMC
European heart journal,
Volume 34, Issue 48, 11 2 2013, Pages 3699-3706
Mast cells in human carotid atherosclerotic plaques are associated with intraplaque microvessel density and the occurrence of future cardiovascular events.
Willems S, Vink A, Bot I, Quax PH, de Borst GJ, de Vries JP, van de Weg SM, Moll FL, Kuiper J, Kovanen PT, de Kleijn DP, Hoefer IE, Pasterkamp G
Aims: Human autopsy, animal, and cell culture studies together have merged in a concept suggesting participation of mast cells (MCs) in the generation of atherosclerotic plaques. More specifically, these studies have suggested MC-induced intraplaque neovascularization as one mechanism by which MCs may render the plaques vulnerable. The present study was designed to assess the association between MC numbers and neovascularization in human atherosclerotic plaques, and to relate the abundance of pl...
Abstract
Cited 17 times since 2013 (1.4 per year)
source: EuropePMC
Breast cancer research and treatment,
Volume 139, Issue 3, 5 1 2013, Pages 649-655
CYP2C19 2 predicts substantial tamoxifen benefit in postmenopausal breast cancer patients randomized between adjuvant tamoxifen and no systemic treatment.
Beelen K, Opdam M, Severson TM, Koornstra RH, Vincent AD, Hauptmann M, van Schaik RH, Berns EM, Vermorken JB, van Diest PJ, Linn SC
Estrogen catabolism is a major function of CYP2C19. The effect of CYP2C19 polymorphisms on tamoxifen sensitivity may therefore not only be mediated by a variation in tamoxifen metabolite levels but also by an effect on breast cancer risk and molecular subtype due to variation in lifelong exposure to estrogens. We determined the association between these polymorphisms and tamoxifen sensitivity in the context of a randomized trial, which allows for the discernment of prognosis from prediction. We...
Abstract
Cited 78 times since 2013 (6.4 per year)
source: EuropePMC
Medical image analysis,
Volume 17, Issue 8, 4 1 2013, Pages 859-876
Standardized evaluation framework for evaluating coronary artery stenosis detection, stenosis quantification and lumen segmentation algorithms in computed tomography angiography.
Kirişli HA, Schaap M, Metz CT, Dharampal AS, Meijboom WB, Papadopoulou SL, Dedic A, Nieman K, de Graaf MA, Meijs MF, Cramer MJ, Broersen A, Cetin S, Eslami A, Flórez-Valencia L, Lor KL, Matuszewski B, Melki I, Mohr B, Oksüz I, Shahzad R, Wang C, Kitslaar PH, Unal G, Katouzian A, Örkisz M, Chen CM, Precioso F, Najman L, Masood S, Ünay D, van Vliet L, Moreno R, Goldenberg R, Vuçini E, Krestin GP, Niessen WJ, van Walsum T
Though conventional coronary angiography (CCA) has been the standard of reference for diagnosing coronary artery disease in the past decades, computed tomography angiography (CTA) has rapidly emerged, and is nowadays widely used in clinical practice. Here, we introduce a standardized evaluation framework to reliably evaluate and compare the performance of the algorithms devised to detect and quantify the coronary artery stenoses, and to segment the coronary artery lumen in CTA data. The objectiv...
Abstract
Cited 14 times since 2013 (1.1 per year)
source: Scopus
Interactive cardiovascular and thoracic surgery,
Volume 17, Issue 3, 4 1 2013, Pages 523-530
Pre-existing endothelial cell activation predicts vasoplegia after mitral valve surgery.
Kortekaas KA, Lindeman JH, Reinders ME, Palmen M, Klautz RJ, de Groot PG, Roest M
Objectives: Post-cardiac surgery vasoplegia is a common complication of cardiac surgery, characterized by profound loss of systemic vascular resistance. This results in severe hypotension, high cardiac output and metabolic acidosis reflecting inadequate tissue perfusion. The pathophysiological mechanisms underlying this syndrome remain unknown. We hypothesized that this vasoplegia reflects endothelial dysfunction, either as pre-existing condition or as a consequence of the surgical procedure. Me...
Abstract
Cited 3 times since 2013 (0.2 per year)
source: EuropePMC
International journal of geriatric psychiatry,
Volume 29, Issue 2, 4 1 2013, Pages 191-197
Preventing depression in homes for older adults: are effects sustained over 2 years?
van Schaik DJ, Dozeman E, van Marwijk HW, Stek ML, Smit F, Beekman AT, van der Horst HE
Objectives: The objective of this study was to evaluate the 2-year effects of a stepped-care programme to prevent the onset of a major depressive disorder (MDD) in older people living in residential homes. Methods: A 2-year follow-up study of a pragmatic randomised controlled trial was conducted in 14 residential homes in the Netherlands. A total of 185 residents (Center for Epidemiologic Studies Depression Scale score >7), who did not meet the diagnostic criteria for MDD, were randomised to...
Abstract
Cited 1 times since 2013 (0.1 per year)
source: EuropePMC
The Behavioral and brain sciences,
Volume 36, Issue 3, 1 1 2013, Pages 294-295
The cognitive economy: the probabilistic turn in psychology and human cognition.
Kusev P, van Schaik P
According to the foundations of economic theory, agents have stable and coherent "global" preferences that guide their choices among alternatives. However, people are constrained by information-processing and memory limitations and hence have a propensity to avoid cognitive load. We propose that this in turn will encourage them to respond to "local" preferences and goals influenced by context and memory representations.
Abstract
Cited 31 times since 2013 (2.5 per year)
source: EuropePMC
British journal of clinical pharmacology,
Volume 75, Issue 6, 1 1 2013, Pages 1506-1515
The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery.
Ahlers SJ, Elens LL, van Gulik L, van Schaik RH, van Dongen EP, Bruins P, Tibboel D, Knibbe CA
Aims: The catechol-O-methyltransferase (COMT) Val158Met polymorphism affected pain sensitivity of healthy volunteers upon application of experimental pain stimuli. The relevance of these findings in morphine-treated postoperative cardiac patients undergoing painful healthcare procedures is unknown; therefore, the aim of this study was to investigate whether the COMT Val158Met polymorphism increases pain sensitivity in morphine-treated patients undergoing an unavoidable painful routine procedure...
Abstract
Cited 33 times since 2013 (2.7 per year)
source: EuropePMC
British journal of clinical pharmacology,
Volume 75, Issue 6, 1 1 2013, Pages 1545-1547
The CYP3A4*22 allele affects the predictive value of a pharmacogenetic algorithm predicting tacrolimus predose concentrations.
Elens L, Hesselink DA, van Schaik RH, van Gelder T
Abstract
Cited 16 times since 2013 (1.3 per year)
source: EuropePMC
The Indian journal of medical research,
Volume 137, Issue 6, 1 1 2013, Pages 1111-1120
Adaptation of heart to training: a comparative study using echocardiography & impedance cardiography in male & female athletes.
Yilmaz DC, Buyukakilli B, Gurgul S, Rencuzogullari I
Background & objectives: Intensive regular physical exercise training is associated with a physiological changes in left ventricular (LV) morphology and functions. This cardiac remodeling observed in the athletes is associated with the specific haemodynamic requirements of the exercise undertaken. The main objective of this study is to evaluate the effect of endurance training on cardiac morphology, systolic and diastolic LV functions and haemodynamic parameters both in male and female athle...
Abstract
Cited 30 times since 2013 (2.5 per year)
source: EuropePMC
Atherosclerosis,
Volume 229, Issue 2, 1 1 2013, Pages 423-429
Abdominal adiposity largely explains associations between insulin resistance, hyperglycemia and subclinical atherosclerosis: the NEO study.
Gast KB, Smit JW, den Heijer M, Middeldorp S, Rippe RC, le Cessie S, de Koning EJ, Jukema JW, Rabelink TJ, de Roos A, Rosendaal FR, de Mutsert R, NEO study group
Objective: The relative importance of insulin resistance and hyperglycemia to the development of atherosclerosis remains unclear. Furthermore, adiposity may be responsible for observed associations. Our aim was to study the relative contributions of adiposity, insulin resistance and hyperglycemia to subclinical atherosclerosis. Methods: In this cross-sectional analysis of the Netherlands Epidemiology of Obesity (NEO) study, a cohort of persons of 45-65 years, BMI, waist circumference (WC), fasti...
Abstract
Cited 3 times since 2013 (0.2 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 21, Issue 6, 1 1 2013, Pages 266-267
NVVC/NHJ Durrer Prizes 2012.
van der Wall EE, Schalij MJ, Umans VA
At the annual Spring Congress of the NVVC the Durrer prizes were awarded to the authors of the best original/review articles published in the year 2012, one paper being more basically-oriented and one paper being more clinically-oriented. This annual tradition exists already since the year 2006.
Abstract
Cited 18 times since 2013 (1.5 per year)
source: EuropePMC
Anesthesiology,
Volume 118, Issue 6, 1 1 2013, Pages 1385-1394
Xenon and isoflurane reduce left ventricular remodeling after myocardial infarction in the rat.
Roehl AB, Funcke S, Becker MM, Goetzenich A, Bleilevens C, Rossaint R, Steendijk P, Hein M
Background: Xenon and isoflurane are known to have cardioprotective properties. We tested the hypothesis that these anesthetics positively influence myocardial remodeling 28 days after experimental perioperative myocardial infarction and compared their effects. Methods: A total of 60 male Sprague-Dawley rats were subjected to 60 min of coronary artery occlusion and 120 min of reperfusion. Prior to ischemia, the animals were randomized for the different narcotic regimes (0.6 vol% isoflurane, 70 v...
Abstract
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
Archivos espanoles de urologia,
Volume 66, Issue 5, 1 1 2013, Pages 432-439
The role of methylation in urological tumours.
van der Heijden AG
Alterations in DNA methylation have been described in human cancer for more than thirty years now. Since the last decade DNA methylation gets more and more important in cancer research. In this review the different alterations of DNA methylation are discussed in testicular germ cell tumours, Wilms'tumours, renal cell carcinomas, urothelial cell carcinomas of the bladder and adenocarcinomas of the prostate. Eventually, the potential use in diagnostics, prognostics and therapy are discussed.
Abstract
Cited 9 times since 2013 (0.7 per year)
source: EuropePMC
European journal of preventive cardiology,
Volume 20, Issue 2 Suppl, 1 1 2013, Pages 8-12
Remote monitoring of patients with implanted devices: data exchange and integration.
Van der Velde ET, Atsma DE, Foeken H, Witteman TA, Hoekstra WH
Background: Remote follow-up of implanted implantable cardioverter defibrillators (ICDs) may offer a solution to the problem of overcrowded outpatient clinics, and may also be effective in detecting clinical events early. Data obtained from remote follow up systems, as developed by all major device companies, are stored in a central database system, operated and owned by the device company. A problem now arises that the patient's clinical information is partly stored in the local electronic...
Abstract
