9618 results
Cited 42 times since 2013 (3.4 per year)
source: EuropePMC
American journal of physiology. Heart and circulatory physiology,
Volume 305, Issue 3, 31 5 2013, Pages H354-64
Distinct loading conditions reveal various patterns of right ventricular adaptation.
Borgdorff MA, Bartelds B, Dickinson MG, Steendijk P, de Vroomen M, Berger RM
Right ventricular (RV) failure due to chronically abnormal loading is a main determinant of outcome in pulmonary hypertension (PH) and congenital heart disease. However, distinct types of RV loading have been associated with different outcomes. To determine whether the adaptive RV response depends on loading type, we compared hemodynamics, exercise, and hypertrophy in models of pressure overload due to pulmonary artery banding (PAB), pressure overload due to PH, combined pressure and volume over...
Abstract
Cited 24 times since 2013 (2 per year)
source: EuropePMC
PloS one,
Volume 8, Issue 5, 31 5 2013, Pages e65224
The Enterococcus faecium enterococcal biofilm regulator, EbrB, regulates the esp operon and is implicated in biofilm formation and intestinal colonization.
Top J, Paganelli FL, Zhang X, van Schaik W, Leavis HL, van Luit-Asbroek M, van der Poll T, Leendertse M, Bonten MJ, Willems RJ
Nowadays, Enterococcus faecium is one of the leading nosocomial pathogens worldwide. Strains causing clinical infections or hospital outbreaks are enriched in the enterococcal surface protein (Esp) encoding ICEEfm1 mobile genetic element. Previous studies showed that Esp is involved in biofilm formation, endocarditis and urinary tract infections. In this study, we characterized the role of the putative AraC type of regulator (locus tag EfmE1162_2351), which we renamed ebrB and which is, based on...
Abstract
Cited 24 times since 2013 (2 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 99, Issue 17, 30 5 2013, Pages 1244-1249
Gender-specific differences in clinical outcome of primary prevention implantable cardioverter defibrillator recipients.
van der Heijden AC, Thijssen J, Borleffs CJ, van Rees JB, Höke U, van der Velde ET, van Erven L, Schalij MJ
Objective: To assess differences in clinical outcome of implantable cardioverter-defibrillator (ICD) treatment in men and women. Design: Prospective cohort study. Setting: University Medical Center. Patients: 1946 primary prevention ICD recipients (1528 (79%) men and 418 (21%) women). Patients with congenital heart disease were excluded for this analysis. Main outcome measures: All-cause mortality, ICD therapy (antitachycardia pacing and shock) and ICD shock. Results: During a median follow-up o...
Abstract
Cited 3 times since 2013 (0.2 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 40, Issue 8, 29 5 2013, Pages 1171-1180
Automated quantitative coronary computed tomography correlates of myocardial ischaemia on gated myocardial perfusion SPECT.
de Graaf MA, El-Naggar HM, Boogers MJ, Veltman CE, Broersen A, Kitslaar PH, Dijkstra J, Kroft LJ, Al Younis I, Reiber JH, Bax JJ, Delgado V, Scholte AJ
Purpose: Automated software tools have permitted more comprehensive, robust and reproducible quantification of coronary stenosis, plaque burden and plaque location of coronary computed tomography angiography (CTA) data. The association between these quantitative CTA (QCT) parameters and the presence of myocardial ischaemia has not been explored. The aim of the present investigation was to evaluate the association between QCT parameters of coronary artery lesions and the presence of myocardial is...
Abstract
Cited 74 times since 2013 (6 per year)
source: EuropePMC
European urology,
Volume 64, Issue 4, 25 4 2013, Pages 530-539
Screening for prostate cancer: results of the Rotterdam section of the European randomized study of screening for prostate cancer.
Roobol MJ, Kranse R, Bangma CH, van Leenders AG, Blijenberg BG, van Schaik RH, Kirkels WJ, Otto SJ, van der Kwast TH, de Koning HJ, Schröder FH, ERSPC Rotterdam Study Group
Background: Evidence from randomized trials on the effects of screening for prostate cancer (PCa) on disease-specific mortality accumulates slowly with increasing follow-up. Objective: To assess data on PCa-specific mortality in the Rotterdam section of the European Randomized Study of Screening for Prostate Cancer (ERSPC) trial. Design, setting, and participants: A randomized controlled trial with randomization after signed, written informed consent (efficacy trial). In the period 1993-1999, a...
Abstract
Cited 3 times since 2013 (0.2 per year)
source: EuropePMC
European heart journal,
Volume 34, Issue 31, 24 4 2013, Pages 2432-2435
View point: what should the future design of clinical imaging studies be?
Gaemperli O, Lüscher TF, Bax JJ
Abstract
Cited 5 times since 2013 (0.4 per year)
source: Scopus
The American journal of cardiology,
Volume 112, Issue 5, 24 4 2013, Pages 714-719
Mitral valve geometry and hemodynamics after surgical mitral valve annuloplasty and implications for percutaneous treatment of patients with recurrent mitral regurgitation.
Al Amri I, Debonnaire P, Witkowski T, van der Kley F, Palmen M, de Weger A, Klautz RJ, Bax JJ, Schalij MJ, Ajmone Marsan N, Delgado V
The feasibility of transcatheter mitral valve therapy (edge-to-edge or valve-in-ring technique) in patients with significant mitral regurgitation (MR) recurrence after surgical restrictive mitral valve annuloplasty remains unknown. The aim of the present study was to investigate the eligibility for transcatheter mitral valve therapy of high-surgical-risk patients with significant MR recurrence after initial successful restrictive mitral valve annuloplasty. A total of 47 patients (age 67 ± 10 yea...
Abstract
Cited 35 times since 2013 (2.9 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 99, Issue 14, 23 4 2013, Pages 1018-1023
Suitability for subcutaneous defibrillator implantation: results based on data from routine clinical practice.
de Bie MK, Thijssen J, van Rees JB, Putter H, van der Velde ET, Schalij MJ, van Erven L
Objective: To assess the proportion of current implantable cardioverter defibrillator (ICD) recipients who would be suitable for a subcutaneous lead ICD (S-ICD). Design: A retrospective cohort study. Setting: Tertiary care facility in the Netherlands. Patients: All patients who received a single- or dual-chamber ICD in the Leiden University Medical Center between 2002 and 2011. Patients with a pre-existent indication for cardiac pacing were excluded. Main outcome measure: Suitability for an S-IC...
Abstract
Cited 85 times since 2013 (6.9 per year)
source: EuropePMC
The British journal of surgery,
Volume 100, Issue 8, 21 3 2013, Pages 1037-1044
Clinical trial of combined radio- and fluorescence-guided sentinel lymph node biopsy in breast cancer.
Schaafsma BE, Verbeek FP, Rietbergen DD, van der Hiel B, van der Vorst JR, Liefers GJ, Frangioni JV, van de Velde CJ, van Leeuwen FW, Vahrmeijer AL
Background: Combining radioactive colloids and a near-infrared (NIR) fluorophore permits preoperative planning and intraoperative localization of deeply located sentinel lymph nodes (SLNs) with direct optical guidance by a single lymphatic tracer. The aim of this clinical trial was to evaluate and optimize a hybrid NIR fluorescence and radioactive tracer for SLN detection in patients with breast cancer. Methods: Patients with breast cancer undergoing SLN biopsy were enrolled. The day before surg...
Abstract
Cited 37 times since 2013 (3 per year)
source: EuropePMC
Basic & clinical pharmacology & toxicology,
Volume 113, Issue 2, 20 3 2013, Pages 126-131
Sex difference in formation of propofol metabolites: a replication study.
Choong E, Loryan I, Lindqvist M, Nordling Å, el Bouazzaoui S, van Schaik RH, Johansson I, Jakobsson J, Ingelman-Sundberg M
Women recover faster from propofol anaesthesia and have been described to have a higher incidence of awareness during surgery, compared to men - an effect that may be inherent in sex differences in propofol metabolism. In an observational study, 98 ASA I-II patients treated with continuous propofol infusion were recruited. The associations between sex and CYP2B6 and UGT1A9 polymorphisms with dose- and weight-adjusted area under the total plasma level time curves (AUC) for propofol, and its metab...
Abstract
Cited 17 times since 2013 (1.4 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 45, Issue 1, 17 3 2013, Pages 83-89
Long-term tricuspid valve prosthesis-related complications in patients with congenital heart disease.
van Slooten YJ, Freling HG, van Melle JP, Mulder BJ, Jongbloed MR, Ebels T, Voors AA, Pieper PG
Objectives: In patients with acquired valvar disease, morbidity and mortality rates after tricuspid valve replacement (TVR) are high. However, in adult patients with congenital heart disease, though data concerning outcome after TVR are scarce, even poorer results are suggested in patients with Ebstein anomaly. To investigate the applicability of these results to a broader array of congenital heart disease patients, we report the long-term follow-up of prosthesis-related complications, including...
Abstract
Cited 41 times since 2013 (3.3 per year)
source: EuropePMC
The American journal of cardiology,
Volume 112, Issue 4, 15 3 2013, Pages 560-566
Accuracy of three-dimensional versus two-dimensional echocardiography for quantification of aortic regurgitation and validation by three-dimensional three-directional velocity-encoded magnetic resonance imaging.
Ewe SH, Delgado V, van der Geest R, Westenberg JJ, Haeck ML, Witkowski TG, Auger D, Marsan NA, Holman ER, de Roos A, Schalij MJ, Bax JJ, Sieders A, Siebelink HM
Quantitative assessment of aortic regurgitation (AR) remains challenging. The present study evaluated the accuracy of 2-dimensional (2D) and 3-dimensional (3D) transthoracic echocardiography (TTE) for AR quantification, using 3D 3-directional velocity-encoded magnetic resonance imaging (VE-MRI) as the reference method. Thirty-two AR patients were included. With color Doppler TTE, 2D effective regurgitant orifice area (EROA) was calculated using the proximal isovelocity surface area method. From...
Abstract
Cited 44 times since 2013 (3.6 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 59, Issue 1, 15 3 2013, Pages 192-201.e1
Vascular remodeling and intimal hyperplasia in a novel murine model of arteriovenous fistula failure.
Wong CY, de Vries MR, Wang Y, van der Vorst JR, Vahrmeijer AL, van Zonneveld AJ, Roy-Chaudhury P, Rabelink TJ, Quax PH, Rotmans JI
Objective: The arteriovenous fistula (AVF) still suffers from a high number of failures caused by insufficient outward remodeling and intimal hyperplasia (IH) formation from which the exact mechanism is largely unknown. A suitable animal model is of vital importance in the unraveling of the underlying pathophysiology. However, current murine models of AVF failure do not incorporate the surgical configuration that is commonly used in humans. Because the hemodynamic profile is one of the key deter...
Abstract
Cited 19 times since 2013 (1.5 per year)
source: EuropePMC
Journal of electrocardiology,
Volume 46, Issue 4, 14 2 2013, Pages 302-311
Difference vectors to describe dynamics of the ST segment and the ventricular gradient in acute ischemia.
ter Haar CC, Maan AC, Warren SG, Ringborn M, Horáček BM, Schalij MJ, Swenne CA
Background: The ECG is important in the diagnosis and triage of the acute coronary syndrome (ACS), especially in the hyperacute phase, the "golden hours," during which myocardial salvage possibilities are largest. An important triaging decision to be taken is whether or not a patient requires primary PCI, for which, as mentioned in the guidelines, the presence of an ST elevation (STE) pattern in the ECG is a major criterion. However, preexisting non-zero ST amplitudes (diagnostic, but...
Abstract
Cited 10 times since 2013 (0.8 per year)
source: EuropePMC
Circulation. Cardiovascular quality and outcomes,
Volume 6, Issue 3, 14 2 2013, Pages 360-366
Journey through cholesteryl ester transfer protein inhibition: from bench to bedside.
Karalis I, Rensen PC, Jukema JW
Abstract
Cited 29 times since 2013 (2.4 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 26, Issue 7, 11 2 2013, Pages 691-698
Impact of valvuloarterial impedance on 2-year outcome of patients undergoing transcatheter aortic valve implantation.
Katsanos S, Yiu KH, Clavel MA, Rodés-Cabau J, Leong D, van der Kley F, Ajmone Marsan N, Bax JJ, Pibarot P, Delgado V
Background: Elderly patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) often have increased calcification and fibrosis of the aorta. Indices that account for the severity of valvular obstruction and systemic vascular impedance may better assess total left ventricular afterload. The aims of the present study were to evaluate changes in valvuloarterial impedance (Zva), systemic arterial compliance, and systemic vascular resistance after TAVI and to inves...
Abstract
Cited 16 times since 2013 (1.3 per year)
source: EuropePMC
Bioorganic & medicinal chemistry letters,
Volume 23, Issue 13, 9 2 2013, Pages 3749-3752
Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative.
Slootweg JC, van Schaik TB, Quarles van Ufford HL, Breukink E, Liskamp RM, Rijkers DT
The lipophilic amino acid, (S)-2-aminoundecanoic acid, was synthesized and incorporated at a number of specific positions within the peptide sequence of anoplin. These lipophilic anoplin analogs showed to be more active against Escherichia coli and Staphylococcus aureus compared to native anoplin, while the EC50-value of hemolysis was at least one order of magnitude lower than the MIC values. This was in sharp contrast to the N-acylated anoplin derivative, where a gain in activity also led to a...
Abstract
Cited 107 times since 2013 (8.7 per year)
source: EuropePMC
Epigenetics & chromatin,
Volume 6, Issue 1, 8 2 2013, Pages 12
Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain.
van Nuland R, van Schaik FM, Simonis M, van Heesch S, Cuppen E, Boelens R, Timmers HM, van Ingen H
Background: Recognition of histone modifications by specialized protein domains is a key step in the regulation of DNA-mediated processes like gene transcription. The structural basis of these interactions is usually studied using histone peptide models, neglecting the nucleosomal context. Here, we provide the structural and thermodynamic basis for the recognition of H3K36-methylated (H3K36me) nucleosomes by the PSIP1-PWWP domain, based on extensive mutational analysis, advanced nuclear magnetic...
Abstract
Cited 69 times since 2013 (5.6 per year)
source: EuropePMC
Circulation research,
Volume 113, Issue 2, 8 2 2013, Pages 153-166
Intracoronary infusion of allogeneic mesenchymal precursor cells directly after experimental acute myocardial infarction reduces infarct size, abrogates adverse remodeling, and improves cardiac function.
Houtgraaf JH, de Jong R, Kazemi K, de Groot D, van der Spoel TI, Arslan F, Hoefer I, Pasterkamp G, Itescu S, Zijlstra F, Geleijnse ML, Serruys PW, Duckers HJ
Rationale: Mesenchymal precursor cells (MPCs) are a specific Stro-3+ subpopulation of mesenchymal stem cells isolated from bone marrow. MPCs exert extensive cardioprotective effects, and are considered to be immune privileged. Objective: This study assessed the safety, feasibility, and efficacy of intracoronary delivery of allogeneic MPCs directly after acute myocardial infarction in sheep. Methods and results: Initially, intracoronary delivery conditions were optimized in 20 sheep. These condit...
Abstract
Cited 1 times since 2013 (0.1 per year)
source: EuropePMC
Nature reviews. Cardiology,
Volume 10, Issue 7, 7 1 2013, Pages 370-371
Imaging: myocardial thinning is not always transmural scarring.
Bax JJ
Abstract
