9618 results
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
Cardiology in the young,
Volume 24, Issue 2, 18 3 2013, Pages 376-378
Ruptured aneurysm of the right coronary sinus of Valsalva in a child with Down syndrome.
Lahrouchi N, Rammeloo LA, Koolbergen DR, Hruda J
Aneurysms of one of the aortic sinuses of Valsalva are rare congenital or acquired lesions. Here we present the case of an adolescent with Down syndrome with ruptured aneurysm of the right coronary sinus into the right atrium. All sinuses of Valsalva were normal during cardiological screening owing to Down syndrome at the age of 2 weeks. Paediatricians should have a low threshold for referring patients with Down syndrome for cardiac re-evaluation because of the new onset of cardiac symptoms or c...
Abstract
Cited 25 times since 2013 (2 per year)
source: EuropePMC
Accounts of chemical research,
Volume 46, Issue 12, 18 3 2013, Pages 2910-2923
Bright ion channels and lipid bilayers.
Szymański W, Yilmaz D, Koçer A, Feringa BL
If we look at a simple organism such as a zebrafish under a microscope, we would see many cells working in harmony. If we zoomed in, we would observe each unit performing its own tasks in a special aqueous environment isolated from the other units by a lipid bilayer approximately 5 nm thick. These confined units are social: they communicate with one another by sensing and responding to the chemical changes in their environment through receptors and ion channels. These channels control the highly...
Abstract
Cited 13 times since 2013 (1.1 per year)
source: EuropePMC
PloS one,
Volume 8, Issue 4, 18 3 2013, Pages e61923
Protease-activated receptor (PAR)2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model.
van den Hengel LG, Hellingman AA, Nossent AY, van Oeveren-Rietdijk AM, de Vries MR, Spek CA, van Zonneveld AJ, Reitsma PH, Hamming JF, de Boer HC, Versteeg HH, Quax PH
Aims: In collateral development (i.e. arteriogenesis), mononuclear cells are important and exist as a heterogeneous population consisting of pro-inflammatory and anti-inflammatory/repair-associated cells. Protease-activated receptor (PAR)1 and PAR2 are G-protein-coupled receptors that are both expressed by mononuclear cells and are involved in pro-inflammatory reactions, while PAR2 also plays a role in repair-associated responses. Here, we investigated the physiological role of PAR1 and PAR2 in...
Abstract
Cited 114 times since 2013 (9.2 per year)
source: EuropePMC
International journal of cardiology,
Volume 168, Issue 3, 18 3 2013, Pages 2487-2493
Heart failure admissions in adults with congenital heart disease; risk factors and prognosis.
Zomer AC, Vaartjes I, van der Velde ET, de Jong HM, Konings TC, Wagenaar LJ, Heesen WF, Eerens F, Baur LH, Grobbee DE, Mulder BJ
Background: Heart failure (HF) is a serious complication and often the cause of death in adults with congenital heart disease (CHD). Therefore, our aims were to determine the frequency of HF-admissions, and to assess risk factors of first HF-admission and of mortality after first HF-admission in adults with CHD. Methods: The Dutch CONCOR registry was linked to the Hospital Discharge Registry and National Mortality Registry to obtain data on HF-admissions and mortality. Risk factors for both HF-a...
Abstract
Cited 133 times since 2013 (10.8 per year)
source: EuropePMC
European journal of epidemiology,
Volume 28, Issue 6, 11 2 2013, Pages 513-523
The Netherlands Epidemiology of Obesity (NEO) study: study design and data collection.
de Mutsert R, den Heijer M, Rabelink TJ, Smit JW, Romijn JA, Jukema JW, de Roos A, Cobbaert CM, Kloppenburg M, le Cessie S, Middeldorp S, Rosendaal FR
Obesity is a well-established risk factor for many chronic diseases. Incomplete insight exists in the causal pathways responsible for obesity-related disorders and consequently, in the identification of obese individuals at risk of these disorders. The Netherlands Epidemiology of Obesity (NEO) study is designed for extensive phenotyping to investigate pathways that lead to obesity-related diseases. The NEO study is a population-based, prospective cohort study that includes 6,673 individuals aged...
Abstract
Cited 23 times since 2013 (1.9 per year)
source: Scopus
European journal of heart failure,
Volume 15, Issue 9, 10 2 2013, Pages 1011-1018
Galectin-3 and left ventricular reverse remodelling after surgical mitral valve repair.
Kortekaas KA, Hoogslag GE, de Boer RA, Dokter MM, Versteegh MI, Braun J, Marsan NA, Verwey HF, Delgado V, Schalij MJ, Klautz RJ
Aims: Mitral valve repair in patients with functional mitral regurgitation (FMR) has been associated with beneficial left ventricular (LV) reverse remodelling. Recently, galectin-3 emerged as a marker of myocardial inflammation and fibrosis which may influence LV remodelling after surgery. The aim of the current study was to evaluate the association between pre-operative galectin-3 levels and LV reverse remodelling in heart failure patients with significant FMR who underwent mitral valve repair....
Abstract
Cited 50 times since 2013 (4 per year)
source: EuropePMC
International journal of cardiology,
Volume 168, Issue 3, 10 2 2013, Pages 2441-2446
Circulating transforming growth factor-β as a prognostic biomarker in Marfan syndrome.
Franken R, den Hartog AW, de Waard V, Engele L, Radonic T, Lutter R, Timmermans J, Scholte AJ, van den Berg MP, Zwinderman AH, Groenink M, Mulder BJ
Background: Patients with Marfan syndrome (MFS) are at risk for cardiovascular disease. Marfan associated mutations in the FBN1 gene lead to increased transforming growth factor-β (TGF-β) activation. The aim of this study was to investigate the role of plasma TGF-β as a biomarker for progressive aortic root dilatation and dissection. Methods: Plasma TGF-β level and aortic root diameter by means of echocardiography were assessed in 99 MFS patients. After 38 months of follow-up measurement of the...
Abstract
Cited 24 times since 2013 (1.9 per year)
source: EuropePMC
Philosophical transactions of the Royal Society of London. Series B, Biological sciences,
Volume 368, Issue 1618, 8 2 2013, Pages 20120339
The costs and benefits of flexibility as an expression of behavioural plasticity: a primate perspective.
van Schaik CP
Traditional neo-Darwinism ascribes geographical variation in morphology or in behaviour to varying selection on local genotypes. However, mobile and long-lived organisms cannot achieve local adaptation this way, leading to a renewed interest in plasticity. I examined geographical variation in orang-utan subsistence and social behaviour, and found this to be largely owing to behavioural plasticity, here called flexibility, both in the form of flexible individual decisions and of socially transmit...
Abstract
Cited 8 times since 2013 (0.6 per year)
source: EuropePMC
Journal of neuroimmunology,
Volume 258, Issue 1-2, 5 1 2013, Pages 85-90
Elevated numbers of regulatory T cells, central memory T cells and class-switched B cells in cerebrospinal fluid of patients with anti-Hu antibody associated paraneoplastic neurological syndromes.
de Jongste AH, de Graaf MT, van den Broek PD, Kraan J, Smitt PA, Gratama JW
Multi-parametric flow cytometry was used to study lymphocyte subsets and dendritic cells in paired blood and CSF samples from 11 newly diagnosed patients with progressive anti-Hu antibody associated paraneoplastic neurological syndromes (Hu-PNS), 9 patients with other inflammatory neurologic disorders (IND), and 12 patients with other non-inflammatory neurologic disorders (OND). Hu-PNS patients had elevated numbers of regulatory T cells, central memory T cells, class-switched B cells and dendrit...
Abstract
Cited 10 times since 2013 (0.8 per year)
source: EuropePMC
Clinical journal of the American Society of Nephrology : CJASN,
Volume 8, Issue 8, 4 1 2013, Pages 1358-1366
Candidate gene analysis of arteriovenous fistula failure in hemodialysis patients.
Verschuren JJ, Ocak G, Dekker FW, Rabelink TJ, Jukema JW, Rotmans JI
Background and objectives: Arteriovenous fistula (AVF) failure remains an important cause of morbidity in hemodialysis patients. The exact underlying mechanisms responsible for AVF failure are unknown but processes like proliferation, inflammation, vascular remodeling, and thrombosis are thought to be involved. The current objective was to investigate the association between AVF failure and single nucleotide polymorphisms (SNPs) in genes related to these pathophysiologic processes in a large pop...
Abstract
Cited 3 times since 2013 (0.2 per year)
source: EuropePMC
PloS one,
Volume 8, Issue 4, 3 1 2013, Pages e60467
Toll-Like Receptor induced CD11b and L-selectin response in patients with coronary artery disease.
Elsenberg EH, Hillaert MA, den Ruijter HM, Sels JW, Scholtes VP, Nathoe HM, Kuiper J, Jukema JW, Doevendans PA, Pasterkamp G, Hoefer IE
Toll-Like Receptor (TLR) -2 and -4 expression and TLR-induced cytokine response of inflammatory cells are related to atherogenesis and atherosclerotic plaque progression. We examined whether immediate TLR induced changes in CD11b and L-selectin (CD62L) expression are able to discriminate the presence and severity of atherosclerotic disease by exploring single dose whole blood TLR stimulation and detailed dose-response curves. Blood samples were obtained from 125 coronary artery disease (CAD) pat...
Abstract
Cited 1 times since 2013 (0.1 per year)
source: EuropePMC
Applied optics,
Volume 52, Issue 10, 1 1 2013, Pages 2173-2186
Feasibility study of integral property retrieval for tropospheric aerosol from Raman lidar data using principal component analysis.
de Graaf M, Apituley A, Donovan DP
A method is introduced to derive integral properties of the aerosol size distribution, e.g., aerosol mass, from tropospheric multiwavelength Raman lidar aerosol extinction and backscatter data, using an adapted form of the principal component analysis (PCA) technique. Since the refractive index of general tropospheric aerosols is variable and aerosol types can vary within one profile, an inversion technique applied in the troposphere should account for varying aerosol refractive indices. Using P...
Abstract
Cited 6 times since 2013 (0.5 per year)
source: EuropePMC
The Netherlands journal of medicine,
Volume 71, Issue 3, 1 1 2013, Pages 145-152
A clinical approach to pharmacogenetics.
de Graaff LC, van Schaik RH, van Gelder T
Taking into account the high frequency of adverse drug reactions (ADRs) in the clinic and taking into account the growing knowledge of the genetic mechanisms underlying some of these ADRs, we believe that every clinician should know at least the basic principles of pharmacogenetics. However, our experience is that many clinicians are unaware of the potential contribution of pharmacogenetic testing and have not implemented this new modality in their daily practice. We present a case of Stevens-Jo...
Abstract
Cited 2 times since 2013 (0.2 per year)
source: EuropePMC
Cyberpsychology, behavior and social networking,
Volume 16, Issue 4, 1 1 2013, Pages 309-314
Exploring the role of computers in sex and relationship education within British families.
Turnbull T, van Schaik P, van Wersch A
In this study, we aimed to identify the impact that computers can have in relation to sex and relationship education, as well as to provide a communication model that can be used within British families. We used a mixed-methods approach to explore the factors that influence communication of sexual matters within British families. Twenty families from the northeast of England were recruited through purposive sampling. First, semistructured interviews were conducted to identify how sexual matters...
Abstract
Annals of translational medicine,
Volume 1, Issue 1, 1 1 2013, Pages 2
Statins reduce the risk of cancer-related mortality in cancer-diagnosed patients. A true phenomenon?
Trompet S, de Craen AJ, Jukema JW
Abstract
Journal of the American College of Cardiology,
Volume 61, Issue 13, 1 1 2013, Pages e157
Fishing in the heart: removal of a free closure device inside the left atrium.
Montero-Cabezas JM, Velázquez-Martín MT, Fernández-Casares S, Albarrán-González-Trevilla A, López-Melgar B, Centeno-Rodríguez J, Tascón-Pérez JC
Abstract
Cited 2 times since 2013 (0.2 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 21, Issue 4, 1 1 2013, Pages 183-188
Neurocardiological differences between musicians and control subjects.
Burggraaf JL, Elffers TW, Segeth FM, Austie FM, Plug MB, Gademan MG, Maan AC, Man S, de Muynck M, Soekkha T, Simonsz A, van der Wall EE, Schalij MJ, Swenne CA
Background: Exercise training is beneficial in health and disease. Part of the training effect materialises in the brainstem due to the exercise-associated somatosensory nerve traffic. Because active music making also involves somatosensory nerve traffic, we hypothesised that this will have training effects resembling those of physical exercise. Methods: We compared two groups of healthy, young subjects between 18 and 30 years: 25 music students (13/12 male/female, group M) and 28 controls (12/1...
Abstract
Cited 68 times since 2013 (5.5 per year)
source: EuropePMC
PloS one,
Volume 8, Issue 3, 29 5 2013, Pages e59697
Cardioprotective properties of omentin-1 in type 2 diabetes: evidence from clinical and in vitro studies.
Greulich S, Chen WJ, Maxhera B, Rijzewijk LJ, van der Meer RW, Jonker JT, Mueller H, de Wiza DH, Floerke RR, Smiris K, Lamb HJ, de Roos A, Bax JJ, Romijn JA, Smit JW, Akhyari P, Lichtenberg A, Eckel J, Diamant M, Ouwens DM
Context: Adipokines are linked to the development of cardiovascular dysfunction in type 2 diabetes (DM2). In DM2-patients, circulating levels of omentin-1, an adipokine preferentially expressed in epicardial adipose tissue, are decreased. This study investigated whether omentin-1 has a cardioprotective function. Methods: Omentin-1 levels in plasma and cardiac fat depots were determined in DM2-patients versus controls. Moreover, the relation between omentin-1 levels and cardiac function was exami...
Abstract
Cited 105 times since 2013 (8.5 per year)
source: EuropePMC
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
Volume 28, Issue 5, 29 5 2013, Pages 1085-1092
Arteriovenous access failure: more than just intimal hyperplasia?
Rothuizen TC, Wong C, Quax PH, van Zonneveld AJ, Rabelink TJ, Rotmans JI
Haemodialysis vascular access patency is severely compromised by fistula non-maturation and access stenosis. Intimal hyperplasia (IH) is considered the culprit lesion in failed fistulas, resulting in luminal narrowing and stenosis. This review focuses on the biology and pathophysiology of fistula failure and highlights not only the classically associated IH but also some relatively neglected but potentially important contributors such as inadequate outward remodelling. In addition, the complex p...
Abstract
Cited 51 times since 2013 (4.1 per year)
source: EuropePMC
Journal of neurology, neurosurgery, and psychiatry,
Volume 84, Issue 8, 28 4 2013, Pages 859-861
Serum IgG levels in IV immunoglobulin treated chronic inflammatory demyelinating polyneuropathy.
Kuitwaard K, van Doorn PA, Vermeulen M, van den Berg LH, Brusse E, van der Kooi AJ, van der Pol WL, van Schaik IN, Notermans N, Tio-Gillen AP, van Rijs W, van Gelder T, Jacobs BC
Objective: To determine the variability of serum IgG in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Methods: All 25 CIDP patients had active but stable disease and were treated with individually optimised fixed dose IVIg regimens. IgG was measured by turbidimetry and variability was defined as coefficient of variation (CV). Results: The intra-patient variability of the pre-treatment IgG levels, post-treatment levels and increase in serum IgG shortly after IVIg (ΔIgG)...
Abstract
