Research

Publications

Below you can find a list of our published research.

9618 results

Cited 37 times since 2013 (3 per year) source: EuropePMC

American heart journal, Volume 165, Issue 5, 27 4 2013, Pages 793-99, 799.e1 Contrast-induced acute kidney injury and clinical outcomes after intra-arterial and intravenous contrast administration: risk comparison adjusted for patient characteristics by design. Kooiman J, Le Haen PA, Gezgin G, de Vries JP, Boersma D, Brulez HF, Sijpkens YW, van der Molen AJ, Cannegieter SC, Hamming JF, Huisman MV

Background: Direct comparisons between risk of contrast induced acute kidney injury (CI-AKI) after intra-arterial versus intravenous contrast administration are scarce. We estimated and compared the risk of CI-AKI and its clinical course after both modes of contrast administration in patients who underwent both. Methods: One hundred seventy patients who received both intra-arterial and intravenous contrast injections within one year between 2001 and 2010 were included. Primary outcome was occurr... Abstract

Cited 56 times since 2013 (4.5 per year) source: EuropePMC

Circulation research, Volume 112, Issue 10, 26 4 2013, Pages 1310-1322 Unique cardiac Purkinje fiber transient outward current β-subunit composition: a potential molecular link to idiopathic ventricular fibrillation. Xiao L, Koopmann TT, Ördög B, Postema PG, Verkerk AO, Iyer V, Sampson KJ, Boink GJ, Mamarbachi MA, Varro A, Jordaens L, Res J, Kass RS, Wilde AA, Bezzina CR, Nattel S

Rationale: A chromosomal haplotype producing cardiac overexpression of dipeptidyl peptidase-like protein-6 (DPP6) causes familial idiopathic ventricular fibrillation. The molecular basis of transient outward current (I(to)) in Purkinje fibers (PFs) is poorly understood. We hypothesized that DPP6 contributes to PF I(to) and that its overexpression might specifically alter PF I(to) properties and repolarization. Objective: To assess the potential role of DPP6 in PF I(to). Methods and results: Clin... Abstract

Cited 17 times since 2013 (1.4 per year) source: EuropePMC

The British journal of nutrition, Volume 110, Issue 8, 26 4 2013, Pages 1454-1464 Maternal first-trimester dietary intake and childhood blood pressure: the Generation R Study. van den Hil LC, Rob Taal H, de Jonge LL, Heppe DH, Steegers EA, Hofman A, van der Heijden AJ, Jaddoe VW

Suboptimal maternal dietary intake during pregnancy might lead to fetal cardiovascular adaptations and higher blood pressure in the offspring. The aim of the present study was to investigate the associations of maternal first-trimester dietary intake with blood pressure in children at the age of 6 years. We assessed first-trimester maternal daily dietary intake by a FFQ and measured folate, homocysteine and vitamin B₁₂ concentrations in the blood, in a population-based prospective cohort study a... Abstract

Cited 73 times since 2013 (5.9 per year) source: Scopus

Antioxidants & redox signaling, Volume 19, Issue 6, 26 4 2013, Pages 535-545 Oxidative damage in clinical ischemia/reperfusion injury: a reappraisal. de Vries DK, Kortekaas KA, Tsikas D, Wijermars LG, van Noorden CJ, Suchy MT, Cobbaert CM, Klautz RJ, Schaapherder AF, Lindeman JH

Aims: Ischemia/reperfusion (I/R) injury is a common clinical problem. Although the pathophysiological mechanisms underlying I/R injury are unclear, oxidative damage is considered a key factor in the initiation of I/R injury. Findings from preclinical studies consistently show that quenching reactive oxygen and nitrogen species (RONS), thus limiting oxidative damage, alleviates I/R injury. Results from clinical intervention studies on the other hand are largely inconclusive. In this study, we sys... Abstract

Cited 100 times since 2013 (8.1 per year) source: Scopus

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 44, Issue 1, 25 4 2013, Pages e8-15 Transcatheter valve-in-ring implantation after failure of surgical mitral repair. Descoutures F, Himbert D, Maisano F, Casselman F, de Weger A, Bodea O, Van der Kley F, Colombo A, Giannini C, Rein KA, De Bruyne B, Petronio AS, Dahle G, Alfieri O, Vahanian A

Objectives: Redo surgery after failed mitral valve repair may be high risk, or contraindicated in patients with comorbidities. Because of this high risk, other interventional possibilities like transcatheter valve implantation might be of benefit. We report our experience with transcatheter mitral valve-in-ring implantation (TVIR) in high-risk patients after failure of surgical ring annuloplasty. Methods: From January 2010 to February 2012, following a multidisciplinary discussion, 17 high-risk... Abstract

Cited 42 times since 2013 (3.4 per year) source: EuropePMC

European journal of cardiovascular nursing, Volume 13, Issue 1, 22 4 2013, Pages 86-94 Illness perceptions of adults with congenital heart disease and their predictive value for quality of life two years later. Schoormans D, Mulder BJ, van Melle JP, Pieper PG, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Sprangers MA

Background: To improve patients' quality of life (QoL) we need to identify modifiable determinants, such as illness perceptions. Patients' illness perceptions are known to regulate emotional responses and health-behaviour. Illness perceptions comprise several components: consequences, control, coherence, changeability and emotional representations. Aims: To examine (a) the relation between patient characteristics and illness perceptions, and (b) the independent predictive value of illn... Abstract

Cited 4 times since 2013 (0.3 per year) source: EuropePMC

General and comparative endocrinology, Volume 187, 22 4 2013, Pages 23-31 The reproductive cycle of the male house gecko, Hemidactylus flaviviridis, in relation to plasma steroid concentrations, progesterone receptors, and steroidogenic ultrastructural features, in Oman. Al-Amri IS, Mahmoud IY, Waring CP, Alkindi AY, Khan T, Bakheit C, Al-Mawali KM

The annual testicular cycle of the house gecko Hemidactylus flaviviridis in Oman was studied. Plasma testosterone (T), estradiol (E2) and progesterone (P) concentrations were measured using a sensitive HPLC-MS/MS detection technique. The ultrastructural steroidogenic features in Sertoli and Leydig cells, which were the major source of steriodogenesis, were examined, using transmission electron microscopy (TEM). In addition, progesterone receptors (PR) were examined throughout the testicular cycl... Abstract

Cited 44 times since 2013 (3.5 per year) source: EuropePMC

Proceedings. Biological sciences, Volume 280, Issue 1759, 20 3 2013, Pages 20130081 The collective action problem in primate territory economics. Willems EP, Hellriegel B, van Schaik CP

Group-living animals often do not maintain territories, but instead have highly overlapping ranges, even though in principle these are economically defendable. We investigate whether this absence of range defence reflects a collective action problem, since a territory can be considered a public good. In a comparative analysis comprising 135 primate species, we find a positive association between range overlap and group size, controlling for economic defendability and phylogenetic non-independenc... Abstract

Cited 15 times since 2013 (1.2 per year) source: EuropePMC

Frontiers in zoology, Volume 10, Issue 1, 19 3 2013, Pages 12 Variation in developmental arrest among male orangutans: a comparison between a Sumatran and a Bornean population. Dunkel LP, Arora N, van Noordwijk MA, Atmoko SS, Putra AP, Krützen M, van Schaik CP

Introduction: The presence of two sexually active male morphs with different reproductive tactics in a single species is rare among mammals. The most striking case of bimaturism among primates is exhibited by the orangutan (Pongo spp), in which one adult morph, the unflanged male, irreversibly develops into another one, the flanged form, but may remain arrested in the unflanged state for many years. However, it has been suggested that such arrest is less common among Bornean orangutans (Pongo py... Abstract

Cited 18 times since 2013 (1.4 per year) source: EuropePMC

Neural networks : the official journal of the International Neural Network Society, Volume 45, 14 2 2013, Pages 94-100 Learning the pseudoinverse solution to network weights. Tapson J, van Schaik A

The last decade has seen the parallel emergence in computational neuroscience and machine learning of neural network structures which spread the input signal randomly to a higher dimensional space; perform a nonlinear activation; and then solve for a regression or classification output by means of a mathematical pseudoinverse operation. In the field of neuromorphic engineering, these methods are increasingly popular for synthesizing biologically plausible neural networks, but the "learning... Abstract

Cited 35 times since 2013 (2.8 per year) source: EuropePMC

PloS one, Volume 8, Issue 3, 12 2 2013, Pages e59199 Subclinical thyroid dysfunction and cognitive decline in old age. Wijsman LW, de Craen AJ, Trompet S, Gussekloo J, Stott DJ, Rodondi N, Welsh P, Jukema JW, Westendorp RG, Mooijaart SP

Background: Subclinical thyroid dysfunction has been implicated as a risk factor for cognitive decline in old age, but results are inconsistent. We investigated the association between subclinical thyroid dysfunction and cognitive decline in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Methods: Prospective longitudinal study of men and women aged 70-82 years with pre-existing vascular disease or more than one risk factor to develop this condition (N = 5,154). Participan... Abstract

Cited 74 times since 2013 (5.9 per year) source: EuropePMC

Journal of internal medicine, Volume 274, Issue 1, 11 2 2013, Pages 77-85 Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study. Mooijaart SP, Sattar N, Trompet S, Lucke J, Stott DJ, Ford I, Jukema JW, Westendorp RG, de Craen AJ, PROSPER Study Group

Background: Inflammation is involved in the pathogenesis of cardiovascular disease and cognitive decline. Interleukin-6 (IL-6) has a role in cardiovascular disease, but the association of IL-6 concentration and the functional IL-6 -174 polymorphism with cognitive decline has not been demonstrated unequivocally. The objective of this study was to investigate the associations between both high concentration of IL-6 and the -174 promoter polymorphism, and increased cognitive decline in old age. Met... Abstract

Cited 102 times since 2013 (8.2 per year) source: EuropePMC

Microbial ecology, Volume 65, Issue 4, 9 2 2013, Pages 1011-1023 A microbial signature approach to identify fecal pollution in the waters off an urbanized coast of Lake Michigan. Newton RJ, Bootsma MJ, Morrison HG, Sogin ML, McLellan SL

Urban coasts receive watershed drainage from ecosystems that include highly developed lands with sewer and stormwater infrastructure. In these complex ecosystems, coastal waters are often contaminated with fecal pollution, where multiple delivery mechanisms that often contain multiple fecal sources make it difficult to mitigate the pollution. Here, we exploit bacterial community sequencing of the V6 and V6V4 hypervariable regions of the bacterial 16S rRNA gene to identify bacterial distributions... Abstract

Cited 92 times since 2013 (7.4 per year) source: EuropePMC

International journal of medical microbiology : IJMM, Volume 303, Issue 6-7, 8 2 2013, Pages 360-379 Antibiotic resistant enterococci-tales of a drug resistance gene trafficker. Werner G, Coque TM, Franz CM, Grohmann E, Hegstad K, Jensen L, van Schaik W, Weaver K

Enterococci have been recognized as important hospital-acquired pathogens in recent years, and isolates of E. faecalis and E. faecium are the third- to fourth-most prevalent nosocomial pathogen worldwide. Acquired resistances, especially against penicilin/ampicillin, aminoglycosides (high-level) and glycopeptides are therapeutically important and reported in increasing numbers. On the other hand, isolates of E. faecalis and E. faecium are commensals of the intestines of humans, many vertebrate a... Abstract

Cited 16 times since 2013 (1.3 per year) source: EuropePMC

PloS one, Volume 8, Issue 3, 6 1 2013, Pages e58572 Small hydrophobic protein of human metapneumovirus does not affect virus replication and host gene expression in vitro. de Graaf M, Herfst S, Aarbiou J, Burgers PC, Zaaraoui-Boutahar F, Bijl M, van Ijcken W, Schrauwen EJ, Osterhaus AD, Luider TM, Scholte BJ, Fouchier RA, Andeweg AC

Human metapneumovirus (HMPV) encodes a small hydrophobic (SH) protein of unknown function. HMPV from which the SH open reading frame was deleted (HMPVΔSH) was viable and displayed similar replication kinetics, cytopathic effect and plaque size compared with wild type HMPV in several cell-lines. In addition, no differences were observed in infection efficiency or cell-to-cell spreading in human primary bronchial epithelial cells (HPBEC) cultured at an air-liquid interphase. Host gene expression w... Abstract

Cited 5 times since 2013 (0.4 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 99, Issue 8, 6 1 2013, Pages 556-561 Association between discharge heart rate and left ventricular adverse remodelling in ST segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention. Joyce E, Hoogslag GE, Leong DP, Fox K, Schalij MJ, Marsan NA, Bax JJ, Delgado V

Objective: Left ventricular (LV) adverse remodelling is an important determinant of mortality after ST segment elevation myocardial infarction (STEMI). Recently, discharge heart rate (DHR) has been associated with long-term outcomes after STEMI. Whether DHR is related to the development of LV remodelling after STEMI remains unknown. The present study evaluated the association between DHR after STEMI and the occurrence of LV remodelling at 6 months. DESIGN, SETTING, PATIENTS AND INTERVENTIONS: In... Abstract

Cited 25 times since 2013 (2 per year) source: EuropePMC

The pharmacogenomics journal, Volume 14, Issue 1, 5 1 2013, Pages 6-13 Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. Avery CL, Sitlani CM, Arking DE, Arnett DK, Bis JC, Boerwinkle E, Buckley BM, Ida Chen YD, de Craen AJ, Eijgelsheim M, Enquobahrie D, Evans DS, Ford I, Garcia ME, Gudnason V, Harris TB, Heckbert SR, Hochner H, Hofman A, Hsueh WC, Isaacs A, Jukema JW, Knekt P, Kors JA, Krijthe BP, Kristiansson K, Laaksonen M, Liu Y, Li X, Macfarlane PW, Newton-Cheh C, Nieminen MS, Oostra BA, Peloso GM, Porthan K, Rice K, Rivadeneira FF, Rotter JI, Salomaa V, Sattar N, Siscovick DS, Slagboom PE, Smith AV, Sotoodehnia N, Stott DJ, Stricker BH, Stürmer T, Trompet S, Uitterlinden AG, van Duijn C, Westendorp RG, Witteman JC, Whitsel EA, Psaty BM

Variability in response to drug use is common and heritable, suggesting that genome-wide pharmacogenomics studies may help explain the 'missing heritability' of complex traits. Here, we describe four independent analyses in 33 781 participants of European ancestry from 10 cohorts that were designed to identify genetic variants modifying the effects of drugs on QT interval duration (QT). Each analysis cross-sectionally examined four therapeutic classes: thiazide diuretics (prevalence of... Abstract

Cited 143 times since 2013 (11.5 per year) source: EuropePMC

Annals of neurology, Volume 73, Issue 3, 4 1 2013, Pages 397-407 Autoantibodies to cytosolic 5'-nucleotidase 1A in inclusion body myositis. Pluk H, van Hoeve BJ, van Dooren SH, Stammen-Vogelzangs J, van der Heijden A, Schelhaas HJ, Verbeek MM, Badrising UA, Arnardottir S, Gheorghe K, Lundberg IE, Boelens WC, van Engelen BG, Pruijn GJ

Objective: Sporadic inclusion body myositis (sIBM) is an inflammatory myopathy characterized by both degenerative and autoimmune features. In contrast to other inflammatory myopathies, myositis-specific autoantibodies had not been found in sIBM patients until recently. We used human skeletal muscle extracts as a source of antigens to detect autoantibodies in sIBM and to characterize the corresponding antigen. Methods: Autoantibodies to skeletal muscle antigens were detected by immunoblotting. Th... Abstract

Cited 194 times since 2013 (15.6 per year) source: EuropePMC

Circulation, Volume 127, Issue 14, 4 1 2013, Pages 1466-75, 1475e1-28 MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation. Dawson K, Wakili R, Ordög B, Clauss S, Chen Y, Iwasaki Y, Voigt N, Qi XY, Sinner MF, Dobrev D, Kääb S, Nattel S

Background: Congestive heart failure (CHF) causes atrial fibrotic remodeling, a substrate for atrial fibrillation (AF) maintenance. MicroRNA29 (miR29) targets extracellular matrix proteins. In the present study, we examined miR29b changes in patients with AF and/or CHF and in a CHF-related AF animal model and assessed its potential role in controlling atrial fibrous tissue production. Methods and results: Control dogs were compared with dogs subjected to ventricular tachypacing for 24 hours, 1 w... Abstract

Cited 20 times since 2013 (1.6 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 21, Issue 3, 1 1 2013, Pages 113-117 Ebstein's anomaly may be caused by mutations in the sarcomere protein gene MYH7. van Engelen K, Postma AV, van de Meerakker JB, Roos-Hesselink JW, Helderman-van den Enden AT, Vliegen HW, Rahman T, Baars MJ, Sels JW, Bauer U, Pickardt T, Sperling SR, Moorman AF, Keavney B, Goodship J, Klaassen S, Mulder BJ

Ebstein's anomaly is a rare congenital heart malformation characterised by adherence of the septal and posterior leaflets of the tricuspid valve to the underlying myocardium. Associated abnormalities of left ventricular morphology and function including left ventricular noncompaction (LVNC) have been observed. An association between Ebstein's anomaly with LVNC and mutations in the sarcomeric protein gene MYH7, encoding β-myosin heavy chain, has been shown by recent studies. This might... Abstract