Research

Publications

Below you can find a list of our published research.

8892 results

Cited 43 times since 2013 (3.5 per year) source: EuropePMC

Pharmacogenomics, Volume 14, Issue 9, 1 1 2013, Pages 1027-1036 CYP3A4*22 and CYP3A combined genotypes both correlate with tacrolimus disposition in pediatric heart transplant recipients. Gijsen VM, van Schaik RH, Elens L, Soldin OP, Soldin SJ, Koren G, de Wildt SN

Background: Tacrolimus metabolism depends on CYP3A4 and CYP3A5. We aimed to determine the relationship between the CYP3A4*22 polymorphism and combined CYP3A genotypes with tacrolimus disposition in pediatric heart transplant recipients. Methods: Sixty pediatric heart transplant recipients were included. Tacrolimus doses and trough concentrations were collected in the first 14 days post-transplantation. CYP3A phenotypes were defined as extensive (CYP3A5*1 + CYP3A4*1/*1 carriers), intermediate (CY... Abstract

Cited 16 times since 2013 (1.3 per year) source: EuropePMC

Radiology, Volume 269, Issue 2, 25 4 2013, Pages 370-377 Aortic disease in patients with Marfan syndrome: aortic volume assessment for surveillance. den Hartog AW, Franken R, de Witte P, Radonic T, Marquering HA, van der Steen WE, Timmermans J, Scholte AJ, van den Berg MP, Zwinderman AH, Mulder BJ, Groenink M

Purpose: To assess the reproducibility of aortic volume estimates and to serially test their use in patients with Marfan syndrome. Materials and methods: The study was approved by the medical ethics committee and all subjects gave written informed consent. In 81 patients with Marfan syndrome and seven healthy control subjects, aortic volumes and diameters at baseline were estimated by means of contrast material-enhanced magnetic resonance (MR) imaging. At 3 years of follow-up, aortic expansion r... Abstract

Cited 1260 times since 2013 (102.3 per year) source: EuropePMC

European heart journal, Volume 34, Issue 29, 24 4 2013, Pages 2281-2329 2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA, Cleland J, Deharo JC, Delgado V, Elliott PM, Gorenek B, Israel CW, Leclercq C, Linde C, Mont L, Padeletti L, Sutton R, Vardas PE, ESC Committee for Practice Guidelines (CPG), Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Document Reviewers, Kirchhof P, Blomstrom-Lundqvist C, Badano LP, Aliyev F, Bänsch D, Baumgartner H, Bsata W, Buser P, Charron P, Daubert JC, Dobreanu D, Faerestrand S, Hasdai D, Hoes AW, Le Heuzey JY, Mavrakis H, McDonagh T, Merino JL, Nawar MM, Nielsen JC, Pieske B, Poposka L, Ruschitzka F, Tendera M, Van Gelder IC, Wilson CM

Abstract

Cited 14 times since 2013 (1.1 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 96, Issue 2, 24 4 2013, Pages 629-636 Enhanced characterization of ventricular performance after coarctation repair in neonates and young children. Klitsie LM, Roest AA, Kuipers IM, Van der Hulst AE, Hazekamp MG, Blom NA, Ten Harkel AD

Background: Within the group of patients undergoing coarctectomy today, two subgroups can be identified: neonates with a critical coarctation and nonneonatal patients. We hypothesize that patients who have to undergo repair in the neonatal period will have more persistent impairment of ventricular performance postoperatively. Accordingly, we aimed to characterize biventricular performance after coarctectomy in neonatal and nonneonatal patients. Methods: Children (aged 0 to 17 years) undergoing a... Abstract

Cited 694 times since 2013 (56.3 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 15, Issue 8, 24 4 2013, Pages 1070-1118 2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: the task force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). European Society of Cardiology (ESC), European Heart Rhythm Association (EHRA), Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA, Cleland J, Deharo JC, Delgado V, Elliott PM, Gorenek B, Israel CW, Leclercq C, Linde C, Mont L, Padeletti L, Sutton R, Vardas PE

Abstract

Cited 193 times since 2013 (15.7 per year) source: EuropePMC

Nature reviews. Microbiology, Volume 11, Issue 8, 24 4 2013, Pages 561-573 Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii. van Schaik EJ, Chen C, Mertens K, Weber MM, Samuel JE

The agent of Q fever, Coxiella burnetii, is an obligate intracellular bacterium that causes acute and chronic infections. The study of C. burnetii pathogenesis has benefited from two recent fundamental advances: improved genetic tools and the ability to grow the bacterium in extracellular media. In this Review, we describe how these recent advances have improved our understanding of C. burnetii invasion and host cell modulation, including the formation of replication-permissive Coxiella-containi... Abstract

Cited 29 times since 2013 (2.4 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 15, Issue 1, 21 3 2013, Pages 41-47 Changes in multidirectional LV strain in asymptomatic patients with type 2 diabetes mellitus: a 2-year follow-up study. Roos CJ, Scholte AJ, Kharagjitsingh AV, Bax JJ, Delgado V

Aims: Asymptomatic patients with diabetes mellitus (DM) and normal left ventricular (LV) ejection fraction (EF) may have LV dysfunction as assessed with speckle tracking echocardiography. Whether this subtle LV dysfunction may progress or not over time remains unknown. The present evaluation assessed changes in LV function with two-dimensional (2D) speckle tracking analysis in asymptomatic clinically stable patients with type 2 DM and normal LVEF after 2-year follow-up. Methods and results: A to... Abstract

Cited 200 times since 2013 (16.2 per year) source: EuropePMC

Cancer, Volume 119, Issue 18, 21 3 2013, Pages 3411-3418 Near-infrared fluorescence-guided resection of colorectal liver metastases. van der Vorst JR, Schaafsma BE, Hutteman M, Verbeek FP, Liefers GJ, Hartgrink HH, Smit VT, Löwik CW, van de Velde CJ, Frangioni JV, Vahrmeijer AL

Background: The fundamental principle of oncologic surgery is the complete resection of malignant cells. However, small tumors are often difficult to find during surgery using conventional techniques. The objectives of this study were to determine if optical imaging, using a contrast agent already approved for other indications, could improve hepatic metastasectomy with curative intent, to optimize dose and timing, and to determine the mechanism of contrast agent accumulation. Methods: The high... Abstract

Cited 18 times since 2013 (1.5 per year) source: EuropePMC

Intensive care medicine, Volume 39, Issue 9, 21 3 2013, Pages 1610-1617 Autonomic dysfunction in ICU-acquired weakness: a prospective observational pilot study. Wieske L, Chan Pin Yin DR, Verhamme C, Schultz MJ, van Schaik IN, Horn J

Purpose: Intensive care unit-acquired weakness (ICU-AW) is a frequent complication of critical illness. It is unknown if patients with ICU-AW also have autonomic dysfunction, another frequent neurological complication of critical illness. We hypothesized that patients who develop ICU-AW also develop autonomic dysfunction. Furthermore, we hypothesized that patients with ICU-AW are more prone to develop autonomic dysfunction compared to patients without ICU-AW. Methods: This was an observational c... Abstract

Cited 49 times since 2013 (4 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 33, Issue 8, 20 3 2013, Pages 1902-1910 Lysine acetyltransferase PCAF is a key regulator of arteriogenesis. Bastiaansen AJ, Ewing MM, de Boer HC, van der Pouw Kraan TC, de Vries MR, Peters EA, Welten SM, Arens R, Moore SM, Faber JE, Jukema JW, Hamming JF, Nossent AY, Quax PH

Objective: Therapeutic arteriogenesis, that is, expansive remodeling of preexisting collaterals, using single-action factor therapies has not been as successful as anticipated. Modulation of factors that act as a master switch for relevant gene programs may prove more effective. Transcriptional coactivator p300-CBP-associated factor (PCAF) has histone acetylating activity and promotes transcription of multiple inflammatory genes. Because arteriogenesis is an inflammation-driven process, we hypot... Abstract

Cited 31 times since 2013 (2.5 per year) source: EuropePMC

PloS one, Volume 8, Issue 6, 19 3 2013, Pages e66467 Niacin Reduces Atherosclerosis Development in APOE*3Leiden.CETP Mice Mainly by Reducing NonHDL-Cholesterol. Kühnast S, Louwe MC, Heemskerk MM, Pieterman EJ, van Klinken JB, van den Berg SA, van den Berg SA, Smit JW, Havekes LM, Rensen PC, van der Hoorn JW, Princen HM, Jukema JW

Objective: Niacin potently lowers triglycerides, mildly decreases LDL-cholesterol, and largely increases HDL-cholesterol. Despite evidence for an atheroprotective effect of niacin from previous small clinical studies, the large outcome trials, AIM-HIGH and HPS2-THRIVE did not reveal additional beneficial effects of niacin (alone or in combination with laropiprant) on top of statin treatment. We aimed to address this apparent discrepancy by investigating the effects of niacin without and with sim... Abstract

Cited 2816 times since 2013 (228.1 per year) source: EuropePMC

European heart journal, Volume 34, Issue 28, 14 2 2013, Pages 2159-2219 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM, Schmieder RE, Sirnes PA, Sleight P, Viigimaa M, Waeber B, Zannad F, Redon J, Dominiczak A, Narkiewicz K, Nilsson PM, Burnier M, Viigimaa M, Ambrosioni E, Caufield M, Coca A, Olsen MH, Schmieder RE, Tsioufis C, van de Borne P, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Clement DL, Coca A, Gillebert TC, Tendera M, Rosei EA, Ambrosioni E, Anker SD, Bauersachs J, Hitij JB, Caulfield M, De Buyzere M, De Geest S, Derumeaux GA, Erdine S, Farsang C, Funck-Brentano C, Gerc V, Germano G, Gielen S, Haller H, Hoes AW, Jordan J, Kahan T, Komajda M, Lovic D

Abstract

Cited 19 times since 2013 (1.5 per year) source: EuropePMC

International journal of geriatric psychiatry, Volume 29, Issue 2, 13 2 2013, Pages 182-190 Cost-effectiveness of a stepped care programme to prevent depression and anxiety in residents in homes for the older people: a randomised controlled trial. Bosmans JE, Dozeman E, van Marwijk HW, van Schaik DJ, Stek ML, Beekman AT, van der Horst HE

Background: Depression and anxiety are common in residents of elderly homes. Both disorders have negative effects on functioning, well-being and health-care utilisation. Besides treatment, prevention can be an option to reduce the burden of mental disorders. The objective of this study was to evaluate the cost-effectiveness of a stepped care programme to prevent the onset of depression and anxiety disorders in residents of elderly homes compared with usual care from a societal perspective. Metho... Abstract

Cited 69 times since 2013 (5.6 per year) source: EuropePMC

European heart journal, Volume 34, Issue 48, 11 2 2013, Pages 3699-3706 Mast cells in human carotid atherosclerotic plaques are associated with intraplaque microvessel density and the occurrence of future cardiovascular events. Willems S, Vink A, Bot I, Quax PH, de Borst GJ, de Vries JP, van de Weg SM, Moll FL, Kuiper J, Kovanen PT, de Kleijn DP, Hoefer IE, Pasterkamp G

Aims: Human autopsy, animal, and cell culture studies together have merged in a concept suggesting participation of mast cells (MCs) in the generation of atherosclerotic plaques. More specifically, these studies have suggested MC-induced intraplaque neovascularization as one mechanism by which MCs may render the plaques vulnerable. The present study was designed to assess the association between MC numbers and neovascularization in human atherosclerotic plaques, and to relate the abundance of pl... Abstract

Cited 17 times since 2013 (1.4 per year) source: EuropePMC

Breast cancer research and treatment, Volume 139, Issue 3, 5 1 2013, Pages 649-655 CYP2C19 2 predicts substantial tamoxifen benefit in postmenopausal breast cancer patients randomized between adjuvant tamoxifen and no systemic treatment. Beelen K, Opdam M, Severson TM, Koornstra RH, Vincent AD, Hauptmann M, van Schaik RH, Berns EM, Vermorken JB, van Diest PJ, Linn SC

Estrogen catabolism is a major function of CYP2C19. The effect of CYP2C19 polymorphisms on tamoxifen sensitivity may therefore not only be mediated by a variation in tamoxifen metabolite levels but also by an effect on breast cancer risk and molecular subtype due to variation in lifelong exposure to estrogens. We determined the association between these polymorphisms and tamoxifen sensitivity in the context of a randomized trial, which allows for the discernment of prognosis from prediction. We... Abstract

Cited 92 times since 2013 (7.4 per year) source: EuropePMC

Medical image analysis, Volume 17, Issue 8, 4 1 2013, Pages 859-876 Standardized evaluation framework for evaluating coronary artery stenosis detection, stenosis quantification and lumen segmentation algorithms in computed tomography angiography. Kirişli HA, Schaap M, Metz CT, Dharampal AS, Meijboom WB, Papadopoulou SL, Dedic A, Nieman K, de Graaf MA, Meijs MF, Cramer MJ, Broersen A, Cetin S, Eslami A, Flórez-Valencia L, Lor KL, Matuszewski B, Melki I, Mohr B, Oksüz I, Shahzad R, Wang C, Kitslaar PH, Unal G, Katouzian A, Örkisz M, Chen CM, Precioso F, Najman L, Masood S, Ünay D, van Vliet L, Moreno R, Goldenberg R, Vuçini E, Krestin GP, Niessen WJ, van Walsum T

Though conventional coronary angiography (CCA) has been the standard of reference for diagnosing coronary artery disease in the past decades, computed tomography angiography (CTA) has rapidly emerged, and is nowadays widely used in clinical practice. Here, we introduce a standardized evaluation framework to reliably evaluate and compare the performance of the algorithms devised to detect and quantify the coronary artery stenoses, and to segment the coronary artery lumen in CTA data. The objectiv... Abstract

Cited 14 times since 2013 (1.1 per year) source: Scopus

Interactive cardiovascular and thoracic surgery, Volume 17, Issue 3, 4 1 2013, Pages 523-530 Pre-existing endothelial cell activation predicts vasoplegia after mitral valve surgery. Kortekaas KA, Lindeman JH, Reinders ME, Palmen M, Klautz RJ, de Groot PG, Roest M

Objectives: Post-cardiac surgery vasoplegia is a common complication of cardiac surgery, characterized by profound loss of systemic vascular resistance. This results in severe hypotension, high cardiac output and metabolic acidosis reflecting inadequate tissue perfusion. The pathophysiological mechanisms underlying this syndrome remain unknown. We hypothesized that this vasoplegia reflects endothelial dysfunction, either as pre-existing condition or as a consequence of the surgical procedure. Me... Abstract

Cited 3 times since 2013 (0.2 per year) source: EuropePMC

International journal of geriatric psychiatry, Volume 29, Issue 2, 4 1 2013, Pages 191-197 Preventing depression in homes for older adults: are effects sustained over 2 years? van Schaik DJ, Dozeman E, van Marwijk HW, Stek ML, Smit F, Beekman AT, van der Horst HE

Objectives: The objective of this study was to evaluate the 2-year effects of a stepped-care programme to prevent the onset of a major depressive disorder (MDD) in older people living in residential homes. Methods: A 2-year follow-up study of a pragmatic randomised controlled trial was conducted in 14 residential homes in the Netherlands. A total of 185 residents (Center for Epidemiologic Studies Depression Scale score >7), who did not meet the diagnostic criteria for MDD, were randomised to... Abstract

Cited 1 times since 2013 (0.1 per year) source: EuropePMC

The Behavioral and brain sciences, Volume 36, Issue 3, 1 1 2013, Pages 294-295 The cognitive economy: the probabilistic turn in psychology and human cognition. Kusev P, van Schaik P

According to the foundations of economic theory, agents have stable and coherent "global" preferences that guide their choices among alternatives. However, people are constrained by information-processing and memory limitations and hence have a propensity to avoid cognitive load. We propose that this in turn will encourage them to respond to "local" preferences and goals influenced by context and memory representations. Abstract

Cited 31 times since 2013 (2.5 per year) source: EuropePMC

British journal of clinical pharmacology, Volume 75, Issue 6, 1 1 2013, Pages 1506-1515 The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery. Ahlers SJ, Elens LL, van Gulik L, van Schaik RH, van Dongen EP, Bruins P, Tibboel D, Knibbe CA

Aims: The catechol-O-methyltransferase (COMT) Val158Met polymorphism affected pain sensitivity of healthy volunteers upon application of experimental pain stimuli. The relevance of these findings in morphine-treated postoperative cardiac patients undergoing painful healthcare procedures is unknown; therefore, the aim of this study was to investigate whether the COMT Val158Met polymorphism increases pain sensitivity in morphine-treated patients undergoing an unavoidable painful routine procedure... Abstract