Research

Publications

Below you can find a list of our published research.

9618 results

Cited 16 times since 2013 (1.3 per year) source: EuropePMC

The Journal of surgical research, Volume 183, Issue 1, 25 4 2013, Pages 253-257 Ex vivo sentinel node mapping in colon cancer combining blue dye staining and fluorescence imaging. Schaafsma BE, Verbeek FP, van der Vorst JR, Hutteman M, Kuppen PJ, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Background: The sentinel lymph node procedure has been proposed to improve nodal staging in colon cancer patients. The aim of this study was to assess the added value of near-infrared (NIR) fluorescence imaging to conventional blue dye staining for ex vivo sentinel lymph node mapping. Materials and methods: We included 22 consecutive patients undergoing surgery for colon cancer. After tumor resection, we submucosally injected a premixed cocktail of the near-infrared lymphatic tracer HSA800 and b... Abstract

Cited 23 times since 2013 (1.8 per year) source: EuropePMC

Journal of affective disorders, Volume 147, Issue 1-3, 23 4 2013, Pages 9-16 Bridging the gap for ethnic minority adult outpatients with depression and anxiety disorders by culturally adapted treatments. van Loon A, van Schaik A, Dekker J, Beekman A

Background: Culturally adapted guideline driven depression and anxiety treatments have been developed for ethnic minority patients in Western countries to boost effectiveness for these growing and vulnerable groups. The aims of this study are to systematically review the empirical literature of outcomes associated with culturally adapted guideline driven depression and anxiety interventions, to describe the cultural adaptation and to identify the contribution of the cultural adaptation and appro... Abstract

Cited 91 times since 2013 (7.2 per year) source: EuropePMC

International journal of cardiology, Volume 168, Issue 3, 23 4 2013, Pages 1965-1974 T-cell co-stimulation by CD28-CD80/86 and its negative regulator CTLA-4 strongly influence accelerated atherosclerosis development. Ewing MM, Karper JC, Abdul S, de Jong RC, Peters HA, de Vries MR, Redeker A, Kuiper J, Toes RE, Arens R, Jukema JW, Quax PH

Objective: T-cells are central to the immune response responsible for native atherosclerosis. The objective of this study is to investigate T-cell contribution to post-interventional accelerated atherosclerosis development, as well as the role of the CD28-CD80/86 co-stimulatory and Cytotoxic T-Lymphocyte Antigen (CTLA)-4 co-inhibitory pathways controlling T-cell activation status in this process. Methods and results: The role of T-cells and the CD28-CD80/86 co-stimulatory and CTLA-4 co-inhibitor... Abstract

Cited 9 times since 2013 (0.7 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 15, Issue 5, 22 4 2013, Pages 690-696 Duty-cycled bipolar/unipolar radiofrequency ablation for symptomatic atrial fibrillation induces significant pulmonary vein narrowing at long-term follow-up. Compier MG, Leong DP, Marsan NA, Delgado V, Zeppenfeld K, Schalij MJ, Trines SA

Aims: A novel duty-cycled bipolar/unipolar ablation catheter pulmonary vein ablation catheter (PVAC) has been developed to achieve pulmonary vein (PV) isolation in patients with atrial fibrillation (AF). Ablation with PVAC was recently found to induce PV narrowing at 3 months follow-up. The long-term effects of this catheter on PV dimensions are however unknown and were evaluated with this study. Methods and results: Patients (n = 62, 71% male, age 60 ± 7 years) with drug-refractory AF scheduled... Abstract

Cited 68 times since 2013 (5.4 per year) source: EuropePMC

PloS one, Volume 8, Issue 1, 22 4 2013, Pages e53882 A clinical evaluation of statin pleiotropy: statins selectively and dose-dependently reduce vascular inflammation. van der Meij E, Koning GG, Vriens PW, Peeters MF, Meijer CA, Kortekaas KE, Dalman RL, van Bockel JH, Hanemaaijer R, Kooistra T, Kleemann R, Lindeman JH

Statins are thought to reduce vascular inflammation through lipid independent mechanisms. Evaluation of such an effect in atherosclerotic disease is complicated by simultaneous effects on lipid metabolism. Abdominal aortic aneurysms (AAA) are part of the atherosclerotic spectrum of diseases. Unlike atherosclerotic occlusive disease, AAA is not lipid driven, thus allowing direct evaluation of putative anti-inflammatory effects. The anti-inflammatory potency of increasing doses (0, 20 or 40 mg/day... Abstract

Cited 44 times since 2013 (3.5 per year) source: EuropePMC

Journal of behavioral medicine, Volume 37, Issue 2, 19 3 2013, Pages 308-321 A self-regulation lifestyle program for post-cardiac rehabilitation patients has long-term effects on exercise adherence. Janssen V, De Gucht V, van Exel H, Maes S

As maintenance of lifestyle change and risk factor modification following completion of cardiac rehabilitation has been shown to be notoriously difficult, we developed a brief self-regulation lifestyle program for post-cardiac rehabilitation patients. Randomized-controlled trial. Following completion of cardiac rehabilitation 210 patients were randomized to receive either a lifestyle maintenance program (n = 112) or standard care (n = 98). The program was based on self-regulation principles and... Abstract

Cited 10 times since 2013 (0.8 per year) source: EuropePMC

Preventive veterinary medicine, Volume 108, Issue 4, 16 3 2013, Pages 276-284 Estimation of the reproduction ratio (R(0)) of bluetongue based on serological field data and comparison with other BTV transmission models. Santman-Berends IM, Stegeman JA, Vellema P, van Schaik G

Bluetongue virus serotype 8 (BTV-8) emerged in north-western Europe in 2006. In 2007, one of the affected countries (the Netherlands) implemented a sentinel network in dairy cattle. This data offered the opportunity to estimate transmission parameters. From our field data, the number of secondary infected cows that became infected by one infectious cow in a completely susceptible herd through the bites of infectious Culicoides i.e. the basic reproduction ratio (R(0)) was calculated. With that in... Abstract

Cited 4 times since 2013 (0.3 per year) source: EuropePMC

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Volume 56, Issue 8, 16 3 2013, Pages 1075-1077 Unraveling the dynamics of community-associated methicillin-resistant Staphylococcus aureus. Bootsma MC, Bonten MJ

Abstract

Cited 29 times since 2013 (2.3 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 145, Issue 6, 16 3 2013, Pages 1611-6, 1616.e1-4 Antifibrinolytics attenuate inflammatory gene expression after cardiac surgery. Later AF, Sitniakowsky LS, van Hilten JA, van de Watering L, Brand A, Smit NP, Klautz RJ

Objectives: Anti-inflammatory effects of tranexamic acid and aprotinin, used to abate perioperative blood loss, are reported and might be of substantial clinical relevance. The study of messenger ribonucleic acid synthesis provides a valuable asset in evaluating the inflammatory pathways involved. Methods: Whole-blood messenger ribonucleic acid expression of 114 inflammatory genes was compared pre- and postoperatively in 35 patients randomized to receive either placebo, tranexamic acid, or aprot... Abstract

Cited 62 times since 2013 (4.9 per year) source: EuropePMC

Journal of immunology (Baltimore, Md. : 1950), Volume 190, Issue 4, 14 2 2013, Pages 1659-1671 An unbiased genome-wide Mycobacterium tuberculosis gene expression approach to discover antigens targeted by human T cells expressed during pulmonary infection. Commandeur S, van Meijgaarden KE, Prins C, Pichugin AV, Dijkman K, van den Eeden SJ, Friggen AH, Franken KL, Dolganov G, Kramnik I, Schoolnik GK, Oftung F, Korsvold GE, Geluk A, Ottenhoff TH

Mycobacterium tuberculosis is responsible for almost 2 million deaths annually. Mycobacterium bovis bacillus Calmette-Guérin, the only vaccine available against tuberculosis (TB), induces highly variable protection against TB, and better TB vaccines are urgently needed. A prerequisite for candidate vaccine Ags is that they are immunogenic and expressed by M. tuberculosis during infection of the primary target organ, that is, the lungs of susceptible individuals. In search of new TB vaccine candi... Abstract

Cited 771 times since 2013 (61.2 per year) source: EuropePMC

Stem cell research, Volume 10, Issue 3, 14 2 2013, Pages 301-312 Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Arslan F, Lai RC, Smeets MB, Akeroyd L, Choo A, Aguor EN, Timmers L, van Rijen HV, Doevendans PA, Pasterkamp G, Lim SK, de Kleijn DP

We have previously identified exosomes as the paracrine factor secreted by mesenchymal stem cells. Recently, we found that the key features of reperfusion injury, namely loss of ATP/NADH, increased oxidative stress and cell death were underpinned by proteomic deficiencies in ischemic/reperfused myocardium, and could be ameliorated by proteins in exosomes. To test this hypothesis in vivo, mice (C57Bl6/J) underwent 30 min ischemia, followed by reperfusion (I/R injury). Purified exosomes or saline... Abstract

Cited 34 times since 2013 (2.7 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 99, Issue 10, 12 2 2013, Pages 722-728 Right ventricular function and survival following cardiac resynchronisation therapy. Leong DP, Höke U, Delgado V, Auger D, Witkowski T, Thijssen J, van Erven L, Bax JJ, Schalij MJ, Marsan NA

Objectives: Right ventricular (RV) function is an important prognostic marker in heart failure. However, its impact on all-cause mortality following cardiac resynchronisation therapy (CRT) independent of confounding factors has not been evaluated. Furthermore, evidence concerning the effect of CRT on RV function is limited. The study's aims were to: (1) assess the prognostic importance of RV function among CRT recipients, and (2) characterise RV functional change following CRT and its deter... Abstract

Cited 17 times since 2013 (1.3 per year) source: EuropePMC

Intensive care medicine, Volume 39, Issue 4, 10 2 2013, Pages 661-671 Effects of infection control measures on acquisition of five antimicrobial drug-resistant microorganisms in a tetanus intensive care unit in Vietnam. Schultsz C, Bootsma MC, Loan HT, Nga TT, Thao le TP, Thuy TT, Campbell J, Vien le M, Hoa NT, Hoang NV, Wit F, Chau NV, Farrar J, Bonten MJ, Yen LM

Purpose: To quantify the effects of barrier precautions and antibiotic mixing on prevalence and acquisition of five drug-resistant microorganisms within a single tetanus intensive care unit at a tertiary referral hospital in Ho Chi Minh City, Vietnam. Methods: All patients admitted within the study period were included. After a 1-year baseline period, barrier precautions were implemented and the single empirical treatment ceftazidime was changed to mixing (per consecutive patient) of three diffe... Abstract

Cited 16 times since 2013 (1.3 per year) source: EuropePMC

American journal of physiology. Lung cellular and molecular physiology, Volume 304, Issue 4, 4 1 2013, Pages L264-75 Ambrisentan reduces pulmonary arterial hypertension but does not stimulate alveolar and vascular development in neonatal rats with hyperoxic lung injury. Wagenaar GT, Laghmani el H, de Visser YP, Sengers RM, Steendijk P, Baelde HJ, Walther FJ

Ambrisentan, an endothelin receptor type A antagonist, may be a novel therapeutic agent in neonatal chronic lung disease (CLD) by blocking the adverse effects of the vasoconstrictor endothelin-1, especially pulmonary arterial hypertension (PAH)-induced right ventricular hypertrophy (RVH). We determined the cardiopulmonary effects of ambrisentan treatment (1-20 mg·kg(-1)·day(-1)) in neonatal rats with CLD in 2 models: early treatment during continuous exposure to hyperoxia for 10 days and late tr... Abstract

Cited 28 times since 2013 (2.2 per year) source: EuropePMC

Journal of bacteriology, Volume 195, Issue 6, 4 1 2013, Pages 1204-1213 Identification of CodY targets in Bacillus anthracis by genome-wide in vitro binding analysis. Château A, van Schaik W, Joseph P, Handke LD, McBride SM, Smeets FM, Sonenshein AL, Fouet A

In Gram-positive bacteria, CodY is an important regulator of genes whose expression changes under conditions of nutrient limitation. Bacillus anthracis CodY represses or activates directly or indirectly approximately 500 genes. Affinity purification of CodY-DNA complexes was used to identify the direct targets of CodY. Of the 389 DNA binding sites that were copurified with CodY, 132 sites were in or near the regulatory regions governing the expression of 197 CodY-controlled genes, indicating tha... Abstract

Cited 98 times since 2013 (7.8 per year) source: EuropePMC

International orthopaedics, Volume 37, Issue 3, 4 1 2013, Pages 489-494 The timing of ankle fracture surgery and the effect on infectious complications; a case series and systematic review of the literature. Schepers T, De Vries MR, Van Lieshout EM, Van der Elst M

Purpose: Information about the influence of delayed surgery on infectious wound complications is ambiguous. A clinical audit was performed to test the hypothesis that early surgery lowers the rate of infectious wound complications. Secondly we looked at the influence of surgical delay and complications on patient reported functional outcome. Methods: All consecutive, closed distal fibular fractures treated surgically with a plate were included and retrospectively analysed for the delay in operat... Abstract

Cited 28 times since 2013 (2.2 per year) source: EuropePMC

Trends in cardiovascular medicine, Volume 23, Issue 3, 3 1 2013, Pages 71-79 Visualizing novel concepts of cardiovascular calcification. Hjortnaes J, New SE, Aikawa E

Cardiovascular calcification is currently viewed as an active disease process similar to embryonic bone formation. Cardiovascular calcification mainly affects the aortic valve and arteries and is associated with increased mortality risk. Aortic valve and arterial calcification share similar risk factors, including age, gender, diabetes, chronic renal disease, and smoking. However, the exact cellular and molecular mechanism of cardiovascular calcification is unknown. Late-stage cardiovascular cal... Abstract

Cited 1 times since 2013 (0.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 61, Issue 3, 1 1 2013, Pages 357-385 Highlights of the year in JACC 2012. DeMaria AN, Bax JJ, Feld GK, Greenberg BH, Hall JL, Hlatky MA, Lew WY, Lima JA, Mahmud E, Maisel AS, Narayan SM, Nissen SE, Sahn DJ, Tsimikas S

Abstract

Studies in health technology and informatics, Volume 194, 1 1 2013, Pages 126-132 How to co-develop services, work, and information systems in healthcare: the daisy approach. Korpela M, Ikävalko P, Luukkonen I, Martikainen S, Palmén M, Tiihonen T, Toivanen M, Vainikainen V

Information systems in healthcare need to be designed and developed in a collaborative way. However, existing collaborative methodologies for the parallel development of healthcare work and information systems are vague and fragmented. Furthermore, they neither address people-centred healthcare nor limited-resource contexts. In this paper we introduce an emerging holistic approach, based on a unifying theoretical basis, for co-developing the services, work and information systems in healthcare.... Abstract

Cited 1 times since 2013 (0.1 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 8, Issue 9, 1 1 2013, Pages 1103-1109 How should I treat acute aortic annulus rupture during transcatheter aortic valve implantation? Debonnaire P, Van Herck PL, Katsanos S, van der Kley F, de Weger A, Palmen M, Marsan NA, Schalij MJ, Delgado V

Abstract